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Results for "

anxiolytic activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (43) Adenosine Receptor (1) Adrenergic Receptor (11) Akt (4) Apoptosis (9) Bacterial (8) Bcl-2 Family (3) Biochemical Assay Reagents (1) Calcium Channel (3) CFTR (1) Cholecystokinin Receptor (2) CRFR (1) Dopamine Receptor (11) Drug Derivative (1) Drug Metabolite (3) Endogenous Metabolite (7) Environmental Pollutants (3) Fluorescent Dye (2) Formyl Peptide Receptor (FPR) (2) GABA Receptor (39) Guanylate Cyclase (1) Histamine Receptor (3) iGluR (6) Interleukin Related (2) Isotope-Labeled Compounds (12) Keap1-Nrf2 (1) MCHR1 (GPR24) (2) Melanocortin Receptor (1) Melatonin Receptor (4) mGluR (15) MMP (1) Monoamine Oxidase (2) mTOR (5) nAChR (6) NO Synthase (3) Nucleoside Antimetabolite/Analog (57) Opioid Receptor (2) P-glycoprotein (5) p38 MAPK (2) Parasite (9) Phosphodiesterase (PDE) (4) Phosphoramidites (4) Phytohormone (1) PI3K (7) PKC (2) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (2) Reactive Oxygen Species (ROS) (4) Reference Standards (26) Serotonin Transporter (5) Sigma Receptor (3) SOD (2) Somatostatin Receptor (1) TGF-β Receptor (1) TNF Receptor (5) Trk Receptor (6) TRP Channel (1) Tryptophan Hydroxylase (1) Vasopressin Receptor (1) VEGFR (1) Wnt (1)
By Research Areas:	Cancer (42) Cardiovascular Disease (6) Endocrinology (2) Infection (10) Inflammation/Immunology (20) Metabolic Disease (5) Neurological Disease (167)
Click Chemistry:	Azide (4) Alkynes (2)
Oligonucleotides:	Nucleoside Analogs (52) Uridine (51) Uracil (4) Phosphoramidites (4)

238

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1178

Cyclotraxin B 3 Publications Verification	Trk Receptor p38 MAPK	Neurological Disease
Cyclotraxin B is a BBB-penetrable and selective TrkB inhibitor. Cyclotraxin B inhibits BDNF-induced TrkB activity in a non-competitive manner, with an IC₅₀ of 0.30 nM. Cyclotraxin B has analgesic and anxiolytic effects .

HY-12598

(S)-3,5-DHPG	mGluR	Neurological Disease
(S)-3,5-DHPG is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with K_i values of 0.9 μM and 3.9 μM for mGluR1a and mGluR5a, respectively . (S)-3,5-DHPG exhibits anxiolytic activity in rats subjected to hypoxia .

HY-14895

Fabomotizole CM346	Parasite Monoamine Oxidase Sigma Receptor P-glycoprotein	Infection Cardiovascular Disease Neurological Disease
Fabomotizole (CM346) is an insecticide with anxiolytic, antianxiety, and neuroprotective activities and a substrate of p-glycoprotein. Fabomotizole inhibits the ST-segment depression induced by isoproterenol in a rat model of acute subendocardial ischemia. Fabomotizole also inhibits Giardia lamblia and has the potential to inhibit giardiasis. Fabomotizole also targets Sigma1R, NRH:quinone reductase 2 (NQO2), and MAO-A to exert anxiolytic effects .

HY-103207

Amibegron hydrochloride SR 58611A	Adrenergic Receptor	Neurological Disease Endocrinology
Amibegron hydrochloride is a selective β3-adrenoceptor agonist, with an EC₅₀ of 3.5 nM for β-adrenoceptor in rat colon; Amibegron hydrochloride has anxiolytic and antidepressant activity.

HY-15856B

Flupentixol dihydrochloride 2 Publications Verification Flupenthixol dihydrochloride	Dopamine Receptor PI3K Apoptosis	Neurological Disease Cancer
Flupentixol is an orally active D₁/D₂ dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC₅₀=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research .

