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Results for "

adenosine kinase

" in MedChemExpress (MCE) Product Catalog:

標的別:	Adenosine Deaminase (1) Adenosine Kinase (13) Adenosine Receptor (6) Amino Acid Derivatives (2) AMPK (11) Antibiotic (4) Apoptosis (11) ATP Synthase (1) Aurora Kinase (1) Autophagy (3) Bacterial (2) Biochemical Assay Reagents (1) Calmodulin (1) CDK (2) Creatine Kinase (1) Fructose-1,6-bisphosphate aldolase (1) Fungal (2) Interleukin Related (1) IRE1 (2) Isotope-Labeled Compounds (2) MMP (2) NF-κB (1) p38 MAPK (1) Parasite (2) PARP (1) Phosphodiesterase (PDE) (2) Phytohormone (1) PKA (9) Potassium Channel (2) Pyruvate Kinase (2) Ras (1) Reactive Oxygen Species (ROS) (5) Reference Standards (6) Salt-inducible Kinase (SIK) (1) TNF Receptor (2)
研究分野別:	Cancer (26) Cardiovascular Disease (7) Endocrinology (1) Infection (6) Inflammation/Immunology (19) Metabolic Disease (8) Neurological Disease (12)

標的別:

Adenosine Deaminase (1)

Adenosine Kinase (13)

Adenosine Receptor (6)

Amino Acid Derivatives (2)

AMPK (11)

Antibiotic (4)

Apoptosis (11)

ATP Synthase (1)

Aurora Kinase (1)

Autophagy (3)

Bacterial (2)

Biochemical Assay Reagents (1)

Calmodulin (1)

CDK (2)

Creatine Kinase (1)

Fructose-1,6-bisphosphate aldolase (1)

Fungal (2)

Interleukin Related (1)

IRE1 (2)

Isotope-Labeled Compounds (2)

MMP (2)

NF-κB (1)

p38 MAPK (1)

Parasite (2)

PARP (1)

Phosphodiesterase (PDE) (2)

Phytohormone (1)

PKA (9)

Potassium Channel (2)

Pyruvate Kinase (2)

Ras (1)

Reactive Oxygen Species (ROS) (5)

Reference Standards (6)

Salt-inducible Kinase (SIK) (1)

TNF Receptor (2)

研究分野別:

Cancer (26)

Cardiovascular Disease (7)

Endocrinology (1)

Infection (6)

Inflammation/Immunology (19)

Metabolic Disease (8)

Neurological Disease (12)

阻害剤およびアゴニスト

ペプチド

天然物

組換えタンパク質

同位体標識化合物

抗体

Targets Recommended: Adenosine Kinase Adenosine Deaminase Adenosine Receptor

製品番号	製品名	Target	研究分野	構造式

HY-B0764

Bucladesine sodium Maximum Cited Publications 41 Publications Verification Dibutyryl cAMP sodium; DBcAMP sodium	PKA Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) sodium is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

HY-15424

5-Iodotubercidin 10+ Cited Publications NSC 113939; 5-ITu	Adenosine Kinase	Cancer
5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent **adenosine kinase inhibitor with an IC₅₀** of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin .

HY-N0262

Cordycepin 10+ Cited Publications 3'-Deoxyadenosine	TNF Receptor MMP Bacterial Autophagy Antibiotic	Infection Inflammation/Immunology Cancer
Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills *Mycobacterium tuberculosis* through hijacking the bacterial adenosine kinase .

HY-103161

ABT-702 dihydrochloride 3 Publications Verification	Adenosine Kinase	Inflammation/Immunology
ABT-702 dihydrochloride is a potent **adenosine kinase (AK) inhibitor (IC₅₀**=1.7 nM).

HY-103248

Toyocamycin 5+ Cited Publications Vengicide	IRE1 Fungal Antibiotic Apoptosis CDK	Infection Cancer
Toyocamycin (Vengicide) is an adenosine analog produced by Streptomyces diastatochromogenes, acts as an XBP1 inhibitor. Toyocamycin blocks RNA synthesis and ribosome function, and induces apoptosis. Toyocamycin affects IRE1α-XBP1 pathway, and inhibits XBP1 mRNA cleavage with an IC₅₀ value of 80 nM with affecting IRE1α auto-phosphorylation. Toyocamycin specifically inhibits CDK9 with an IC₅₀ value of 79 nM .

