72 Results for "

TPP

" in MedChemExpress (MCE) Product Catalog:
Products (72)

72 Results for "TPP" in MCE Product Catalog:

164
164 Publications Verification
Cat. No.: HY-100116A
CAS No.: 845959-50-4
Purity:  99.09%
Synonyms: MitoQ mesylate; MitoQ10 mesylate
Research Areas:  

Metabolic Disease Cancer

Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant in order to protect against oxidative damage .
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16
16 Cited Publications
Cat. No.: HY-102007A
CAS No.: 1131626-47-5
Purity:  99.68%
Target:  

HSP

Research Areas:  

Cancer

Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
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5
5 Cited Publications
Cat. No.: HY-125623
CAS No.: 1392820-50-6
Purity:  98.14%
MitoPerOx is a mitochondrial-targeted, lipid peroxidation-indicating fluorescent probe with BODIPY581/591 fluorophores. The triphenylphosphine cation (TPP+) of MitoPerOx can be selectively enriched in mitochondria (depending on membrane potential) and can be used to detect lipid peroxidation in the inner mitochondrial membrane. Under the action of lipid peroxides, the BODIPY581/591 fluorophores of MitoPerOx shift their emission wavelength from 590 nm (reduced state) to 520 nm (oxidized state), and ratiometric detection can be performed at an excitation wavelength of 488 nm. MitoPerOx can specifically monitor the peroxidation of mitochondrial phospholipids (especially cardiolipin) and is used in the study of oxidative stress-related diseases (such as aging, neurodegenerative diseases, and mitochondrial dysfunction)[1][2].
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3
3 Cited Publications
Cat. No.: HY-135869
CAS No.: 1254044-38-6
Purity:  99.84%
Research Areas:  

Neurological Disease

Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP + cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function .
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2
2 Cited Publications
Cat. No.: HY-107759
CAS No.: 185213-03-0
Purity:  98.98%
Synonyms: UCL-1397 oxalate
Target:  

Ser/Thr Protease

Research Areas:  

Neurological Disease

Butabindide (UCL-1397) oxalate is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation .
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1
1 Cited Publications
Cat. No.: HY-144768
Purity:  96.50%
(R)-Chol-TPP a mitochondria targeting liposome ligand could be used in pH-redox responsive .
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Cat. No.: HY-W111141
CAS No.: 1263166-90-0
Synonyms: endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne
BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is an alcohol functionalized cyclooctyne derivative. BCN-OH can act as a raw material for synthesizing other probes (such as BCN-TPP). BCN-OH is used to construct targeted probes by coupling with carboxyl-containing compounds (such as TPP-COOH). BCN-OH can be used as control reagent for BCN-TPP .
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Cat. No.: HY-P3139
CAS No.: 2426685-25-6
Target:  

PD-1/PD-L1

Research Areas:  

Cancer

TPP-1 is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 binds specifically to PD-L1 with a high affinity (KD=95 nM). TPP-1 inhibits human tumor growth in vivo via reactivating T-cell function .
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Cat. No.: HY-103656
CAS No.: 917-23-7
Purity:  99.43%
Synonyms: TPP; Tetraphenylporphine; meso-Tetraphenylporphyrin
Target:  

MOFs

Research Areas:  

Cancer

Tetraphenylporphyrin (TPP) is a symmetrically substituted porphyrin-based heterocyclic compound and used as a structural block for supramolecular synthesis. Tetraphenylporphyrin derivatives can be used for cancer research .
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Cat. No.: HY-DY1073
CAS No.: 1392820-50-6
MitoPerOx (solution) is a mitochondrial-targeted, lipid peroxidation-indicating fluorescent probe with BODIPY581/591 fluorophores. The triphenylphosphine cation (TPP+) of MitoPerOx can be selectively enriched in mitochondria (depending on membrane potential) and can be used to detect lipid peroxidation in the inner mitochondrial membrane. Under the action of lipid peroxides, the BODIPY581/591 fluorophores of MitoPerOx shift their emission wavelength from 590 nm (reduced state) to 520 nm (oxidized state) , and ratiometric detection can be performed at an excitation wavelength of 488 nm. MitoPerOx can specifically monitor the peroxidation of mitochondrial phospholipids (especially cardiolipin) and is used in the study of oxidative stress-related diseases (such as aging, neurodegenerative diseases, and mitochondrial dysfunction) .
Solvent and concentration: DMSO: 2 mM
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Cat. No.: HY-102007
CAS No.: 1131626-46-4
Target:  

