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Results for "

asthma and atopic dermatitis

" in MedChemExpress (MCE) Product Catalog:

22

Inhibitors & Agonists

1

Fluorescent Dyes

2

Biochemical Assay Reagents

14

Inhibitory Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99025
    Lebrikizumab
    1 Publications Verification

    TNX-650; MILR1444A; RG3637

    		 Interleukin Related Neurological Disease Inflammation/Immunology
    Lebrikizumab (TNX-650) is an IgG4 humanized anti-interleukin-13 (IL-13) mAb with anti-itch effects that specifically binds to IL-13 in a non-receptor binding domain and inhibits its function. Lebrikizumab inhibits the IL-13 driven Th2 inflammatory response and blocks the signaling of IL-4Rα/IL-13Rα1. Lebrikizumab can be used for the research of asthma, atopic dermatitis and neuroinflammatory diseases .
    Lebrikizumab
  • HY-148074
    Zelnecirnon

    RPT193

    		 CCR Inflammation/Immunology
    Zelnecirnon (RPT193) is an orally active inhibitor of CCR4, blocks the recruitment of Th2 inflammatory immune cells into inflamed tissues. Zelnecirnon can be used for allergic inflammation in atopic dermatitis, asthma, and other diseases research .
    Zelnecirnon
  • HY-P99673
    Itepekimab
    1 Publications Verification

    REGN-3500; SAR-440340

    		 Interleukin Related NF-κB Inflammation/Immunology
    Itepekimab (REGN-3500) is an IgG4 monoclonal antibody against IL-33. Itepekimab reduced airway inflammation and related tissue damage in preliminary clinical studies. Itepekimab has potential effects in asthma, chronic obstructive pulmonary disease (COPD), and atopic dermatitis (AD) .
    Itepekimab
  • HY-P991162
    Tilrekimig

    PF-07275315

    		 Interleukin Related Inflammation/Immunology
    Tilrekimig (PF-07275315) is a monoclonal antibody targeting human interleukin-4 (IL-4), interleukin-13 (IL-13) and thymic stromal lymphopoietin (TSLP). Tilrekimig can be used in the research of allergic and inflammatory diseases, such as asthma and atopic dermatitis .
    Tilrekimig
  • HY-P990735
    Donzakimig

    		Interleukin Related Inflammation/Immunology
    Donzakimig is a trispecific anti-IL-13/IL-22/HSA antibody. Donzakimig adopts a Fab-scFv-scFv structural format (without an Fc region), in which the Fab domain is linked to the scFv domains via a S (G4S)2 linker. Donzakimig binds to and inhibits the activities of IL-13 and IL-22, thereby blocking the signal transduction of these two cytokines. Donzakimig can extend its serum half-life by binding to human serum albumin, enhancing its in vivo stability and achieving long-acting efficacy. Donzakimig can be used in research on moderate-to-severe atopic dermatitis, moderate-to-severe asthma (especially eosinophilic type), psoriasis, inflammatory bowel disease, and other conditions .
    Donzakimig
  • HY-P99053
    Tralokinumab
    2 Publications Verification

    CAT354

    		 Interleukin Related Apoptosis Caspase Cadherin Inflammation/Immunology
    Tralokinumab (CAT354) is a humanized IgG4 monoclonal antibody that specifically binds to and neutralizes IL-13. Tralokinumab can be used in the research of diseases such as asthma, atopic dermatitis, and pulmonary fibrosis .
    Tralokinumab
  • HY-114354
    BODIPY FL alkyne

    BOD FL alkyne

    		 Fluorescent Dye Inflammation/Immunology
    BODIPY (BOD) FL alkyne is an alkyne-containing BODIPY fluorophore derivative. BODIPY FL alkyne is a bioorthogonal labeling reagent with low toxicity and extremely low non-specific reactivity, and it is widely used in fluorescent bioimaging. BODIPY FL alkyne specifically labels azide groups on intracellular glycoconjugates mainly via strain-promoted azide-alkyne cycloaddition (SPAAC), or mediates site-specific conjugation with proteins such as IL-33, and supports positive cross-linking with other probes (e.g., DBCO-SCy5) for dual labeling. With the advantages of high specificity and low background interference, BODIPY FL alkyne can be used in the research of related diseases such as asthma, atopic dermatitis and inflammatory bowel disease .
    BODIPY FL alkyne
  • HY-P991252
    XmAb-7195

    AIMab-7195

    		 Histamine Receptor Inflammation/Immunology
    XmAb-7195 (AIMab-7195) is a human monoclonal antibody (mAb) targeting IGHE. XmAb-7195 can be used in Food hypersensitivity, Allergic asthma, Allergic rhinitis, Atopic dermatitis and Conjunctivitis research .
    XmAb-7195
  • HY-P990090
    Rademikibart

    CBP-201

    		 Interleukin Related STAT Inflammation/Immunology
    Rademikibart (CBP-201) is a human monoclonal antibody targeting IL-4Rα and IL-4Rα inhibitor with a KD of 20.7 pM when binding to human IL-4Rα epitopes . Rademikibart does not bind to IL-4Rα from other species. Rademikibart inhibits IL-4 and IL-13-mediated STAT6 signaling, TF-1 cell proliferation and thymus activation regulated chemokine (TRAC) production. Rademikibart can be used for the research of atopic dermatitis and asthma .
    Rademikibart
  • HY-18706
    trans-Tranilast

    trans-MK-341; trans-SB 252218

    		 Angiotensin Receptor Drug Isomer Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    trans-Tranilast (trans-MK-341) is an isomer of Tranilast (HY-B0195), and an anti-allergy agent used in studies of bronchial asthma, allergic rhinitis, and atopic dermatitis .
    trans-Tranilast
  • HY-P991258
    CNTO-5825