HY-B0764A

Bucladesine hemicalcium Maximum Cited Publications 41 Publications Verification Dibutyryl cAMP hemicalcium; DBcAMP hemicalcium	PKA Apoptosis Reactive Oxygen Species (ROS)	Neurological Disease Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) hemicalcium is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

HY-175747

PF-07293893	AMPK	Cardiovascular Disease
PF-07293893 is an AMPKγ3 activator. PF-07293893 increases glycogen content, improves lipid oxidation, enhances mitochondrial biogenesis and promotes vascular repair. PF-07293893 is applicable to research related to heart failure .

HY-148189

Aldometanib 5+ Cited Publications LXY-05-029	Fructose-1,6-bisphosphate aldolase AMPK	Metabolic Disease
Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis .

HY-112482

ABT-702 3 Publications Verification	Adenosine Kinase Adenosine Receptor	Neurological Disease Inflammation/Immunology
ABT-702 (Adenosine Kinase Inhibitor) is a potent, orally active, and selective adenosine kinase (AK) inhibitor with an IC₅₀ of 1.7 nM. ABT-702 shows >1300-fold selectivity for AK over other biological targets, including cyclooxygenases-1 and -2. ABT-702 attenuates inflammation in diabetic retinopathy by increasing free adenosine levels. ABT-702 shows analgesic and anti-inflammatory effects in vivo. ABT-702 can be used for diabetic retinopathy research .

HY-N7844

N6-Benzyladenosine Benzyladenosine	Apoptosis Adenosine Receptor	Inflammation/Immunology Cancer
N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma ^- .

HY-112482A

ABT-702 hydrochloride 3 Publications Verification	Adenosine Kinase Adenosine Receptor	Neurological Disease Inflammation/Immunology
ABT-702 hydrochloride is a potent, orally active, and selective adenosine kinase (AK) inhibitor with an IC₅₀ of 1.7 nM. ABT-702 hydrochloride shows >1300-fold selectivity for AK over other biological targets, including cyclooxygenases-1 and -2. ABT-702 hydrochloride attenuates inflammation in diabetic retinopathy by increasing free adenosine levels. ABT-702 hydrochloride shows analgesic and anti-inflammatory effects in vivo. ABT-702 hydrochloride can be used for diabetic retinopathy research .

HY-103322

6-Bnz-cAMP sodium salt	PKA Potassium Channel	Metabolic Disease Cancer
6-Bnz-cAMP sodium, a derivative of cyclic adenosine monophosphate (cAMP), is a selective PKA activator with inhibitory activity against the bTREK-1 K ⁺ channel. 6-Bnz-cAMP sodium does not activate the Epac signaling pathway. It inhibits the bTREK-1 K ⁺ channel via a voltage-independent, ATP-dependent mechanism that is independent of the PKA/Epac/calmodulin kinase/MAP kinase pathway. 6-Bnz-cAMP sodium activates CREB phosphorylation to regulate osteoblast-specific gene expression, induces osteoblast differentiation, promotes extracellular matrix mineralization, supports osteoblast proliferation, and shows no cytotoxicity toward osteoblasts. It can be used in studies related to bone tissue repair and regeneration .

HY-148327

AK-IN-1	Adenosine Kinase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
AK-IN-1 (compound 4072-2732) is an **adenosine kinase** (AK) inhibitor that is competitive for adenosine (Ado) but not for ATP. AK-IN-1 inhibits 86%, 87% and 89% of AK activity at concentrations of 2, 4 and 10 µM, respectively. AK-IN-1 has good potential for research in many disease areas, including ischaemia, inflammation and seizures .

HY-N6631

7-Methoxyisoflavone 4 Publications Verification	AMPK	Metabolic Disease Cancer
7-Methoxyisoflavone is an isoflavone derivative and also an activator of adenosine monophosphate-activated protein kinase (AMPK).

HY-B0764B

Bucladesine Dibutyryl cAMP; DBcAMP	PKA Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

HY-19259

GP3269	Adenosine Kinase	Neurological Disease
GP3269 is a selective and orally active human adenosine kinase (AK) inhibitor with an IC₅₀ of 11 nM against human adenosine kinase. GP3269 increases adenosine levels at epileptic foci, activates A1 receptors on excitatory neurons, and exhibits anticonvulsant activity in rats. GP3269 does not induce hemodynamic effects including changes in blood pressure or heart rate in rats. GP3269 can be used for epilepsy-related research .

