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Results for "

Metalloproteases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADAMTS (2) Amino Acid Derivatives (1) Angiotensin-converting Enzyme (ACE) (3) Apoptosis (1) Bacterial (8) Biochemical Assay Reagents (1) Collagen (1) COX (1) DNA/RNA Synthesis (1) Drug Derivative (1) Drug Intermediate (1) Elastase (1) Endogenous Metabolite (5) ERK (2) Fluorescent Dye (1) HSV (1) IDE (1) IFNAR (1) Interleukin Related (2) JNK (2) MMP (20) Neprilysin (2) Prostaglandin Receptor (1) Proteasome (2) Reference Standards (3) SARS-CoV (3) Ser/Thr Protease (2) TGF-beta/Smad (1) Toll-like Receptor (TLR) (1) TRP Channel (1)
By Research Areas:	Cancer (19) Cardiovascular Disease (6) Infection (8) Inflammation/Immunology (9) Metabolic Disease (6) Neurological Disease (2)

By Targets:

ADAMTS (2)

Amino Acid Derivatives (1)

Angiotensin-converting Enzyme (ACE) (3)

Apoptosis (1)

Bacterial (8)

Biochemical Assay Reagents (1)

Collagen (1)

COX (1)

DNA/RNA Synthesis (1)

Drug Derivative (1)

Drug Intermediate (1)

Elastase (1)

Endogenous Metabolite (5)

ERK (2)

Fluorescent Dye (1)

HSV (1)

IDE (1)

IFNAR (1)

Interleukin Related (2)

JNK (2)

MMP (20)

Neprilysin (2)

Prostaglandin Receptor (1)

Proteasome (2)

Reference Standards (3)

SARS-CoV (3)

Ser/Thr Protease (2)

TGF-beta/Smad (1)

Toll-like Receptor (TLR) (1)

TRP Channel (1)

By Research Areas:

Cancer (19)

Cardiovascular Disease (6)

Infection (8)

Inflammation/Immunology (9)

Metabolic Disease (6)

Neurological Disease (2)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15768

Ilomastat Maximum Cited Publications 61 Publications Verification GM6001; Galardin	MMP	Cancer
Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC₅₀s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a K_i of 0.4 nM for human skin fibroblast collagenase (MMP-1).

HY-N0431

Astragaloside IV 30+ Cited Publications	MMP ERK JNK	Cancer
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.

HY-100211

TAPI-2 5 Publications Verification TNF Protease Inhibitor 2	MMP SARS-CoV	Cancer
TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC₅₀ of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .

HY-107394

UK 356618 5+ Cited Publications	MMP	Inflammation/Immunology Cancer
UK 356618 (Compound 4j) is a potent and selective inhibitor of *matrix metalloprotease-3 (MMP-3)* with an IC₅₀ of 5.9 nM. UK 356618 is less potent against MMP-1, MMP-2, MMP-9, MMP-13 and MMP-14 compared with MMP-3 .

HY-18208

Omapatrilat 2 Publications Verification BMS-186716	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Omapatrilat is a dual inhibitor of the metalloproteases ACE and NEP with K_i values of 0.64 and 0.45 nM, respectively.

HY-N2021A

Phosphoramidon disodium	MMP Angiotensin-converting Enzyme (ACE) Neprilysin Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Cancer
Phosphoramidon disodium, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC₅₀ of 0.4 μg/mL. Phosphoramidon disodium also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC₅₀ values of 3.5, 0.034, and 78 μM, respectively .

HY-E70196

Endoproteinase Asp-N (MS grade) Asp-N	MMP	Others
Endoproteinase Asp-N (MS grade) is a metalloprotease that can specifically cleave the N-terminal side of aspartyl and cysteic acid residues .

HY-155482

NA-184 1 Publications Verification	Proteasome	Neurological Disease
NA-184 is a selective and brain-penetrant calpain-2 inhibitor with an IC₅₀ of 134 nM for mouse calpain-2. NA-184 has weak inhibitory activity on calpain-1 (IC₅₀ of 2826 nM). NA-184 does not exhibit significant inhibition on a variety of other cysteine-, serine- or metallo-proteases. NA-184 shows significant neuroprotection and can be used for the study of traumatic brain injury (TBI) .

HY-E70562

Mucinase StcE	Bacterial	Infection Cancer
Mucinase StcE is a zinc metalloproteinase belonging to the M66 family, which is secreted by enterohemorrhagic Escherichia coli via the type II general secretion pathway. Mucinase StcE specifically recognizes and cleaves the '*TXT' motif in mucin-type glycoproteins with α-O-glycans (such as MUC2, Mucin 7, Glycoprotein 340, CD45, CD43, C1 Esterase Inhibitor** (HY-P991629), etc.). By degrading the mucus layer to reduce its viscosity, inhibiting complement cascade activation, and localizing complement regulatory factors to the cell membrane, Mucinase StcE helps bacteria penetrate the mucosal barrier, adhere to host cells, and evade immune clearance. Mucinase StcE can serve as a mucin-specific proteolytic tool for research on mucinous carcinomas derived from the colon, esophagus, and salivary glands .