    		Interleukin Related Inflammation/Immunology
    CNTO-5825 is a humanized monoclonal antibody inhibitor targeting interleukin-13 (IL-13). CNTO-5825 is promising for research of Th2-type inflammatory related diseases such as asthma and atopic dermatitis .
    CNTO-5825
  • HY-DNP159AF
    House dust mite extract, from D.pteronyssinus (biotinylated)

    		Biochemical Assay Reagents Others
    House dust mite extract, from D.pteronyssinus (biotinylated), the most common source of indoor allergens, induces a variety of allergic diseases, including allergic rhinitis, conjunctivitis, allergic asthma, and atopic dermatitis .
    House dust mite extract, from D.pteronyssinus (biotinylated)
  • HY-P991150
    Ompekimig

    		Interleukin Related Inflammation/Immunology
    Ompekimig is a humanized immunoglobulin monoclonal antibody targeting human interleukin 4 (IL-4) and interleukin 13 (IL-13). Ompekimig is promising for research of immune-mediated inflammatory diseases, such as asthma and atopic dermatitis .
    Ompekimig
  • HY-P991256
    FB-825

    		Interleukin Related Inflammation/Immunology
    FB-825 is a human monoclonal antibody (mAb) targeting IGHE. FB-825 targets the CεmX domain of membrane IgE (mIgE), resulting in the downregulation of mIgE-positive B cells and the production of IgE. FB-825 can be used in Allergic asthma, Atopic dermatitis, Job syndrome and Allergic rhinitis research .
    FB-825
  • HY-P991720
    Tepilukimig

    		Interleukin Related Inflammation/Immunology
    Tepilukimig is a bivalent humanized IgG1κ monoclonal antibody inhibitor targeting TSLP-IL7Rα and TSLP-CRLF2. Tepilukimig inhibits the binding of TSLP to its receptors (IL7Rα and CRLF2) on the cell surface, thereby completely interrupting the inflammatory signaling pathway driven by TSLP. Tepilukimig can be used for allergic and inflammatory diseases like atopic dermatitis and asthma research .
    Tepilukimig
  • HY-P991152
    Oturkibart

    QX-005N

    		 Interleukin Related Inflammation/Immunology
    Oturkibart is a humanized immunoglobulin G4-κ monoclonal antibody targeting the human interleukin 4 receptor (IL4R). Oturkibart is promising for research of inflammatory diseases, such as asthma and atopic dermatitis .
    Oturkibart
  • HY-DNP159F
    House dust mite extract, from D.farinae (biotinylated)

    		Biochemical Assay Reagents Others
    House dust mite extract, from D.farinae (biotinylated), the most common source of indoor allergens, induces a variety of allergic diseases, including allergic rhinitis, conjunctivitis, allergic asthma, and atopic dermatitis .
    House dust mite extract, from D.farinae (biotinylated)
  • HY-P992474
    TAVO101

    		Interleukin Related STAT CCR Fc Receptor (FcR) Inflammation/Immunology
    TAVO101 is a humanized anti-TSLP antibody with an EC50 of 0.19 nM against hTSLP. TAVO101 inhibits STAT5 activation and CCL17 release. TAVO101 carries Fc region mutations that enhance its binding to FcRn while reducing its binding to FcγRI, FcγRIIIA and C1q, thereby attenuating effector functions. TAVO101 reduces the levels of inflammatory markers, cell infiltration and histopathological damage in preclinical models of asthma, psoriasis and atopic dermatitis. TAVO101 can be used for research related to asthma, psoriasis and atopic dermatitis .
    TAVO101
  • HY-174771
    Human CCL11 mRNA

    		mRNA Inflammation/Immunology
    Human CCL11 mRNA encodes the human C-C motif chemokine ligand 11 (CCL11) protein, a member of the CC subfamily. CCL11 is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections.
    Human CCL11 mRNA
  • HY-182736
    YM-344484

    		CCR Histamine Receptor Calcium Channel Inflammation/Immunology
    YM-344484 is an orally active dual antagonist of chemokine CCR3 receptor and histamine histamine H1 receptor. YM-344484 inhibits ligand-induced Ca 2+ influx, chemotaxis of CCR3-expressing cells, histamine-induced Ca 2+ influx, increased vascular permeability and eosinophil accumulation. YM-344484 suppresses vascular permeability and inhibits eosinophil infiltration in a mouse asthma model. YM-344484 can be used in research related to asthma, allergic rhinitis and atopic dermatitis .
    YM-344484
  • HY-206870
    BP79

    		Interleukin Related STAT Inflammation/Immunology
    BP79 is a potent TSLP receptor inhibitor. BP79 disrupts TSLP-mediated ternary complex formation, blocks TSLPR-IL7Rα co-localization, binds and stabilizes TSLPR, and inhibits phosphorylated STAT3/6. BP79 suppresses immune cell infiltration, secretion of IL-13, IL-4. BP79 can be used for the research of inflammation diseases, such as atopic dermatitis, allergic asthma, and allergic rhinitis .
    BP79
  • HY-P992034
    APG808

    PR001

    		 Interleukin Related Inflammation/Immunology
    APG808 (PR001) is an anti-human IL-4Rα monoclonal antibody. APG808 binds to IL-4Rα, prevents IL-13Rα1/IL-4Rα heterodimer formation, and disrupts IL-13 and IL-4 mediated signaling. APG808 ablates Fc and complement effector functions. APG808 can be used for the research of chronic obstructive pulmonary disease, asthma, atopic dermatitis .
    APG808

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