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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
Lipase inhibitory activity
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "Lipase inhibitory activity" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-N7072
CAS No.: 84929-27-1
Category:
Natural Products Vitis vinifera cv. Zalema Metabolic Disease Plants Vitaceae Disease Research Fields Inflammation/Immunology
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1
1 Cited Publications
Cat. No.: HY-18540
CAS No.: 1402612-55-8
Research Areas:
KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC50 of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGLα. KT109 shows inhibitory activity against PLA2G7 (IC50=1 µM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-Arachidonoylglycerol (HY-W011051), Arachidonic acid (HY-109590) and eicosanoids in mouse peritoneal macrophages .
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1 Cited Publications
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XEN445 is a potent, selective and orally active endothelial lipase (EL) inhibitor with an IC50 value of 0.237 μM. XEN445 selectively inhibits phospholipase enzymatic activity of LIPG. XEN445 raises plasma HDL and cholesterol levles. XEN445 induces G1 cell cycle arrest, reduces cell viability, suppresses cancer stem cell self-renewal, and inhibits tumor formation in LIPG-expressing triple-negative breast cancer cells, while showing no inhibitory effect on invasiveness or cancer stem cell stemness in these cells. XEN445 can be used for the research of cancer and metabolic disease, such as triple-negative breast cancer .
Cat. No.: HY-18522
CAS No.: 1312782-34-5
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AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. AA26-9 shows inhibitory activity against approximately 1/3 of the 40+ serine hydrolases detected in immortalized T cell lines .
Cat. No.: HY-N0555
CAS No.: 26339-90-2
Category:
Triterpenes Hippocastanaceae Terpenoids Aesculus hippocastanum Metabolic Disease Plants Disease Research Fields
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Cat. No.: HY-126031A
CAS No.: 2055172-61-5
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(S)-KT109 is an inhibitor of diacylglycerol lipase β (DAGLβ) with low inhibitory activity (IC50 = 39.81 nM). (S)-KT109 has relatively low inhibitory activity against DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC50 = 794.3 nM). (S)-KT109 also has relatively low inhibitory activity against α/β-amidase domain-containing 6 (ABHD6) (IC50 = 630.9 nM) .
Cat. No.: HY-126564
CAS No.: 76808-16-7
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Cat. No.: HY-112828
CAS No.: 1800327-36-9
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LEI105 is a highly selective and reversible diacylglycerol lipase (DAGL) inhibitor that exhibits significant inhibitory activity against human DAGLα and DAGLβ (e.g., the pIC50 value against human DAGLα is 8.5, and the IC50 against human DAGLβ is 32 nM). LEI105 effectively reduces intracellular 2-arachidonoylglycerol levels and inhibits CB1 receptor-mediated short-term synaptic plasticity. LEI105 can be used to investigate the on-demand biosynthesis of 2-AG in retrograde signaling .
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3,4,5-Trihydroxycinnamic acid decyl ester is an excellent inhibitor of lipid absorption and accumulation, with anti-obesity properties. 3,4,5-Trihydroxycinnamic acid decyl ester is a pancreatic lipase inhibitor, with an EC50 of approximately 0.9 μM .
4-Nitrophenyl octanoate (p-Nitrophenyl caprylate) is an aromatic ester compound which can be used as a substrate for pancreatic lipase.
4-Nitrophenyl octanoate contains an ester bond that can be hydrolyzed under the action of lipase, releasing p-nitrophenol as a yellow product.
4-Nitrophenyl octanoate can be used to assay the activities of lipases and esterases .
Cat. No.: HY-N0555R
CAS No.: 26339-90-2
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Cat. No.: HY-N11999
CAS No.: 838826-34-9
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Cat. No.: HY-W719455
CAS No.: 55483-00-6
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Cat. No.: HY-N17777
CAS No.: 1403937-45-0
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Cat. No.: HY-187714
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α-Glucosidase-IN-123, a hybrid derivative of baicalein and cinnamic acid, acts as an inhibitor of α-glucosidase. α-Glucosidase-IN-123 enhances glucose uptake in insulin-resistant hepatocytes without significant cytotoxicity. α-Glucosidase-IN-123 exhibits lipase inhibitory activity and DPPH free radical scavenging activity, and it can be used in the research of type 2 diabetes .
Cat. No.: HY-N21863
CAS No.: 105591-35-3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
