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Results for "

PKC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PKC (356) 5-HT Receptor (7) Adenosine Kinase (2) Akt (28) Aldose Reductase (1) AMPK (9) Amyloid-β (1) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (12) Apoptosis (88) Aquaporin (2) Arrestin (1) ATM/ATR (2) Aurora Kinase (2) Autophagy (28) Bacterial (15) Bcl-2 Family (9) Beta-lactamase (3) Biochemical Assay Reagents (4) Btk (1) c-Kit (4) Cadherin (2) Calcineurin (1) Calcium Channel (16) CaMK (8) Casein Kinase (2) Caspase (13) Cathepsin (1) CDK (11) Checkpoint Kinase (Chk) (2) CMV (2) COX (4) Cytochrome P450 (2) DAGL (1) Dengue Virus (1) DNA-PK (10) DNA/RNA Synthesis (2) DOCK (3) Dopamine Receptor (4) Dopamine β-hydroxylase (2) Drug Derivative (3) Drug Metabolite (9) EGFR (6) Endogenous Metabolite (35) Environmental Pollutants (1) ERK (18) Estrogen Receptor/ERR (5) FAK (1) Ferroptosis (4) FLT3 (5) Fluorescent Dye (1) Fungal (7) G Protein-coupled Receptor Kinase (GRK) (3) GABA Receptor (2) GLUT (1) Glutathione Peroxidase (1) Glycosidase (2) GlyT (3) GPR55 (3) GSK-3 (13) HBV (4) HDAC (2) Heme Oxygenase (HO) (1) HIV (15) HSV (2) IFNAR (1) iGluR (2) IKK (3) Influenza Virus (5) Insulin Receptor (1) Integrin (2) Interleukin Related (5) Isotope-Labeled Compounds (21) JAK (4) JNK (13) Keap1-Nrf2 (6) Kisspeptin Receptor (2) Liposome (1) Lipoxygenase (2) MAGL (1) MARCKS (3) MDM-2/p53 (1) MEK (1) mGluR (5) MMP (6) MNK (3) Monoamine Oxidase (6) mRNA (2) mTOR (8) Myosin (8) nAChR (2) NADPH Oxidase (1) NF-κB (12) NO Synthase (9) NOD-like Receptor (NLR) (4) Nuclear Factor of activated T Cells (NFAT) (1) Nucleoside Antimetabolite/Analog (2) Orexin Receptor (OX Receptor) (1) Orthopoxvirus (7) p38 MAPK (18) PAK (1) Parasite (7) PARP (3) PDGFR (1) PDK-1 (2) Phosphatase (7) Phosphodiesterase (PDE) (1) Phospholipase (1) PI3K (16) PKA (35) PKD (1) Potassium Channel (1) PPAR (2) Pregnane X Receptor (PXR) (2) PROTACs (1) Protease Activated Receptor (PAR) (3) Proteasome (1) PTHR (1) Pyroptosis (1) Pyruvate Kinase (1) RABV (1) Ras (2) Reactive Oxygen Species (ROS) (18) Reference Standards (59) Reverse Transcriptase (3) ROCK (19) SARS-CoV (2) Ser/Thr Kinase (1) Ser/Thr Protease (1) Serine Racemase (SR) (1) SHP2 (2) Sirtuin (6) Small Interfering RNA (siRNA) (2) SOD (1) SphK (2) Src (3) STAT (9) Survivin (1) Syk (2) Tau Protein (1) Telomerase (2) TGF-beta/Smad (1) TGF-β Receptor (1) TNF Receptor (5) Toll-like Receptor (TLR) (2) Topoisomerase (8) Trk Receptor (4) TRP Channel (5) TSH Receptor (1) Tyrosinase (7) VEGFR (5) VSV (2)
By Research Areas:	Cancer (233) Cardiovascular Disease (35) Endocrinology (8) Infection (47) Inflammation/Immunology (104) Metabolic Disease (53) Neurological Disease (83)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) mRNA (2) Phospholipids (2) Human Pre-designed siRNA Sets (1) Antisense Oligonucleotides (1) siRNAs (2)

445

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

114

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Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Targets Recommended: PKC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13689

Go 6983 80+ Cited Publications Gö 6983; Goe 6983	PKC	Cancer
Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC₅₀ of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.

HY-10230

Midostaurin 35+ Cited Publications PKC412; CGP 41251	PKC VEGFR c-Kit NO Synthase Apoptosis	Cancer
Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

HY-10343

Sotrastaurin 20+ Cited Publications AEB071	MARCKS PKC	Inflammation/Immunology Cancer
Sotrastaurin (AEB071) is a potent and orally-active pan-PKC inhibitor, with K_is of 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively .

HY-B0719

Ingenol Mebutate 5 Publications Verification Ingenol 3-angelate; PEP005	PKC	Inflammation/Immunology Cancer
Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent *PKC* modulator, with K_is of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.

HY-107421

Prostratin 4 Publications Verification	PKC HIV	Infection Cancer
Prostratin, a natural terpenoid compound, is a *PKC* activator, with a K_i of 12.5 nM and shows inhibitory effect on HIV-1.

HY-N6791

KT5823 10+ Cited Publications	PKA PKC Bacterial Apoptosis Antibiotic	Infection Inflammation/Immunology
KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an K_i value of 0.23 μM, it also inhibits PKA and *PKC* with K_i values of 10 μM and 4 μM, respectively. KT5823 is a Staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na ⁺/I ^- symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation .

HY-109076

Tigilanol tiglate EBC-46	PKC Caspase	Cancer
Tigilanol tiglate (EBC-46) is a protein kinase C (PKC)/C1 domain activator. Tigilanol tiglate is associated with mitochondrial/endoplasmic reticulum (ER) dysfunction, leading to activation of the unfolded protein response (UPRmt/ER) and subsequent induction of ATP depletion, organelles expansion, Caspase activation, gasdermin E cleavage, and terminal necrosis. Tigilanol tiglate, as a small anti-tumor molecule with immunomodulatory effects, can be used in the study of head and neck squamous cell carcinoma and soft tissue sarcoma .

HY-131897

1-Stearoyl-2-arachidonoyl-sn-glycerol 1 Publications Verification	PKC TRP Channel Endogenous Metabolite	Neurological Disease
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate *PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC)* activity .