HY-P1576A

AMARA peptide TFA	Salt-inducible Kinase (SIK) AMPK	Others
AMARA peptide (TFA) is a substrate for salt-inducible kinase (SIK) and adenosine monophosphate activated protein kinase (AMPK).

HY-N0262R

Cordycepin (Standard) 3'-Deoxyadenosine (Standard)	TNF Receptor Reference Standards MMP Bacterial Autophagy Antibiotic	Infection Inflammation/Immunology Cancer
Cordycepin (Standard) is the analytical standard of Cordycepin. This product is intended for research and analytical applications. Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase .

HY-108047

MK-0873	Phosphodiesterase (PDE)	Metabolic Disease Inflammation/Immunology
MK-0873 is a selective phosphodiesterase-4 (PDE4) inhibitor. MK-0873 increases intracellular levels of cyclic adenosine phosphate (cAMP) by inhibiting the activity of the PDE4 enzyme and subsequently activates protein kinase A (PKA). Activated PKA inhibits the activity of inflammatory cells and leads to direct relaxation of airway smooth muscle. MK-0873 can be used in studies of chronic obstructive pulmonary disease (COPD) .

HY-B0764G

Bucladesine sodium Dibutyryl cAMP sodium; DBcAMP sodium	PKA Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) sodium (GMP) is a Bucladesine sodium (HY-B0764) produced by using GMP guidelines. Bucladesine (Dibutyryl cAMP; DBcAMP) is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

HY-116005

A-286501	Adenosine Kinase	Neurological Disease Inflammation/Immunology
A-286501 is an orally active and potent carbocyclic nucleoside **adenosine kinase inhibitor with an IC₅₀** value of 0.47 nM, which shows analgesic and anti-inflammatory effects. A-286501 reduces nociception in animal models of acute (thermal), inflammatory (formalin and carrageenan) and neuropathic (L5/L6 nerve ligation and streptozotocin-induced diabetic) pain. A-286501 also reduces Carrageenan (HY-125474)-induced paw edema and myeloperoxidase activity in the injured paw. A-286501 is promising for research of analgesic and anti-inflammatory agents .

HY-15424R

5-Iodotubercidin (Standard) NSC 113939 (Standard); 5-ITu (Standard)	Adenosine Kinase Reference Standards	Cancer
5-Iodotubercidin (Standard) is the analytical standard of 5-Iodotubercidin. This product is intended for research and analytical applications. 5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin .

HY-B0764R

Bucladesine sodium (Standard) Dibutyryl cAMP sodium (Standard); DBcAMP sodium (Standard)	Reference Standards PKA Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Bucladesine (Dibutyryl cAMP; DBcAMP) sodium (Standard) is the analytical standard of Bucladesine sodiumn (HY-B0764). This product is intended for research and analytical applications. Bucladesine is a membrane-permeable 3′, 5′-cyclic adenosine monophosphate (cAMP) analog. Bucladesine selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine significantly attenuates MDMA-induced increases in hippocampal mitochondrial ROS formation, mitochondrial outer membrane damage, cytochrome c release, and hippocampal ADP/ATP ratio, thereby improving spatial learning and memory impairments. Bucladesine exhibit anti-nociceptive and anti-inflammation effect. Bucladesine can inhibit cancer cells proliferation, induce apoptosis. Bucladesine can be used for the researches of neurological disease, cancer, inflammation .

HY-114901

A-134974	Adenosine Kinase	Neurological Disease
A-134974 is a novel, high-selectivity **adenosine kinase (IC₅₀** = 60 pM) inhibitor. A-134974 enhances endogenous adenosine signaling in the spinal cord, effectively alleviates neuropathic pain, and does not cause movement disorders. A-134974 can be used for the study of neuropathic pain .

HY-179690

Antiparasitic agent-30	Parasite Adenosine Kinase	Infection
Antiparasitic agent-30 is a potent **adenosine kinase TbrAK** modulator and antitrypanosomal agent. Antiparasitic agent-30 exhibits significant inhibitory activity against Trypanosoma brucei rhodesiense, while enhancing the activity of recombinant TbrAK(EC₅₀=38 nM, K_a=75 nM-497 nM). Antiparasitic agent-30 exerts its pharmacological effects by eliminating intrinsic substrate inhibition and hyperactivating TbrAK in Trypanosoma brucei rhodesiense. Antiparasitic agent-30 serves as a valuable tool molecule for studying acute African human trypanosomiasis (sleeping sickness) .

