2 Results for "

NSC34396

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "NSC34396" in MCE Product Catalog:

Glaucine
Glaucine
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Cat. No.: HY-N3945
CAS No.: 475-81-0
Synonyms: O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396
Category:  

Infection Alkaloids other families Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology Glaucium flavum Papaveraceae

Target:  

Phosphodiesterase (PDE) Calcium Channel MMP NF-κB

Glaucine (O,O-Dimethylisoboldine) is an alkaloid extracted from Glaucium flavum that possesses various activities, including cough relief, bronchodilation, anti-inflammatory effects, analgesia, antipyretic properties, and anticancer effects. Glaucine acts as a selective and orally active inhibitor of phosphodiesterase 4 (PDE4), with a Ki of 3.4 µM in human bronchial tissues and polymorphonuclear leukocytes. Glaucine induces relaxation of human isolated bronchi by antagonizing calcium channels. Additionally, Glaucine inhibits the activation of NF-κB, leading to a reduction in the expression of the MMP-9 gene, thereby suppressing the migration and invasion of breast cancer cells. Therefore, Glaucine holds potential for research in asthma and breast cancer .
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Glaucine (Standard)
Glaucine (Standard)
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Cat. No.: HY-N3945R
CAS No.: 475-81-0
Synonyms: O,O-Dimethylisoboldine (Standard); S-(+)-Glaucine (Standard); NSC 34396 (Standard)
Category:  

Alkaloids other families Plants Isoquinoline Alkaloids Glaucium flavum Papaveraceae

Target:  

Reference Standards Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus

Glaucine (Standard) is the analytical standard of Glaucine. This product is intended for research and analytical applications. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 μM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities .
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