HY-117610A

Bisindolylmaleimide XI hydrochloride 3 Publications Verification Ro 32-0432; Ro 31-8830 hydrochloride	PKC	Inflammation/Immunology
Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is a potent, selective and orally active *PKC* inhibitor with IC₅₀s of 9 nM, 28 nM, 31 nM, 37 nM, and 108 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCε, respectively .

HY-112681

PKC-theta inhibitor 2	PKC	Others
PKC-theta inhibitor 2 is a potent and selective *PKC-θ* inhibitor with an IC₅₀ value of 18 nM .

HY-N4322

Decursinol angelate 1 Publications Verification	PKC	Inflammation/Immunology Cancer
Decursinol angelate acts as a *PKC* activator and GDH inhibitor, with an IC₅₀ of 1.432 μM against human GDH. Decursinol angelate activates *PKC, downregulates PKCα and PKCβII isoforms, and exerts cytotoxic activity against cancer cells. Decursinol angelate binds to GDH* and inhibits its enzymatic activity. Decursinol angelate inhibits VEGF-induced autophosphorylation of VEGFR2, downstream p42/44 ERK and JNK-MAPK signaling pathways, as well as the angiogenesis process. Decursinol angelate is applicable to research related to cancer and leukemia .

HY-N7144A

Citronellyl acetate	Environmental Pollutants PKC TRP Channel PKA	Neurological Disease
Citronellyl acetate, a monoterpene product of the secondary metabolism of plants, is an orally active antinociceptive agent. Citronellyl acetate modulates TRPV1, TRPM8, ASIC, glutamate receptors, *PKC, and PKA*-mediated nociception. Citronellyl acetate can be used for the research of acute pain .

HY-126146

PKC-iota inhibitor 1 2 Publications Verification	PKC AMPK	Metabolic Disease Cancer
PKC-iota inhibitor 1 is a protein kinase C-iota (PKC-ι) inhibitor with an IC₅₀ value of 0.34 μM. PKC-iota inhibitor 1 can be used for the study of cancer .

HY-126328

PKC-theta inhibitor 1	PKC Interleukin Related	Inflammation/Immunology
PKC-theta inhibitor 1 is an orally active and selective ATP-competitive inhibitor of Protein Kinase Cθ (PKCθ), with a K_i value of 6 nM. PKC-theta inhibitor 1 inhibits T-cell-mediated inflammatory responses by suppressing the release of proinflammatory cytokines (IL-2 IC₅₀ = 0.21 μM in anti-CD3/CD28-stimulated PBMCs; IL-17 IC₅₀ = 1 μM in CD3/CD28-stimulated Th17 cells) PKC-theta inhibitor 1 significantly reduces symptoms in mice with ongoing experimental autoimmune encephalomyelitis (EAE). PKC-theta inhibitor 1 can be used for the study of T-cell-mediated inflammatory diseases such as multiple sclerosis .

HY-16903

MS-553	PKC	Inflammation/Immunology
MS-553 is a potent, ATP-competitive and reversible inhibitor of conventional *PKC* enzymes with K_is of 5.3 and 10.4 nM for human PKCβ and PKCα, and IC₅₀s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM for PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε, respectively.

HY-13335

PKCβ inhibitor 1 1 Publications Verification	PKC Apoptosis	Cancer
PKCβ inhibitor 1 is a potent, ATP-competitive, and selective PKCβ inhibitor with IC₅₀s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively. PKCβ inhibitor 1 exhibits selectivity of more than 60-fold in favor of PKCβ2 relative to other PKC isozymes (PKCα, PKCγ, and PKCε) .

HY-13867A

Bisindolylmaleimide I hydrochloride 35+ Cited Publications GF109203X hydrochloride; Go 6850 hydrochloride	PKC GSK-3	Metabolic Disease Cancer
Bisindolylmaleimide I (GF109203X) hydrochloride is a cell-permeable and reversible *PKC* inhibitor (IC₅₀ of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ. Bisindolylmaleimide I hydrochloride is also a GSK-3 inhibitor .

HY-100931

SC-10	PKC	Cancer
SC-10 is a direct activator of *PKC* .

HY-P1595

CREBtide	PKA PKC	Metabolic Disease
CREBtide is a CREB (cAMP response element binding protein)-like peptide. CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA and *PKC* substrate.

HY-101195

DL-erythro-Dihydrosphingosine	PKC Phospholipase Bcl-2 Family Apoptosis MMP	Inflammation/Immunology Cancer
DL-erythro-Dihydrosphingosine is a sphingosine-based *PKC* inhibitor. DL-erythro-Dihydrosphingosine directly inhibits the enzymatic activity of PLA2. DL-erythro-Dihydrosphingosine inhibits the activity of Bcl-2 protein involved in apoptosis. DL-erythro-Dihydrosphingosine inhibits the activity of matrix metalloproteinases (MMP). DL-erythro-Dihydrosphingosine is applicable for research on cancer and inflammatory diseases .

HY-129491

O-Desmethyl Midostaurin CGP62221; O-Desmethyl PKC412	PKC	Cancer
O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo . Midostaurin is a multi-targeted protein kinase inhibitor with IC₅₀ ranging from 22-500 nM.

HY-112412

PDGFR Tyrosine kinase-IN-1	PDGFR	Neurological Disease
PDGFR Tyrosine kinase-IN-1, a multikinase inhibitor, inhibits PDGFR, EGFR, FGFR, PKA, and PKC, respectively. PDGFR Tyrosine kinase-IN-1 can be used for the research of amyotrophic lateral sclerosis .

HY-164756

PKCTheta-IN-2	PKC	Inflammation/Immunology
PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor with an IC₅₀ of 0.25 nM. PKCTheta-IN-2 shows good selectivity over a wide range of kinases, including the PKC subfamily (30 kinases). PKCTheta-IN-2 inhibits the IL-2 production in a mouse (IC₅₀ of 682 nM) .

HY-P1746

Protein Kinase C (19-31) 1 Publications Verification PKC (19-31)	PKC	Inflammation/Immunology
Protein Kinase C (19-31), a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), is used as protein kinase C substrate peptide for testing the protein kinase C activity .

