21 Results for "

carboxylesterase 2

" in MedChemExpress (MCE) Product Catalog:
Products (21)

21 Results for "carboxylesterase 2" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-N1951
CAS No.: 27210-57-7
Synonyms: Rosmariquinone
Miltirone is an orally active natural compound found in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC50 of 0.3 μM. Miltirone induces ROS - and-p53 dependent apoptosis. Miltirone inhibits carboxylesterase 2 (CES2; Ki = 0.04 μM) and SARS-CoV main protease (Mpro) .
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2
2 Cited Publications
Cat. No.: HY-N0235
CAS No.: 10309-37-2
Synonyms: (S)-(+)-Bakuchiol
Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2) , with IC50s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory , antibacterial , antitumor therapies, as well as drug metabolism regulation.
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1
1 Cited Publications
Cat. No.: HY-134124
CAS No.: 92614-59-0
Purity:  95.8%
Research Areas:  

Metabolic Disease

Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .
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1
1 Cited Publications
Cat. No.: HY-114879
CAS No.: 118290-05-4
Purity:  98.43%
DDAO is a promising near-infrared (NIR) red fluorescent probewith tunable excitation wavelength (600-650nm) and longemission wavelength(λem=656nm). DDAO can de desiged for detection of the activities of different enzymes such asβ-galactosidase,sulfatase, proteinphosphatase2A,carboxylesterase 2, humanalbumin andesterases .
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Cat. No.: HY-114118S
Semaglutide-d8 is the deuterium labeled Semaglutide (HY-114118). Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .
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Cat. No.: HY-114118S1
Semaglutide-d8 tetraTFA is the deuterium labeled Semaglutide (HY-114118). Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .
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Cat. No.: HY-N3474
CAS No.: 94805-83-1
Isolicoflavonol potently inhibits hCES2A (Human carboxylesterase 2)-mediated fluorescein diacetate hydrolysis in a reversible and mixed inhibition manner, with Ki values less than 1.0 μM .
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Cat. No.: HY-N0855
CAS No.: 155521-46-3
Synonyms: Alisol-G; 25-Anhydroalisol A
Alisol G (25-Anhydroalisol A) is a human carboxylesterase 2 (hCES2) inhibitor with an IC50 of 3.85 μM. Alisol G exhibits cytotoxic activity against human cancer cells, antibacterial activity against Gram-positive strains, and anti-hepatitis B virus activity. Alisol G can be used in research related to lung cancer, breast cancer, prostate cancer, bacterial infections, and HBV infections .
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Cat. No.: HY-N1951R
CAS No.: 27210-57-7
Synonyms: Rosmariquinone (Standard)
Miltirone is an orally active natural compound found in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC50 of 0.3 μM. Miltirone induces ROS - and-p53 dependent apoptosis. Miltirone inhibits carboxylesterase 2 (CES2; Ki = 0.04 μM) and SARS-CoV main protease (Mpro) .
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Cat. No.: HY-N3921
CAS No.: 126716-36-7
Gancaonin I, an Isoflavone, exhibits moderate inhibition on human carboxylesterase 2 (hCES2A) with IC50 of 1.72 μM. Gancaonin I inhibits hCES2A-mediated fluorescein diacetate (FD) hydrolysis .
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Cat. No.: HY-N3413
CAS No.: 254886-77-6
Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and human carboxylesterase 2 (hCE2) inhibitor with IC50s of 2.07 μM and 3.05 μM, respectively .
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Cat. No.: HY-P2424
CAS No.: 144396-38-3
Synonyms: CCK-J
Target:  

Calcium Channel

Research Areas:  

Others

Cholecystokinin-J (CCK-J), a cholecystokinin, stimulates Ca 2+ release .
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Cat. No.: HY-N0235R
CAS No.: 10309-37-2
Synonyms: (S)-(+)-Bakuchiol (Standard)
Bakuchiol (Standard) is the analytical standard of Bakuchiol. This product is intended for research and analytical applications. Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2) , with IC50s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory , antibacterial , antitumor therapies, as well as drug metabolism regulation.
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Cat. No.: HY-184061
CAS No.: 2590661-64-4
Research Areas:  

Others

Carboxylesterase 2-IN-1 is a potent carboxylesterase CES2 inhibitor with an IC50 of 0.13 μM. Carboxylesterase 2-IN-1 blocks the hydrolysis of fluorescein diacetate by CES2 via non-competitive inhibition. Carboxylesterase 2-IN-1 also effectively inhibits adipogenesis induced in mouse preadipocytes .
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Cat. No.: HY-P76193
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CES2; carboxylesterase 2 (Intestine, Liver); carboxylesterase 2; Cocaine Esterase; CE-2; Intestinal carboxylesterase; Liver carboxylesterase-2; ICE; Carboxylic Ester Hydrolase; CES2A1; PCE-2; Methylumbelliferyl-Acetate Deacetylase 2; HCE-2
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P76192A
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CES2; carboxylesterase 2 (Intestine, Liver); carboxylesterase 2; Cocaine Esterase; CE-2; Intestinal carboxylesterase; Liver carboxylesterase-2; ICE; Carboxylic Ester Hydrolase; CES2A1; PCE-2; Methylumbelliferyl-Acetate Deacetylase 2; HCE-2
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P76192
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CES2; carboxylesterase 2 (Intestine, Liver); carboxylesterase 2; Cocaine Esterase; CE-2; Intestinal carboxylesterase; Liver carboxylesterase-2; ICE; Carboxylic Ester Hydrolase; CES2A1; PCE-2; Methylumbelliferyl-Acetate Deacetylase 2; HCE-2
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-176465
CAS No.: 3037959-47-7
Research Areas:  

Inflammation/Immunology

CES2A-IN-3 (Compound 9d) is a potent serine-targeting covalent human carboxylesterase 2A (hCES2A) inhibitor with an IC50 value of 0.12 nM. CES2A-IN-3 is promising for research of diarrhea and ulcerative colitis .
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Cat. No.: HY-155228
Research Areas:  

Inflammation/Immunology

hCES2A-IN-2 (Compound 44) is an orally active human carboxylesterase 2 (hCES2A) inhibitor (IC50: 5.02 μM). hCES2A-IN-2 improves Irinotecan (HY-16562)-induced delayed diarrhea .
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Cat. No.: HY-147915
CAS No.: 2416220-53-4
Benz-AP is a potent photosensitizer. Benz-AP produces singlet oxygen, with a negative correlation with hCES2 (Human carboxylesterase 2) activity. Benz-AP displays a higher photocytotoxicity potency in cancer cells under low hCES2 environments. Upon TPE (Two-photon excitation), Benz-AP produces ROS and kills cancer cells and tumor spheroids .
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