HY-135710

ADAMTS-5-IN-2	ADAMTS Bacterial	Infection Inflammation/Immunology
ADAMTS-5-IN-2 is an inhibitor of ADAMTS-5 (IC₅₀: 9.6 μM) and BoNT/A LC (IC₅₀: 0.71 μM). ADAMTS-5-IN-2 can be used in research related to botulism, osteoarthritis, and other conditions .

HY-110197

6bK TFA 2 Publications Verification	IDE	Metabolic Disease
6bK TFA is a selective insulin-degrading enzyme (IDE) inhibitor with an IC₅₀ of 50 nM. 6bK TFA binds to the distal pocket of IDE, thereby blocking substrate binding, peptide unfolding and cleavage processes, and reducing the degradation of insulin, glucagon and amylin. 6bK TFA improves oral glucose tolerance but impairs intraperitoneal glucose tolerance. 6bK TFA can be used in research related to type 2 diabetes .

HY-P2980

Carboxypeptidase A, Bovine pancreas EC 3.4.2.1	Endogenous Metabolite	Others
Carboxypeptidase A, Bovine pancreas (EC 3.4.2.1) is a zinc-containing metalloprotease, is often used in biochemical studies. Carboxypeptidase A catalyzes the hydrolysis of the peptide bonds that are adjacent to the C-terminal end of a polypeptide chain. Carboxypeptidase A is a prototypical enzyme for metalloproteases that plays important roles in biological systems .

HY-N0431R

Astragaloside IV (Standard)	Reference Standards MMP ERK JNK	Cancer
Astragaloside IV (Standard) is the analytical standard of Astragaloside IV. This product is intended for research and analytical applications. Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.

HY-162284

BAY-9835	ADAMTS	Cardiovascular Disease
BAY-9835, a chemical probe, is an orally active ADAMTS7 and ADAMTS12 antagonist with IC₅₀s of 6 nM and 30 nM, respectively. BAY-9835 exhibits inhibitory potencies vs mouse (mIC₅₀ = 8 nM) and rat (rIC₅₀ = 27 nM) ADAMTS7 enzymes. BAY-9835 is very selective against a range of off-targets and metalloproteases. BAY-9835 can be used for the study of atherogenesis .

HY-E70127

Serratiopeptidase Brasan; Dasen	Ser/Thr Protease COX Bacterial Prostaglandin Receptor Interleukin Related	Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology Cancer
Serratiopeptidase (Brasan; Dasen) is an orally active zinc-containing metalloprotease belonging to the serralysin family. Serratiopeptidase reduces the release of inflammatory mediators such as prostaglandins, thromboxanes and interleukins by inhibiting COX, thereby relieving pain, swelling and redness. Serratiopeptidase exhibits antibiofilm, mucolytic and wound-healing activities. As a serine protease, Serratiopeptidase has the ability to dissolve blood clots, fibrin and atherosclerotic plaques. Serratiopeptidase degrades amyloid fibrils and has potential anti-Alzheimer's effects. Serratiopeptidase shows cytotoxicity against colon cancer cells .

HY-P3722

Mca-PLAQAV-Dpa-RSSSR-NH2 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent substrate peptide that can be used to detect ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17). Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-162038

RXP03	MMP	Others
RXP03 is a MMPs inhibitor with the K_i of 20 nM, 2.5 nM, 10 nM, 5nM and 105 nM for MMP-2, MMP-8, MMP-9, MMP-11, MMP-14, respectively .

HY-W101299

*N-Acetyl-D-allo-isoleucine*	Amino Acid Derivatives	Metabolic Disease
N-Acetyl-D-allo-isoleucine is an amino acid derivative. N-Acetyl-D-allo-isoleucine is promising for research of amino acid metabolism, such as abnormal isoleucine metabolism .

HY-147745

MMP2-IN-2	MMP	Cancer
MMP2-IN-2 (compound 42) is a potent and selective MMP-2 (matrix metalloproteinases) inhibitor, with an IC₅₀ of 4.2 μM. MMP2-IN-2 also shows inhibitory activity against MMP-13, MMP-9 and MMP-8, with IC₅₀ values of 12, 23.3, and 25 μM, respectively .