HY-115767

(±)-1,2-Diolein 1,2-Dioleoyl-rac-glycerol	PKC	Others
(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) is a *PKC* activator. (±)-1,2-Diolein increases myotubes Ca ²⁺ influx .

HY-167548

L-α-Phosphatidylinositol-4,5-bisphosphate ammonium	PKC Potassium Channel	Others
L-α-Phosphatidylinositol-4,5-bisphosphate ammonium is a key signaling lipid. L-α-Phosphatidylinositol-4,5-bisphosphate ammonium is an activator of *PKC* in the presence of calcium ions and phospholipid serine. L-α-Phosphatidylinositol-4,5-bisphosphate ammonium is also an antagonist of the KIR3.4 (ATP-sensitive potassium, KATP) channel. L-α-Phosphatidylinositol-4,5-bisphosphate ammonium can be used in research related to signal transduction, ion channel regulation, and membrane transport.

HY-112291

SB 220025	p38 MAPK Src PKC	Inflammation/Immunology
SB 220025 is a reversible, orally active, cell-permeable, ATP-competitive and selective human p38 MAPK inhibitor (IC₅₀ = 60 nM). SB 220025 also inhibits p56 ^Lck and *PKC* with IC₅₀ values of 3.5 and 2.89 µM, respectively. SB 220025 inhibits the expression of IL-8 gene in response to globular adiponectin (gAd), reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 effectively prevents the progression of arthritis in a chronic inflammatory disease model and can be used in the study of inflammation .

HY-P1286

PKC β pseudosubstrate	PKC	Neurological Disease
PKC β pseudosubstrate is a selective cell-permeable inhibitor of *PKC* .

HY-120497

PKCζ-IN-1	PKC CDK	Cancer
PKCζ-IN-1 is a compound that inhibits PKCζ and CDK2, showing an IC50 value of 5.18 nM for PKCζ and 1.04 μM for CDK2, with significant selectivity of 200-fold. PKCζ-IN-1 can reduce the activity of CDK2 while inhibiting PKCζ.

HY-128142

PKC/PKD-IN-1	PKD PKC	Cardiovascular Disease
PKC/PKD-IN-1 (Compound 13C) is an orally active dual protein kinase C/D (PKC/PKD) inhibitor with an IC₅₀ value of 0.6 nM for PKD1. PKC/PKD-IN-1 can attenuate high-salt diet-induced cardiac hypertrophy and can be used in the study of heart failure .

HY-N11003

Vanicoside A 1 Publications Verification	PKC Reactive Oxygen Species (ROS)	Cancer
Vanicoside A is a phenylpropanoid glycoside. Vanicoside A can be isolated from Polygonum pensylvanicum. Vanicoside A inhibits protein kinase C (PKC), induces substantial ROS production. Vanicoside A exhibits anticancer activity against melanoma .

HY-P4987

TRAP-7	Protease Activated Receptor (PAR)	Cardiovascular Disease
TRAP-7 is a thrombin receptor (PAR) activating peptide. TRAP-7 stimulates total inositol phosphate (IP) accumulation and phosphorylation of a specific endogenous substrate for activated *PKC*. TRAP-7 can be used in cardiovascular disease research .

HY-P3818

PKCδ Peptide Substrate	PKC	Others
PKCδ Peptide Substrate is an absolutely specific substrate for the δ-type of PKC, with a sequence corresponding to sequence 422-443 of murine eEF-1α and containing Thr-431 .

HY-W013852

PKC-IN-6	Ser/Thr Kinase Tyrosinase PKA PKC EGFR	Cancer
PKC-IN-6 (Compound 21) is a selective inhibitor of tyrosine and serine kinases. PKC-IN-6 shows inhibitory activity against *PKC-α, PKC-δ, PKA, EGF-R* with IC₅₀ values of 240, >500, >500, >100 μM, respectively. PKC-IN-6 is promising for research of cancers .

HY-P1402

*[Glu27]-PKC* (19-36)**	PKC	Others
[Glu27]-PKC (19-36) is an inactive control for protein kinase C (PKC) (19-36). PKC (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C, it may be responsible for maintaining the enzyme in the inactive form in the absence of allosteric activators such as phospholipids .

HY-P1288

Protein Kinase C (530-558) PKC fragment (530-558)	PKC	Others
Protein Kinase C (530-558), a peptide fragment of protein kinase C (PKC), is a potent *PKC* activator. Protein Kinase C (530-558) significantly inhibits osteoclastic bone resorption .

HY-P3770

Phosphate acceptor peptide	PKC	Others
Phosphate acceptor peptide is a substrate for cAMP-dependent protein kinase (PKA). phosphate acceptor peptide is also a weak *PKC* inhibitor .

HY-P3940

Ac-MBP (4-14) Peptide	PKC	Others
Ac-MBP (4-14) Peptide is an acetylated MBP (4-14) peptide. MBP (4-14) Peptide is a very selective (protein kinase C) PKC substrate. Ac-MBP (4-14) Peptide can be used for PKC assay in extracts without prior purification to eliminate interfering protein kinases or phosphatases .

HY-10230S

Midostaurin-d5 PKC412-d₅; CGP 41251-d₅	Isotope-Labeled Compounds PKC Syk Akt PKA c-Kit	Cancer
Midostaurin-d₅ (PKC412-d₅) is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM .

HY-120515

7-Oxostaurosporine	PKC	Cancer
7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway .

HY-118442

Sphingosine (d14:1) Tetradecasphing-4-enine	PKC	Cancer
Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent Protein kinase C (PKC) inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters .

HY-P3816

PKCε Inhibitor Scramble Peptide	PKC	Others
PKCε Inhibitor Scramble Peptide is a scrambled peptide with identical amino acid composition to PKCε inhibitor peptide.

HY-122858A

PKCiota-IN-2 formic	PKC	Cancer
PKCiota-IN-2 formic is a potent PKCiota (PKC-ι) inhibitor with an IC₅₀ of 2.8 nM. PKCiota-IN-2 formic also inhibits *PKC-α* and *PKC-ε* with IC₅₀s of 71 nM and 350 nM, respectively .

HY-P5884A

PKCθ pseudosubstrate peptide inhibitor,myristoylated TFA	PKC	Others
PKCθ pseudosubstrate peptide inhibitor, myristoylated TFA is a synthetic peptide that can be used to study the mechanism of action of PKCθ .

