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broad biological activities

" in MedChemExpress (MCE) Product Catalog:

33

Inhibitors & Agonists

2

Screening Libraries

1

Biochemical Assay Reagents

4

Peptides

8

Natural
Products

3

Isotope-Labeled Compounds

5

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N1950
    Hispidulin
    5+ Cited Publications

    Dinatin

    		 Pim Cancer
    Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM.
    Hispidulin
  • HY-N0328
    alpha-Mangostin
    Maximum Cited Publications
    10 Publications Verification

    α-Mangostin

    		 Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal Virus Protease Cancer
    alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.
    alpha-Mangostin
  • HY-P1939
    Cyclo(L-Leu-L-Pro)

    Cyclo(L-prolyl-L-leucyl)

    		 Fungal Bacterial Influenza Virus Infection
    Cyclo(L-Leu-L-Pro) is a cyclic dipeptide with broad-spectrum antibacterial, antiviral and antifungal activities. Its biological activity is highly dependent on the stereoconfiguration and is widely present in microbial metabolites. Cyclo(L-Leu-L-Pro) efficiently and specifically inhibits the production of aflatoxin by Aspergillus flavus. The cis configuration of Cyclo(L-Leu-L-Pro) (cis-cyclo(L-Leu-L-Pro)) has broad-spectrum antibacterial activity against multi-drug resistant bacteria and significantly inhibits the influenza A virus H3N2 .
    Cyclo(L-Leu-L-Pro)
  • HY-138800
    Spinosad
    4 Publications Verification

    		 nAChR Neurological Disease
    Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete (Saccharopolyspora spinosa), is a biological neurotoxic insecticide with a broader action spectrum. Spinosad targets the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system. Spinosad has an excellent environmental and mammalian toxicological profile. Larvicidal activity .
    Spinosad
  • HY-P10373
    pJAK2(1001-1013)

    		JAK IFNAR Interleukin Related Infection Inflammation/Immunology
    pJAK2(1001-1013) is a cell-penetrating peptide that corresponds to the activation loop of JAK2 tyrosine kinase and functions as a SOCS1/3antagonist. pJAK2 (1001-1013) blocks SOCS1-mediated negative regulation of immune function, and enhances the biological activity of cytokines such as IFNγ and IL6. pJAK2(1001-1013) inhibits the replication of a broad range of viruses and exerts dose-dependent protective efficacy against lethal viral infections. pJAK2(1001-1013) can be used for the study of immune regulation and infection .
    pJAK2(1001-1013)
  • HY-40294
    Indazole

    		Monoamine Oxidase GSK-3 LRRK2 Cardiovascular Disease Neurological Disease Cancer
    Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases .
    Indazole
  • HY-N0616
    Trifolirhizin

    		Tyrosinase TNF Receptor Bacterial Apoptosis Autophagy AMPK mTOR ERK NF-κB Infection Metabolic Disease Inflammation/Immunology Cancer
    Trifolirhizin is a pterocarpan flavonoid found in the roots of Sophora flavescens. Trifolirhizin is a tyrosinase inhibitor with an IC50 value of 506.77 μM. Trifolirhizin reduces intracellular melanin production and modulates multiple signaling pathways including NFκB-MAPK, AMPK/mTOR, PI3K/Akt, MAPK-NFATc1 and EGFR-MAPK. Trifolirhizin targets biological molecules including PTK6 and COX-2, inhibits the activities of hyaluronidase, collagenase and elastase, induces apoptosis, autophagy and cell cycle arrest, and suppresses the proliferation, migration and invasion of cancer cells. Trifolirhizin exerts diverse pharmacological effects including anti-inflammatory, anti-asthmatic, bone-protective, renoprotective, antibacterial, antifungal, hepatoprotective, antiplatelet, estrogenic and wound-healing activities. Trifolirhizin can be used to investigate a broad range of malignant, inflammatory, metabolic and infectious disorders .
    Trifolirhizin
  • HY-B1805
    Triclocarban
    3 Publications Verification

    3,4,4′-Trichlorocarbanilide

    		 Environmental Pollutants Bacterial Infection
    Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
    Triclocarban
  • HY-N8599
    Cichoriin
    2 Publications Verification

