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acquired resistance

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) ATP Synthase (1) Bacterial (6) Biochemical Assay Reagents (1) c-Met/HGFR (1) COX (3) DNA/RNA Synthesis (1) EGFR (3) Environmental Pollutants (2) FGFR (1) Fungal (3) HIV (1) NAMPT (1) PARP (1) PROTACs (1) Reactive Oxygen Species (ROS) (1) Reference Standards (4) Reverse Transcriptase (1) SOS1 (1) TMV (1) YAP (2)
By Research Areas:	Cancer (13) Infection (6) Inflammation/Immunology (6) Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: BCRP P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147214

GNE-7883 5 Publications Verification	YAP	Cancer
GNE-7883 is a pan-TEAD inhibitor that blocks the association of YAP/TAZ with TEAD. GNE-7883 effectively reduces chromatin accessibility at TEAD motifs, inhibits cell proliferation in multiple cell line models, and achieves strong anti-tumor efficacy in vivo. In addition, GNE-7883 effectively overcomes intrinsic and acquired resistance to KRAS (Kirsten rat sarcoma viral oncogene homolog) G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation .

HY-147245

Basroparib STP1002	PARP	Cancer
Basroparib (STP1002) is a selective, orally active inhibitor of tankyrase (TNKS1/TNKS2) with IC₅₀ of 29.94 nM and 3.68 nM for TNKS1 and TNKS2, respectively. Basroparib has an IC₅₀ of >10 μM for PARP1. Basroparib binds to TNKS, stabilizes AXIN1/2 proteins, blocks Wnt/β-catenin signaling pathway, inhibits tumor cell proliferation and induces apoptosis, while reducing cancer stem cell properties. Basroparib can be used in colorectal cancer (CRC) studies with KRAS mutations (such as G12V/G12D) to overcome acquired resistance to MEK inhibitors. STP1002 has synergistic antitumor activity with MEK inhibitors .

HY-N7378

N-Hydroxypipecolic acid 5 Publications Verification 1-Hydroxy-2-piperidinecarboxylic acid; NHP	Bacterial	Inflammation/Immunology
N-Hydroxypipecolic acid (1-Hydroxy-2-piperidinecarboxylic acid), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid induces SAR to bacterial and oomycete infection .

HY-Y0189

Methyl Salicylate Salicylic acid methyl ester	Environmental Pollutants COX	Inflammation/Immunology
Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products . A systemic acquired resistance (SAR) signal in tobacco . A topical nonsteroidal anti-inflammatory agent (NSAID). Methyl salicylate lactoside is a COX inhibitor .

HY-107636

DC_AC50 Maximum Cited Publications 6 Publications Verification	Apoptosis	Cancer
DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance .

HY-175839

PROTAC EGFR degrader 15	PROTACs EGFR ATP Synthase	Cancer
PROTAC EGFR degrader 15 is a Pomalidomide (HY-10984)-based Gefitinib (HY-50895) EGFR PROTAC degrader. PROTAC EGFR degrader 15 triggers EGFR degradation via ubiquitin-proteasome-dependent proteolysis and autophagy-lysosome activation pathways. PROTAC EGFR degrader 15 targets ETFA to enhance ATP production. PROTAC EGFR degrader 15 significantly suppresses tumor growth in a Gefitinib-acquired resistant HCC-827 xenograft model. PROTAC EGFR degrader 15 can be used for the study of non-small cell lung cancer (NSCLC) (Pink: EGFR ligand (HY-W109039); Blue: CRBN ligand (HY-10984); Black: Linker (HY-W679737)) .

HY-116541

Acibenzolar-S-methyl ASM	Environmental Pollutants Fungal Bacterial	Infection
Acibenzolar-S-methyl (ASM) is a plant resistance inducer that mimics pathogen-host interactions and leads to systemic acquired resistance in plants. Acibenzolar-S-methyl helps reduce the use of pesticides and can be used in research to prevent plant diseases .