HY-P4520

(Trp4)-Kemptide	Amino Acid Derivatives	Others
(Trp4)-Kemptide is a peptide substrate for adenosine 3',5'-cyclic monophosphate-dependent protein kinase .

HY-E70648

AMPK alpha 1 Recombinant Human Active Protein Kinase	AMPK	Cancer
AMPK is an αβγ heterotrimeric serinethreonine kinase activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. AMPK alpha 1 Recombinant Human Active Protein Kinase is obtained by co-expressing AMPKα1 proteins .

HY-E70793

Biotin-AMPKα1β1γ1 Recombinant Human Active Protein Kinase	AMPK	Cancer
AMPK is an αβγ heterotrimeric serinethreonine kinase activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. Biotin-AMPKα1β1γ1 Recombinant Human Active Protein Kinase is obtained by co-expressing AMPKα1, AMPKβ1, and AMPKγ1 proteins and is biotinylated .

HY-174157

AR493	Autophagy AMPK	Neurological Disease Metabolic Disease
AR493 is an autophagy activator acting on AMPK (adenosine monophosphate-activated protein kinase). AR493 regulates pathways related to cellular energy sensing and increases autophagy levels. AR493 is promising for research of aging-associated diseases (such as diabetes, neurodegenerative diseases) and autophagy regulation .

HY-134263

8-Br-cAMP-AM	PKA Ras	Cardiovascular Disease
8-Br-cAMP-AM is a cyclic adenosine monophosphate (cAMP) analog that activates two major signal transduction pathways in the heart by mimicking the effects of cAMP: protein kinase A (PKA) and guanosine nucleotide exchange factor (Epac), which is directly activated by cAMP. 8-Br-cAMP-AM can be used to study cardiac ischemia and reperfusion injury .

HY-134283

8-Benzylthio-cAMP	PKA Apoptosis	Others
8-Benzylthio-cAMP is a derivative of cyclic adenosine monophosphate (cAMP). 8-Bn-cAMP is a site-selective activator of cAMP-dependent protein kinases. Compared with cyclic adenosine monophosphate, it is more stable to phosphodiesterase (PDE) hydrolysis and has higher membrane permeability. 8-Bn-cAMP can be used to study the role of cAMP in regulating cell proliferation, differentiation and apoptosis .

HY-110124

ML202	Pyruvate Kinase	Cancer
ML202 is a highly specific allosteric activator of human pyruvate kinase M2 (hPK-M2), which can affect the cooperativity of phosphoenolpyruvate (PEP) binding, while adenosine diphosphate (ADP) binding almost no effect .

HY-E70787

AMPK α1β1γ1 Recombinant Human Active Protein Kinase	AMPK	Cancer
AMPK is an αβγ heterotrimeric serinethreonine kinase activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. AMPK α1β1γ1 Recombinant Human Active Protein Kinase is an ortholog of AMPK. AMPK α1β1γ1 Recombinant Human Active Protein Kinase is obtained by co-expressing AMPKα1, AMPKβ1, and AMPKγ1 proteins .

HY-E70796

Biotin-AMPKα2β1γ1 Recombinant Human Active Protein Kinase	AMPK	Cancer
AMPK is an αβγ heterotrimeric serinethreonine kinase activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. Biotin-AMPKα2β1γ1 Recombinant Human Active Protein Kinase is obtained by co-expressing AMPKα2, AMPKβ1, and AMPKγ1 proteins and is biotinylated .

HY-E70795

Biotin-AMPKα1β2γ1 Recombinant Human Active Protein Kinase	AMPK	Cancer
AMPK is an αβγ heterotrimeric serinethreonine kinase activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. Biotin-AMPKα1β2γ1 Recombinant Human Active Protein Kinase is obtained by co-expressing AMPKα1, AMPKβ2, and AMPKγ1 proteins and is biotinylated .

HY-12689C

Mitapivat hydrochloride AG-348 hydrochloride	Pyruvate Kinase	Cardiovascular Disease Metabolic Disease
Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric pyruvate kinase R (PK-R) activator. Mitapivat hydrochloride accelerates the reaction of PK-R catalyzing the conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolytic pathway, increasing the production of adenosine triphosphate (ATP) in red blood cells, and reducing the level of 2,3-diphosphoglycerate (2,3-DPG). Mitapivat hydrochloride is promising for research of pyruvate kinase deficiency and other anemia-related diseases .

