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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
Krabbe
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "Krabbe" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-N7745
CAS No.: 52050-17-6
Synonyms: Glucopsychosine; Lyso-Gb1; Lyso-GL1
Target:
1
1 Cited Publications
Target:
Research Areas:
Acid Ceramidase-IN-1 is orally active and blood-brain barrier penetrant acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 μM). Acid Ceramidase-IN-1 reduces AC activity, accumulates ceramide species (Cer (d18:0/16:0), Cer (d18:1/16:0)), and decreases sphingosine levels. Acid Ceramidase-IN-1 can be used for the study of severe neurological lysosomal storage diseases (LSDs) such as Gaucher’s disease (GD) and Krabbe’s disease (KD) .
Target:
Research Areas:
Psychosine (Galactosylsphingosine), a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease . Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell types including, most relevantly to globoid cell leukodystrophy (GLD), oligodendrocytes. Psychosine causes cell death at least in part via apoptosis. Psychosine also is an inhibitor of PKC .
Synonyms: Galactosylsphingosine-d5
Cat. No.: HY-136490S1
CAS No.: 2315262-31-6
Synonyms: Galactosylsphingosine-d7
Cat. No.: HY-N7745S2
CAS No.: 299172-48-8
Synonyms: Glucopsychosine-13C6; Lyso-Gb1-13C6; Lyso-GL1-13C6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