HY-105042

Selank Selanc; TP-7	GABA Receptor	Neurological Disease
Selank (Selanc; TP-7) is a GABAA receptor modulator with anxiolytic activity. Selank allosterically modulates the specific binding of GABA to GABAA receptors and alters the affinity of endogenous ligands for these receptors. Selank reduces elevated anxiety levels, attenuates stress-induced exacerbation of anxiety, and produces a synergistic anxiolytic effect with diazepam. Selank can be used in the research of anxiety disorders .

HY-B1196

Tiapride hydrochloride	Dopamine Receptor	Neurological Disease
Tiapride hydrochloride is a selective and orally active D₂ and D₃ dopamine receptors antagonist with IC₅₀ values of 110-320 nM and 180 nM, respectively. Tiapride hydrochloride shows anti-dyskinetic activity and anxiolytic activity. Tiapride hydrochloride is a neuroleptic agent .

HY-108710

VU0650786 2 Publications Verification	mGluR	Neurological Disease
VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC₅₀ of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents .

HY-12129

CP 154526 hydrochloride	CFTR	Neurological Disease
CP 154526 hydrochloride is a potent, brain-penetrant and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist with a K_i of 2.7 nM. CP 154526 hydrochloride shows selective for CRF1 over CRF2 (K_i = >10 μM). CP 154526 hydrochloride has anxiolytic activities .

HY-P2602

α-Casozepine	GABA Receptor	Neurological Disease
α-Casozepine is an orally effective anxiolytic that binds to the benzodiazepine site of the GABAA receptor in bovine samples with an IC₅₀ of 88 μM. α-Casozepine exerts anxiolytic and anti-stress effects on cats exposed to unfamiliar environments and dogs undergoing road transport . α-Casozepine exhibits significant anxiolytic activity in rats. α-Casozepine can be used in studies related to fear, anxiety and stress .

HY-B1737

Pirenperone R 47465	5-HT Receptor	Neurological Disease
Pirenperone (R 47465) is a 5-HT₂ serotonin receptor antagonist. Pirenperone exhibits modest anxiolytic activity .

HY-114871

SL651498	GABA Receptor	Neurological Disease
SL651498 is a full agonist of α2 and α3 GABAA receptors, and a partial agonist of α1 and α5 GABAA receptors. SL651498 shows anxiolytic and anticonvulsant activities .

HY-14895A

Fabomotizole hydrochloride CM346 hydrochloride	Parasite	Neurological Disease
Fabomotizole (CM346) hydrochloride is a compound with anxiolytic and neuroprotective activities. Fabomotizole (CM346) hydrochloride also has activity against Giardia lamblia and has the potential to inhibit giardiasis.

HY-19477

SB-616234-A	5-HT Receptor	Neurological Disease
SB-616234-A is a selective and orally bioavailable 5-HT1B receptor antagonist, with anxiolytic and antidepressant activity.

HY-110278

ADX71743	mGluR	Neurological Disease
ADX71743 is a highly selective, noncompetitive and brain-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM). ADX71743 can cross the blood-brain barrier (BBB) and possesses anxiolytic activity. .

HY-116800

FR194921	Adenosine Receptor	Neurological Disease
FR194921 is a potent, selective and orally active and cross the blood-brain barrier Adenosine A1 antagonist with K_i value of 6.6, 5400 nM for A1, A2A, respectively. FR194921 shows cognitive-enhancing and anxiolytic activity .

HY-N9502

Linalool oxide	Endogenous Metabolite	Neurological Disease
Linalool oxide is a monoterpene and found in aromatic plant essential oils and is a secondary metabolite in elongating wheat plants. Linalool oxide has antinociceptive, anticonvulsant, and anxiolytic activity. Linalool oxide can be used for the research of pain, epilepsy, anxiety disorders .

HY-100140

Pipequaline 1 Publications Verification PK-8165	GABA Receptor	Neurological Disease
Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity .

HY-N6648

Cirsimaritin	GABA Receptor	Neurological Disease
Cirsimaritin binds weakly to the benzodiazepine site on GABA_A receptors, with antidepressant, anxiolytic and antinociceptive activities.

HY-117820

TASP0390325	Vasopressin Receptor	Cardiovascular Disease Neurological Disease
TASP0390325 is a high affinity and orally active arginine vasopressin receptor 1B (V1B receptor) antagonist with antidepressant and anxiolytic activities .

