3569-10-6
Chemical Structure
Valerenic acid
Synonym(s): (-)-Valerenic Acid
- CAS No.: 3569-10-6
- Formula:C15H22O2
- Molecular Weight:234.33
IUPAC Name: (E)-3-((4S,7R,7aR)-3,7-dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl)-2-methylacrylic acid
InChIKey: FEBNTWHYQKGEIQ-SUKRRCERSA-N
SMILES: O=C(O)/C(C)=C/[C@H]1C2=C(C)CC[C@]2([H])[C@H](C)CC1
Biological Activity: Valerenic acid ((-)-Valerenic Acid), a sesquiterpenoid, is an orally active positive allosteric modulator of GABAA receptors. Valerenic acid is also a partial agonist of the 5-HT5a receptor. Valerenic acid mediates anxiolytic activity via GABAA receptors containing the β3 subunit. Valerenic acid also exhibits potent antioxidant properties[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Valerenic acid | 99.95% | Valerenic acid ((-)-Valerenic Acid), a sesquiterpenoid, is an orally active positive allosteric modulator of GABAA receptors. Valerenic acid is also a partial agonist of the 5-HT5a receptor. Valerenic acid mediates anxiolytic activity via GABAA receptors containing the β3 subunit. Valerenic acid also exhibits potent antioxidant properties. | ||||||||||||||||||||
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Valerenic acid (Standard) | ≥98% | Valerenic acid (Standard) is the analytical standard of Valerenic acid. This product is intended for research and analytical applications. Valerenic acid ((-)-Valerenic Acid), a sesquiterpenoid, is an orally active positive allosteric modulator of GABAA receptors. Valerenic acid is also a partial agonist of the 5-HT5a receptor. Valerenic acid mediates anxiolytic activity via GABAA receptors containing the β3 subunit. Valerenic acid also exhibits potent antioxidant properties. | ||||||||||||||||||||
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Similarity Score 0.84
HY-N16466Valerenal -
Similarity Score 0.80
HY-N7262RHydroxyvalerenic acid (Standard) -
Similarity Score 0.73
HY-167702(Rac)-Acetoxyvalerenic acid -
Similarity Score 0.73
HY-N9414RAcetoxyvalerenic acid (Standard) -
Similarity Score 0.68
HY-N1984RArtemisic acid (Standard) -
Similarity Score 0.67
HY-N4106Dihydroartemisinic acid -
Similarity Score 0.67
HY-N3016Rupestonic acid -
Similarity Score 0.66
HY-N13466(-)-Cadin-4,10(15)-dien-11-oic acid -
Similarity Score 0.65
HY-N19774(+)-Sclerosporin -
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References
- [1]. Benke D, et, al. GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology. 2009 Jan;56(1):174-81. [Content Brief]
- [2]. Dietz BM, et, al. Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Brain Res Mol Brain Res. 2005 Aug 18;138(2):191-7. [Content Brief]
- [3]. Kara M, et, al. Ameliorative Effects of the Sesquiterpenoid Valerenic Acid on Oxidative Stress Induced in HepG2 Cells after Exposure to the Fungicide Benomyl. Antioxidants (Basel). 2021 May 8;10(5):746. [Content Brief]