HY-N2021

Phosphoramidon	MMP Angiotensin-converting Enzyme (ACE) Neprilysin Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Cancer
Phosphoramidon, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC₅₀ of 0.4 μg/mL. Phosphoramidon also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC₅₀ values of 3.5, 0.034, and 78 μM, respectively .

HY-P4582

Suc-Phe-Ala-Ala-Phe-pNA Suc-FAAF-pNA	Ser/Thr Protease	Others
Suc-Phe-Ala-Ala-Phe-pNA (Suc-FAAF-pNA) is a chromogenic polypeptide substrate that can be used for the quantitative activity assay of intracellular subtilisin (ISP) and neutral metalloprotease (NPS) derived from Saccharomonospora canescens. Suc-Phe-Ala-Ala-Phe-pNA is hydrolyzed by the catalytic triad of mature proteases to release the chromophore pNA. Suc-Phe-Ala-Ala-Phe-pNA is applicable to enzymological studies .

HY-P5419A

WAAG-3R TFA	Biochemical Assay Reagents	Others
WAAG-3R TFA is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)

HY-N4298

Epitheaflagallin 3-O-gallate	MMP	Metabolic Disease Inflammation/Immunology
Epitheaflagallin 3-O-gallate is a minor polyphenol in black tea. Epitheaflagallin 3-O-gallate exhibits versatile physiological functions in vivo and in vitro, including antioxidative activity, pancreatic lipase inhibition, Streptococcus sorbinusglycosyltransferase inhibition, and an inhibiting effect on the activity of matrix metalloprotease-1 and -3 and their synthesis by human gingival fibroblasts .

HY-14237

SC-77964	MMP	Inflammation/Immunology Cancer
SC-77964 is a potent, selective and orally active matrix metalloprotease (MMP) inhibitor. SC-77964 shows IC₅₀ values < 0.1 nM against MMP-2, MMP-9, and MMP-13. SC-77964 can be used for the research of cancer and inflammation, such as melanoma .

HY-15768R

Ilomastat (Standard) GM6001 (Standard); Galardin (Standard)	MMP Reference Standards	Cancer
Ilomastat (Standard) is the analytical standard of Ilomastat. This product is intended for research and analytical applications. Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC50s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a Ki of 0.4 nM for human skin fibroblast collagenase (MMP-1).

HY-P4910

Baceridin	Proteasome Apoptosis	Cancer
Baceridin is a proteasome inhibitor and a cyclic hexapeptide. Baceridin can be isolated from the culture medium of Epiphytic Bacillus. Baceridin can inhibit cell cycle progression and induce tumor cell apoptosis through a p53-independent pathway. Baceridin can be used in cancer research .

HY-P2120

Pseudobactin A	Bacterial	Others
Pseudobactin A is a non-fluorescent extracellular iron carrier produced by the plant growth-promoting bacterium Pseudomonas B10 .

HY-174313

Antibacterial agent 284	Bacterial Toll-like Receptor (TLR) Collagen	Infection Inflammation/Immunology
Antibacterial agent 284 (Compound 7) is an Antibacterial agent. Antibacterial agent 284 has a zinc-binding structure and potent inhibitory activity against Legionella pneumophila metalloprotease ProA (IC₅₀: 0.96 μM) with zinc-binding structure. Antibacterial agent 284 significantly inactivates the cleavage of collagen IV and flagellin (ProA substrates) and reduces immune evasion from the TLR5-NF-κB pathway and PMN-mediated inflammation in human lung tissue explants. Antibacterial agent 284 is promising for Legionnaires' disease research .

HY-152035

Mycobacterial Zmp1-IN-1	Bacterial	Infection Inflammation/Immunology
Mycobacterial Zmp1-IN-1 is a *mycobacterial zinc metalloprotease-1 (Zmp1)* inhibitor. Mycobacterial Zmp1-IN-1 has anti-mycobacterial activity for Mtb H37Ra in dose-dependent inhibition. Mycobacterial Zmp1-IN-1 can be used for the research of tuberculosis (TB) .

HY-167242

ZTB23(R)	Bacterial	Infection
ZTB23(R) is a potent and selective Mycobacterium tuberculosis zinc metalloproteinase-1 (Zmp1) inhibitor with K_i value of 0.054 μM. ZTB23(R) can be used for tuberculosis (TB) research .

HY-147746

MMP2-IN-3	MMP	Cancer
MMP2-IN-3 (compound 2) is a potent MMP-2 (matrix metalloproteinases) inhibitor, with an IC₅₀ of 31 μM. MMP2-IN-3 also shows inhibitory activity against MMP-9 and MMP-8, with IC₅₀ values of 26.6, and 32 μM, respectively .

