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Prostaglandin E synthase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NO Synthase (3) PGE synthase (19) Prostaglandin Receptor (3) Akt (1) Apoptosis (2) COX (3) FLAP (1) JAK (1) Lipoxygenase (3) NF-κB (2) PI3K (1) PPAR (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) STAT (1) TGF-beta/Smad (1) TGF-β Receptor (1) YB-1 (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (21) Metabolic Disease (1) Neurological Disease (2)

Inhibitors & Agonists

Natural
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Antibodies

Targets Recommended: PGE synthase Prostaglandin Receptor Acetolactate Synthase (ALS) Thymidylate Synthase Cellulose Synthase ATP Synthase GSK-3 Fatty Acid Synthase (FASN) Glucosylceramide Synthase (GCS) Cyclic GMP-AMP Synthase NO Synthase

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-N6966

Ethyl Caffeate 2 Publications Verification	NF-κB NO Synthase COX PGE synthase	Inflammation/Immunology Cancer
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, *inducible nitric oxide synthase* (iNOS), cyclooxygenase-2 (COX-2)*, and prostaglandin* E₂ (PGE₂) in vitro or in mouse skin .

HY-147416

Vipoglanstat BI 1029539; GS-248; OX-MPI	PGE synthase	Infection Cancer
Vipoglanstat (BI 1029539), a carboxamide, is a potent and selective, non-peptide and orally active small molecular inhibitor of human prostaglandin E synthase 1 (mPGES-1). Vipoglanstat also has anti-inflammatory activity .

HY-118119

CAY10526 1 Publications Verification	PGE synthase YB-1 Apoptosis JAK STAT TGF-β Receptor TGF-beta/Smad PI3K Akt	Cancer
CAY10526 is an inhibitor of Y-box binding protein 1 (YB-1) and microsomal prostaglandin E2 synthase 1 (mPGES1). CAY10526 inhibits the production of PGE₂ by suppressing YB-1 and mPGES1. CAY10526 induces cell apoptosis (apoptosis) and inhibits the JAK/STAT, TGF-β/Smad3 and PI3K/AKT signaling pathways. CAY10526 can be used in research related to melanoma, prostate cancer, esophageal adenocarcinoma, T-cell lymphoma, etc .

HY-105005

Crisdesalazine AAD-2004	Prostaglandin Receptor PGE synthase Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology
Crisdesalazine (AAD-2004) is a microsomal prostaglandin E₂ synthase-1 (mPGES-1) inhibitor. Crisdesalazine acts as a potent free radical scavenger that directly neutralizes reactive oxygen species (ROS) including hydrogen peroxide, exerting neuroprotective effects against apoptosis and axonal damage. Crisdesalazine inhibits PGE₂ production, mediates inflammatory responses, and promotes the conversion of macrophages from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype. Crisdesalazine is applicable to neuroprotection research in multiple sclerosis and spinal cord injury .

HY-162387

UK4b	PGE synthase	Cardiovascular Disease Inflammation/Immunology Cancer
UK4b is a highly selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. UK4b possesses anti-inflammatory and analgesic effects. UK4b can block the growth of abdominal aortic aneurysms in mice .

HY-19622

PF-9184	PGE synthase	Inflammation/Immunology
PF-9184 is a potent and highly selective inhibitor of human *microsomal prostaglandin* E synthase-1 (mPGES-1), with an IC₅₀** of 16.5 nM. PF-9184 inhibits IL-1β-induced PGE₂ synthesis in vitro .

HY-149202

UT-11	PGE synthase	Neurological Disease Inflammation/Immunology
UT-11 is a potent and blood-brain barrier-permeable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC₅₀s of 0.10 μM and 2.00 μM for inhibiting PGE₂ production in human (SK-N-AS) and murine (BV2) cells, respectively .

HY-111140

YS121	PGE synthase Lipoxygenase PPAR	Inflammation/Immunology
YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC₅₀ = 3.4 μM) and 5-lipoxygenase (5-LOX; IC₅₀ = 6.5 μM). YS121 exhibits direct, reversible, and specific binding to mPGES-1 (K_D = 10-14 μM) . YS121 dose-dependently reduces PGE₂ production with an EC₅₀ of 12 μM in IL-1β-stimulated A549 cells . YS121 (compound 9) activates PPAR-α and -γ (EC₅₀ = 1 and 3.6 μM, respectively) . YS121 exhibits anti-inflammatory efficiency in human whole blood as well as in vivo. YS121 can be used for pleurisy research .

HY-156612

Friluglanstat	PGE synthase	Inflammation/Immunology
Friluglanstat is a prostaglandin E synthase (mPGES-1) inhibitor, with anti-inflammatory activity .

HY-125415

PF-4693627	PGE synthase	Inflammation/Immunology
PF-4693627 is a potent, selective and orally bioavailable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC₅₀=3 nM) for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA) .

