18 Results for "

Notch2

" in MedChemExpress (MCE) Product Catalog:
Products (18)

18 Results for "Notch2" in MCE Product Catalog:

  • Targets Recommended:
  • Recombinant Proteins Recommended:
3
3 Cited Publications
Cat. No.: HY-15670
CAS No.: 1401066-79-2
Purity:  99.91%
Target:  

γ-secretase Notch

Research Areas:  

Cancer

BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC50s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity [2].
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2
2 Cited Publications
Cat. No.: HY-N6727
CAS No.: 67-99-2
Synonyms: Aspergillin
Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis [2]. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells . Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells .
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Cat. No.: HY-P99320
CAS No.: 1359940-55-8
Synonyms: OMP 59R5; Anti-Human Notch2 Recombinant Antibody

Target:  

Notch

Research Areas:  

Cancer

Tarextumab (OMP-59R5) is a cross-reactive, fully human IgG2 antibody that selectively inhibits Notch2 and Notch3 signaling. Tarextumab demonstrates broad-spectrum antitumor efficacy in xenograft models of epithelial tumors. Tarextumab can be used for the study of pancreatic cancer [2].
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Cat. No.: HY-RS09448
Research Areas:  

Others

NOTCH2 Human Pre-designed siRNA Set A contains three designed siRNAs for NOTCH2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS19796
Research Areas:  

Others

Notch2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Notch2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS26292
Research Areas:  

Others

Notch2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Notch2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P992278

Target:  

Notch

Research Areas:  

Inflammation/Immunology

Anti-Notch2 Antibody is a monoclonal antibody targeting Notch2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-Notch2 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-P86442
Synonyms: Notch2; Neurogenic locus Notch homolog protein 2; Notch 2; hN2

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, ELISA

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P71167
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AGS2; hN2; Notch homolog 2; Notch2; Notch-2; HJCYS
Species:  
Source:  
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Cat. No.: HY-P76519
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AGS2; hN2; Notch homolog 2; Notch2; Notch-2; HJCYS
Species:  
Source:  
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Cat. No.: HY-P78185
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: AGS2; Notch-2; Notch2; N2ECD; HJCYS; N2
Species:  
Source:  
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Cat. No.: HY-P704828
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AGS2; hN2; Notch homolog 2; Notch2; Notch-2; HJCYS
Species:  
Source:  
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Cat. No.: HY-RS09449
Research Areas:  

Others

NOTCH2NLA Human Pre-designed siRNA Set A contains three designed siRNAs for NOTCH2NLA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS09450
Research Areas:  

Others

NOTCH2NLC Human Pre-designed siRNA Set A contains three designed siRNAs for NOTCH2NLC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P84481
Synonyms: hN2; AGS2; HJCYS

Host:  

Mouse

Application:  

IHC-P, ICC/IF, FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-P84481A
Synonyms: hN2; AGS2; HJCYS

Host:  

Mouse

Application:  

IHC-P, ICC/IF, FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-P990206

Research Areas:  

Inflammation/Immunology

Anti-Mouse Jagged 2 Antibody (HMJ2-1) is an anti-mouse Jagged 2 IgG monoclonal antibody. Anti-Mouse Jagged 2 Antibody (HMJ2-1) regulates Treg/Th17 balance through IL-9. Anti-Mouse Jagged 2 Antibody (HMJ2-1) increases Jagged2-Notch signaling through activation of RBP-Jk. Anti-Mouse Jagged 2 Antibody (HMJ2-1) can be used for researches on inflammation conditions and xenotransplantation such as experimental autoimmune encephalomyelitis (EAE) [2] .
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Cat. No.: HY-P77107
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Notch homolog 2 N-terminal-like protein A; Notch2NLA; N2N
Species:  
Source:  
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