HY-152358

N3-Methyl-2’-O-methyluridine	Nucleoside Antimetabolite/Analog	Others
N3-Methyl-2’-O-methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-15856A

Flupentixol Flupenthixol	Dopamine Receptor PI3K Apoptosis	Neurological Disease
Flupentixol is an orally active D₁/D₂ dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC₅₀=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research .

HY-141795

Posovolone Co 134444	Drug Derivative	Neurological Disease
Posovolone (Co 134444) is an orally active, neuroactive steroid. Posovolone has anticonvulsant and anxiolytic-like activity as well as ataxic effects .

HY-103571

VU0285683	mGluR	Neurological Disease
VU0285683 is a selective mGluR5 positive allosteric modulator (PAM). VU0285683 has anxiolytic-like activity in rodent models for anxiety .

HY-101387

rel-ACPT-I	mGluR	Neurological Disease
rel-ACPT-I is an agonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects .

HY-12130

CP 154526	CRFR	Neurological Disease
CP 154526 is a potent, brain-penetrant and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist with a K_i of 2.7 nM. CP 154526 shows selective for CRF1 over CRF2 (K_i = >10 μM). CP 154526 has anxiolytic activities .

HY-107626

ATC0065	MCHR1 (GPR24) 5-HT Receptor	Neurological Disease
ATC0065 is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC₅₀ of 15.7 nM for human MCHR1. ATC0065 does not exhibits significant activity for MCHR2. ATC0065 has anxiolytic and antidepressant activities .

HY-123840

MRK-623	GABA Receptor	Neurological Disease
MRK-623 (Compound 14k) is an orally active, high-affinity GABA_A receptor agonist, with the K_i values of 0.85 nM, 3.7 nM, 4.0 nM, and 0.53 nM for α1, α2, α3, and α5, respectively. MRK-623 shows anxiolytic effect .

HY-N3940

Gelsevirine	Others	Neurological Disease Cancer
Gelsevirine is the major alkaloid in Gelsemium elegans with potent anxiolytic effects. The anxiolytic mechanism of Gelsevirine may be involved in the agonist action of the glycine receptor in the brain. Gelsevirine has anti-proliferation activity with IC₅₀ values of 1.41 mM and 1.22 mM for SW480 cells and MGC80-3 cells, respectively .

HY-106316

CGS 20625	GABA Receptor	Neurological Disease
CGS 20625 is a potent, selective and orally active partial agonist for the central benzodiazepine receptor. CGS 20625 inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors with an IC₅₀ of 1.3 nM. CGS 20625 enhances GABA in Xenopus laevis oocytes . CGS 20625 can be used for the research of pentylenetetrazol-induced seizures and anxiety .

HY-B1196A

Tiapride	Dopamine Receptor	Neurological Disease
Tiapride is a selective and orally active D₂ and D₃ dopamine receptors antagonist with IC₅₀ values of 110-320 nM and 180 nM, respectively. Tiapride shows anti-dyskinetic activity and anxiolytic activity. Tiapride is a neuroleptic agent .

HY-105170B

ABT-418 hydrochloride	nAChR	Neurological Disease
ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease .

HY-152732

6-Methyluridine	Nucleoside Antimetabolite/Analog	Others
6-Methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-110001

(S)-WAY 100135 dihydrochloride	5-HT Receptor	Neurological Disease
(S)-WAY 100135 dihydrochloride is a highly selective and potent antagonist of 5-HT _1A (IC₅₀=33.9 nM). (S)-WAY 100135 dihydrochloride has anxiolytic activity in animal models .

HY-154285

3’-O-(2-Methoxyethyl) uridine	Nucleoside Antimetabolite/Analog	Cancer
3’-O-(2-Methoxyethyl) uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-W399186

Methylclonazepam	Parasite	Infection Neurological Disease
Methylclonazepam is a benzodiazepine with anxiolytic activity. Methylclonazepam inhibits the absorption of 5-hydroxytryptamine by Schistosoma mansoni. Methylclonazepam derivatives have anti-Schistosoma mansoni activity .

HY-107626A

ATC0065 free base	MCHR1 (GPR24) 5-HT Receptor	Neurological Disease
ATC0065 free base is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC₅₀ of 15.7 nM for human MCHR1. ATC0065 free base does not exhibits significant activity for MCHR2. ATC0065 free base has anxiolytic and antidepressant activities .