HY-N7844S

N6-Benzyladenosine-d5 Benzyladenosine-d₅	Isotope-Labeled Compounds Apoptosis Adenosine Receptor	Inflammation/Immunology Cancer
N6-Benzyladenosine-d₅ (Benzyladenosine-d₅) is deuterium labeled N6-Benzyladenosine. N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma .

HY-10250S1

Triciribine phosphate-d3 TCN-P-d₃	Isotope-Labeled Compounds ATP Synthase	Metabolic Disease
Triciribine phosphate-d3 (TCN-P-d3) is a deuterated compound of Triciribine phosphate (TCN-P). TCN-P inhibits adenosine monophosphate (AMP)-activated protein kinase through an allosteric mechanism, affecting the first key step in de novo purine biosynthesis. Triciribine phosphate also inhibits inosine monophosphate dehydrogenase, which is the first key step in guanosine nucleotide synthesis. Triciribine phosphate does not affect ligase activity .

HY-137381

6-Bnz-cAMP N6-Benzoyl-cAMP	PKA Potassium Channel	Metabolic Disease
6-Bnz-cAMP, a derivative of cyclic adenosine monophosphate (cAMP), is a selective PKA activator with inhibitory activity against the bTREK-1 K ⁺ channel. 6-Bnz-cAMP does not activate the Epac signaling pathway. 6-Bnz-cAMP inhibits the bTREK-1 K ⁺ channel via a voltage-independent, ATP-dependent mechanism that is independent of the PKA/Epac/calmodulin kinase/MAP kinase pathway. 6-Bnz-cAMP activates CREB phosphorylation to regulate osteoblast-specific gene expression, induces osteoblast differentiation, promotes extracellular matrix mineralization, supports osteoblast proliferation, and shows no cytotoxicity toward osteoblasts. 6-Bnz-cAMP can be used in studies related to bone tissue repair and regeneration .

HY-115862

Benzo[c][1,8]naphthyridin-6(5H)-one	Adenosine Receptor PARP Aurora Kinase	Cardiovascular Disease Cancer
Benzo[c][1,8]naphthyridin-6(5H)-one exhibits low micromolar affinity to human adenosine receptor (AR) A₁ and hA_2A, with K_i of 4.6 and 4.8 μM. Benzo[c][1,8]naphthyridin-6(5H)-one is inhibitor for poly ADP-ribose polymerase-1 (PARP-1) and aurora kinase A, with IC₅₀ of 0.311 and 5.5 μM .

HY-103248R

Toyocamycin (Standard) Vengicide (Standard)	Reference Standards IRE1 Fungal Antibiotic Apoptosis CDK	Infection Cancer
DL-Aspartic acid (Standard) is the analytical standard of DL-Aspartic acid. This product is intended for research and analytical applications. DL-Aspartic acid (DL-Asp-OH) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-182503

GP515	Adenosine Kinase	Others Inflammation/Immunology
GP515 is a potent and selective **adenosine kinase inhibitor with a human IC₅₀ of 4 nM. GP515 exerts tissue protective effects, produces long-lasting hepatic microcirculation effects after hemorrhagic shock, and induces dose- and time-related VEGF mRNA and protein expression in normoxic rat myocardial myoblasts, with additive VEGF increases during mild hypoxia and no effect during severe hypoxia. GP515 suppresses IFNγ synthesis and CD69 expression in DSS-induced colitis. GP515 also shows a dose-dependent suppression of TNF-α production with an IC₅₀ of 80 μM and can be reversed in the presence of the cAMP** antagonist (Rp)-cAMPS. Combinations of GP515 with either adenosine or rolipram led to an additive inhibition of TNF-α synthesis. GP515 can be used for the research of hemorrhagic shock .

HY-183362

Antileishmanial agent-42	Parasite Adenosine Kinase	Infection
Antileishmanial agent-42 is an antileishmanial agent. Antileishmanial agent-42 has favorable interactions with key active site residues (e.g., Ser63, Asn66/295/299) of **adenosine kinase*. Antileishmanial agent-42 exerts activity against promastigote and amastigote forms of L. amazonensis, L. braziliensis, L. infantum, and L. donovani* .

