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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
Ptch1
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "Ptch1" in MCE Product Catalog:
Cat. No.: HY-P10875
CAS No.: 2130846-15-8
Cat. No.: HY-RS11356
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PTCH1 Human Pre-designed siRNA Set A contains three designed siRNAs for PTCH1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18678
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Ptch1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptch1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25164
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Ptch1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptch1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-137567
CAS No.: 210976-81-1
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Prostaglandin E1 ethanolamide is an analog of prostaglandin E1 (PGE1) and may effectively inhibit GLI2-induced expression of target genes, including Gli1 and Ptch1, and tumor growth [1].
Cat. No.: HY-183335
Anticancer agent 321 is a Smoothened (SMO) inhibitor with a human IC50 of 0.12 μM, enhanced aqueous solubility, good plasma and metabolic stability, moderate therapeutic index, preliminary safety profile, and moderate oral bioavailability in rats.Anticancer agent 321 binds to SMO’s 7-transmembrane helical channel, forming hydrogen bonds with Asp384 and hydrophobic/π-π interactions with His470, Phe391, Tyr394, stabilizing SMO’s inactive conformation to inhibit Hedgehog/GLI signaling.Anticancer agent 321 inhibits proliferation, suppresses colony formation, induces apoptosis, and downregulates Hedgehog/GLI pathway target genes GLI1, GLI2, Ptch1, HHip in cancer cells.Anticancer agent 321 inhibits tumor growth, downregulates Ki67 and SOX2, and upregulates cleaved-caspase 3 in tumor tissues.Anticancer agent 321 can be used for the research of cutaneous squamous cell carcinoma [1].
Cat. No.: HY-P87021
Synonyms: A230106A15Rik antibody; BCNS antibody; FLJ26746 antibody; FLJ42602 antibody; Holoprosencephaly 7 antibody; HPE7 antibody; mes antibody; NBCCS antibody; OTTHUMP00000021709 antibody; OTTHUMP00000021710 antibody; A230106A15Rik antibody; BCNS antibody; FLJ26746 antibody; FLJ42602 antibody; Holoprosencephaly 7 antibody; HPE7 antibody; mes antibody; NBCCS antibody; OTTHUMP00000021709 antibody; OTTHUMP00000021710 antibody; Patched antibody; Patched (Drosophila) homolog antibody; Patched 1 antibody; Patched homolog (Drosophila) antibody; Patched homolog 1 (Drosophila) antibody; Patched homolog 1 antibody; Patched protein homolog 1 antibody; Protein patched homolog 1 antibody; PTC antibody; PTC1 antibody; PTC1_HUMAN antibody; Ptch antibody; Ptch protein +12b antibody; Ptch protein +4' antibody; Ptch protein -10 antibody; Ptch protein antibody; Ptch1 antibody; Ptch1 protein antibody; Ptch11 antibody; Ptch2 antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