HY-N6966A

Ethyl trans-caffeate	Others	Inflammation/Immunology
Ethyl trans-caffeate is the trans form of Ethyl Caffeate (HY-N6966). Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, *inducible nitric oxide synthase* (iNOS), cyclooxygenase-2 (COX-2)*, and prostaglandin* E₂ (PGE₂) in vitro or in mouse skin .

HY-178794

AGU661	PGE synthase	Inflammation/Immunology
AGU661 is a *Microsomal prostaglandin* E2 synthase 1 (mPGES-1) inhibitor with an IC₅₀** of 0.22  nM. AGU661 lowers PGE2 formation in human pro-inflammatory M1 macrophages and activated monocytes without affecting other lipid mediator pathways. AGU661 has unfavorable physicochemical properties with poor metabolic stability and strong plasma protein binding tendencies. AGU661 into PLGA-based NPs significantly enhances its bioactivity. AGU661 can be used for inflammatory disorders research .

HY-178505

mPGES1-IN-10	PGE synthase	Inflammation/Immunology Cancer
mPGES1-IN-10 (Compound 7d) is a potent microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor with an IC₅₀ value of 1.0 μM. mPGES1-IN-10 is promising for research of chronic inflammation-related diseases and malignancies such as colorectal cancer .

HY-N3535

Canniprene	Prostaglandin Receptor Lipoxygenase	Inflammation/Immunology
Canniprene, an isoprenylated bibenzyl unique to Cannabis sativa, is a potent inhibitor of 5-lipoxygenase (5-LO) activity (IC₅₀=0.4 μM) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE₂; IC₅₀=10 μM). Canniprene inhibits the production of inflammatory eicosanoids and affects the generation of prostaglandins .

HY-100864

mPGES1-IN-3	PGE synthase	Inflammation/Immunology
mPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor, which exhibits excellent mPGES-1 enzyme (IC₅₀: 8 nM), cell (A549 IC₅₀: 16.24 nM) and human whole blood potency (IC₅₀: 249.9 nM) .

HY-169858

Prostaglandin E2 Inhibitor 3	PGE synthase	Inflammation/Immunology
Prostaglandin E2 Inhibitor 3 (Compound 3) is a selectivity microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC₅₀ = 0.2 µM). Prostaglandin E2 Inhibitor 3 has higher selectivity for mPGES-1 than cyclooxygenases (COX)-1/2, 5-lipoxygenase (5-LO), and soluble epoxide hydrolase (sEH). Prostaglandin E2 Inhibitor 3 has anti-inflammatory activity and can attenuate zymosan-induced peritoneal leukocyte migration in mice .

HY-106119

Camonagrel	Prostaglandin Receptor	Infection
Camonagrel is a compound that has inhibitory effects on Prostaglandin E2. Camonagrel is a potent thromboxane synthase inhibitor .

HY-13475

mPGES1-IN-8	PGE synthase	Inflammation/Immunology
mPGES1-IN-8, is a novel microsomal prostaglandin E synthase 1 (mPGES1) inhibitor .

HY-122178

5-trans U-44069	PGE synthase	Cardiovascular Disease
5-trans U-44069 is the trans isomer of the thromboxane receptor agonist U-44069 (HY-121825). 5-trans U-44069 inhibits **prostaglandin E2 synthase** activity .

HY-N9814

Shanciol B	NO Synthase	Inflammation/Immunology
Shanciol B, isolated from the ethyl acetate extract of the air-dried whole plant of Pholidota imbricate Hook, inhibits nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity . Shanciol B is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with anti-inflammatory activity .

HY-126898

5-LO/mPGES1-IN-1	Lipoxygenase PGE synthase	Inflammation/Immunology
5-LO/mPGES1-IN-1 (Compound 16) is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO). IC₅₀ values are 0.3 and 0.4 μM, respectively. 5-LO/mPGES1-IN-1 has anti-inflammatory activity .

HY-N6966R

Ethyl Caffeate (Standard)	Reference Standards NF-κB NO Synthase COX PGE synthase	Inflammation/Immunology Cancer
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) in vitro or in mouse skin .

HY-131626

1a,1b-Dihomo prostaglandin E2 1a,1b-Dihomo PGE2	COX	Metabolic Disease
1a,1b-Dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid. 1a,1b-Dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid. This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.

HY-N8936

Narchinol B	Others	Inflammation/Immunology
Narchinol B (Compound 4) is a sesquiter penoid compound. Narchinol B has anti-inflammatory effects. Narchinol B works by inhibiting proinflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as proinflammatory cytokines, such as interleukin-1b, IL-6, and tumor necrosis factor-α (TNF-α). Narchinol B significantly inhibits LPS-induced overproduction of NO in BV2 cells (IC₅₀=2.43 μM) .

