Acibenzolar-S-methyl
Based on 1 Customer Validation
Acibenzolar-S-methyl (ASM) is a synthetic analog of Salicylic acid (HY-B0167) and a plant activator. Acibenzolar‑S‑methyl induces increased activities of defense-related enzymes such as peroxidase and chitinase, activates stomatal defense responses and PR defense gene expression, induces the production of ROS, triggers local and systemic acquired resistance, and inhibits the proliferation of bacterial and fungal pathogens in plants. Acibenzolar‑S‑methyl can be used in studies related to plant infection.
For research use only. We do not sell to patients.
- Purity : 99.77%
- CAS No.: 135158-54-2
- Formula: C8H6N2OS2
- Molecular Weight:210.28
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
In Vitro
Acibenzolar‑S‑methyl (ASM) inhibits lesion formation by this pathogen, reduces bacterial abundance in both treated leaves and untreated systemic leaves of the Japanese radish (Raphanus sativus var. longipinnatus cultivar Natsutsukasa); triggers local and systemic stomatal closure mediated by peroxidase-derived reactive oxygen species, and enhances stomata-associated disease resistance; induces local and systemic expression of the leaf defense genes PR1, PR2, and PR3 at 4 h post-administration[1].
Acibenzolar-S-methyl (ASM) (0.2 mg/mL) increases the activities of peroxidase and chitinase in crude enzyme extracts from leaf tissues of tomato (cv. F144)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 135158-54-2
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Appearance Solid
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Molecular Weight 210.28
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Formula C8H6N2OS2
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Color White to off-white
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SMILES
O=C(SC)C1=C2SN=NC2=CC=C1
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Synonyms
ASM
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 31.25 mg/mL (148.61 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (291 KB)
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SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7556 mL | 23.7778 mL | 47.5556 mL | 118.8891 mL |
| 5 mM | 0.9511 mL | 4.7556 mL | 9.5111 mL | 23.7778 mL | |
| 10 mM | 0.4756 mL | 2.3778 mL | 4.7556 mL | 11.8889 mL | |
| 15 mM | 0.3170 mL | 1.5852 mL | 3.1704 mL | 7.9259 mL | |
| 20 mM | 0.2378 mL | 1.1889 mL | 2.3778 mL | 5.9445 mL | |
| 25 mM | 0.1902 mL | 0.9511 mL | 1.9022 mL | 4.7556 mL | |
| 30 mM | 0.1585 mL | 0.7926 mL | 1.5852 mL | 3.9630 mL | |
| 40 mM | 0.1189 mL | 0.5944 mL | 1.1889 mL | 2.9722 mL | |
| 50 mM | 0.0951 mL | 0.4756 mL | 0.9511 mL | 2.3778 mL | |
| 60 mM | 0.0793 mL | 0.3963 mL | 0.7926 mL | 1.9815 mL | |
| 80 mM | 0.0594 mL | 0.2972 mL | 0.5944 mL | 1.4861 mL | |
| 100 mM | 0.0476 mL | 0.2378 mL | 0.4756 mL | 1.1889 mL |
Acibenzolar-S-methyl Related Classifications
HY-116541 Related Classifications
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Keywords
- Acibenzolar-S-methyl
- 135158-54-2
- ASM
- Drug Derivative
- Fungal
- Bacterial
- Reactive Oxygen Species (ROS)
- Pseudomonas cannabina pv. alisalensis
- reactive oxygen species (ROS)
- PR3
- Clavibacter michiganensis ssp. michiganensis
- salicylic acid
- SA-binding protein (SABP2)
- Raphanus sativus var. longipinnatus
- PR1
- PR2
- systemic acquired resistance (SAR)
- Inhibitor
- inhibitor
- inhibit