HY-P5437

PKCε (85-92)	PKC	Others
PKCε (85-92) is a biological active peptide. (This peptide is the e-PKC specific activator, it also activates MARCKS phosphorylation in wild type cells, and has no effect on MARCKS phosphorylation in the cells derived from knockout mice.)

HY-P5881

PKCα (C2-4) inhibitor peptide	PKC	Cardiovascular Disease
PKCα (C2-4) inhibitor peptide is a PKCα specific inhibitor peptide that blocks the inhibition of I_Kr by the α_1A adrenoreceptor agonist A-61603 (HY-101366) .

HY-P10967

EGFR Peptide	PKC	Metabolic Disease
EGFR Peptide is a selective substrate peptide for *PKC. EGFR Peptide can used to measure PKC* activity .

HY-P5988

N-myristoyl-RKRTLRRL	PKC	Cancer
N-myristoyl-RKRTLRRL inhibits binding of *PKC* substrates. N-myristoyl-RKRTLRRL inhibits Ca ²⁺- and phosphatidylserine (PS)-dependent histone phosphorylation with IC₅₀ of 5 μM. histone phosphorylation with IC₅₀ of 80 μM .

HY-10230R

Midostaurin (Standard) PKC412 (Standard); CGP 41251 (Standard)	Reference Standards PKC VEGFR c-Kit NO Synthase Apoptosis	Cancer
Midostaurin (Standard) is the analytical standard of Midostaurin. This product is intended for research and analytical applications. Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

HY-110013

Terreic acid	Btk Antibiotic	Infection Inflammation/Immunology
Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC₅₀ of approximately 100 μM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15141

Staurosporine 205+ Cited Publications Antibiotic AM-2282; STS; AM-2282	Infection Structural Classification Alkaloids Microorganisms Classification of Application Fields Marine natural products Marine microorganism Disease Research Fields Indole Alkaloids Source Classification	PKC PKA Apoptosis Bacterial Fungal Antibiotic
Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC₅₀s of 6 nM, 15 nM, 2 nM, and 3 nM for *PKC, PKA, c-Fgr, and Phosphorylase kinase* respectively. Staurosporine also inhibits TAOK2 with an IC₅₀ of 3 μM. Staurosporine is an apoptosis inducer .

HY-18739

Phorbol 12-myristate 13-acetate Maximum Cited Publications 726 Publications Verification PMA; TPA; Phorbol myristate acetate	Ketones, Aldehydes, Acids Croton tiglium Linn. Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	PKC SphK NF-κB
Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator . Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells (Validated by MedChemExpress (MCE)) .

HY-13434

Ionomycin 115+ Cited Publications SQ23377	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) .

HY-13434A

Ionomycin calcium 115+ Cited Publications SQ23377 calcium	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) .

HY-N2027

Taurochenodeoxycholic acid 5+ Cited Publications 12-Deoxycholyltaurine	Microorganisms Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	Caspase Apoptosis Endogenous Metabolite
Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties .

HY-13502

Mitoxantrone 45+ Cited Publications Mitozantrone; NSC 301739	Infection Quinones Classification of Application Fields Anthraquinones Endogenous metabolite Disease Research Fields Source Classification Cancer	Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity . Mitoxantrone also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-N0021

Verbascoside 10+ Cited Publications Acteoside; Kusaginin; TJC160	Acanthaceae Neurological Disease Classification of Application Fields Anti-aging Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Cremanthodium helianthus (Franch.) W. W. Sm. Cancer	PKC Apoptosis Bacterial HSV
Verbascoside is isolated from Acanthus mollis, acts as an ATP-competitive inhibitor of *PKC, with an IC₅₀* of 25 μM, and has antitumor, anti-inflammatory and antineuropathic pain activity.

HY-B0719

Ingenol Mebutate 5 Publications Verification Ingenol 3-angelate; PEP005	Classification of Application Fields Terpenoids Euphorbia peplus Linn. Diterpenoids Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields	PKC
Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent *PKC* modulator, with K_is of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.

HY-N0453

Hypericin 5+ Cited Publications	Quinones Structural Classification Classification of Application Fields Anthraquinones Guttiferae Hyperlcurn perforatum L. Plants Disease Research Fields Source Classification Cancer	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of *PKC* (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-18980

Rottlerin 20+ Cited Publications Mallotoxin; NSC 56346; NSC 94525	Structural Classification Chalcones Flavonoids Classification of Application Fields Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields Mallotus philippensis Source Classification Cancer	PKC Autophagy Apoptosis HIV RABV
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific *PKC* inhibitor, with IC₅₀ values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation . Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection .

HY-101047

D-erythro-Sphingosine 4 Publications Verification Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	PKC Phosphatase Endogenous Metabolite
D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .

HY-126477

NNK 2 Publications Verification	Structural Classification Alkaloids Classification of Application Fields Pyridine Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser ⁷⁰ and c-Myc at Thr ⁵⁸ and Ser ⁶² through activation of both ERK1/2 and PKCα . NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure .

HY-W013242

Gondoic acid cis-11-Eicosenoic acid	Classification of Application Fields Cardiospermum halicacabum Ketones, Aldehydes, Acids Sapindaceae Other Diseases Plants Disease Research Fields Source Classification	Endogenous Metabolite Reactive Oxygen Species (ROS) PKC ERK STAT
Gondoic acid (cis-11-Eicosenoic acid), a monounsaturated long-chain fatty acid, is contained in a variety of plant oils and nuts. Gondoic acid can exert anti-inflammatory activity by inhibiting the production of ROS and the PKCθ/ERK/STAT3 signaling pathway. Gondoic acid can be used as a raw material for medical supplies and a moisturizing ingredient in cosmetic creams .

HY-13502A

Mitoxantrone dihydrochloride 45+ Cited Publications Mitozantrone dihydrochloride; NSC 301739 dihydrochloride	Infection Quinones Classification of Application Fields Anthraquinones Endogenous metabolite Disease Research Fields Source Classification Cancer	Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-107421

Prostratin 4 Publications Verification	Infection Classification of Application Fields Terpenoids Thymelaeaceae Diterpenoids Plants Disease Research Fields Wikstroemia chamaedaphne Meisn. Source Classification	PKC HIV
Prostratin, a natural terpenoid compound, is a *PKC* activator, with a K_i of 12.5 nM and shows inhibitory effect on HIV-1.