    		 Amylases Glycosidase Lipase Dipeptidyl Peptidase p38 MAPK PPAR P2Y Receptor NOD-like Receptor (NLR) SARS-CoV Pyroptosis GLUT Angiotensin-converting Enzyme (ACE) NF-κB Infection Metabolic Disease Inflammation/Immunology
    Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against α-amylase, α-glucosidase, pancreatic lipase and DPP-IV, with IC50 values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y14R (IC50 = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2 .
    Cichoriin
  • HY-W010649
    Isoxazole

    		HSP Epigenetic Reader Domain ATP-binding cassette (ABC) transporters Bacterial Fungal Antibiotic Infection Metabolic Disease Inflammation/Immunology Cancer
    Isoxazole is a member of the five-membered heterocycle drug scaffold. Isoxazole has been used as a BET bromodomain inhibitor and can improve β-cell function in a diabetic mouse model. Isoxazole and its derivatives exhibit broad biological activities (such as antimicrobial, antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, immunomodulatory, analgesic, anti-tuberculosis, and anti-diabetic effects). For example, the bicyclic Isoxazole can act as an HSP90 inhibitor, and the tricyclic Isoxazole is promising as a selective multidrug resistance protein (MRP1) inhibitor​ .
    Isoxazole
  • HY-B1128A
    Cefamandole sodium

    Cephamandole sodium

    		 Antibiotic Bacterial Infection
    Cefamandole (Cephamandole) sodium is a semi-synthetic second-generation cephalosporin antibiotic with broad-spectrum antimicrobial activity. Cefamandole sodium is resistant to hydrolysis by β-lactamases produced by some Gram-negative bacteria. Cefamandole sodium kills Gram-positive cocci and various Gram-negative bacilli mainly by inhibiting cell wall synthesis, but it is inactive against Pseudomonas, Proteus vulgaris and Providencia stuartii, and its efficacy is affected by inoculum size. The plasma elimination half-life of Cefamandole sodium in rats is only 0.4 h, it is mainly excreted in urine in biologically active form, and it hardly penetrates the non-inflamed blood-brain barrier. Cefamandole sodium is widely used in studies related to bacterial infections .
    Cefamandole sodium
  • HY-N0328R
    alpha-Mangostin (Standard)
    Maximum Cited Publications
    10 Publications Verification

    α-Mangostin (Standard)

    		 Fungal Reactive Oxygen Species (ROS) Bacterial Apoptosis Virus Protease Reference Standards Cancer
    alpha-Mangostin (Standard) is the analytical standard of alpha-Mangostin. This product is intended for research and analytical applications. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.
    alpha-Mangostin (Standard)
  • HY-P5486
    Tet-20

    		Bacterial Others
    Tet-20 is a biological active peptide. (Tet-20, is a synthetic cathelicidin-derived peptide. It was tested as infection-resistant coating for medical devices. When tethered on an implant surface Tet-20 exhibited broad antimicrobial activities both in vivo and in vitro. It can stop biofilm formation and appears to be non-toxic to eukaryotic cells)
    Tet-20
  • HY-W585956
    Triclocarban-13C6

    3,4,4′-Trichlorocarbanilide-13C6

    		 Isotope-Labeled Compounds Others
    Triclocarban- 13C6 is the 13C labeled isotope of Triclocarban (HY-B1805). Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
    Triclocarban-13C6
  • HY-B1805R
    Triclocarban (Standard)

    3,4,4′-Trichlorocarbanilide (Standard)

    		 Reference Standards Bacterial Infection Endocrinology
    Triclocarban (Standard) (3,4,4′-Trichlorocarbanilide (Standard)) is the analytical standard of Triclocarban (HY-B1805). This product is intended for research and analytical applications. Triclocarban, a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
    Triclocarban (Standard)
  • HY-W391625
    (Rac)-Dehydrocostus Lactone