HY-125147

A-1293201	NAMPT	Cancer
A-1293201 is a substrate-independent NAMPT inhibitor with antitumor activity. A-1293201 effectively reduces the total cellular NAD ⁺/NADH (NADt) level, subsequently leading to ATP depletion and cancer cell death. In addition, A-1293201 can effectively overcome the acquired resistance mechanism of the NAMPT Y18 mutant to CHS-828 (HY-10079) .

HY-Y0189R

Methyl Salicylate (Standard) Salicylic acid methyl ester (Standard)	Reference Standards COX	Inflammation/Immunology
Methyl Salicylate (Standard) is the analytical standard of Methyl Salicylate. This product is intended for research and analytical applications. Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products . A systemic acquired resistance (SAR) signal in tobacco . A topical nonsteroidal anti-inflammatory agent (NSAID). Methyl salicylate lactoside is a COX inhibitor .

HY-17517

Tiadinil	Fungal Biochemical Assay Reagents	Infection
Tiadinil is a systemic acquired resistance (SAR) inducer, plant elicitor and antifungal agent. Tiadinil promotes the production of herbivore-induced plant volatiles in Camellia sinensis (tea plant). Tiadinil inhibits mycelial growth, spore germination and germ tube elongation of Stagonosporopsis citrulli in vitro. Tiadinil can be used in studies related to vine blight .

HY-116541R

Acibenzolar-S-methyl (Standard) ASM (Standard)	Bacterial Fungal Reference Standards	Infection
Acibenzolar-S-methyl (Standard) is the analytical standard of Acibenzolar-S-methyl. This product is intended for research and analytical applications. Acibenzolar-S-methyl (ASM) is a plant resistance inducer that mimics pathogen-host interactions and leads to systemic acquired resistance in plants. Acibenzolar-S-methyl helps reduce the use of pesticides and can be used in research to prevent plant diseases .

HY-Y0189S

Methyl Salicylate-d4 Wintergreen oil-d₄	COX	Inflammation/Immunology
Methyl Salicylate-d₄ is the deuterium labeled Methyl Salicylate . Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products . A systemic acquired resistance (SAR) signal in tobacco . A topical nonsteroidal anti-inflammatory agent (NSAID). Methyl salicylate lactoside is a COX inhibitor .

HY-Q66655

YRDC-IN-1	DNA/RNA Synthesis Reactive Oxygen Species (ROS)	Neurological Disease Cancer
YRDC-IN-1 is a blood-brain barrier-permeable YRDC inhibitor. YRDC is a key enzyme that catalyzes the formation of N ⁶-threonylcarbamoyladenosine at position 37 of tRNA (t ⁶A₃₇). YRDC-IN-1 selectively inhibits the translation of ANN codon-enriched FABP7, thereby reducing lipid droplet formation, increasing ROS, and reversing the acquired resistance of GBM to Temozolomide (TMZ) (HY-17364). YRDC-IN-1 can be used for the research of glioblastoma .

HY-174387

KIN-8741	c-Met/HGFR	Cancer
KIN-8741 is a highly selective Type IIb c-Met inhibitor. KIN-8741 has broad activity against c-Met kinase mutations. KIN-8741 shows antitumor activity in MET gene amplified and exon 14 deleted non-small cell lung cancer models. KIN-8741 can be used in the research of c-Met driven cancers, especially advanced tumors carrying MET exon 14 jump mutations, acquired drug resistance mutations, etc .

HY-174303

NNRT-IN-9	HIV Reverse Transcriptase	Infection
NNRT-IN-9 (Compound EG28) is a non-nucleoside reverse transcriptase (NNRT) inhibitor. NNRT-IN-9 has potent antiviral and anti-resistance activity against wild-type (WT) HIV-1 and various clinically relevant mutations (E138K and K103N + Y181C) with EC₅₀s of 55, 67 and 3910 nM, respectively. NNRT-IN-9 can be used for acquired immune deficiency syndrome (AIDS) research .

HY-167948

Dacomitinib metabolite M1/2	EGFR	Cancer
Dacomitinib metabolite M1/2 is a potent inhibitor of both wild-type (WT) EGFR and the T790M mutation, demonstrating significant activity against acquired resistance mechanisms in EGFR-mutant non-small-cell lung cancer (NSCLC).