HY-N6732

K-252a 25+ Cited Publications SF2370; Antibiotic K 252a; Antibiotic SF 2370	Alkaloids Structural Classification Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Indole Alkaloids Source Classification	Autophagy PKA PKC Trk Receptor CaMK
K-252a, a staurosporine analog, inhibits protein kinase, with IC₅₀ values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca ²⁺/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively . K-252a is a potent inhibitor (IC₅₀ of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene .

HY-113308A

Taurolithocholic acid sodium salt 5+ Cited Publications	Structural Classification Animals Classification of Application Fields Metabolic Disease Disease Research Fields Steroids Source Classification	Calcium Channel Ferroptosis PI3K Reactive Oxygen Species (ROS) Akt HBV
Taurolithocholic acid sodium salt is an orally active bile acid and antiviral agent. Taurolithocholic acid sodium salt upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV-induced ferroptosis, viral replication and viral entry of HBV/HDV, while reducing the release of IL-1β, lipid ROS and LDH. While exerting antiviral protective effects, Taurolithocholic acid sodium salt also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid sodium salt serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid sodium salt shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid sodium salt not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis .

HY-N0152

Myricitrin 3 Publications Verification	Cardiovascular Disease Flavonols Flavonoids Classification of Application Fields Phenols Polyphenols Metabolic Disease Myrica nagi Plants Disease Research Fields Source Classification Myricaceae	PKC NO Synthase TNF Receptor Parasite
Myricitrin, a naturally occurring flavonoid, is an orally active nitric oxide (NO) and *PKC* inhibitor. Myricitrin has central nervous system activity, including anxiolytic-like action. Myricitrin possesses antioxidant, anti-inflammatory, antifibrotic and anti-malarial effects .

HY-W015546

β-N-methylamino-L-alanine hydrochloride 2 Publications Verification BMAA hydrochloride	Structural Classification Microorganisms Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Bacterial mGluR PKC
β-N-methylamino-L-alanine hydrochloride (BMAA hydrochloride) is a neurotoxin produced by cyanobacteria. β-N-methylamino-L-alanine hydrochloride activates mGluR3 and inhibits *PKC*. β-N-methylamino-L-alanine hydrochloride can be used in the research of neurodegenerative diseases and immune diseases .

HY-N0551

Wedelolactone 20+ Cited Publications	Classification of Application Fields Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields	Caspase Lipoxygenase Apoptosis
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC₅₀ of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-N1429

Taurochenodeoxycholic acid sodium 5+ Cited Publications 12-Deoxycholyltaurine sodium	Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	Apoptosis Endogenous Metabolite
Taurochenodeoxycholic acid (12-Deoxycholyltaurine) sodium is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and immune regulation properties .

HY-105231

Bryostatin 1 2 Publications Verification	Anti-inflammation/Immunoregulatory Neurological Disease Classification of Application Fields Marine natural products Other marine organisms Disease Research Infection Macrolide Antibiotics Animals Antibiotics Anticancer Inflammation/Immunology Disease Research Fields Source Classification	PKC HIV Bacterial
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable *PKC* modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with K_is of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties .

HY-N0281

Daphnetin 5+ Cited Publications 7,8-Dihydroxycoumarin	Daphne Classification of Application Fields Thymelaeaceae Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species (ROS) Caspase Bcl-2 Family PARP Parasite
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1β, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

HY-N0865

Ingenol (-)-Ingenol	Classification of Application Fields Terpenoids Gramineae Diterpenoids Leptochloa chinensis (Linn.) Nees Plants Disease Research Fields Source Classification Cancer	PKC
Ingenol is a *PKC* activator, with a K_i of 30 μM, with antitumor activity.

HY-113202

Stearoylcarnitine 1 Publications Verification	Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite PKC GlyT
Stearoylcarnitine, a fatty ester lipid molecule, is an endogenous metabolite. Stearoylcarnitine can be used as *PKC* inhibitor. Stearoylcarnitine accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoylcarnitine inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoylcarnitine acts as a metabolomics biomarker for Parkinson’s disease. Stearoylcarnitine is a less potent inhibitor of GlyT2 .

HY-N0699

Daphnoretin 3 Publications Verification Dephnoretin; Thymelol	Infection Structural Classification Monophenols Classification of Application Fields Thymelaeaceae Coumarins Phenols Phenylpropanoids Plants Disease Research Fields Source Classification Wikstroemia indica	PKC Influenza Virus NOD-like Receptor (NLR) Apoptosis HBV JNK PI3K Akt CDK Caspase Bcl-2 Family
Daphnoretin (Dephnoretin; Thymelol) is a protein kinase C (PKC) activator that inhibits the expression of hepatitis B virus (HBV) surface antigen (HBsAg) and exhibits antiviral activity. Daphnoretin exerts its antitumor effects by inhibiting the activation of the PI3K/AKT signaling pathway and triggers the mitochondrial apoptosis pathway. Daphnoretin alleviates chondrocyte apoptosis and inflammatory responses by inhibiting endoplasmic reticulum stress and activation of the NLRP3 inflammasome. Daphnoretin regulates the differentiation and maturation of dendritic cells, inhibits their immunostimulatory function by downregulating the phosphorylation level of JNK, and thus exerts a protective effect in skin graft rejection .

HY-131897

1-Stearoyl-2-arachidonoyl-sn-glycerol 1 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Lipid Source Classification	PKC TRP Channel Endogenous Metabolite
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate *PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC)* activity .