HSP

Research Areas:  

Cancer

Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
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Cat. No.: HY-W073013
CAS No.: 14172-90-8
5,10,15,20-Tetraphenyl-21H,23H-porphine cobalt(II), commonly known as CoTPP or cobalt porphyrin, is a coordination compound. 5,10,15,20-Tetraphenyl-21H,23H-porphine cobalt(II) is widely used in various fields such as catalysis, sensing, and organic electronics because of its unique electronic and optical properties. An efficient catalyst for reactions including oxidation, reduction, and CH bond activation, moreover, it has been used as a fluorescent probe for detecting oxygen content in biological systems and as an active material in organic solar cells.
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Cat. No.: HY-159734
Target:  

Apoptosis

Research Areas:  

Cancer

TPP-resveratrol is a conjugate of Resveratrol (HY-16561) and triphenylphosphine (TPP) with anticancer activity. TPP-resveratrol increases the potency of Resveratrol through mitochondrial-targeted delivery and induces mitochondria-mediated apoptosis .
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Cat. No.: HY-158189
CAS No.: 3030629-73-0
TPP-Ce6 is a mitochondria-targeted photosensitizer formed by the ester bond conjugation of chlorophyll e6 (Ce6) with triphenylphosphine (TPP). Under light irradiation or ultrasound exposure, TPP-Ce6 generates reactive oxygen species, induces cell apoptosis, and triggers immunogenic cell death. TPP-Ce6 can serve as a component of carrier-free co-delivery systems, undergo enzyme-induced self-assembly within tumors, and modulate tumor hypoxia. TPP-Ce6 is applicable to research on breast cancer and glioblastoma .
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Cat. No.: HY-W582504
CAS No.: 15709-76-9
Synonyms: CuCl(TPP)3
Target:  

DNA Stain Bacterial Fungal

Research Areas:  

Infection Cancer

Chlorotris(triphenylphosphine)copper (CuCl(TPP)₃) is a DNA-targeted metal complex. Chlorotris(triphenylphosphine)copper involves non-covalent interactions (such as groove binding mode) through the copper(I) center to affect DNA function, showing inhibitory activity against bacteria, fungi, and tumor cells. Chlorotris(triphenylphosphine)copper is promising for research of antibacterial, antitumor, and antioxidant agents .
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Cat. No.: HY-150070
CAS No.: 175553-48-7
Synonyms: UCL-1397
Target:  

Ser/Thr Protease

Research Areas:  

Neurological Disease

Butabindide (UCL-1397) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation .
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Cat. No.: HY-174953A
TPP-PEG2000-Mal is a PEG derivative composed of triphenyl phosphate (TPP), PEG units, and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
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Cat. No.: HY-174953B
TPP-PEG3400-Mal is a PEG derivative composed of triphenyl phosphate (TPP), PEG units, and Maleimide (HY-W007324). Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups .
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Cat. No.: HY-W854649
CAS No.: 15695-27-9
Target:  

HSP

Research Areas:  

Cancer

[Au(TPP)]Cl inhibits the refolding activity of the Hsp60-Hsp10 complex with significant anticancer activities .
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Cat. No.: HY-W075353
CAS No.: 35218-75-8
Target:  

Fluorescent Dye MOFs

Research Areas:  

Cancer

TPPS can be used as a non-cytotoxic probe for detecting tumor location .
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