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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
dihydroquinoline
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "dihydroquinoline" in MCE Product Catalog:
Art. -Nr.: HY-148852
CAS. Nr.: 282536-25-8
PNU-183792, a 4-oxo-dihydroquinoline, is an orally active HSV polymerases inhibitor. PNU-183792 shows a broad-spectrum antiviral activity, with IC50 values of 0.69 μM, 0.37 μM and 0.58 μM for human cytomegalovirus (HCM), varicella zoster virus and HSV polymerases, respectively. PNU-183792 is inactive against human α, γ and δ polymerases. PNU-183792 also inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV) .
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DQP-997-74 (compound 2i) is a selective negative allosteric modulator of N-methyl-d-aspartate receptor (NMDAR), specifically targeting GluN2C/D (IC50: 0.069 μM and 0.035 μM), with blood-brain barrier penetrability. Where DQP refers to dihydroquinoline-pyrazoline. DQP-997-74 acts synergistically with the agonist glutamate to exhibit time-dependent enhanced potency in inhibiting hypersynchronous activity driven by high-frequency excitatory synaptic transmission. DQP-997-74 reduces the number of epileptogenesis in a murine model of tuberous sclerosis complex (TSC)-induced epilepsy. DQP-997-74 can be used for research on NMDAR-related neurological diseases .
Art. -Nr.: HY-24418
CAS. Nr.: 158577-01-6
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1-Isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid is a drug intermediate for synthesis of various active compounds.
Art. -Nr.: HY-W285163S
Synonyms: Formyl Ciprofloxacin-d8
Art. -Nr.: HY-W756467
CAS. Nr.: 2733149-80-7
Synonyms: 1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid-13C,d3
Art. -Nr.: HY-W015237R
CAS. Nr.: 15733-89-8
Synonyms: 2-Hydroxyquinoline-4-carboxylic acid (Standard)
Target:
2-Oxo-1,2-dihydroquinoline-4-carboxylic acid (Standard) is the analytical standard of 2-Oxo-1,2-dihydroquinoline-4-carboxylic acid. This product is intended for research and analytical applications.
Art. -Nr.: HY-W092987
CAS. Nr.: 99429-64-8
Forschungsgebiete:
Ethyl 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate is a quinoline compound that targets the angiotensin-converting enzyme ACE2 receptor and exhibits anti-SARS-CoV-2 activity. Ethyl 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate blocks the binding of SARS-CoV-2 to host cells and is used in research on coronavirus disease 2019 (COVID-19) .
Art. -Nr.: HY-W043493R
CAS. Nr.: 68077-26-9
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7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (Standard) is the analytical standard of 7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. This product is intended for research and analytical applications.
Art. -Nr.: HY-W099069R
CAS. Nr.: 112811-71-9
Target:
Ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate (Standard) is the analytical standard of Ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate. This product is intended for research and analytical applications.
Art. -Nr.: HY-187691S
Synonyms: Ofivacaftor-M1-d4
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Forschungsgebiete:
N-(2-(tert-Butyl)-5-hydroxy-4-(2-hydroxypropan-2-yl)phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide-d4 is the deuterated-labeled N-(2-(tert-Butyl)-5-hydroxy-4-(2-hydroxypropan-2-yl)phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide.
Art. -Nr.: HY-W073260R
CAS. Nr.: 417721-34-7
Target:
7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylic acid (Standard) is the analytical standard of 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylic acid. This product is intended for research and analytical applications.
Art. -Nr.: HY-E71899
Target:
Forschungsgebiete:
5,6-Dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase (EC 1.3.1.65) is an oxidoreductase that can convert 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one and NAD + into 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline, NADH and H +.
Art. -Nr.: HY-W053722
CAS. Nr.: 147-47-7
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Forschungsgebiete:
1,2-Dihydro-2,2,4-trimethylquinoline is a dihydroquinoline (tetrahydroquinoline) derivative. In the NTP carcinogenicity bioassay via the skin route, 1,2-Dihydro-2,2,4-trimethylquinoline shows no evidence of carcinogenicity in the female mouse model, while TOPKAT predicts it to be carcinogenic in that model .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
