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MCAK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aurora Kinase (1) Kinesin (3) Microtubule/Tubulin (2) Mitosis (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-173522

KIF2C-IN-1	Kinesin Microtubule/Tubulin	Cancer
KIF2C-IN-1 is a cell-penetrating, selective KIF2C inhibitor with fluorescent properties (E_x/E_m = 410/510 nm). KIF2C-IN-1 exhibits notable cytotoxicity and weak inhibitory effects on KIF2A/B. KIF2C-IN-1 prohibits the dissociation of KIF2C from microtubules. KIF2C-IN-1 inhibiting KIF2C reverses cross-resistance to microtubule-targeting agents. KIF2C-IN-1 reduces tumorigenesis in chemoresistant triple-negative breast cancer (TNBC) model in mice with the combination of Paclitaxel (HY-B0015) .

HY-122236

UMK57	Mitosis Kinesin Microtubule/Tubulin Aurora Kinase	Cancer
UMK57 is a *MCAK* activator and kinetochore-microtubule destabilizer. UMK57 enhances *MCAK*-dependent microtubule depolymerization, increases kinetochore-microtubule turnover, reduces chromosome mis-segregation and lagging chromosomes, and inhibits cancer cell proliferation. UMK57 triggers adaptive resistance in Aurora B cancer cells via reversible Aurora B signaling pathway alterations. UMK57 can be used for the research of solid tumors .

HY-RS07284

KIF2C Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
KIF2C Human Pre-designed siRNA Set A contains three designed siRNAs for KIF2C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

KIF2C Human Pre-designed siRNA Set A KIF2C Human Pre-designed siRNA Set A

HY-RS20434

Kif2c Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kif2c Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kif2c gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kif2c Mouse Pre-designed siRNA Set A Kif2c Mouse Pre-designed siRNA Set A

HY-177898

DHTP	Kinesin	Cancer
DHTP is a kinesin-13 family of microtubule depolymerases selective allosteric inhibitor that inhibits kinesin-13 ATPase activity and microtubule depolymerization activity. DHTP inhibits Kif2a and *MCAK* with IC₅₀ values of 1.2 μM and 4.6 μM, respectively, and does not inhibit other kinesin families. DHTP modulates microtubule dynamics in cells, leading to less dynamic microtubules. DHTP links kinesin-13 overexpression to cancer and Paclitaxel (HY-B0015) resistance. DHTP can be used for the research of cancer .

HY-RS26943

Kif2c Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kif2c Rat Pre-designed siRNA Set A contains three designed siRNAs for Kif2c gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kif2c Rat Pre-designed siRNA Set A Kif2c Rat Pre-designed siRNA Set A

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82669

	MCAK Antibody (YA2414) KIF2C; KNSL6; Kinesin-like protein KIF2C; Kinesin-like protein 6; Mitotic centromere-associated kinesin; MCAK	WB, ICC/IF, FC	Human
	MCAK Antibody (YA2414) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MCAK.

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KIF2C Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
KIF2C Human Pre-designed siRNA Set A contains three designed siRNAs for KIF2C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kif2c Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Kif2c Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kif2c gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kif2c Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Kif2c Rat Pre-designed siRNA Set A contains three designed siRNAs for Kif2c gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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