HY-E70413

Amino acid arylamidase, hog kidney	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Amino acid arylamidase, hog kidney is a metalloprotease that can hydrolyze proteins or peptides containing free α-amino or α-imino groups, playing a crucial role in amino acid metabolism and protein digestion. Its hydrolytic activity can be blocked by acetylation of the N-terminus. Amino acid arylamidase, hog kidney can be used in research on hepatic diseases, biliary diseases, and heart failure .

HY-100211A

(R)-TAPI-2 (R)-TNF Protease Inhibitor 2	SARS-CoV MMP	Cancer
(R)-TAPI-2 is the isomer of TAPI-2 (HY-100211A). TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC₅₀ of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .

HY-P4905

Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2	MMP	Cancer
Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is highly selective substrate for matrix metalloproteases 12 (MMP12) substrate with a kcat/Km value of 1.8510 ⁵ M ^-1s ^-1, and poor substrate of other MMPs with the exception of MMP13* (kcat/Km = 0.5310 ⁵ M ^-1s ^-1) and MMP9* (0.33*10 ⁵ M ^-1s ^-1) .

HY-165060

(±)2-(14,15-Epoxyeicosatrienoyl) glycerol (±)2-14,15-EG	DNA/RNA Synthesis	Metabolic Disease
(±)2-(14,15-Epoxyeicosatrienoyl) glycerol ((±)2-14,15-EG) is a novel CYP450 metabolite of 2-Arachidonoyl glycerol (2-AG) in the kidney. (±)2-(14,15-Epoxyeicosatrienoyl) glycerol is a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells. (±)2-(14,15-Epoxyeicosatrienoyl) glycerol activates the metalloprotease ADAM17, which cleaves proTGF-α and releases TGF-α as a ligand that initiates the EGFR-ERK signalling pathway .

HY-P4613

*Fmoc-D-allo-Thr-OH*	Drug Derivative Drug Intermediate	Others
Fmoc-D-allo-Thr-OH is a derivative of D-allothreonine (HY-W001959), which is commonly used as a building block in solid-phase peptide synthesis (SPPS) .

HY-100211R

TAPI-2 (Standard) TNF Protease Inhibitor 2 (Standard)	MMP Reference Standards SARS-CoV	Cancer
TAPI-2 (Standard) is the analytical standard of TAPI-2 (HY-100211). This product is intended for research and analytical applications. TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .

HY-P992406

MEDI-3622	MMP IFNAR	Cancer
MEDI-3622 is a human monoclonal antibody against ADAM17. MEDI-3622 blocks the ADAM17-mediated shedding of CD16A and CD62L on NK cells, and binds with high specificity to a surface loop unique to the metalloprotease catalytic domain of ADAM17. MEDI-3622 enhances IFNγ production by NK cells when they bind to antibody-coated tumor cells. MEDI-3622 can be used in the research of ovarian cancer, Burkitt lymphoma, head and neck cancer, and colorectal cancer .

HY-P11022

TL-119 A-3302-B	Endogenous Metabolite HSV TRP Channel	Infection Cancer
TL-119 (A-3302-B) is a polypeptide. TL-119 can be isolated from the bacteria Micromonospora sp. MAG 9-7 and Saccharomonospora sp. CNQ-490. TL-119 inhibits TRPV-1. TL-119 exhibits antiviral activity against HSV-2. TL-119 possesses anticancer activity against gastric cancer and colorectal cancer .

HY-182795

Colchicine derivative-1	MMP Interleukin Related TGF-beta/Smad	Metabolic Disease
Colchicine derivative-1 is a colchicine derivative. Colchicine derivative-1 exhibits cytotoxicity against various cells. Colchicine derivative-1 arrests cancer cells at the G2/M phase of the cell cycle. Colchicine derivative-1 increases the levels of MMP-2, MMP-8, MMP-9, IL-2, IL-6, IL-17A, IL-22, IL-4, and IL-5 in the blood, inhibits the gene expression of hepatic fibrinogen α, β, γ and TGF-β1, and alleviates hepatic fibrosis symptoms in mice. Colchicine derivative-1 has antifibrotic activity and can be used in studies related to hepatic fibrosis .

HY-181647

LasB-IN-3	Bacterial Elastase	Infection
LasB-IN-3 is a protease elastase (LasB) inhibitor of Pseudomonas aeruginosa with an IC₅₀ value of 8.5 nM. LasB-IN-3 shows an IC₅₀ of 58.9 nM for the Met128Val mutant. LasB-IN-3 binds to active sites of wild-type and Met128Val mutant LasB, coordinates zinc ions, forms hydrogen bonds and CH-π interactions, and inhibits LasB proteolytic activity. LasB-IN-3 increases survival rate in LasB-induced acute lung injury mice models. LasB-IN-3 can be used for the research of Pseudomonas aeruginosa infection .

Cat. No.	Product Name	Target	Research Area