HY-149013

Anti-MRSA agent 5	Bacterial	Infection
Anti-MRSA agent 5 (B14) is a potent MRSA agent with MIC₅₀ values of 0.38 μg/mL and has low hERG activity with an IC₅₀ values of >40 μM. Anti-MRSA agent 5 (B14) also has low cytotoxicity to mammal cells and unlikely to acquire bacterial resistance .

HY-N1836

3-Acetonyl-3-hydroxyoxindole 3-Hydroxy-3-acetonyloxindole	TMV	Infection
3-Acetonyl-3-hydroxyoxindole (AHO) is a potent *systemic acquired* resistance (SAR)** inducer in plants. 3-Acetonyl-3-hydroxyoxindole induces resistance in tobacco plants against infection with tobacco mosaic virus (TMV) and the fungal pathogen Erysiphe cichoracearum. 3-Acetonyl-3-hydroxyoxindole increases the level of pathogenesis-related gene 1 (PR-1) expression, salicylic acid (SA) accumulation and phenylalanine ammonia-lyase activity .

HY-N7378A

N-Hydroxypipecolic acid potassium 1-Hydroxy-2-piperidinecarboxylic acid potassium; NHP potassium	Bacterial	Inflammation/Immunology
N-Hydroxypipecolic acid potassium (1-Hydroxy-2-piperidinecarboxylic acid potassium), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid potassium accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid potassium induces SAR to bacterial and oomycete infection .

HY-172922

FGFR-IN-19	FGFR	Cancer
Arg-IN-1 is a selective Arginine (Arg)-targeting covalent inhibitor with IC₅₀s of 9.7 nM and 30.4 nM for FGFR2 and FGFR3,respectively. Arg-IN-1 has the potential to avoid FGFR1/4-targeted toxicity as well as conquer acquired on-target resistance, potential for FGFR-targeting cancer therapy .

HY-157166

EGFR kinase inhibitor 2	EGFR	Cancer
EGFR kinase inhibitor 2 (compound A-7) is a potent EGFR inhibitor targeting EGFRL858R/T790M/C797S and EGFRDel19/T790M/C797S mutants. EGFR kinase inhibitor 2 has the potential to address acquired resistance in the treatment of non-small cell lung cancer .

HY-175326

SOS1-IN-21	SOS1	Cancer
SOS1-IN-21 is an orally active inhibitor of son of Sevenless 1 (SOS1) with an IC₅₀ of 15 nM. SOS1 is a guanine nucleotide exchange factor (GEF) that activates KRAS by facilitating the exchange of GDP for GTP. SOS1-IN-21 exhibits potent antiproliferative activity, with IC₅₀ values of 16 nM in NCI-H358 and 17 nM in Mia Paca-2 cell proliferation assays. SOS1-IN-21 exhibits significant antitumor activity in the Mia Paca-2 xenograft model. SOS1-IN-21 can be used for the study of KRAS mutant tumors, such as pancreatic cancer .

HY-107636R

DC_AC50 (Standard)	Reference Standards Apoptosis	Cancer
DC_AC50 (Standard) is the analytical standard of DC_AC50 (HY-107636). This product is intended for research and analytical applications. DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance .

HY-N7378R

N-Hydroxypipecolic acid (Standard) 1-Hydroxy-2-piperidinecarboxylic acid (Standard); NHP (Standard)	Bacterial Reference Standards	Inflammation/Immunology
N-Hydroxypipecolic acid (Standard) (1-Hydroxy-2-piperidinecarboxylic acid (Standard); NHP (Standard)) is the analytical standard of N-Hydroxypipecolic acid (HY-N7378). This product is intended for research and analytical applications. N-Hydroxypipecolic acid (1-Hydroxy-2-piperidinecarboxylic acid), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid induces SAR to bacterial and oomycete infection .

HY-179559

OPN-9643	YAP	Cancer
OPN-9643 is a covalent inhibitor targeting the central palmitate binding pocket of TEADs with an IC₅₀ of 15 nM, preventing autopalmitoylation and reducing TEAD-driven luciferase activity and canonical TEAD targets, CTGF and CYR61. OPN-9643 can be used for the research of cancer, such as melanoma .

