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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
cardiac hypertrophic
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "cardiac hypertrophic" in MCE Product Catalog:
52
Category:
Alkaloids Neurological Disease Other Alkaloids Endogenous metabolite Disease Research Fields Endocrinology
Target:
52
Category:
Cardiovascular Disease Alkaloids Natural Products Neurological Disease Other Alkaloids Ranunculaceae Aconitum carmichaeli Debx. Plants Disease Research Fields
Target:
3
3 Cited Publications
Synonyms: CK-274; CK-3773274
Target:
Research Areas:
Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM) .
1
1 Cited Publications
Research Areas:
KR-39038 is an orally active and potent GRK5 (G protein-coupled receptor kinase 5) inhibitor, with an IC50 of 0.02 μM. KR-39038 significantly inhibits angiotensin II-induced cellular hypertrophy through suppression of HDAC5 pathway in neonatal cardiomyocytes. KR-39038 shows profound anti-hypertrophic effects and improved cardiac function. KR-39038 can be used for heart failure research .
Cat. No.: HY-159821
CAS No.: 2830607-59-3
Synonyms: CK-4021586; CK-586
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Research Areas:
Ulacamten (CK-4021586; CK-586) is an orally active cardiac myosin inhibitor and an inhibitor of the double-headed cardiac heavy meromyosin (HMM)ATPase (excluding single-headed myosin subfragment-1), with an EC50 of 2.9 μM. Ulacamten regulates cardiac myosin, reduces excessive myocardial contractility, and alleviates left ventricular outflow tract obstruction. Ulacamten increases the left ventricular short-axis systolic internal diameter, inhibits dobutamine-induced exacerbation of obstruction, and exerts only a mild reducing effect on left ventricular systolic function. Ulacamten also inhibits the fractional shortening of the short axis without altering calcium transients. Ulacamten shows good safety and tolerability in purpose-bred cats with naturally occurring obstructive hypertrophic cardiomyopathy .
Cat. No.: HY-B0573S1
CAS No.: 344298-99-3
Cat. No.: HY-B0573BS
CAS No.: 98897-23-5
Cat. No.: HY-B0573S
CAS No.: 1613439-56-7
Category:
Cat. No.: HY-172424
CAS No.: 2417411-02-8
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Delocamten is an orally active, selective Cardiac Myosin inhibitor with an IC50 of approximately 1.11 μM. Delocamten directly modulates myosin complexes, inhibits excessive myocardial contraction, and improves diastolic function. Delocamten can be used in studies of hypertrophic cardiomyopathy (HCM), left ventricular hypertrophy, and diastolic dysfunction .
Cat. No.: HY-161663
CAS No.: 3047610-96-5
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Phosphodiesterase-IN-2 (Compound C7) is a selective, orally active inhibitor for phosphodiesterase 10A (PDE10A), with an IC50 of 11.9 nM. Phosphodiesterase-IN-2 improves the stability of liver microsomes, and lowers BBB permeability. Phosphodiesterase-IN-2 exhibits good pharmacokinetic characters, and attenuates isoprenaline (HY-108353)-induced cardiac hypertrophic in mouse models .
Cat. No.: HY-W759845
Synonyms: CK-274-d3; CK-3773274-d3
Cat. No.: HY-152206
CAS No.: 2417988-00-0
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JB062 is a nonmuscle myosin inhibitor with IC50 values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin, Cardiac muscle myosin, and Smooth muscle myosin II, respectively. JB062 has cytotoxic to human cancer cells but not normal cells. JB062 can be used in research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy .
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GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4–NKX2-5 transcriptional synergy with an IC50 of 3 μM. GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression .
Cat. No.: HY-17681
CAS No.: 2839464-02-5
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Myosin-IN-5 (example 3) is a selective cardiac myosin inhibitor with an IC50 of 1.5 μM. Myosin-IN-5 shows much less effective in inhibiting skeletal myofibril activity (IC50 of 43.4 μM). Myosin-IN-5 can be used for the study of hypertrophic cardiomyopathy (HCM) and cardiac diseases .
Cat. No.: HY-P703646
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNNT2; cardiac Muscle Troponin T; Prev. CMD1D; Troponin T Type 2 cardiac; Prev. CMH2; cardiac Troponin T; Troponin T, cardiac Muscle; LVNC6; CMPD2; TnTC; Cardiomyopathy, Dilated 1D (Autosomal Dominant); RCM3; Cardiomyopathy, hypertrophic 2; TnTc; Troponin
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P81144
Synonyms: troponin I type 3 (cardiac); cardiac troponin I; Troponin I, cardiac muscle; Cardiomyopathy, familial hypertrophic, 7, included; CMD1FF; CMD2A; CMH7; cTnI; Familial hypertrophic cardiomyopathy 7; MGC116817; RCM1; Tn1; Tni; TNN I3; TNNC 1; TNNC-1; TNNC1; TNNI3; Troponin I cardiac; Troponin I cardiac muscle; Troponin I cardiac muscle isoform; Troponin I type 3 cardiac; troponin I, cardiac 3; TroponinI; Troponin I; TNNI3_HUMAN.
Cat. No.: HY-P82974
Synonyms: TNNT2; cardiac muscle troponin T; Troponin T; cardiac muscle; troponin T type 2 (cardiac); cardiac muscle troponin T antibody
Cardiomyopathy dilated 1D (autosomal dominant) antibody;
Cardiomyopathy hypertrophic 2 antibody;
CMD1D antibody;
CMH2 antibody;
CMPD2 antibody;
cTnT antibody;
LVNC6 antibody;
MGC3889 antibody;
OTTHUMP00000033864 antibody;
RCM3 antibody;
TNNT 2 antibody;
TNNT2 antibody;
TNNT2_HUMAN antibody;
TnTc antibody;
Troponin T cardiac muscle antibody;
Troponin T2 cardiac antibody
Cat. No.: HY-W192276
CAS No.: 20862-11-7
Synonyms: N-Desisopropylpropranolol
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Endocrinology Cancer
(±)-Desisopropylpropranolol (N-Desisopropylpropranolol) is a metabolite of Propranolol (HY-B0573B). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Kis of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [ 3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .
Cat. No.: HY-103484R
CAS No.: 544681-96-1
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GATA4-NKX2-5-IN-1 (Standard) is the analytical standard of GATA4-NKX2-5-IN-1 (HY-103484). This product is intended for research and analytical applications. GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4–NKX2-5 transcriptional synergy with an IC50 of 3 μM. GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