HY-121393

Imidazenil	GABA Receptor	Neurological Disease
Imidazenil is a partial positive allosteric modulator of GABA_A receptors with anxiolytic, antipanic and anticonvulsant activities.

HY-116590

(±)-Glaziovine	VEGFR	Neurological Disease
(±)-Glaziovine, a proaporphine alkaloid, has anxiolytic activity. (±)-Glaziovine can be used for neuropharmacological research .

HY-101322A

MM 77 dihydrochloride	5-HT Receptor	Neurological Disease
MM 77 dihydrochloride is a potent postsynaptic antagonist of the 5-HT_1A receptor. MM 77 dihydrochloride exhibits anxiolytic-like activity .

HY-19046

AGN-2979 hydrochloride SC 48274 hydrochloride	Tryptophan Hydroxylase	Neurological Disease
AGN-2979 (SC 48274) hydrochloride is a tryptophan hydroxylase activation inhibitor. AGN-2979 hydrochloride exhibits antidepressant and anxiolytic activities .

HY-124393

GRN-529	mGluR	Neurological Disease
GRN-529 is a negative allosteric modulator (NAM) for mGluR5. GRN-259 modulates sleep-wake activity, and exhibits anxiolytic efficacy in rats .

HY-129810

PD 135158 CAM 1028	Cholecystokinin Receptor	Neurological Disease
PD 135158 (CAM 1028) is a selective CCK_B receptor antagonist with an IC₅₀ of 2.8 nM against mouse cortex CCK_B. PD 135158 shows anxiolytic activity .

HY-A0198

Adinazolam U 41123	GABA Receptor	Neurological Disease
Adinazolam (U 41123) is a triazolobenzodiazepine. Adinazolam binds to peripheral-type benzodiazepine receptors which interact allosterically with GABA receptors. Adinazolam has dual anxiolytic and antidepressant activities .

HY-W020098

2'-C-methyluridine	Nucleoside Antimetabolite/Analog	Cancer
2'-C-methyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-W740297

Methyl Clonazepam-d3	Isotope-Labeled Compounds Parasite	Infection
Methyl Clonazepam-d₃ is the deuterium labeled Methylclonazepam (HY-W399186). Methylclonazepam is a benzodiazepine with anxiolytic activity. Methylclonazepam inhibits the absorption of 5-hydroxytryptamine by Schistosoma mansoni. Methylclonazepam derivatives have anti-Schistosoma mansoni activity .

HY-B1196R

Tiapride hydrochloride (Standard)	Reference Standards Dopamine Receptor	Neurological Disease
Tiapride (hydrochloride) (Standard) is the analytical standard of Tiapride (hydrochloride). This product is intended for research and analytical applications. Tiapride hydrochloride is a selective and orally active D2 and D3 dopamine receptors antagonist with IC₅₀ values of 110-320 nM and 180 nM, respectively. Tiapride hydrochloride shows anti-dyskinetic activity and anxiolytic activity. Tiapride hydrochloride is a neuroleptic agent .

HY-123106

MCL-0129	Melanocortin Receptor	Others
MCL-0129 is a compound with anxiolytic and antidepressant activity and is a selective MC4 receptor antagonist that exhibits anxiolytic and antidepressant-like behaviors in multiple rodent models.

HY-116236

THIIC LY2607540	mGluR	Others
THIIC (LY2607540) is a compound with anxiolytic and antidepressant potential. It is a positive allosteric modulator of mGlu receptors, exhibits anxiolytic and antidepressant-like activities in multiple animal models, and can also affect sleep and neurochemical changes.

HY-100140A

Pipequaline hydrochloride 1 Publications Verification PK-8165 hydrochloride	GABA Receptor	Neurological Disease
Pipequaline hydrochloride (PK-8165 hydrochloride) is a partial benzodiazepine receptor agonist with anxiolytic activity .

Cat. No.	Product Name	Type

HY-NP009

α-Lactalbumin

Biochemical Assay Reagents

α-Lactalbumin is a globular whey protein that exists in milk. α-Lactalbumin binds Ca ²⁺, Mg ²⁺, Mn ²⁺, Na ⁺, K ⁺ and Zn ²⁺ ions; among these, Ca ²⁺ binding enhances protein stability, while Zn ²⁺ binding reduces stability and induces aggregation. α-Lactalbumin forms amyloid fibrils, amorphous aggregates, nanoparticles and nanotubes depending on external conditions. α-Lactalbumin exhibits bactericidal and antiviral activities. α-Lactalbumin has anxiolytic and antidepressant activities, and its effects are enhanced under stress conditions .