Cat. No.	Product Name

HY-L932V0

Kinase Macrocyclic Compound Virtual Library	2,000,000 compounds
Macrocyclic compounds (≥12-atom cyclic small molecules/peptides) have unique physicochemical properties. They form preorganized conformations with high binding affinity/selectivity, target traditional small-molecule-inaccessible proteins, and bridge small-molecule drugs and biological agents. As key protein phosphorylation enzymes, kinases are linked to tumors, COPD, etc., and are critical therapeutic targets. Traditional small-molecule kinase inhibitors lack selectivity, causing off-target toxicity, low bioavailability, and acquired resistance. Macrocycles’ semi-rigid structure restricts conformations, boosts binding selectivity, optimizes pharmacokinetics, and makes macrocyclization a core kinase inhibitor optimization strategy. Thousands of bioactive macrocycles were curated from ChEMBL. Via Transformer, macrocyclization was converted into a chemical language translation task, enabling end-to-end macrocycle generation from linear precursors with simplified inputs. Macformer achieves efficient, automated linear molecule macrocyclization via deep learning; generated macrocycles have diversity, novelty, biocompatibility, and cover broader chemical space. MCE collected thousands of marketed/clinical kinase inhibitors, using their fragments for macrocyclization to generate derivatives. After evaluating synthetic accessibility and physicochemical properties, a million-scale virtual macrocyclic library was built for kinase-related virtual and AI-driven screening.

Kinase Macrocyclic Compound Virtual Library

2,000,000 compounds

Macrocyclic compounds (≥12-atom cyclic small molecules/peptides) have unique physicochemical properties. They form preorganized conformations with high binding affinity/selectivity, target traditional small-molecule-inaccessible proteins, and bridge small-molecule drugs and biological agents. As key protein phosphorylation enzymes, kinases are linked to tumors, COPD, etc., and are critical therapeutic targets. Traditional small-molecule kinase inhibitors lack selectivity, causing off-target toxicity, low bioavailability, and acquired resistance. Macrocycles’ semi-rigid structure restricts conformations, boosts binding selectivity, optimizes pharmacokinetics, and makes macrocyclization a core kinase inhibitor optimization strategy.

Thousands of bioactive macrocycles were curated from ChEMBL. Via Transformer, macrocyclization was converted into a chemical language translation task, enabling end-to-end macrocycle generation from linear precursors with simplified inputs. Macformer achieves efficient, automated linear molecule macrocyclization via deep learning; generated macrocycles have diversity, novelty, biocompatibility, and cover broader chemical space.

MCE collected thousands of marketed/clinical kinase inhibitors, using their fragments for macrocyclization to generate derivatives. After evaluating synthetic accessibility and physicochemical properties, a million-scale virtual macrocyclic library was built for kinase-related virtual and AI-driven screening.

HY-L932V

Kinase Macrocyclic Compound Virtual Library	2,000,000 compounds
Macrocyclic compounds (≥12-atom cyclic small molecules/peptides) have unique physicochemical properties. They form preorganized conformations with high binding affinity/selectivity, target traditional small-molecule-inaccessible proteins, and bridge small-molecule drugs and biological agents. As key protein phosphorylation enzymes, kinases are linked to tumors, COPD, etc., and are critical therapeutic targets. Traditional small-molecule kinase inhibitors lack selectivity, causing off-target toxicity, low bioavailability, and acquired resistance. Macrocycles’ semi-rigid structure restricts conformations, boosts binding selectivity, optimizes pharmacokinetics, and makes macrocyclization a core kinase inhibitor optimization strategy. Thousands of bioactive macrocycles were curated from ChEMBL. Via Transformer, macrocyclization was converted into a chemical language translation task, enabling end-to-end macrocycle generation from linear precursors with simplified inputs. Macformer achieves efficient, automated linear molecule macrocyclization via deep learning; generated macrocycles have diversity, novelty, biocompatibility, and cover broader chemical space. MCE collected thousands of marketed/clinical kinase inhibitors, using their fragments for macrocyclization to generate derivatives. After evaluating synthetic accessibility and physicochemical properties, a million-scale virtual macrocyclic library was built for kinase-related virtual and AI-driven screening.