HY-182647

LY3023703	PGE synthase	Inflammation/Immunology
LY3023703 is an orally active microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor. LY3023703 inhibits the production of PGE₂. LY3023703 is applicable to research related to inflammatory diseases and osteoarthritis pain .

HY-118506

BRP-7	FLAP	Inflammation/Immunology
BRP-7 is a 5-lipoxygenase activating protein (FLAP) inhibitor with an IC₅₀ of 0.31 μM. BRP-7 inhibits the co-localization of 5-lipoxygenase (5-LOX) and FLAP by targeting FLAP, thereby blocking the transfer of arachidonic acid (AA) to 5-LOX and suppressing the production of leukotrienes (LTs) (IC₅₀ = 0.15 μM). BRP-7 does not inhibit cyclooxygenase (COX-1/COX-2) or microsomal prostaglandin E₂ synthase-1 (mPGES-1), and does not affect cell viability or AA release. BRP-7 exhibits significant anti-inflammatory effects in rat pleurisy and mouse peritonitis models. BRP-7 can be used for the study of inflammatory diseases .

Ethyl Caffeate 2 Publications Verification	Classification of Application Fields Phenols Polyphenols Amburana cearensis (Allemão) A.C.Sm. Plants Compositae Inflammation/Immunology Disease Research Fields Cancer	NF-κB NO Synthase COX PGE synthase
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, *inducible nitric oxide synthase* (iNOS), cyclooxygenase-2 (COX-2)*, and prostaglandin* E₂ (PGE₂) in vitro or in mouse skin .

Ethyl trans-caffeate	Erythrophleum fordii Oliv. Plants Compositae Source Classification	Others
Ethyl trans-caffeate is the trans form of Ethyl Caffeate (HY-N6966). Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, *inducible nitric oxide synthase* (iNOS), cyclooxygenase-2 (COX-2)*, and prostaglandin* E₂ (PGE₂) in vitro or in mouse skin .

Canniprene	Monophenols Cannabis sativa L Classification of Application Fields Phenols Plants Moraceae Inflammation/Immunology Disease Research Fields Source Classification	Prostaglandin Receptor Lipoxygenase
Canniprene, an isoprenylated bibenzyl unique to Cannabis sativa, is a potent inhibitor of 5-lipoxygenase (5-LO) activity (IC₅₀=0.4 μM) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE₂; IC₅₀=10 μM). Canniprene inhibits the production of inflammatory eicosanoids and affects the generation of prostaglandins .

Shanciol B	Pholidota imbricata Hook. Classification of Application Fields Orchidaceae Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Source Classification	NO Synthase
Shanciol B, isolated from the ethyl acetate extract of the air-dried whole plant of Pholidota imbricate Hook, inhibits nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity . Shanciol B is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with anti-inflammatory activity .

Ethyl Caffeate (Standard)	Structural Classification Phenols Polyphenols Amburana cearensis (Allemão) A.C.Sm. Plants Compositae	Reference Standards NF-κB NO Synthase COX PGE synthase
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) in vitro or in mouse skin .

Narchinol B	Terpenoids Sesquiterpenes Nardostachys jatamansi (D. Don) DC. Plants Valerianaceae Source Classification	Others
Narchinol B (Compound 4) is a sesquiter penoid compound. Narchinol B has anti-inflammatory effects. Narchinol B works by inhibiting proinflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as proinflammatory cytokines, such as interleukin-1b, IL-6, and tumor necrosis factor-α (TNF-α). Narchinol B significantly inhibits LPS-induced overproduction of NO in BV2 cells (IC₅₀=2.43 μM) .

Host:	Rabbit (4)
Reactivity:	Human (4) Rat (4) Mouse (4)
Application:	ICC/IF (2) IP (2) WB (4)
Isotype:	IgG (4)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	상품명	Application	Reactivity	Image

HY-P83386

	p23 Antibody (YA3131) PTGES3; P23; TEBP; Prostaglandin E synthase 3; Cytosolic Prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23	WB, ICC/IF, IP	Human, Mouse, Rat
	p23 Antibody (YA3131) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p23.

HY-P83386A

	p23 Antibody (YA3131)(PBS only) PTGES3; P23; TEBP; Prostaglandin E synthase 3; Cytosolic Prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23	WB, ICC/IF, IP	Human, Mouse, Rat
	p23 Antibody (YA3131) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p23.

HY-P81996

	Prostaglandin E Synthase Antibody (YA1741) PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1	WB	Human, Mouse, Rat
	Prostaglandin E Synthase Antibody (YA1741) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Prostaglandin E Synthase.

HY-P81996A

	Prostaglandin E Synthase Antibody (YA1741)(PBS only) PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1	WB	Human, Mouse, Rat
	Prostaglandin E Synthase Antibody (YA1741) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Prostaglandin E Synthase.

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Prostaglandin E synthase

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