1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    GPCR/G Protein
  2. GABA Receptor
    5-HT Receptor
  3. Valerenic acid

Valerenic acid (Synonyms: (-)-Valerenic Acid)

Cat. No.: HY-103524
Handling Instructions

Valerenic acid ((-)-Valerenic Acid), a sesquiterpenoid, is an orally active positive allosteric modulator of GABAA receptors. Valerenic acid is also a partial agonist of the 5-HT5a receptor. Valerenic acid mediates anxiolytic activity via GABAA receptors containing the β3 subunit. Valerenic acid also exhibits potent antioxidant properties.

For research use only. We do not sell to patients.

Valerenic acid Chemical Structure

Valerenic acid Chemical Structure

CAS No. : 3569-10-6

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Description

Valerenic acid ((-)-Valerenic Acid), a sesquiterpenoid, is an orally active positive allosteric modulator of GABAA receptors. Valerenic acid is also a partial agonist of the 5-HT5a receptor. Valerenic acid mediates anxiolytic activity via GABAA receptors containing the β3 subunit. Valerenic acid also exhibits potent antioxidant properties[1][2][3].

IC50 & Target[1][2]

GABAA

 

5-HT5A Receptor

17.2 μM (IC50)

In Vitro

Valerenic acid (1-100 μM) enhances the whole cell currents on GABAA receptors expressed in HEK 293 cells[1].
Valerenic acid exhibits significant affinity for the 5-HT5a receptor, with an IC50 of 17.2 μM (Ki=10.7 μM)[2].
[3H]Valerenic acid binds to brain membranes reveals both a high affinity binding site (KD=25 nM) and a low affinity site (KD=16 μM)[1].
[3H]Valerenic acid is displaced by Valerenol with high potency (IC50=3 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Valerenic acid (1-6 mg/kg i.p. or 10 mg/kg p.o.) decreases the aversion of wild type mice to the lit area[2].
Valerenic acid (10 mg/kg; p.o.) increases the proportion of time 129X1/SvJ mice spent onto the open arms[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

234.33

Formula

C₁₅H₂₂O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Valerenic acid
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HY-103524
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