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Parishin

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By Targets:	5-HT Receptor (2) Biochemical Assay Reagents (1) Caspase (2) iGluR (2) Interleukin Related (2) NF-κB (2) Reactive Oxygen Species (ROS) (2) Reference Standards (4) SOD (2) TNF Receptor (2)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Inflammation/Immunology (2) Neurological Disease (5)

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Natural
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2031

*Parishin* 4 Publications Verification	Others	Neurological Disease
Parishin is a phenolic glucoside isolated from Gastrodia elata. Parishin exhibits antiaging effects and extends the lifespan of yeast via regulation of Sir2/Uth1/TOR signaling pathway .

HY-N2124

Parishin B 1 Publications Verification	Reactive Oxygen Species (ROS)	Cancer
Parishin B is a parishin metabolite that can be isolated from Gastrodia elata with antioxidant activity .

HY-N2126

Parishin E	Others	Others
Parishin E, a parishin derivative isolated from Gastrodia elata, may have antioxidant property .

HY-N2125

Parishin C	5-HT Receptor iGluR Caspase Interleukin Related TNF Receptor SOD NF-κB	Neurological Disease Inflammation/Immunology
Parishin C is a brain-penetrant major bioactive component found in Gastrodia elata Blume. Parishin C is a 5-HT1A receptor agonist with an EC₅₀ of 34 nM. Parishin C has antipsychotic and neuroprotective effects. Parishin C protects against Aβ-induced long-term potentiation damage and NMDA receptor current impairment. Parishin C reduces oxidative stress, pro-inflammatory cytokine levels, caspase activity, brain water content, and cerebral infarct volume; increases antioxidant enzyme activity and BDNF levels; improves nerve function and histopathological brain damage. Parishin C attenuates phencyclidine-induced immobility time increases, sociability deficits, and visual recognition memory impairment. Parishin C can be used for the research of ischemic stroke, Alzheimer's disease, and schizophrenia-like psychosis .

HY-N12395

Parishin G	Others	Neurological Disease
Parishin G is a Parishin (HY-N2031) derivative that can be isolated from Gastrodia elata. Parishin G has antioxidant activity .

HY-N2124R

Parishin B (Standard)	Reference Standards Reactive Oxygen Species (ROS)	Cancer
Parishin B (Standard) is the analytical standard of Parishin B. This product is intended for research and analytical applications. Parishin B is a parishin metabolite that can be isolated from Gastrodia elata with antioxidant activity .

HY-N2126R

Parishin E (Standard)	Reference Standards Others	Others
Parishin E (Standard) is the analytical standard of Parishin E. This product is intended for research and analytical applications. Parishin E, a parishin derivative isolated from Gastrodia elata, may have antioxidant property .

HY-N2031R

Parishin (Standard)	Reference Standards Others	Neurological Disease
Parishin (Standard) is the analytical standard of Parishin. This product is intended for research and analytical applications. Parishin is a phenolic glucoside isolated from Gastrodia elata. Parishin exhibits antiaging effects and extends the lifespan of yeast via regulation of Sir2/Uth1/TOR signaling pathway .

HY-N12019

Parishin K	Biochemical Assay Reagents	Cardiovascular Disease
Parishin K is a cardioprotective agent obtained from the roots of Gastrodia elata Bl. Parishin K can be used in cardiovascular disease research .

HY-N2125R

Parishin C (Standard)	Reference Standards 5-HT Receptor iGluR Caspase Interleukin Related TNF Receptor SOD NF-κB	Neurological Disease Inflammation/Immunology
Parishin C (Standard) is the analytical standard of Parishin C (HY-N2125). This product is intended for research and analytical applications. Parishin C is a brain-penetrant major bioactive component found in Gastrodia elata Blume. Parishin C is a 5-HT1A receptor agonist with an EC₅₀ of 34 nM. Parishin C has antipsychotic and neuroprotective effects. Parishin C protects against Aβ-induced long-term potentiation damage and NMDA receptor current impairment. Parishin C reduces oxidative stress, pro-inflammatory cytokine levels, caspase activity, brain water content, and cerebral infarct volume; increases antioxidant enzyme activity and BDNF levels; improves nerve function and histopathological brain damage. Parishin C attenuates phencyclidine-induced immobility time increases, sociability deficits, and visual recognition memory impairment. Parishin C can be used for the research of ischemic stroke, Alzheimer's disease, and schizophrenia-like psychosis .

*Parishin* 4 Publications Verification	Other Terpenoids Gastrodia elata Bl. Terpenoids Orchidaceae Plants Source Classification	Others
Parishin is a phenolic glucoside isolated from Gastrodia elata. Parishin exhibits antiaging effects and extends the lifespan of yeast via regulation of Sir2/Uth1/TOR signaling pathway .