    (Rac)-Epiligulyl oxide

    		 Fungal Cancer
    (Rac)-Dehydrocostus Lactone ((Rac)-Epiligulyl oxide) is a natural product with antiparasitic activity. (Rac)-Dehydrocostus Lactone can significantly inhibit the growth of Trypanosoma brucei rhodesiense. (Rac)-Dehydrocostus Lactone exhibits a broad spectrum of biological effects, including anti-inflammatory, anticancer, antiviral and antimicrobial activities. (Rac)-Dehydrocostus Lactone also has antifungal, antioxidant, antidiabetic, antiulcer and antihelminthic effects. (Rac)-Dehydrocostus Lactone exhibits different IC(50) values in cytotoxicity tests and has a high selectivity index .
    (Rac)-Dehydrocostus Lactone
  • HY-B1128
    Cefamandole

    Cephamandole

    		 Antibiotic Bacterial Infection
    Cefamandole (Cephamandole) is a semi-synthetic second-generation cephalosporin antibiotic with broad-spectrum antimicrobial activity. Cefamandole is resistant to hydrolysis by β-lactamases produced by some Gram-negative bacteria. Cefamandole kills Gram-positive cocci and various Gram-negative bacilli mainly by inhibiting cell wall synthesis, but it is inactive against Pseudomonas, Proteus vulgaris and Providencia stuartii, and its efficacy is affected by inoculum size. The plasma elimination half-life of Cefamandole in rats is only 0.4 h, it is mainly excreted in urine in biologically active form, and it hardly penetrates the non-inflamed blood-brain barrier. Cefamandole is widely used in studies related to bacterial infections .
    Cefamandole
  • HY-N1950R
    Hispidulin (Standard)

    Dinatin (Standard)

    		 Reference Standards Pim Cancer
    Hispidulin (Standard) is the analytical standard of Hispidulin. This product is intended for research and analytical applications. Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM.
    Hispidulin (Standard)
  • HY-174642
    Human IL12A mRNA

    		mRNA Inflammation/Immunology
    Human IL12A mRNA encodes the human interleukin 12A (IL12A) protein, a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL12A is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells.
    Human IL12A mRNA
  • HY-174641
    Human IL12B mRNA

    		mRNA Inflammation/Immunology
    Human IL12B mRNA encodes the human interleukin 12B (IL12B) protein, a subunit of interleukin 12, is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL12B has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen.
    Human IL12B mRNA
  • HY-40294R
    Indazole (Standard)

    		Monoamine Oxidase GSK-3 LRRK2 Cardiovascular Disease Neurological Disease Cancer
    Indazole (Standard) is the analytical standard of Indazole. This product is intended for research and analytical applications. Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases .
    Indazole (Standard)
  • HY-P11102
    Temporin-SHa

    		Bacterial Fungal HIV Parasite Infection Cancer
    Temporin-Sha is an antibacterial peptide with extensive biological activity. Temporin-Sha exhibits broad-spectrum antibacterial activity (e.g., against L. ivanovii, MIC = 6.25 μM), and is effective against Gram-negative bacteria (such as Escherichia coli, MIC = 10 μM), including drug-resistant strains (such as Methicillin (HY-121544)-resistant Staphylococcus aureus). Temporin-Sha also has inhibitory effects on Candida albicans (MIC = 25 μM), Saccharomyces cerevisiae (MIC = 12 μM), the pre-flagellated and non-flagellated forms of Leishmania infantum (IC50 = 5-20 μM), and Trypanosoma cruzi (IC50 = 17 μM). Temporin-Sha exhibits antiviral activity against HSV-1 and has anti-cancer effects (cytotoxicity against breast cancer cells MCF-7 and lung cancer cells H460, etc.) .
    Temporin-SHa
  • HY-W010649R
    Isoxazole (Standard)

    		HSP Reference Standards Epigenetic Reader Domain ATP-binding cassette (ABC) transporters Bacterial Fungal Antibiotic Infection Metabolic Disease Inflammation/Immunology Cancer
    Amfenac (Sodium Hydrate) (Standard) is the analytical standard of Amfenac (Sodium Hydrate). This product is intended for research and analytical applications. Amfenac Sodium Hydrate is a COX-2 inhibitor.
    Isoxazole (Standard)
  • HY-N14984
    Galbonolides A

