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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
MID
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "MID" in MCE Product Catalog:
7
7 Cited Publications
Target:
Forschungsgebiete:
LM11A-31 dihydrochloride, a non-peptide p75 NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 dihydrochloride is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. LM11A-31 dihydrochloride reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression .
7
7 Cited Publications
Target:
Forschungsgebiete:
LM11A-31, a non-peptide p75 NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. LM11A-31 reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression .
Art. -Nr.: HY-P99317
CAS. Nr.: 955085-14-0
Synonyms: LY-2062430
Target:
Forschungsgebiete:
Solanezumab (LY-2062430) is a humanized monoclonal IgG1 antibody directed against the mid-domain of the amyloid-β (Aβ) peptide. Solanezumab binds to the mid-domain of monomeric amyloid-beta to slow brain amyloid accumulation. Solanezumab can be used for the research of Alzheimer’s disease .
Art. -Nr.: HY-W854844A
CAS. Nr.: 3065021-33-9
Forschungsgebiete:
JP-2-196 (TFA) is a molecular glue handle that can bind to the E3-ubiquitin ligases (RNF126, LRSAM1, RNF40, MID2, and RNF14) in vitro. JP-2-196 (TFA) can be used to synthesize molecular glue degraders .
Art. -Nr.: HY-W683499
CAS. Nr.: 13197-76-7
Synonyms: LHSB
Target:
Forschungsgebiete:
Lauryl hydroxysultaine, 35% in H2O (LHSB) is a zwitterionic surfactant used in mid-to-high-end shampoos and body washes. Lauryl hydroxysultaine, 35% in H2O can also be applied in oil extraction, metal rust-preventive cleaners, paint removers, hard surface cleaners, and other fields .
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Forschungsgebiete:
MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake .
Art. -Nr.: HY-176975
CAS. Nr.: 3056559-92-0
Target:
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
DRP1 Allosteric-IN-3 (Compound 2b) is an allosteric inhibitor of DRP1. Its IC50 value for the DRP1:MiD49 protein-protein interaction is 11 μM. DRP1 Allosteric-IN-3 can be used to study various diseases related to mitochondrial division disorders .
Art. -Nr.: HY-P5444
CAS. Nr.: 149924-99-2
Art. -Nr.: HY-W710399
CAS. Nr.: 17708-08-6
Synonyms: DG(16:0/0:0/18:0); 1-Palmitin-3-Stearin
Target:
Forschungsgebiete:
1-Palmitoyl-3-stearoyl-rac-glycerol is a diacylglycerol that contains palmitic acid (HY-N0830) at the sn-1 position and stearic acid (HY-B2219) at the sn-3 position. It has been found in palm-based diacylglycerols produced from palm stearin, palm mid fraction, palm oil, and palm olein, as well as in wheat bran and brewer’s spent grain extracts.
Art. -Nr.: HY-W854844B
Forschungsgebiete:
JP-2-196 hydrochloride is a molecular glue that covalently targets the RING family E3 ligase RNF126. JP-2-196 hydrochloride also binds to RNF40, MID2, RNF219, RNF14, and LRSAM1. JP-2-196 hydrochloride induces the formation of ternary complexes between RNF126 and target proteins (e.g., BRD4, AR-V7), thereby promoting their ubiquitination and proteasomal degradation. JP-2-196 hydrochloride has potential for cancer research (such as prostate cancer and leukemia) .
Art. -Nr.: HY-RS08434
Target:
Forschungsgebiete:
MID1 Human Pre-designed siRNA Set A contains three designed siRNAs for MID1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS08436
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Forschungsgebiete:
MID2 Human Pre-designed siRNA Set A contains three designed siRNAs for MID2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS08435
Target:
Forschungsgebiete:
MID1IP1 Human Pre-designed siRNA Set A contains three designed siRNAs for MID1IP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS19281
Target:
Forschungsgebiete:
Mid1ip1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mid1ip1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS25771
Target:
Forschungsgebiete:
Mid1ip1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mid1ip1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-N12921
CAS. Nr.: 42513-42-8
Category:
Target:
Art. -Nr.: HY-RS18951
Target:
Forschungsgebiete:
Mid1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mid1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS25441
Target:
Forschungsgebiete:
Mid1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mid1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-P812014
Synonyms: MIG12, MID1IP1, MID1-interacting protein 1, Gastrulation-specific G12-like protein, MID1-interacting G12-like protein, Protein STRAIT11499, Spot 14-related protein, S14R, Spot 14-R
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