HY-N7844R

N6-Benzyladenosine (Standard) Benzyladenosine (Standard)	Apoptosis Adenosine Receptor Phytohormone Reference Standards	Inflammation/Immunology Cancer
N6-Benzyladenosine (Standard) (Benzyladenosine (Standard)) is the analytical standard of N6-Benzyladenosine (HY-N7844). This product is intended for research and analytical applications. N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma - .

HY-W384897

L-Amidinoproline	Biochemical Assay Reagents Amino Acid Derivatives	Others
L-Amidinoproline is a derivitive of L-Proline (HY-Y0252), can be used for chemical synthesis .

HY-103161R

ABT-702 dihydrochloride (Standard)	Reference Standards Adenosine Kinase	Inflammation/Immunology
ABT-702 dihydrochloride (Standard) is the analytical standard of ABT-702 dihydrochloride (HY-103161). This product is intended for research and analytical applications. ABT-702 dihydrochloride is a potent adenosine kinase (AK) inhibitor (IC₅₀=1.7 nM).

HY-E70794

Biotin-AMPKα1β1γ2 Recombinant Human Active Protein Kinase	AMPK	Cancer
AMPK is an αβγ heterotrimeric serinethreonine kinase activated by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP concentrations. Biotin-AMPKα1β1γ2 Recombinant Human Active Protein Kinase is obtained by co-expressing AMPKα1, AMPKβ1, and AMPKγ2 proteins and is biotinylated .

HY-117232

KS 501	Calmodulin	Cancer
KS 501 is a potent and selective calmodulin inhibitor. KS 501 inhibits the activation of calmodulin kinase I and II, but has less effect against cyclic adenosine 3’,5’-monophosphate (cyclic AMP)-sensitive kinase. KS 501 inhibits the enzyme through interfering with calmodulin activation rather than through a direct effect on the enzyme. KS 501 can be used for the study of leukemia .

HY-148150A

Cyclocreatine phosphate dilithium	Creatine Kinase	Cardiovascular Disease Inflammation/Immunology Cancer
Cyclocreatine phosphate dilithium is a synthetic intracellular energy buffer. Cyclocreatine phosphate dilithium mediates antiproliferative activity in cells with high creatine kinase levels and inhibits solid tumor growth. Cyclocreatine phosphate dilithium maintains adenosine triphosphate (ATP) levels and protects tissues from hypoxia, cellular damage and inflammation during ischemic events. Cyclocreatine phosphate dilithium accumulates in skeletal muscle, reduces muscle phosphocreatine and total creatine levels, and acts both as a bioenergetic/anti-inflammatory agent and an experimental tool for the assessment of ischemic injury. Cyclocreatine phosphate dilithium can be used in studies related to solid tumors, heart failure and ischemia .

HY-N8529

Eupalestin	NF-κB p38 MAPK Adenosine Deaminase Interleukin Related	Inflammation/Immunology
Eupalestin is an anti-inflammatory agent. Eupalestin reduces the levels of p-p65 NF-κB and p-p38 MAPK. Eupalestin inhibits MPO and adenosine deaminase. Eupalestin decreases the levels of pro-inflammatory cytokines including IL-17A, IL-6, TNF and IFN-γ. Eupalestin exerts anti-inflammatory activity in a carrageenan (HY-125474)-induced mouse pleurisy model .

製品番号	製品名	Target	研究分野

HY-P1576A

AMARA peptide TFA	Salt-inducible Kinase (SIK) AMPK	Others
AMARA peptide (TFA) is a substrate for salt-inducible kinase (SIK) and adenosine monophosphate activated protein kinase (AMPK).

HY-P4520

(Trp4)-Kemptide	Amino Acid Derivatives	Others
(Trp4)-Kemptide is a peptide substrate for adenosine 3',5'-cyclic monophosphate-dependent protein kinase .

Species:	Human (4)
Tag:	His (2) Tag Free (2) GST (1)
Source:	HEK293 (1) Sf9 insect cells (1) E. coli (2)

製品番号	Compare	製品名	Species	Source	Image

HY-P75530

	*ADK/Adenosine* Kinase Protein, Human (HEK293)** adenosine kinase; AK; adenosine 5'-phosphotransferase; ADK	Human	HEK293
	ADK is an enzyme that catalyzes the transfer of gamma-phosphate from adenosine triphosphate (ATP) to adenosine (Ado) to form adenosine monophosphate (AMP). ADK acts as a potential regulator of extracellular adenosine and intracellular adenine nucleotide concentrations. ADK is a therapeutic target for controlling obesity and non-alcoholic fatty liver disease. ADK/Adenosine Kinase Protein, Human (HEK293) is the recombinant human-derived ADK/Adenosine Kinase protein, expressed by HEK293 , with tag free.

