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Results for "

PIK3C3

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Recombinant Proteins

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12481
    SAR405
    30+ Cited Publications

    		 PI3K Autophagy Cancer
    SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM). SAR405 inhibits autophagy induced either by starvation or by mTOR inhibition. Anticancer activity .
    SAR405
  • HY-137506
    XST-14
    2 Publications Verification

    		 ULK p38 MAPK TGF-β Receptor Anaplastic lymphoma kinase (ALK) CaMK Apoptosis Cancer
    XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects .
    XST-14
  • HY-12481A
    SAR405 R enantiomer

    		PI3K Cancer
    SAR405 R enantiomer is the less active enantiomer of SAR405. SAR405 is a PIK3C3/Vps34 inhibitor.
    SAR405 R enantiomer
  • HY-RS10520
    PIK3C3 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PIK3C3 Human Pre-designed siRNA Set A contains three designed siRNAs for PIK3C3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PIK3C3 Human Pre-designed siRNA Set A
    PIK3C3 Human Pre-designed siRNA Set A
  • HY-RS10521
    Pik3c3 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Pik3c3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pik3c3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pik3c3 Mouse Pre-designed siRNA Set A
    Pik3c3 Mouse Pre-designed siRNA Set A
  • HY-RS10522
    Pik3c3 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Pik3c3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pik3c3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pik3c3 Rat Pre-designed siRNA Set A
    Pik3c3 Rat Pre-designed siRNA Set A
  • HY-122888
    MPT0L145

    		PI3K FGFR Autophagy CDK Reactive Oxygen Species (ROS) Cancer
    MPT0L145 is a PIK3C3/FGFR inhibitor, with a Kd value of 0.53 nM for PIK3C3. MPT0L145 decreases the phosphorylation of FGFR1, FGFR3 and their downstream proteins (FRS2, ERK and Akt). MPT0L145 induces G0/G1 cell cycle arrest and decreased protein levels of cyclin E. MPT0L145 promotes mitochondrial dysfunction, ROS production, and DNA damage. MPT0L145 is an autophagy inhibitor. MPT0L145 significantly sensitizes cancer cells to targeted or chemotherapeutic agents. MPT0L145 can be used for cancer research, such as bladder cancer and NSCLC .
    MPT0L145
  • HY-181062
    VWK147

    		HSP Apoptosis Autophagy ULK RIP kinase CDK Cancer
    VWK147 is a second-generation HSP90 C-terminal domain (CTD) inhibitor. VWK147 targets the CTD dimerization interface, prevents HSP90 CTD dimerization, disrupts co-chaperone PPID binding to HSP90 CTD, and inhibits HSP90 chaperone function dependent on dimerization. VWK147 reduces protein levels of HSP90 client proteins ULK1, RIPK1, and CDK4 without inducing a heat shock response. VWK147 induces cell death, including apoptosis, in Cisplatin (HY-17394)-sensitive and -resistant urothelial carcinoma cells. VWK147 induces LC3-II accumulation, inhibits autophagosome-lysosome fusion to block canonical autophagy, and induces non-canonical LC3 lipidation independent of ULK1 and PIK3C3 complexes. VWK147 can be used for the research of urothelial carcinoma .
    VWK147

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