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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
Lomitapide
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "Lomitapide" in MCE Product Catalog:
7
7 Cited Publications
Synonyms: AEGR-733; BMS-201038
Research Areas:
Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.
7
7 Cited Publications
Synonyms: AEGR-733 mesylate; BMS-201038 mesylate
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Lomitapide (AEGR-733; BMS-201038) mesylate is an orally active microsomal triglyceride transfer protein (MTP) inhibitor and a selective mTORC1 inhibitor with lipid-lowering activity and BBB permeability. Lomitapide mesylate significantly reduces plasma LDL levels by blocking the assembly and secretion of very-low-density lipoprotein (VLDL). Lomitapide mesylate inhibits mTORC1 in an ATP-dependent manner, thereby inducing AMPK-independent autophagic cell death and suppressing cancer cell growth and apoptosis. Lomitapide mesylate also enhances tumor infiltration of CD8 + T cells. In addition, Lomitapide mesylate inhibits HDAC, improves endothelial function, effectively alleviates vascular inflammation and oxidative stress, and exerts neuroprotective effects in a cerebral ischemia/reperfusion injury model. Lomitapide mesylate can be used in research on related diseases such as colorectal cancer, breast cancer, melanoma, ischemic stroke, and familial hypercholesterolemia .
Cat. No.: HY-14667R
CAS No.: 182431-12-5
Synonyms: AEGR-733 (Standard); BMS-201038 (Standard)
Research Areas:
Lomitapide (Standard) is the analytical standard of Lomitapide. This product is intended for research and analytical applications. Lomitapide (AEGR-733; BMS-201038) is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.
Cat. No.: HY-14668R
CAS No.: 202914-84-9
Synonyms: AEGR-733 mesylate (Standard); BMS-201038 mesylate (Standard)
Research Areas:
Lomitapide (mesylate) (Standard) is the analytical standard of Lomitapide (mesylate). This product is intended for research and analytical applications. Lomitapide (AEGR-733; BMS-201038) mesylate is a highly effective MTP protein inhibitor with an in vitro IC50 value of 8nM.
Cat. No.: HY-14667S
CAS No.: 2459377-96-7
Synonyms: AEGR-733-d8; BMS-201038-d8
Cat. No.: HY-14667S1
CAS No.: 857296-42-5
Synonyms: AEGR-733-d4; BMS-201038-d4
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Protocols
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