HY-N5063

Plantainoside D 2 Publications Verification	Cardiovascular Disease Structural Classification Classification of Application Fields Simple Phenylpropanols Phenols Polyphenols Scrophulariaceae Phenylpropanoids Plants Picrorhiza scrophulariiflora Pennell Disease Research Fields Source Classification	Angiotensin-converting Enzyme (ACE) IKK Calcium Channel PKC Reactive Oxygen Species (ROS) NF-κB Apoptosis Sirtuin NOD-like Receptor (NLR)
Plantainoside D, a phenylethanoid glycosides, is a IKK-β inhibitor with diverse biological activities. Plantainoside D shows inhibitory activity of angiotensin-converting enzyme (ACE) with an IC₅₀ of 2.17 mM. Plantainoside D significantly reduces the release of glutamate from nerve terminals in the cerebral cortex of rats by inhibiting the voltage-dependent calcium channel (VDCCs) and protein kinase C (PKC) signaling cascade. Plantainoside D significantly alleviates cell apoptosis by inhibiting the generation of ROS and the activation of NF-κB. Plantainoside D significantly improves acute lung injury (ALI) induced by sepsis by regulating the Sirt3/NLRP3 signaling pathway. Plantainoside D can be used for the study of neuroprotection, antioxidant, anti-inflammation, antihypertension .

HY-100618

Hispidin 1 Publications Verification	Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Phenols Polyphenols Endogenous metabolite Disease Research Fields Source Classification	PKC Endogenous Metabolite Ferroptosis Reactive Oxygen Species (ROS) p38 MAPK JAK STAT JNK Akt GSK-3 ERK Keap1-Nrf2
Hispidin, a *PKC* inhibitor and a phenolic compound can be found in Phellinus linteus, has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties .

HY-N7675

Flavanomarein	Cardiovascular Disease Structural Classification Classification of Application Fields Cercis chinensis Bunge Metabolic Disease Plants Compositae Flavonoids other families Flavonones Phenols Polyphenols Disease Research Fields Source Classification	NF-κB TGF-beta/Smad Syk
Flavanomarein is a substance with cytoprotective, anti-inflammatory and antioxidant activities, with a K_a of 3.064e-5 M against human Syk. Flavanomarein enhances the phosphorylation level of AKT, regulates the expression of PKC-δ, P85α, PKC-β1, Sirt1, Bcl-2 and ICAD, and inhibits the nuclear translocation of NF-κB p65. Flavanomarein regulates EMT marker proteins, promotes the proliferation of HK-2 cells, and protects neuronal cells from 6-OHDA-induced neurotoxic damage. Flavanomarein can be used in studies related to Parkinson's disease and diabetic nephropathy.

HY-N2575

Hypocrellin A 2 Publications Verification	Infection Quinones Structural Classification Microorganisms other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	PKC Bacterial Parasite HIV VSV VEGFR Bcl-2 Family Apoptosis
Hypocrellin A is a *PKC* inhibitor that exerts antidiabetic activity by reversing the effects of high glucose on endothelin (ET-1) expression. Hypocrellin A is also a photosensitizer for photodynamic therapy (PDT) with anticancer, antibacterial and antiviral activities, especially against human immunodeficiency virus (HIV). In addition, Hypocrellin-A also possesses anti-Leishmania activity (IC₅₀=0.27 μg/ml) .

HY-N5072

Desmethylglycitein 3 Publications Verification 4',6,7-Trihydroxyisoflavone	Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Phenols Polyphenols Plants Disease Research Fields Isoflavones Source Classification Cancer	CDK PI3K PKC
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity . Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .

HY-N4322

Decursinol angelate 1 Publications Verification	Structural Classification Pseudognaphalium affine (D. Don) Anderberg Classification of Application Fields Coumarins Phenylpropanoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Source Classification Cancer	PKC
Decursinol angelate acts as a *PKC* activator and GDH inhibitor, with an IC₅₀ of 1.432 μM against human GDH. Decursinol angelate activates *PKC, downregulates PKCα and PKCβII isoforms, and exerts cytotoxic activity against cancer cells. Decursinol angelate binds to GDH* and inhibits its enzymatic activity. Decursinol angelate inhibits VEGF-induced autophosphorylation of VEGFR2, downstream p42/44 ERK and JNK-MAPK signaling pathways, as well as the angiogenesis process. Decursinol angelate is applicable to research related to cancer and leukemia .

HY-N7144A

Citronellyl acetate	Infection Structural Classification Natural Products Classification of Application Fields Pelargonium hortorum Plants Geraniaceae Disease Research Fields Source Classification	Environmental Pollutants PKC TRP Channel PKA
Citronellyl acetate, a monoterpene product of the secondary metabolism of plants, is an orally active antinociceptive agent. Citronellyl acetate modulates TRPV1, TRPM8, ASIC, glutamate receptors, *PKC, and PKA*-mediated nociception. Citronellyl acetate can be used for the research of acute pain .

HY-107207

Kaempferol 3-neohesperidoside 3 Publications Verification Kaempferol 3-O-neohesperidoside	Flavonols Structural Classification Flavonoids Typhaceae Classification of Application Fields Typha orientalis Presl Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification	Insulin Receptor PI3K PKC
Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) is a flavonoid. Kaempferol 3-neohesperidoside mimics insulin action via the *PI3K/PKC* pathway, significantly promoting glucose uptake and increasing muscle glycogen content in rat soleus muscles. Kaempferol 3-neohesperidoside also exhibits anti-glycation activity. Kaempferol 3-neohesperidoside binds to albumin through hydrogen bonding and hydrophobic interactions, and inhibits the formation of advanced glycation end products. Kaempferol 3-neohesperidoside can be used in studies of diabetes and its related complications .

HY-118384

Sangivamycin 3 Publications Verification NSC 65346; BA-90912	Natural Products Microorganisms Classification of Application Fields Disease Research Fields Cancer Source Classification	PKC Nucleoside Antimetabolite/Analog
Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an K_i of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers .

HY-N6786

Ochratoxin B	Structural Classification Monophenols Microorganisms Classification of Application Fields Coumarins Phenols Phenylpropanoids Disease Research Fields Source Classification Cancer	Endogenous Metabolite
Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos .

HY-133680

β-Tocopherol	Monophenols Classification of Application Fields Phenols Metabolic Disease Palmae Plants Disease Research Fields Trachycarpus fortunei (Hook.) H. Wendl. Source Classification	Tyrosinase
β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-N2359

Chelerythrine	Alkaloids Classification of Application Fields Metabolic Disease Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Papaveraceae Source Classification	Beta-lactamase PKC Bcl-2 Family Apoptosis Autophagy
Chelerythrine is a natural alkaloid, acts as a potent and selective Ca ²⁺/phospholopid-dependent *PKC* antagonist, with an IC₅₀ of 0.7 μM . Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity . Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy .

