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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
NaPi-IIb
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "NaPi-IIb" in MCE Product Catalog:
Cat. No.: HY-159978
CAS No.: 1628848-73-6
Synonyms: EOS789
Target:
Research Areas:
Atidafonat is an orally active sodium-dependent phosphate transporter inhibitor, with IC50 values of 6.8, 1.5, and 1.7 μM against human NaPi-IIb, PiT-1, PiT-2, respectively; and IC50 values of 3.9, 1.9, and 1.7 μM against rat NaPi-IIb, PiT-1, PiT-2, respectively. Atidafonat inhibits intestinal phosphate absorption, increases fecal phosphate excretion, reduces urinary phosphate excretion, and decreases the levels of serum phosphate, FGF23, and adult parathyroid hormone. Atidafonat ameliorates ectopic thoracic aortic calcification, renal injury and hyperphosphatemia, and inhibits the expression of fibrosis markers. Atidafonat can be used for the research of hyperphosphatemia and chronic kidney disease-mineral and bone disorder (CKD-MBD) .
Cat. No.: HY-RS13193
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Research Areas:
SLC34A2 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC34A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-157066
CAS No.: 540733-03-7
Target:
Research Areas:
JTP-59557 is an orally active, stereospecific noncompetitive inhibitor of type IIb sodium/phosphate cotransporter (NaPi-IIb). JTP-59557 selectively inhibits type IIb-mediated inorganic phosphate uptake, without affecting Na +-independent inorganic phosphate transport or Na +-dependent D-glucose (HY-B0389) transport. JTP-59557 also suppresses Na +-dependent inorganic phosphate transport in intestinal brush border membrane vesicles. JTP-59557 is applicable to research related to hyperphosphatemia and hyperphosphatemia associated with chronic kidney disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