Cat. No.	Product Name	Target	Research Area

HY-P1178

Cyclotraxin B 3 Publications Verification	Trk Receptor p38 MAPK	Neurological Disease
Cyclotraxin B is a BBB-penetrable and selective TrkB inhibitor. Cyclotraxin B inhibits BDNF-induced TrkB activity in a non-competitive manner, with an IC₅₀ of 0.30 nM. Cyclotraxin B has analgesic and anxiolytic effects .

HY-105042

Selank Selanc; TP-7	GABA Receptor	Neurological Disease
Selank (Selanc; TP-7) is a GABAA receptor modulator with anxiolytic activity. Selank allosterically modulates the specific binding of GABA to GABAA receptors and alters the affinity of endogenous ligands for these receptors. Selank reduces elevated anxiety levels, attenuates stress-induced exacerbation of anxiety, and produces a synergistic anxiolytic effect with diazepam. Selank can be used in the research of anxiety disorders .

HY-P2602

α-Casozepine	GABA Receptor	Neurological Disease
α-Casozepine is an orally effective anxiolytic that binds to the benzodiazepine site of the GABAA receptor in bovine samples with an IC₅₀ of 88 μM. α-Casozepine exerts anxiolytic and anti-stress effects on cats exposed to unfamiliar environments and dogs undergoing road transport . α-Casozepine exhibits significant anxiolytic activity in rats. α-Casozepine can be used in studies related to fear, anxiety and stress .

HY-105042A

Selank diacetate Selanc diacetate; TP-7 diacetate	Peptides	Neurological Disease
Selank (Selanc) acetate is a synthetic peptide derived from tuftsin. Selank acetate has anxiolytic activity, and is a nootropic, neuropsychotropic, antidepressant, and antistress compound .

HY-P1117

MMK1 1 Publications Verification	Formyl Peptide Receptor (FPR) Calcium Channel	Neurological Disease Inflammation/Immunology
MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC₅₀s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity .

HY-P10405A

TAT-D1 peptide acetate	Dopamine Receptor	Neurological Disease
TAT-D1 peptide acetate is a dopamine D1-D2 receptor heterodimer inhibitor. TAT-D1 peptide acetate disrupts the function of dopamine D1-D2 receptor heteromers, enhances subchronic amphetamine-induced locomotor activity, and exacerbates the expression of amphetamine-induced locomotor sensitization. TAT-D1 peptide acetate produces rapid anxiolytic and antidepressant-like effects in rat models of depression and anxiety, and inhibits c-fos expression in the nucleus accumbens of rats. TAT-D1 peptide acetate can be used in the research of psychostimulant addiction, depression and anxiety disorders .

HY-P10405

TAT-D1 peptide	Dopamine Receptor	Neurological Disease
TAT-D1 peptide is a dopamine D1-D2 receptor heterodimer inhibitor. TAT-D1 peptide disrupts the function of dopamine D1-D2 receptor heteromers, enhances subchronic amphetamine-induced locomotor activity, and exacerbates the expression of amphetamine-induced locomotor sensitization. TAT-D1 peptide produces rapid anxiolytic and antidepressant-like effects in rat models of depression and anxiety, and inhibits c-fos expression in the nucleus accumbens of rats. TAT-D1 peptide can be used in the research of psychostimulant addiction, depression and anxiety disorders .

HY-P1178A

Cyclotraxin B TFA	Trk Receptor	Neurological Disease
Cyclotraxin B TFA is a BBB-penetrable and selective TrkB inhibitor. Cyclotraxin B TFA inhibits BDNF-induced TrkB activity in a non-competitive manner, with an IC₅₀ of 0.30 nM. Cyclotraxin B TFA has analgesic and anxiolytic effects .