HY-103382

Arcyriaflavin A	Infection Alkaloids Structural Classification Microorganisms Classification of Application Fields Marine natural products Disease Research Fields Indole Alkaloids Source Classification	Fungal
Arcyriaflavin A is an indolo[2,3-a]carbazole compound and also a cyclin D1/CDK4 inhibitor. Arcyriaflavin A exists in the marine ascidian Eudistoma sp. and the slime mold Arcyria denudata. Arcyriaflavin A is applicable to research related to colon cancer and lung cancer .

HY-139066

Punicic acid 1 Publications Verification Trichosanic acid	Structural Classification Punica granatum L. Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Punicaceae Plants Disease Research Fields Source Classification	TNF Receptor GLUT Proteasome Tau Protein PKC
Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and ω-5 polyunsaturated fatty acids. Punicic acid has anti-inflammatory and antioxidant activities and can inhibit the expression of inflammatory mediators such as tumor necrosis factor α (TNF-α). Punicic acid can also reduce the formation of β-amyloid deposits and hyperphosphorylation of tau by increasing the expression of GLUT4 protein and inhibiting the overactivation of calpain, and is used to prevent and treat neurodegenerative diseases. In addition, punicic acid also has breast cancer inhibitor properties that depend on lipid peroxidation and PKC pathways .

HY-N0381

Maackiain 1 Publications Verification DL-Maackiain	Infection Structural Classification Natural Products Monophenols other families Classification of Application Fields Phenols Plants Disease Research Fields Source Classification	Keap1-Nrf2 p38 MAPK NOD-like Receptor (NLR) NF-κB mTOR Monoamine Oxidase Nuclear Factor of activated T Cells (NFAT) PKC Apoptosis Pyroptosis Autophagy Dengue Virus
Maackiain (DL-Maackiain) is an orally active multi-target inhibitor with anti-tumor activity and neuroprotective effects. Maackiain activates the AMPK, NLRP3 and Nrf2/HO-1 pathways, and inhibits key targets such as NF-κB, mTOR, MAO-B, NFATc1 and PKCδ, thereby precisely regulating processes including apoptosis, autophagy and pyroptosis. Maackiain also effectively inhibits microglial activation, osteoclast formation, and proliferation and invasion of tumor cells, and protects dopaminergic neurons from damage. Maackiain is applicable to the research of various diseases such as Alzheimer's disease, osteoporosis, sepsis and dengue fever 。

HY-13626

Spisulosine 1 Publications Verification ES-285	Alkaloids Animals Classification of Application Fields Other Alkaloids Marine natural products Other marine organisms Disease Research Fields Source Classification Cancer	PKC Apoptosis
Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .

HY-N2180

(+)-Eudesmin (+)-Eudesmine	Neurological Disease Classification of Application Fields Magnoliaceae Lignans Phenylpropanoids Magnolia biondii Pamp. Plants Disease Research Fields Source Classification	PKC PKA p38 MAPK NO Synthase
Pinoresinol dimethyl ether ((+)-Eudesmin) is a non-phenolic furanoid lignin. Pinoresinol dimethyl ether can be isolated from Magnolia biondii. Pinoresinol dimethyl ether activates MAPK, *PKC, and PKA* upstream pathways and inhibits NO levels. Pinoresinol dimethyl ether has neuroprotective activity .

HY-N6743

Cercosporin CGP049090	Quinones Structural Classification Microorganisms Classification of Application Fields Phenols Polyphenols Disease Research Fields Source Classification Cancer	PKC
Cercosporin is produced by a plant pathogen, Pseudocercosporella capsellae. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations . Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC₅₀ of 0.6-1.3 μM .

HY-129099A

N-Desmethyltamoxifen hydrochloride	Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	PKC Estrogen Receptor/ERR Drug Metabolite Endogenous Metabolite
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .

HY-N2535

Coniferaldehyde 1 Publications Verification 4-Hydroxy-3-methoxycinnamaldehyde	Monophenols other families Classification of Application Fields Simple Phenylpropanols Phenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Keap1-Nrf2 Apoptosis
Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .

HY-16982

Cercosporamide (-)-Cercosporamide	Infection Natural Products Microorganisms Classification of Application Fields Phenols Polyphenols Manihot esculenta Crantz Euphorbiaceae Plants Disease Research Fields Source Classification	Fungal MNK PKC
Cercosporamide is a highly potent, ATP-competitive *PKC* kinase inhibitor targeting to *PKC1, with an IC₅₀* of <50 nM and a K_i of <7 nM. Cercosporamide is a unique Mnk inhibitor.

HY-108262

UCN-02 7-epi-Hydroxystaurosporine	Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification Cancer	PKC PKA
UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor with a PKC IC₅₀ value of 62 nM and a PKA IC₅₀ value of 0.25 μM. UCN-02 can be produced by Streptomyces strain N-126. UCN-02 can be used for the research of breast carcinoma .

HY-137295

Ingenol 3,20-dibenzoate	Classification of Application Fields Terpenoids Diterpenoids Euphorbia esula L. Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	PKC Apoptosis
Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-γ production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells .

Cat. No.	Product Name	Chemical Structure

HY-101047S

D-erythro-Sphingosine-d7 1 Publications Verification
D-erythro-Sphingosine-d₇ is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .

HY-111355S

Cholesterol sulfate-d7 sodium

Cholesterol sulfate sodium-d₇ is the deuterium labeled Cholesterol sulfate sodium. Cholesterol sulfate sodium is a naturally occurring, orally active cholesterol derivative that is widely distributed in various tissues and body fluids. Cholesterol sulfate sodium acts as a DOCK2 inhibitor, with IC₅₀ values of 2 μM and 2.9 μM against mouse and human targets, respectively. Cholesterol sulfate sodium restricts excessive neutrophil infiltration and alleviates intestinal inflammation and damage. Cholesterol sulfate sodium serves as an activator of protein kinase C (PKC), which promotes squamous cell differentiation and inhibits skin carcinogenesis. Cholesterol sulfate sodium regulates cholesterol homeostasis and cellular metabolism by activating the AMPK-Sirt1 pathway. Cholesterol sulfate sodium can be used in research related to actinic keratitis, ulcerative colitis, skin cancer, and other conditions.