HY-P75529

	*ADK/Adenosine* Kinase Protein, Human (sf9, His-GST)** adenosine kinase; AK; adenosine 5'-phosphotransferase; ADK	Human	Sf9 insect cells
	ADK is an enzyme that catalyzes the transfer of gamma-phosphate from adenosine triphosphate (ATP) to adenosine (Ado) to form adenosine monophosphate (AMP). ADK acts as a potential regulator of extracellular adenosine and intracellular adenine nucleotide concentrations. ADK is a therapeutic target for controlling obesity and non-alcoholic fatty liver disease. ADK/Adenosine Kinase Protein, Human (sf9, His-GST) is the recombinant human-derived ADK/Adenosine Kinase protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P701966

	PKCi Protein, Human (H114A) HINT1; adenosine 5'-monophosphoramidase HINT1; Desumoylating isopeptidase HINT1; Histidine triad nucleotide-binding protein 1; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1; PKCI-1	Human	E. coli
	PKCi protein has adenosine 5'-monophosphate amidase activity and can hydrolyze compounds such as AMP-NH2. It also acts on AMP-morpholidate, GMP-morpholidate, lysyl-AMP, Met-AMP, His-AMP, Asp-AMP, lysyl-GMP and AMP-N-alanine methyl ester. PKCi Protein, Human (H114A) is the recombinant human-derived PKCi protein, expressed by E. coli , with tag free.

HY-P701967

	PKCi Protein, Human (H114A, His) HINT1; adenosine 5'-monophosphoramidase HINT1; Desumoylating isopeptidase HINT1; Histidine triad nucleotide-binding protein 1; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1; PKCI-1	Human	E. coli
	PKCi protein has adenosine 5'-monophosphate amidase activity and can hydrolyze compounds such as AMP-NH2. It also acts on AMP-morpholidate, GMP-morpholidate, lysyl-AMP, Met-AMP, His-AMP, Asp-AMP, lysyl-GMP and AMP-N-alanine methyl ester. PKCi Protein, Human (H114A, His) is the recombinant human-derived PKCi protein, expressed by E. coli , with N-6*His labeled tag.

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製品番号	製品名	構造式

HY-N7844S

N6-Benzyladenosine-d5
N6-Benzyladenosine-d₅ (Benzyladenosine-d₅) is deuterium labeled N6-Benzyladenosine. N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma .

HY-10250S1

Triciribine phosphate-d3

Triciribine phosphate-d3 (TCN-P-d3) is a deuterated compound of Triciribine phosphate (TCN-P). TCN-P inhibits adenosine monophosphate (AMP)-activated protein kinase through an allosteric mechanism, affecting the first key step in de novo purine biosynthesis. Triciribine phosphate also inhibits inosine monophosphate dehydrogenase, which is the first key step in guanosine nucleotide synthesis. Triciribine phosphate does not affect ligase activity .

Host:	Rabbit (4)
Reactivity:	Human (4) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (2) IP (2) WB (4)
Isotype:	IgG (4)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

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HY-P82944

	ADK Antibody (YA2689) ADK; adenosine kinase; AK; adenosine 5'-phosphotransferase	WB, IHC-P	Human, Mouse, Rat
	ADK Antibody (YA2689) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ADK.

HY-P82944A

	ADK Antibody (YA2689)(PBS only) ADK; adenosine kinase; AK; adenosine 5'-phosphotransferase	WB, IHC-P	Human, Mouse, Rat
	ADK Antibody (YA2689) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ADK.

HY-P83238

	HINT1 Antibody (YA2983) HINT1; HINT; PKCI1; PRKCNH1; Histidine triad nucleotide-binding protein 1; adenosine 5'-monophosphoramidase; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1; PKCI-1	WB, ICC/IF, IP	Human
	HINT1 Antibody (YA2983) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HINT1.

HY-P83238A

	HINT1 Antibody (YA2983)(PBS only) HINT1; HINT; PKCI1; PRKCNH1; Histidine triad nucleotide-binding protein 1; adenosine 5'-monophosphoramidase; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1; PKCI-1	WB, ICC/IF, IP	Human
	HINT1 Antibody (YA2983) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HINT1.

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