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Results for "

YEATS2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Bcl-2 Family (1) Biochemical Assay Reagents (1) CDK (1) Epigenetic Reader Domain (3) HDAC (1) Sirtuin (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W105310A

Croconic acid disodium Nacr	HDAC Sirtuin CDK Bcl-2 Family Apoptosis	Others
Croconic acid disodium (Nacr) is a lysine crotonylation (Kcr) activator and electroactive material. Croconic acid disodium reduces the expression of *HDAC2, HDAC3, SIRT1, and SIRT3, and increases the expression of EP300, CITED1, ACSS2, DPF2, CDYL, MLLT3, and YEATS2. Croconic acid disodium elevates intracellular crotonyl-CoA content and global histone lysine crotonylation levels. Croconic acid disodium promotes the growth of bovine fibroblasts, regulates cell cycle progression, and inhibits bovine fibroblast apoptosis (apoptosis*). Croconic acid disodium improves the blastocyst development efficiency of bovine somatic cell nuclear transfer embryos. Croconic acid disodium undergoes reversible lithium intercalation/deintercalation reactions via sodium-lithium ion exchange. Croconic acid disodium is applicable to research related to cell growth promotion ^[2].

HY-162350

TDI-11055	Epigenetic Reader Domain Apoptosis	Cancer
TDI-11055 is a selective and orally active eleven-nineteen leukemia (ENL) inhibitor, which displaces ENL from chromatin by blocking its YEATS domain interaction with acylated histones. TDI-11055 inhibits ENL and AF9 YEATS domains with IC₅₀ values of 50 nM and 70 nM, respectively, and no activity against GAS41 or YEATS2. TDI-11055 decreases chromatin occupancy of ENL-associated complexes, impairs transcription elongation, suppresses key oncogenic gene expression programs, and induces differentiation. TDI-11055 can be used for the research of acute myeloid leukemia ^[2].

HY-155412

PFI-6	Epigenetic Reader Domain	Cancer
PFI-6 is a selective MLLT1 and MLLT3 YEATS domain probe with IC₅₀ values of 0.14 μM and 0.16 μM, respectively. PFI-6 is applicable for cancer research .

HY-RS21976

Yeats2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Yeats2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Yeats2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Yeats2 Mouse Pre-designed siRNA Set A Yeats2 Mouse Pre-designed siRNA Set A

HY-RS15920

YEATS2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
YEATS2 Human Pre-designed siRNA Set A contains three designed siRNAs for YEATS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

YEATS2 Human Pre-designed siRNA Set A YEATS2 Human Pre-designed siRNA Set A

HY-RS28493

Yeats2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Yeats2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Yeats2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Yeats2 Rat Pre-designed siRNA Set A Yeats2 Rat Pre-designed siRNA Set A

HY-176821

PFI-6N	Biochemical Assay Reagents	Cancer
PFI-6N is a negative control compound of PFI-6 (HY-155412). PFI-6N is completely inactive against YEATS domain (MLLT1/3 and YEATS2/4) by methylating the amide of PFI-6 .

HY-181065

LS-170	Epigenetic Reader Domain	Cancer
LS-170 is a *YEATS2* YEATS domain inhibitor with an IC₅₀ of 0.14 μM. LS-170 displays selectivity for the *YEATS2* YEATS domain over other YEATS domain family members and other epigenetic 'reader' and 'eraser' proteins. LS-170 reduces chromatin occupancy of the Ada-two-A-containing (ATAC) complex, decreases ATAC-dependent histone acetylation levels, and downregulates expression of ATAC-governed genes. LS-170 suppresses tumor growth in a lung cancer mouse model. LS-170 can be used for the research of non-small cell lung cancer .

Yeats2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Yeats2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Yeats2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

YEATS2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
YEATS2 Human Pre-designed siRNA Set A contains three designed siRNAs for YEATS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Yeats2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Yeats2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Yeats2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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