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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
46 Results for "
Na+/H+ exchanger
" in MedChemExpress (MCE) Product Catalog:
Products (46)
46 Results for "Na+/H+ exchanger" in MCE Product Catalog:
112
112 Publications Verification
Synonyms: L593754; MH 12-43; Ethylisopropylamiloride
Research Areas:
EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na +/H +-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .
112
112 Publications Verification
Synonyms: L593754 hydrochloride; MH 12-43 hydrochloride; Ethylisopropylamiloride hydrochloride
Research Areas:
EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na +/H +-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .
44
44
12
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Cariporide (HOE-642) is a selective Na +/H + exchange inhibitor.
4
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Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na +/H + exchanger (NHE-1).
3
3 Cited Publications
Synonyms: Hexamethylene amiloride; HMA
Target:
5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na +/H + exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively .
2
2 Cited Publications
Synonyms: CP-597396 hydrochloride hydrate
Target:
Research Areas:
Zoniporide hydrochloride hydrate (CP-597396 hydrochloride hydrate) is a selective Na +/H + exchanger subtype 1 (NHE1) inhibitor with cardioprotective activity, with IC50 values of 67 nM and 73 nM against rat NHE1. Zoniporide hydrochloride hydrate reduces intracellular Na + and Ca 2+ overload, preserves mitochondrial integrity, activates pro-survival ERK1/2 and STAT3 signaling pathways, reduces necrosis and apoptosis, and decreases neutrophil aggregation. Zoniporide hydrochloride hydrate is applicable to research related to myocardial ischemia-reperfusion injury and heart graft ischemia-reperfusion injury .
2
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Research Areas:
Zoniporide (CP-597396) is a selective Na +/H + exchanger subtype 1 (NHE1) inhibitor with cardioprotective activity, with IC50 values of 67 nM and 73 nM against rat NHE1. Zoniporide reduces intracellular Na + and Ca 2+ overload, preserves mitochondrial integrity, activates pro-survival ERK1/2 and STAT3 signaling pathways, reduces necrosis and apoptosis, and decreases neutrophil aggregation. Zoniporide is applicable to research related to myocardial ischemia-reperfusion injury and heart graft ischemia-reperfusion injury .
1
1 Cited Publications
Synonyms: EMD-96785 hydrochloride
Target:
Research Areas:
Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na +/H + exchange inhibitor.
Cat. No.: HY-P1769
CAS No.: 34233-50-6
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NHE3-IN-2 is a Na +/H + exchanger-3 (NHE3) inhibitor ( patent WO2001079186A1, example 6-Chlor-4-phenyl-2-chinazolinyl-guanidin) .
Cat. No.: HY-N0150R
CAS No.: 22373-78-0
Synonyms: Monensin A sodium (Standard)
Cat. No.: HY-19273R
CAS No.: 187870-78-6
Synonyms: EMD-87580 (Standard)
Research Areas:
Rimeporide (Standard) is the analytical standard of Rimeporide. This product is intended for research and analytical applications. Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).
Cat. No.: HY-106150
CAS No.: 176644-21-6
Synonyms: EMD-96785
Cat. No.: HY-P1792
CAS No.: 52580-29-7
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Cat. No.: HY-105402
CAS No.: 339532-12-6
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T 162559 is a potent and selective inhibitor of the Na+/H+ exchanger isoform NHE1 with IC50 values of 0.96 nM. T 162559 does not affect Na+/HCO3- cotransport and Na+/Ca2+ exchange. T 162559 can be used for the research of cardiovascular disease .
Cat. No.: HY-19062
CAS No.: 103898-38-0
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SM-6586 is a calcium channel antagonist and inhibitor of Na +/H + and Na +/Ca 2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.
Cat. No.: HY-19273A
CAS No.: 187870-95-7
Synonyms: EMD-87580 hydrochloride
Target:
Research Areas:
Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na +/H + exchanger (NHE-1).
Cat. No.: HY-177125
CAS No.: 1870822-78-8
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Repunapanor (compound 123) is a potent Na+/H+ exchanger 3 (NHE-3) inhibitor .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