HY-P1117A

MMK1 TFA	Formyl Peptide Receptor (FPR) Calcium Channel	Neurological Disease Inflammation/Immunology
MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC₅₀s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0152

Myricitrin 3 Publications Verification	Cardiovascular Disease Flavonols Flavonoids Classification of Application Fields Phenols Polyphenols Metabolic Disease Myrica nagi Plants Disease Research Fields Source Classification Myricaceae	PKC NO Synthase TNF Receptor Parasite
Myricitrin, a naturally occurring flavonoid, is an orally active nitric oxide (NO) and PKC inhibitor. Myricitrin has central nervous system activity, including anxiolytic-like action. Myricitrin possesses antioxidant, anti-inflammatory, antifibrotic and anti-malarial effects .

HY-N0368

Linalool,98% (stabilized with MEHQ) 4 Publications Verification	Cardiovascular Disease Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Amberboa moschata (L.) DC. Umbelliferae Plants Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Apoptosis iGluR Endogenous Metabolite Bacterial TNF Receptor
Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-B1229

Isovaleramide 1 Publications Verification 3-Methylbutanamide	Structural Classification Natural Products other families Plants Source Classification	GABA Receptor
Isovaleramide (3-Methylbutanamide) is an orally active anticonvulsant. Isovaleramide inhibits alcohol dehydrogenase (ADH) activity and regulates GABAergic system. Isovaleramide reduces acute kidney injury. Isovaleramide has antiepileptic, anxiolytic, sedative and hypnotic effects[1] .

HY-N1440

Koumine	Alkaloids Classification of Application Fields Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Inflammation/Immunology Disease Research Fields Indole Alkaloids Source Classification	Bcl-2 Family
Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

HY-N0008

Orcinol glucoside	Curculigo orchioides Gaertn. Structural Classification Monophenols Phenols Plants Amaryllidaceae Source Classification	Wnt p38 MAPK mTOR Keap1-Nrf2 TGF-β Receptor
Orcinol glucoside is an orally active, blood-brain barrier permeable osteoblast proliferation promoter that targets the Nrf2/Keap1, mTOR and p38 signaling pathways. Orcinol glucoside promotes Nrf2 nuclear translocation, upregulates antioxidant enzyme levels, enhances the phosphorylation of mTOR and p70S6K, and inhibits the enzymatic activity of HAS2 as well as the nuclear translocation of GR. Orcinol glucoside also alleviates oxidative stress, inhibits autophagic flux, osteoclastogenesis and TGF-β1-induced M2 polarization, while reducing collagen deposition and effectively promoting the proliferation, differentiation and mineralization of osteoblasts. Orcinol glucoside also exhibits anti-pulmonary fibrosis, anxiolytic and antidepressant activities. Orcinol glucoside can be used in the research of senile and glucocorticoid-induced osteoporosis, idiopathic pulmonary fibrosis (IPF), anxiety and other related diseases .

HY-N9502

Linalool oxide	Natural Products Neurological Disease Classification of Application Fields Acrostichum speciosum Willd. Myrtaceae Plants Disease Research Fields Source Classification	Endogenous Metabolite
Linalool oxide is a monoterpene and found in aromatic plant essential oils and is a secondary metabolite in elongating wheat plants. Linalool oxide has antinociceptive, anticonvulsant, and anxiolytic activity. Linalool oxide can be used for the research of pain, epilepsy, anxiety disorders .

HY-N6648

Cirsimaritin	Flavonoids Flavones Leguminosae Phenols Polyphenols Abrus precatorius Linn. Plants Source Classification	GABA Receptor
Cirsimaritin binds weakly to the benzodiazepine site on GABA_A receptors, with antidepressant, anxiolytic and antinociceptive activities.

HY-N3940

Gelsevirine	Alkaloids Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Indole Alkaloids Source Classification	Others
Gelsevirine is the major alkaloid in Gelsemium elegans with potent anxiolytic effects. The anxiolytic mechanism of Gelsevirine may be involved in the agonist action of the glycine receptor in the brain. Gelsevirine has anti-proliferation activity with IC₅₀ values of 1.41 mM and 1.22 mM for SW480 cells and MGC80-3 cells, respectively .

HY-116590

(±)-Glaziovine	Alkaloids Other Alkaloids Unonopsis duckei R.E.Fr. Plants Annonaceae Source Classification	VEGFR
(±)-Glaziovine, a proaporphine alkaloid, has anxiolytic activity. (±)-Glaziovine can be used for neuropharmacological research .

