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TCB

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By Targets:	5-HT Receptor (2) Biochemical Assay Reagents (1) CD3 (1) ERK (2) FGFR (2) Interleukin Related (1) Reference Standards (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Inflammation/Immunology (4) Neurological Disease (2)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Inhibitory Antibodies

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990925

Linclatamig BLYG8824A; RG6286	CD3	Inflammation/Immunology
Linclatamig (BLYG8824A) is a humanized IgG1 T-cell engaging bispecific antibody (TCB) targeting LY6G6D and CD3. Linclatamig can bind to LY6G6D and CD3-positive T cells, forming an immunological synapse to promote T cell-mediated killing of LY6G6D-positive cells. Linclatamig can be used in tumor research .

HY-176862

TCB-32	FGFR ERK	Inflammation/Immunology
TCB-32 (Compound I-1) is a FGFR1 agonist with an EC₅₀ of 0.88  μM. TCB-32 significantly increases cell proliferation through activating FGFR1 signaling pathway as bFGF and its downstream ERK1/2 with excellent thermal stability. TCB-32 can replace bFGF in serum-free cell culture media. TCB-32 can be used for tissue repair and wound healing related diseases like psoriasis and eczema research .

HY-103102

TCB2 1 Publications Verification	5-HT Receptor	Neurological Disease
TCB2 is an agonist of serotonin 5-HT_2A receptor.

HY-176862A

TCB-32 hydrochloride	FGFR ERK	Inflammation/Immunology
TCB-32 (Compound I-1) hydrochloride is a FGFR1 agonist with an EC₅₀ of 0.88  μM. TCB-32 hydrochloride significantly increases cell proliferation through activating FGFR1 signaling pathway as bFGF and its downstream ERK1/2 with excellent thermal stability. TCB-32 hydrochloride can replace bFGF in serum-free cell culture media. TCB-32 hydrochloride can be used for tissue repair and wound healing related diseases like psoriasis and eczema research .

HY-RS10602

PKM Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PKM Human Pre-designed siRNA Set A contains three designed siRNAs for PKM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PKM Human Pre-designed siRNA Set A PKM Human Pre-designed siRNA Set A

HY-145675A

*(R)-TCB2*	Interleukin Related	Inflammation/Immunology
(R)-TCB2 is the R-enantiomer of TCB2. TCB2 is a potent anti-human interleukin-2 antibody, facilitates heterodimeric IL-2 receptor signaling and improves anti-tumor immunity .

HY-B0380B

Trimebutine (3-TCBS) GIC-1001	Biochemical Assay Reagents	Others
Trimebutine 3-TCBS (GIC-1001) is an innovative formulation designed to release hydrogen sulfide (H2S) in vivo. This compound combines trimebutine with an H2S-releasing antagonist (phenyl 3-thiocarbamate) and exhibits enhanced anti-nociceptive effects in a mouse colonic distension model, superior to conventional trimebutine. GIC-1001 can reduce visceral pain and discomfort associated with lumen distension in a dose-dependent manner, showing potential superiority .

HY-103102R

TCB2 (Standard)	Reference Standards 5-HT Receptor	Neurological Disease
TCB2 (Standard) is the analytical standard of TCB2 (HY-103102). This product is intended for research and analytical applications. TCB2 is an agonist of serotonin 5-HT2A receptor.

Cat. No.	Product Name	Target	Research Area	Image

HY-P990925

Linclatamig BLYG8824A; RG6286	CD3	Inflammation/Immunology
Linclatamig (BLYG8824A) is a humanized IgG1 T-cell engaging bispecific antibody (TCB) targeting LY6G6D and CD3. Linclatamig can bind to LY6G6D and CD3-positive T cells, forming an immunological synapse to promote T cell-mediated killing of LY6G6D-positive cells. Linclatamig can be used in tumor research .

Host:	Mouse (2) Rabbit (1)
Reactivity:	Human (3) Rat (2) Mouse (2) Monkey (2)
Application:	IHC-P (1) ICC/IF (3) IP (1) IHC-F (1) WB (2) FC (1) ELISA (1)
Isotype:	IgG (1)
Conjugation:	Non-conjugated (3)
Clonality:	Polyclonal (1) Monoclonal (2)
Modification:	Phosphorylated (1) Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85551

	PKM2 Antibody (YA5243) CTHBP; Cytosolic thyroid hormone binding protein; Cytosolic thyroid hormone-binding protein; KPYM_HUMAN; MGC3932; OIP 3; OIP-3; OIP3; OPA interacting protein 3; Opa-interacting protein 3; p58; PK muscle type; PK, muscle type; PK2; PK3; PKM; PKM2; pykm; Pyruvate kinase 2/3; Pyruvate kinase 3; Pyruvate kinase isozymes M1/M2; Pyruvate kinase muscle; Pyruvate kinase muscle isozyme; pyruvate kinase PKM; Pyruvate kinase, muscle 2; TCB; THBP1; Thyroid hormone binding protein 1; Thyroid hormone binding protein cytosolic; Thyroid hormone-binding protein 1; Tumor M2 PK; Tumor M2-PK .	WB, ICC/IF, IP	Human, Mouse, Monkey
	PKM2 Antibody (YA5243) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PKM2.

HY-P85552

	PKM2 Antibody (YA5244) CTHBP; Cytosolic thyroid hormone binding protein; Cytosolic thyroid hormone-binding protein; KPYM_HUMAN; MGC3932; OIP 3; OIP-3; OIP3; OPA interacting protein 3; Opa-interacting protein 3; p58; PK muscle type; PK, muscle type; PK2; PK3; PKM; PKM2; pykm; Pyruvate kinase 2/3; Pyruvate kinase 3; Pyruvate kinase isozymes M1/M2; Pyruvate kinase muscle; Pyruvate kinase muscle isozyme; pyruvate kinase PKM; Pyruvate kinase, muscle 2; TCB; THBP1; Thyroid hormone binding protein 1; Thyroid hormone binding protein cytosolic; Thyroid hormone-binding protein 1; Tumor M2 PK; Tumor M2-PK.	WB, ICC/IF	Human, Mouse, Rat, Monkey
	PKM2 Antibody (YA5244) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PKM2.

HY-P83644

	Phospho-PKM2(Tyr105)Antibody PKM2 (Phospho Tyr105); PKM2 (Phospho Y105); PK 1; PK 2; PK 3; PK Muscle type; PK1; PK2; Pk3; PKL; PKLR; PKM 2; PKM; PYKM; Pyruvate kinase 1; Pyruvate kinase 2/3; Pyruvate kinase 3; Pyruvate kinase isozyme R/L; Pyruvate kinase isozymes M1/M2; Pyruvate kinase liver and blood cell; Pyruvate kinase liver and RBC; Pyruvate kinase liver and RBC type; Pyruvate kinase M2; Pyruvate kinase muscle; Pyruvate kinase muscle isozyme; Pyruvate kinase type L; R type/L type pyruvate kinase; Red cell/liver pyruvate kinase; RPK; TCB; THBP 1; THBP1; Thyroid hormone binding protein cytosolic; CTHBP; Cytosolic thyroid hormone binding protein; MGC3932; OIP 3; Oip3; Tumor M2-PK; p58; OIP-3.	IHC-P, IHC-F, ICC/IF, FC, ELISA	Human, Rat
	Phospho-PKM2(Tyr105)Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-PKM2(Tyr105).

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PKM Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PKM Human Pre-designed siRNA Set A contains three designed siRNAs for PKM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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