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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
activated factor XI
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "activated factor XI" in MCE Product Catalog:
9
9 Cited Publications
Cat. No.: HY-114164H
CAS No.: 9002-04-4
Synonyms: EC 3.4.21.5 (Lyophilized); Human Alpha Thrombin (Lyophilized)
Research Areas:
Human α-Thrombin (EC 3.4.21.5; Human Alpha Thrombin) (Lyophilized) is a terminal serine protease in the coagulation cascade, as well as a potent physiological platelet agonist and fibrin-generating enzyme in vivo. Human α-Thrombin catalyzes the conversion of fibrinogen to fibrin for blood clot formation, and activates platelet aggregation by cleaving the protease-activated receptors PAR1 (major) (Kd = 1 nM) and PAR4 (minor) on the platelet surface to expose tethered ligands. Human α-Thrombin also amplifies coagulation via positive feedback by activating coagulation factors V, VIII, XI (FV/FVIII/FXI), and switches to activate protein C to exert anticoagulant effects after binding to thrombomodulin .
This product is in a freeze-dried form.
This product is in a freeze-dried form.
Synonyms: EP-7041
Target:
Research Areas:
Frunexian (EP-7041) is a small-molecule activated factor XI (FXIa) inhibitor. Frunexian has the characteristics of rapid onset and offset of action, a short half-life, dose-dependent prolongation of activated partial thromboplastin time, and an extremely low risk of bleeding. Frunexian exhibits good safety and tolerability and can be used in research related to thrombocytopenia, thromboembolism, thromboembolic diseases, and COVID-19 .
Cat. No.: HY-175735
CAS No.: 2563884-39-7
Target:
Research Areas:
Factor XI-IN-2 is a Factor XI activation inhibitor with an IC50 of 20 nM. Factor XI-IN-2 does not directly inhibit the enzymatic activity of FXIa, but specifically binds to the FXI enzyme precursor and allosterically inhibits the process by which it is activated by FXIIa. Factor XI-IN-2 inhibits thrombosis in the rabbit arteriovenous (AV) shunt thrombosis model. Factor XI-IN-2 can be used for the study of antithrombus .
Cat. No.: HY-107966A
CAS No.: 37270-89-6
Synonyms: Nadroparin calcium (MW 3600-5000)
Cat. No.: HY-143477
CAS No.: 2720619-72-5
Research Areas:
Factor XI-IN-1 is an activator inhibitor of coagulation factor XI (Factor XI) with an EC50 of 25.14 nM. Factor XI-IN-1 is applicable to research related to thrombosis, embolism, hypercoagulable states and fibrotic changes .
Cat. No.: HY-151196
CAS No.: 2816108-08-2
Target:
Research Areas:
FXIa-IN-10 (Compound 3f) is a potent activated factor XI (FXIa) inhibitor with an Ki of 0.17 nM. FXIa-IN-10 has good oral bioavailability .
Cat. No.: HY-107966
CAS No.: 37270-89-6
Synonyms: Nadroparin calcium (MW 15000-19000)
Cat. No.: HY-156613A
CAS No.: 2416857-24-2
Synonyms: EP-7041 hydrochloride
Target:
Research Areas:
Frunexian (EP-7041) hydrochloride is a small-molecule activated factor XI (FXIa) inhibitor. Frunexian hydrochloride has the characteristics of rapid onset and offset of action, a short half-life, dose-dependent prolongation of activated partial thromboplastin time, and an extremely low risk of bleeding. Frunexian hydrochloride exhibits good safety and tolerability and can be used in research related to thrombocytopenia, thromboembolism, thromboembolic diseases, and COVID-19 .
Cat. No.: HY-183409
CAS No.: 1941243-22-6
Synonyms: ONO-5450598
Target:
Research Areas:
ONO-7684 (ONO-5450598) is an orally active coagulation factor XIa (FXIa) inhibitor with a Ki value of 2 nM against human FXIa. ONO-7684 inhibits human FXIa in a competitive and reversible manner, reduces factor XI coagulation activity, prolongs activated partial thromboplastin time in a dose-dependent manner, and exerts no significant effects on PT/INR and the activity of related serine proteases. ONO-7684 exerts antithrombotic effects in vivo without prolonging bleeding time. ONO-7684 can be used in studies related to thromboembolic diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