Parishin B 1 Publications Verification	Gastrodia elata Bl. Classification of Application Fields Orchidaceae Phenols Plants Disease Research Fields Source Classification Cancer	Reactive Oxygen Species (ROS)
Parishin B is a parishin metabolite that can be isolated from Gastrodia elata with antioxidant activity .

Parishin E	Gastrodia elata Bl. Classification of Application Fields Orchidaceae Other Diseases Phenols Plants Disease Research Fields Source Classification	Others
Parishin E, a parishin derivative isolated from Gastrodia elata, may have antioxidant property .

Parishin C	Structural Classification Gastrodia elata Bl. Orchidaceae Phenols Plants Source Classification	5-HT Receptor iGluR Caspase Interleukin Related TNF Receptor SOD NF-κB
Parishin C is a brain-penetrant major bioactive component found in Gastrodia elata Blume. Parishin C is a 5-HT1A receptor agonist with an EC₅₀ of 34 nM. Parishin C has antipsychotic and neuroprotective effects. Parishin C protects against Aβ-induced long-term potentiation damage and NMDA receptor current impairment. Parishin C reduces oxidative stress, pro-inflammatory cytokine levels, caspase activity, brain water content, and cerebral infarct volume; increases antioxidant enzyme activity and BDNF levels; improves nerve function and histopathological brain damage. Parishin C attenuates phencyclidine-induced immobility time increases, sociability deficits, and visual recognition memory impairment. Parishin C can be used for the research of ischemic stroke, Alzheimer's disease, and schizophrenia-like psychosis .

Parishin G	Gastrodia elata Bl. Ketones, Aldehydes, Acids Orchidaceae Plants Saccharides Monosaccharides Source Classification	Others
Parishin G is a Parishin (HY-N2031) derivative that can be isolated from Gastrodia elata. Parishin G has antioxidant activity .

Parishin B (Standard)	Structural Classification Gastrodia elata Bl. Orchidaceae Phenols Plants Source Classification	Reference Standards Reactive Oxygen Species (ROS)
Parishin B (Standard) is the analytical standard of Parishin B. This product is intended for research and analytical applications. Parishin B is a parishin metabolite that can be isolated from Gastrodia elata with antioxidant activity .

Parishin E (Standard)	Structural Classification Gastrodia elata Bl. Orchidaceae Phenols Plants Source Classification	Reference Standards Others
Parishin E (Standard) is the analytical standard of Parishin E. This product is intended for research and analytical applications. Parishin E, a parishin derivative isolated from Gastrodia elata, may have antioxidant property .

Parishin (Standard)	Other Terpenoids Structural Classification Gastrodia elata Bl. Terpenoids Orchidaceae Plants Source Classification	Reference Standards Others
Parishin (Standard) is the analytical standard of Parishin. This product is intended for research and analytical applications. Parishin is a phenolic glucoside isolated from Gastrodia elata. Parishin exhibits antiaging effects and extends the lifespan of yeast via regulation of Sir2/Uth1/TOR signaling pathway .

Parishin K	Gastrodia elata Bl. Orchidaceae Plants Saccharides Monosaccharides Source Classification	Biochemical Assay Reagents
Parishin K is a cardioprotective agent obtained from the roots of Gastrodia elata Bl. Parishin K can be used in cardiovascular disease research .

Parishin C (Standard)	Structural Classification Gastrodia elata Bl. Orchidaceae Phenols Plants Source Classification	Reference Standards 5-HT Receptor iGluR Caspase Interleukin Related TNF Receptor SOD NF-κB
Parishin C (Standard) is the analytical standard of Parishin C (HY-N2125). This product is intended for research and analytical applications. Parishin C is a brain-penetrant major bioactive component found in Gastrodia elata Blume. Parishin C is a 5-HT1A receptor agonist with an EC₅₀ of 34 nM. Parishin C has antipsychotic and neuroprotective effects. Parishin C protects against Aβ-induced long-term potentiation damage and NMDA receptor current impairment. Parishin C reduces oxidative stress, pro-inflammatory cytokine levels, caspase activity, brain water content, and cerebral infarct volume; increases antioxidant enzyme activity and BDNF levels; improves nerve function and histopathological brain damage. Parishin C attenuates phencyclidine-induced immobility time increases, sociability deficits, and visual recognition memory impairment. Parishin C can be used for the research of ischemic stroke, Alzheimer's disease, and schizophrenia-like psychosis .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Parishin

Inhibitors & Agonists

NaturalProducts

Natural
Products