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Isoforms Recommended:	PRMT7

Results for "

PRMT7

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Epigenetic Reader Domain (1) Histone Demethylase (2) Histone Methyltransferase (11) HSP (1) LYTACs (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (13) Inflammation/Immunology (1) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112445

SGC3027 5+ Cited Publications	Histone Methyltransferase	Cancer
SGC3027 is a histone methyltransferase inhibitor . SGC3027 is the first potent, selective and cell active chemical probe for *PRMT7* .

HY-114211

SGC8158	Histone Methyltransferase HSP	Cancer
SGC8158 is an inhibitor of *PRMT7* and can be used to study the cellular function of PRMT7. SGC8158 decreases monomethylarginine levels of Hsp70 (the best characterized PRMT7 substrate). SGC8158 induces growth inhibition in various cancer cells (IC₅₀: 2-9 μM), as well as multidrug-resistant (MDR) cancer cells. SGC8158 also enhances Doxorubicin (HY-15142A) induced DNA damage and Its cytotoxicity .

HY-173557

PRMT7-IN-2	Histone Methyltransferase Apoptosis	Cancer
PRMT7-IN-2 (A33) is a selective *PRMT7* inhibitor with an IC₅₀ of 0.50 μM. PRMT7-IN-2 arrests cell cycle at G0/G1 phase, induces cell apoptosis, and inhibits cell growth in vivo and in vitro. PRMT7-IN-2 decreases the monomethylarginine level of *PRMT7, increases expression of epithelial marker (E-cadherin, and reduces expression of mesenchymal markers such as N-cadherin, Vimentin, and ZEB2* .

HY-147185

PRMT7-IN-1	Histone Methyltransferase	Cancer
PRMT7-IN-1 (Compound 14) is a *PRMT7* inhibitor with an IC₅₀ of 2.1 μM. PRMT7-IN-1 shows anticancer activity against different cancer cells .

HY-124131

DS-437 1 Publications Verification	Histone Methyltransferase	Inflammation/Immunology Cancer
DS-437 is a dual *PRMT5/7* inhibitor (IC₅₀s of PRMT5/7=6 μM). DS-437 is selective for PRMT5 and PRMT7 over 29 other human protein-, DNA-, and RNA-methyltransferases. DS-437 is a S-adenosylmethionine (SAM)-competitive inhibitor of PRMT5. DS-437 also inhibits DNMT3A and DNMT3B, with IC₅₀s of 52 and 62 μM, respectively. DS-437 inhibits the methylation of FOXP3 .

HY-RS11180

PRMT7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRMT7 Human Pre-designed siRNA Set A contains three designed siRNAs for PRMT7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRMT7 Human Pre-designed siRNA Set A PRMT7 Human Pre-designed siRNA Set A

HY-155814

EML734	Histone Methyltransferase	Cancer
EML734 is a potent and selective *PRMT7/9* inhibitor with IC₅₀ values of 315 nM and 0.89 μM, respectively.

HY-RS11181

Prmt7 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Prmt7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prmt7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prmt7 Mouse Pre-designed siRNA Set A Prmt7 Mouse Pre-designed siRNA Set A

HY-RS11182

Prmt7 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Prmt7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Prmt7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prmt7 Rat Pre-designed siRNA Set A Prmt7 Rat Pre-designed siRNA Set A

HY-120137

CMP-5	Histone Methyltransferase	Cancer
CMP-5 is a potent, specific, and selective *PRMT5* inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 prevents Epstein-Barr virus (EBV)-driven B-lymphocyte transformation but leaving normal B cells unaffected .

HY-113846A

CMP-5 dihydrochloride	Histone Methyltransferase	Cancer
CMP-5 dihydrochloride is a potent, specific, and selective *PRMT5* inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 dihydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 dihydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected .

HY-113846

CMP-5 hydrochloride	Histone Methyltransferase	Cancer
CMP-5 hydrochloride is a potent, specific, and selective *PRMT5* inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 hydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 hydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected .

HY-183061

MrTAC-8	LYTACs Epigenetic Reader Domain	Neurological Disease Cancer
MrTAC-8, methylarginine-targeting chimera (MrTAC), is a BRD4 degrader with DC₅₀ values of 46 nM in HeLa cells. MrTAC-8 recruits *PRMT1, PRMT3, PRMT4, PRMT5, and PRMT7* to target proteins, inducing arginine methylation that triggers lysosomal degradation. MrTAC-8 degrades proteins across diverse subcellular localizations and independent of native proteolytic routes. MrTAC-8 can be used for the research of cervical cancer, glioblastoma .

HY-183653

AK442	Histone Methyltransferase	Cancer
AK442 is a selective *PRMT4* (CARM1) inhibitor with an IC₅₀ of 2.6 nM against human targets. AK442 is applicable to breast cancer-related research .

HY-182891

MC4455	Histone Demethylase	Cancer
MC4455 is a *LSD1/PRMT5* dual inhibitor. MC4455 inhibits the LSD1/CoREST and PRMT5/MEP50 complex with IC₅₀ values of 0.104 μM and 0.014 μM. MC4455 covalently binds to LSD1’s FAD cofactor, stabilizes the LSD1/CoREST complex. MC4455 induces myeloid differentiation, alters transcriptomic profiles, drives alternative splicing changes, and impairs leukemic cell viability in AML cells. MC4455 can be used for the research of acute myeloid leukemia .

HY-182892

MC4491	Histone Demethylase Histone Methyltransferase	Cancer
MC4491 is a selective *LSD1/PRMT5* inhibitor, with an IC₅₀ of 0.152 μM against the LSD1/CoREST complex and an IC₅₀ of 0.043 μM against the *PRMT5/MEP50* complex. MC4491 induces transcriptomic changes and splicing alterations in AML cells. MC4491 is applicable for the research of acute myeloid leukemia .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702910

	PRMT7 Protein, Human (sf9, Flag) KIAA1933	Human	Sf9 insect cells
	PRMT7 Protein, Human (sf9, Flag) is the recombinant human-derived PRMT7, expressed by Sf9 insect cells , with N-Flag labeled tag. ,

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Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

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HY-P81989

	PRMT7 Antibody (YA1734) SBIDDS	WB	Human, Mouse, Rat
	PRMT7 Antibody (YA1734) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PRMT7.

HY-P81989A

	PRMT7 Antibody (YA1734)(PBS only) SBIDDS	WB	Human, Mouse, Rat
	PRMT7 Antibody (YA1734) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PRMT7.

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PRMT7 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRMT7 Human Pre-designed siRNA Set A contains three designed siRNAs for PRMT7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prmt7 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Prmt7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prmt7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prmt7 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Prmt7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Prmt7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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