Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
RICK
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "RICK" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P5522A
Synonyms: L-Ala-γ-D-Glu-meso-diaminopimelic acid dihydrochloride
Research Areas:
Cat. No.: HY-P5522
CAS No.: 877462-71-0
Synonyms: L-Ala-γ-D-Glu-meso-diaminopimelic acid
Research Areas:
Cat. No.: HY-RS11995
Target:
Research Areas:
RIPK2 Human Pre-designed siRNA Set A contains three designed siRNAs for RIPK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS11996
Research Areas:
Ripk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ripk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P5522AS
Synonyms: L-Ala-γ-D-Glu-meso-diaminopimelic acid-13C3,15N dihydrochloride
Target:
Isotope-Labeled Compounds NOD-like Receptor (NLR) NF-κB MAP3K MEK ERK p38 MAPK Interleukin Related SARS-CoV
Research Areas:
TriDAP- 13C3, 15N (L-Ala-γ-D-Glu-meso-diaminopimelic acid- 13C3, 15N) dihydrochloride is the 13C, 15N-labeled TriDAP dihydrochloride (HY-P5522A). TriDAP dihydrochloride (L-Ala-γ-D-Glu-meso-diaminopimelic acid dihydrochloride) is a NOD1 agonist with a Kd value of 34.5 μM. TriDAP dihydrochloride enhances the binding of NOD1-RICK, promotes RICK phosphorylation, and activates the NF-κB, TAK1, MEK/ERK, p38 and interferon response pathways. TriDAP dihydrochloride downregulates Runx2 via increasing ubiquitination and reduces trabecular bone parameters. TriDAP dihydrochloride decreases IκBα levels and increases p65 levels. TriDAP dihydrochloride induces the secretion of proinflammatory mediators IL-8 and prostaglandins, triggers tissue inflammation and innate immune activation, and inhibits SARS-CoV-2 replication in lung epithelial cells. TriDAP dihydrochloride increases the RANKL/OPG ratio in mice, reduces bone mass and enhances osteoclast activity, and inhibits new bone formation by decreasing the mineralization deposition rate in mice. TriDAP dihydrochloride can be used in research related to pulpitis, chronic ulcerative colitis, Crohn's disease and SARS-CoV-2 infection .
Cat. No.: HY-P706241
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RIPK2; Receptor-Interacting Protein (RIP)-Like Interacting Caspase-Like Apoptosis Regulatory Protein (CLARP) Kinase; Receptor Interacting Serine/Threonine Kinase 2; CARD-Containing Interleukin-1 Beta-Converting Enzyme (ICE)-Associated Kinase; CARDIAK; CARD-Containing Interleukin-1 Beta-Converting Enzyme-Associated Kinase; RIP2; Receptor-Interacting Serine-Threonine Kinase 2 Isoform B; RICK; Receptor-Interacting Serine-Threonine Kinase 2 Isoform 2; Receptor-Interacting Serine/Threonine-Protein Kinase 2; Receptor-Interacting Serine-Threonine Kinase 2; Receptor-Interacting Protein 2; RIP-Like-Interacting CLARP Kinase; Tyrosine-Protein Kinase RIPK2; Growth-Inhibiting Gene 30; CARD3; CARD-Carrying Kinase; CARD-Containing IL-1 Beta ICE-Kinase; GIG30; RIP-2; CCK
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P700624
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RIPK2; Receptor-Interacting Protein (RIP)-Like Interacting Caspase-Like Apoptosis Regulatory Protein (CLARP) Kinase; Receptor Interacting Serine/Threonine Kinase 2; CARD-Containing Interleukin-1 Beta-Converting Enzyme (ICE)-Associated Kinase; CARDIAK; CAR
Species:
Human
Source:
P. pastoris
Cat. No.: HY-P87052
Synonyms: CARDIAK; RICK; RIP2; UNQ277/PRO314/PRO34092; RIPK2; Receptor-interacting serine/threonine-protein kinase 2; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; RIP-like-interacting CLARP kinase; Receptor-interacting protein 2; Tyrosine-protein kinase RIPK2; CARD-containing IL-1 beta ICE-kinase; RIP-2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
