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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
STUB1
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "STUB1" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-P71340
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: E3 Ubiquitin-Protein Ligase CHIP; Antigen NY-CO-7; CLL-Associated Antigen KW-8; Carboxy Terminus of Hsp70-Interacting Protein; STIP1 Homology and U Box-Containing Protein 1; STUB1; CHIP
Cat. No.: HY-W1128879
CAS No.: 2271314-01-1
Synonyms: SKPer1
Target:
Research Areas:
XMU-MP-8 (SKPer1) is a potent molecular glue degrader that targets the oncoprotein SKP2. XMU-MP-8 simultaneously binds to the F-box domain of SKP2 (Kd ≈ 36 μM) and the N-terminal TPR domain of the E3 ligase STUB1 (Kd ≈ 2.5 μM), forming a stable SKP2-SKPer1-STUB1 ternary complex (Kd ≈ 8.9 nM) that induces SKP2 ubiquitination and proteasomal degradation. XMU-MP-8 selectively eliminates SKP2-expressing cancer cells. XMU-MP-8 exhibits substantial tumour suppression with good safety profiles in vivo. XMU-MP-8 can be used for cancer research, such as non-small cell lung adenocarcinoma (NSCLC) and prostatic adenocarcinoma [1].
Cat. No.: HY-175686
Target:
Research Areas:
E3 ligase Ligand 67 (Compound 5) is a STUB1/CHIP ligand with a Kd of 8.9 μM for CHIP in fluorescence polarization assay. E3 ligase Ligand 67 is an E3 ligase ligand that can be used for synthesis of PROTACs [1].
Cat. No.: HY-RS13972
Target:
Research Areas:
STUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for STUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17083
Target:
Research Areas:
Stub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23527
Target:
Research Areas:
Stub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Stub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P705928
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: E3 Ubiquitin-Protein Ligase CHIP; Antigen NY-CO-7; CLL-Associated Antigen KW-8; Carboxy Terminus of Hsp70-Interacting Protein; STIP1 Homology and U Box-Containing Protein 1; STUB1; CHIP
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