Kinase Macrocyclic Compound Virtual Library

2,000,000 compounds

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7378

N-Hydroxypipecolic acid 5 Publications Verification 1-Hydroxy-2-piperidinecarboxylic acid; NHP	other families Classification of Application Fields Ketones, Aldehydes, Acids Plants Inflammation/Immunology Disease Research Fields Source Classification	Bacterial
N-Hydroxypipecolic acid (1-Hydroxy-2-piperidinecarboxylic acid), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid induces SAR to bacterial and oomycete infection .

HY-Y0189

Methyl Salicylate Salicylic acid methyl ester	Structural Classification Monophenols Classification of Application Fields Murraya paniculata (L.) Jack. Rutaceae Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Environmental Pollutants COX
Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products . A systemic acquired resistance (SAR) signal in tobacco . A topical nonsteroidal anti-inflammatory agent (NSAID). Methyl salicylate lactoside is a COX inhibitor .

HY-Y0189R

Methyl Salicylate (Standard) Salicylic acid methyl ester (Standard)	Structural Classification Monophenols Microorganisms Murraya paniculata (L.) Jack. Rutaceae Phenols Plants Source Classification	Reference Standards COX
Methyl Salicylate (Standard) is the analytical standard of Methyl Salicylate. This product is intended for research and analytical applications. Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products . A systemic acquired resistance (SAR) signal in tobacco . A topical nonsteroidal anti-inflammatory agent (NSAID). Methyl salicylate lactoside is a COX inhibitor .

HY-N1836

3-Acetonyl-3-hydroxyoxindole 3-Hydroxy-3-acetonyloxindole	Infection Alkaloids Acanthaceae Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Jacobaea cannabifolia (Less.) E. Wiebe Source Classification	TMV
3-Acetonyl-3-hydroxyoxindole (AHO) is a potent *systemic acquired* resistance (SAR)** inducer in plants. 3-Acetonyl-3-hydroxyoxindole induces resistance in tobacco plants against infection with tobacco mosaic virus (TMV) and the fungal pathogen Erysiphe cichoracearum. 3-Acetonyl-3-hydroxyoxindole increases the level of pathogenesis-related gene 1 (PR-1) expression, salicylic acid (SA) accumulation and phenylalanine ammonia-lyase activity .

HY-N7378A

N-Hydroxypipecolic acid potassium 1-Hydroxy-2-piperidinecarboxylic acid potassium; NHP potassium	other families Classification of Application Fields Ketones, Aldehydes, Acids Plants Inflammation/Immunology Disease Research Fields Source Classification	Bacterial
N-Hydroxypipecolic acid potassium (1-Hydroxy-2-piperidinecarboxylic acid potassium), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid potassium accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid potassium induces SAR to bacterial and oomycete infection .

HY-N7378R

N-Hydroxypipecolic acid (Standard) 1-Hydroxy-2-piperidinecarboxylic acid (Standard); NHP (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Plants Source Classification	Bacterial Reference Standards
N-Hydroxypipecolic acid (Standard) (1-Hydroxy-2-piperidinecarboxylic acid (Standard); NHP (Standard)) is the analytical standard of N-Hydroxypipecolic acid (HY-N7378). This product is intended for research and analytical applications. N-Hydroxypipecolic acid (1-Hydroxy-2-piperidinecarboxylic acid), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid induces SAR to bacterial and oomycete infection .

Cat. No.	Product Name	Chemical Structure

HY-Y0189S

Methyl Salicylate-d4
Methyl Salicylate-d₄ is the deuterium labeled Methyl Salicylate . Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products . A systemic acquired resistance (SAR) signal in tobacco . A topical nonsteroidal anti-inflammatory agent (NSAID). Methyl salicylate lactoside is a COX inhibitor .

Methyl Salicylate-d4

Methyl Salicylate-d₄ is the deuterium labeled Methyl Salicylate . Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products . A systemic acquired resistance (SAR) signal in tobacco . A topical nonsteroidal anti-inflammatory agent (NSAID). Methyl salicylate lactoside is a COX inhibitor .

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acquired resistance

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