HY-167825

Barakol	Seeds of Cassia tora Linn. Natural Products Leguminosae Plants Source Classification	MMP Apoptosis Bcl-2 Family Reactive Oxygen Species (ROS)
Barakol is a major compound found in Cassia siamea. Barakol inhibits MMP-3 activity. Barakol potentiates the anti-metastatic effect of Doxorubicin (HY-15142). Barakol induces apoptosis, with ROS generation, increase in expression ratio of Bax/Bcl-2, and caspase-9 activation. Barakol has laxative, anxiolytic, CNS depressant, and antioxidant, anticancer effects .

HY-N12098

d-Laserpitin	Coumarins Sphagneticola calendulacea (L.) Pruski Phenylpropanoids Plants Umbelliferae Source Classification	Others
d-Laserpitin, pyranocoumarin, is a nature product with anxiolytic activity. d-Laserpitin can be isolated from the fruits of Seseli devenyense Simonk .

HY-N0152R

Myricitrin (Standard)	Flavonols Structural Classification Flavonoids Phenols Polyphenols Myrica nagi Plants Source Classification Myricaceae	Reference Standards PKC NO Synthase TNF Receptor Parasite
Myricitrin (Standard) is the analytical standard of Myricitrin. This product is intended for research and analytical applications. Myricitrin, a naturally occurring flavonoid, is an orally active nitric oxide (NO) and PKC inhibitor. Myricitrin has central nervous system activity, including anxiolytic-like action. Myricitrin possesses antioxidant, anti-inflammatory, antifibrotic and anti-malarial effects .

HY-N1440R

Koumine (Standard)	Alkaloids Structural Classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Indole Alkaloids Source Classification	Reference Standards Bcl-2 Family
Koumine (Standard) is the analytical standard of Koumine. This product is intended for research and analytical applications. Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

HY-N9502R

Linalool oxide (Standard)	Natural Products Acrostichum speciosum Willd. Myrtaceae Plants Source Classification	Reference Standards Endogenous Metabolite
Linalool oxide (Standard) is the analytical standard of Linalool oxide (HY-N9502). This product is intended for research and analytical applications. Linalool oxide is a monoterpene and found in aromatic plant essential oils and is a secondary metabolite in elongating wheat plants. Linalool oxide has antinociceptive, anticonvulsant, and anxiolytic activity. Linalool oxide can be used for the research of pain, epilepsy, anxiety disorders .

HY-N9418R

Gibberellin A5 (Standard)	Rosaceae Plants Rosa canina Gremli ex Christ Source Classification	Phytohormone Reference Standards
Trimipramine (Standard) is the analytical standard of Trimipramine. This product is intended for research and analytical applications. Trimipramine is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine has vascular activity and anxiolytic efficacy .

HY-N6648R

Cirsimaritin (Standard)	Structural Classification Flavonoids Flavones Leguminosae Phenols Polyphenols Abrus precatorius Linn. Plants Source Classification	GABA Receptor Reference Standards
Cirsimaritin (Standard) is the analytical standard of Cirsimaritin (HY-N6648). This product is intended for research and analytical applications. Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors, with antidepressant, anxiolytic and antinociceptive activities.

Cat. No.	Product Name	Chemical Structure

HY-152052S

Linalool-d5

Linalool-d₅ is the deuterium labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-W740297

Methyl Clonazepam-d3
Methyl Clonazepam-d₃ is the deuterium labeled Methylclonazepam (HY-W399186). Methylclonazepam is a benzodiazepine with anxiolytic activity. Methylclonazepam inhibits the absorption of 5-hydroxytryptamine by Schistosoma mansoni. Methylclonazepam derivatives have anti-Schistosoma mansoni activity .

HY-N0368S1

Linalool-13C3

Linalool- ¹³C₃ is ¹³C labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-A0198S

Adinazolam-d5
Adinazolam-d₅ (U 41123-d₅) is a deuterium labeled Adinazolam (HY-A0198). Adinazolam is a triazolobenzodiazepine. Adinazolam binds to peripheral-type benzodiazepine receptors which interact allosterically with GABA receptors. Adinazolam has dual anxiolytic and antidepressant activities .