HY-10230S

Midostaurin-d5
Midostaurin-d₅ (PKC412-d₅) is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM .

HY-10195BS

Ruboxistaurin-d6 hydrochloride
Ruboxistaurin-d₆ (hydrochloride) is the deuterium labeled Ruboxistaurin hydrochloride. Ruboxistaurin (LY333531) hydrochloride is an orally active, selective PKC beta inhibitor (Ki=2 nM). Ruboxistaurin hydrochloride exhibits ATP dependent competitive inhibition of PKC beta I with an IC₅₀ of 4.7 nM. Ruboxistaurin hydrochloride inhibits PKC beta II with an IC₅₀ of 5.9 nM .

HY-113202S

Stearoyl-L-carnitine-d3

Stearoyl-L-carnitine-d₃ is the deuterium labeled Stearoylcarnitine. Stearoylcarnitine, a fatty ester lipid molecule, is an endogenous metabolite. Stearoylcarnitine can be used as PKC inhibitor. Stearoylcarnitine accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoylcarnitine inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoylcarnitine acts as a metabolomics biomarker for Parkinson’s disease. Stearoylcarnitine is a less potent inhibitor of GlyT2 .

HY-129491S

O-Desmethyl Midostaurin-d5
O-Desmethyl Midostaurin-d₅ is a deuterium labeled O-Desmethyl PKC412. O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism .

HY-W751179

Midostaurin-13C6

Midostaurin- ¹³C₆ (PKC412- ¹³C₆) is the ¹³C-labeled Midostaurin (HY-10230). Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC₅₀s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .

HY-W751181

O-Desmethyl midostaurin-13C6

O-Desmethyl midostaurin- ¹³C₆ (CGP62221- ¹³C₆; O-Desmethyl PKC412- ¹³C₆) is the ¹³C-labeled O-Desmethyl Midostaurin (HY-129491). O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo . Midostaurin is a multi-targeted protein kinase inhibitor?with?IC₅₀?ranging from 22-500 nM.

HY-W751180

3-Hydroxy Midostaurin-13C6

3-Hydroxy Midostaurin- ¹³C₆ (CGP52421- ¹³C₆) is the ¹³C-labeled 3-Hydroxy Midostaurin (HY-108263). 3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC₅₀s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412 .

HY-13502S

Mitoxantrone-d8
Mitoxantrone-d₈ (mitozantrone-d₈) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM .

HY-108263S

3-Hydroxy Midostaurin-d5
3-Hydroxy Midostaurin-d₅ is a deuterium labeled 3-Hydroxy Midostaurin. 3-Hydroxy Midostaurin is a metabolite of PKC412, which effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC₅₀s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively .

HY-113068S

β-Tocopherol-d3
β-Tocopherol-d₃ is the deuterium labeled β-Tocopherol. β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol can also prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-115767S

(±)-1,2-Diolein-13C3
(±)-1,2-Diolein- ¹³C₃ (1,2-Dioleoyl-rac-glycerol- ¹³C₃) is ¹³C labeled (±)-1,2-Diolein. (±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) is a *PKC* activator. (±)-1,2-Diolein increases myotubes Ca ²⁺ influx .

HY-13626S

Spisulosine-d3
Spisulosine-d₃ (ES-285-d₃) is deuterium labeled Spisulosine (HY-13626). Spisulosine is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .

HY-101047S1

D-erythro-Sphingosine-13C2,d2
D-erythro-Sphingosine-13C2,d2 is a deuterated labeled D-erythro-Sphingosine . D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC₅₀ of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .

HY-13502AS

Mitoxantrone-d8 dihydrochloride

Mitoxantrone-d₈ dihydrochloride is deuterated labeled Mitoxantrone dihydrochloride (HY-13502A). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-13502AS1

Mitoxantrone-d8 hydrochloride

Mitoxantrone-d₈ (hydrochloride) (Mitozantrone-d₈ (hydrochloride)) is deuterium labeled Mitoxantrone (dihydrochloride). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-131897S

1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol
1-Stearoyl-2-Arachidonoyl-d₈-sn-Glycerol is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycerol. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity .

HY-113202S1

Stearoyl-L-carnitine-d9 chloride

Stearoyl-L-carnitine-d9 chloride is the deuterium labeled Stearoyl-L-carnitine chloride. Stearoyl-L-carnitine chloride, a fatty ester lipid molecule, is an endogenous metabolite. Stearoyl-L-carnitine chloride can be used as PKC inhibitor. Stearoyl-L-carnitine chloride accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoyl-L-carnitine chloride inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoyl-L-carnitine chloride acts as a metabolomics biomarker for Parkinson’s disease. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2 .

HY-133680S

β-Tocopherol-d4
β-Tocopherol-d4 is a deuterium labeled β-Tocopherol (HY-133680). β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-N2359S

Chelerythrine-d6 chloride

Chelerythrine-d₆ is the deuterium labeled Chelerythrine (HY-N2359). Chelerythrine is a natural alkaloid, acts as a potent and selective Ca ²⁺/phospholopid-dependent PKC antagonist, with an IC₅₀ of 0.7 μM . Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity . Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with an IC₅₀ of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine triggers apoptosis and autophagy .

HY-134058S

3-Heptanol-d4

3-Heptanol-d₄ (Butylethylcarbinol-d₄) is the deuterium labeled 3-Heptanol (HY-134058). 3-Heptanol is a biotransformation product of n-heptane. 3-Heptanol can act as the building block in the synthesis of 4-(3-adamantan-1-yl-ureido)-butyric acid and cyclohexanecarboxylic acid derivatives as sEH inhibitors. 3-Heptanol can be used as a solvent to form microenvironments around single-walled carbon nanotubes. 3-Heptanol can be used in the preperation of substituted pyrimidine derivatives as C1 domain-targeted isophthalate analogs to study their binding affinities towards PKCα isoform .

Targets Recommended: PKC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18985G

Phorbol 12,13-dibutyrate Phorbol dibutyrate; PDBu	PKC	Cancer
Phorbol 12,13-dibutyrate (Phorbol dibutyrate) (GMP) is Phorbol 12,13-dibutyrate (HY-18985) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Phorbol 12,13-dibutyrate is a *PKC* activator and a potent skin tumor promoter .

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