    		Fungal Infection
    Galbonolides A exhibits biological activity against a broad spectrum of fungi .
    Galbonolides A
  • HY-B1805S
    Triclocarban-d4

    3,4,4′-Trichlorocarbanilide-d4

    		 Bacterial Infection
    Triclocarban-d4 is the deuterium labeled Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
    Triclocarban-d4
  • HY-W777429
    Ceratamine B

    		Biochemical Assay Reagents
    Ceratamine B is a fluorescent substrate with significant biological activity and can be used for cell imaging and biolabeling. Ceratamine B can effectively penetrate cell membranes, facilitating the study of cellular processes. Ceratamine B also shows broad application potential in compound screening and biosensor development.
    Ceratamine B
  • HY-167735
    Salvizol

    Bisdequalinium diacetate

    		 Bacterial Infection
    Salvizol (Bisdequalinium diacetate) is a chemotherapeutic agent with a broad spectrum of bactericidal activity, effective in the apical third of root canals. Salvizol possesses the ability to dissolve organic dentin matrix, facilitating mineralization and tubule exposure. Salvizol maintains a neutral pH, ensuring biological compatibility while exhibiting significant cleansing potency.
    Salvizol
  • HY-B1805S1
    Triclocarban-13C13

    3,4,4'-Trichlorocarbanilide-13C13

    		 Isotope-Labeled Compounds Bacterial Infection
    Triclocarban- 13C13 (3,4,4'-Trichlorocarbanilide- 13C13) is 13C labeled Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
    Triclocarban-13C13
  • HY-174693
    Human FGF7 mRNA

    		mRNA Cancer
    Human FGF7 mRNA encodes the human fibroblast growth factor 7 (FGF7) protein, a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.
    Human FGF7 mRNA
  • HY-174692
    Human FGF8 mRNA

    		mRNA Cancer
    Human FGF8 mRNA encodes the human fibroblast growth factor 8 (FGF8) protein, a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.
    Human FGF8 mRNA
  • HY-174691
    Human FGF9 mRNA

    		mRNA Cancer
    Human FGF9 mRNA encodes the human fibroblast growth factor 9 (FGF9) protein, a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.
    Human FGF9 mRNA
  • HY-B1128B
    Cefamandole lithium

    Cephamandole lithium

    		 Antibiotic Bacterial Infection
    Cefamandole (Cephamandole) lithium is a semi-synthetic second-generation cephalosporin antibiotic with broad-spectrum antimicrobial activity. Cefamandole lithium is resistant to hydrolysis by β-lactamases produced by some Gram-negative bacteria. Cefamandole lithium kills Gram-positive cocci and various Gram-negative bacilli mainly by inhibiting cell wall synthesis, but it is inactive against Pseudomonas, Proteus vulgaris and Providencia stuartii, and its efficacy is affected by inoculum size. The plasma elimination half-life of Cefamandole lithium in rats is only 0.4 h, it is mainly excreted in urine in biologically active form, and it hardly penetrates the non-inflamed blood-brain barrier. Cefamandole lithium is widely used in studies related to bacterial infections .
    Cefamandole lithium
  • HY-B1128AR
    Cefamandole sodium (Standard)

    Cephamandole sodium (Standard)

    		 Reference Standards Antibiotic Bacterial Infection
    Cefamandole (sodium) (Standard) is the analytical standard of Cefamandole (sodium). This product is intended for research and analytical applications. Cefamandole (Cephamandole) sodium is a semi-synthetic second-generation cephalosporin antibiotic with broad-spectrum antimicrobial activity. Cefamandole sodium is resistant to hydrolysis by β-lactamases produced by some Gram-negative bacteria. Cefamandole sodium kills Gram-positive cocci and various Gram-negative bacilli mainly by inhibiting cell wall synthesis, but it is inactive against Pseudomonas, Proteus vulgaris and Providencia stuartii, and its efficacy is affected by inoculum size. The plasma elimination half-life of Cefamandole sodium in rats is only 0.4 h, it is mainly excreted in urine in biologically active form, and it hardly penetrates the non-inflamed blood-brain barrier. Cefamandole sodium is widely used in studies related to bacterial infections .
    Cefamandole sodium (Standard)

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