HY-14264S

Cyamemazine-d6
Cyamemazine-d₆ is the deuterium labeled Cyamemazine. Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore. Cyamemazine is often used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki of 12 nM), 5-HT2A (Ki = 1.5 nM) and 5-HT2C (Ki of 75 nM) receptors antagonist with antipsychotic activity .

HY-14558S

Tandospirone-d8
Tandospirone-d₈ (SM-3997-d₈) is deuterium labeled Tandospirone. Tandospirone (SM-3997) is a potent and selective 5-HT_1A receptor partial agonist, with a K_i of 27 nM. Tandospirone has anxiolytic and antidepressant activities. Tandospirone can be used for the research of the central nervous system disorders and the underlying mechanisms .

HY-12390S

Lofepramine-d3

Lofepramine-d₃ (Lopramine-d₃) is the deuterium labeled Lofepramine. Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties .

HY-W010410S

Oct-1-en-3-ol-d3

Oct-1-en-3-ol-d₃ is deuterated labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-W026772S1

Fluorene-d8

Fluorene-d₈ is the deuterium labeled Fluorene (HY-W026772). Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders .

HY-W777458

Fluorene-13C6

Fluorene- ¹³C₆ is the ¹³C-labeled Fluorene (HY-W026772). Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders .

HY-B0168BS

Levomilnacipran-d5 hydrochloride

Levomilnacipran-d5 ((1S,2R)-Milnacipran-d5) hydrochloride is deuterium labeled Levomilnacipran hydrochloride (HY-B0168B). Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran hydrochloride is a serotonin and norepinephrine reuptake inhibitor, with IC₅₀ values of 10.5 nM and 19.0 nM, and K_i values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran hydrochloride has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression .

HY-14794AS

Levomilnacipran-d10 hydrochloride

Levomilnacipran-d₁₀ ((1S,2R)-Milnacipran-d₁₀) hydrochloride is deuterium labeled Levomilnacipran hydrochloride (HY-B0168B). Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran hydrochloride is a serotonin and norepinephrine reuptake inhibitor, with IC₅₀ values of 10.5 nM and 19.0 nM, and K_i values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran hydrochloride has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression .

HY-W013150S

Alpidem-d14

Alpidem-d₁₄ is the deuterium labeled Alpidem (HY-W013150) . Alpidem, an anxiolytic agent, is an orally active and brain-penetrant GABAA receptor ligand, binds to α1β2γ2 subunit-containing GABAA receptors (IC₅₀ of 17 nM) over α5β2γ2 subunit-containing GABAA receptors (IC₅₀ of >10 μM). Alpidem modulates calcium-induced mitochondrial permeability transition, induces glutathione depletion and hepatocyte necrosis, potentiates TNF-α toxicity, inhibits marble-burying and locomotor activity, enhances stressed rodent feeding behavior, and exerts anticonvulsant effects. Alpidem can be used for the research of anxiety, anxiety disorders, and convulsions.

Cat. No.	Product Name		Classification

HY-152782

4’-Azido-2’-deoxy-2’-fluoro-beta-D-arabinouridine		Azide
4’-Azido-2’-deoxy-2’-fluoro-beta-D-arabinouridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 4’-Azido-2’-deoxy-2’-fluoro-beta-D-arabinouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-152476

3’-β-C-Ethynyluridine		Alkynes
3’-β-C-Ethynyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 3’-β-C-Ethynyluridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-154736

N3-(Butyn-3-yl)uridine		Alkynes
N3-(Butyn-3-yl)uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . N3-(Butyn-3-yl)uridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-152985

3’-Azido-3’-deoxy-4-deoxyuridine		Azide
6-Chloro-N1-(trimethylsilylethoxymethyl)pseudouridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 3’-Azido-3’-deoxy-4-deoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-154590

2’,3’-Di-O-isopropylidene-4’-alpha-C-azidouridine		Azide
2’,3’-Di-O-isopropylidene-4’-alpha-C-azidouridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 2’,3’-Di-O-isopropylidene-4’-alpha-C-azidouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-154357

4’-alpha-C-Azido-2’,3’-bis(O-t-butyldimethylsilyl)uridine		Azide
4’-alpha-C-Azido-2’,3’-bis(O-t-butyldimethylsilyl)uridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents . 4’-alpha-C-Azido-2’,3’-bis(O-t-butyldimethylsilyl)uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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