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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
189 Results for "
elastase
" in MedChemExpress (MCE) Product Catalog:
Products (189)
189 Results for "elastase" in MCE Product Catalog:
36
36 Publications Verification
Referencia número: HY-17443
No. CAS: 127373-66-4
Synonyms: EI546; LY544349; ONO5046
Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19 .
36
36 Publications Verification
Referencia número: HY-17443A
No. CAS: 150374-95-1
Synonyms: ONO5046-Na; Sodium sivelestat; EI546 sodium; LY544349 sodium
Sivelestat (EI546) sodium is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19 .
36
36 Publications Verification
Referencia número: HY-17443B
No. CAS: 201677-61-4
Synonyms: EI546 sodium tetrahydrate; LY544349 sodium tetrahydrate; ONO5046 sodium tetrahydrate
Sivelestat (EI546) sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19 .
13
13 Cited Publications
Synonyms: AZD9668
Target:
Áreas de investigación:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Alvelestat (AZD9668) is an orally active, selective inhibitor of neutrophil elastase. Alvelestat reduces elastase activity, myeloperoxidase release, neutrophil recruitment and activation, and calcium phosphate precipitation; promotes smooth muscle cell colonization and collagen deposition; and inhibits the formation of neutrophil extracellular traps (NETs) as well as NET-derived neutrophil elastase activity. Alvelestat restores endothelial dysfunction, regulates antioxidant factors, improves the expression of endothelial tight junctions, reduces vascular leakage, and accelerates wound healing. Alvelestat prevents pulmonary hemorrhage, matrix protein degradation, airspace enlargement, and small airway wall remodeling; and alleviates cigarette-induced inflammatory responses. Alvelestat inhibits the growth of abdominal aortic aneurysms exacerbated by Porphyromonas gingivalis. Alvelestat can be used in research related to chronic obstructive pulmonary disease, abdominal aortic aneurysm, radiation-induced skin injury, and bronchiectasis .
11
11 Cited Publications
Synonyms: GW311616A
Target:
Áreas de investigación:
GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22 nM and Ki value of 0.31 nM .
7
7 Cited Publications
Referencia número: HY-P2974
No. CAS: 39445-21-1
Synonyms: EC 3.4.21.36; Pancreatopeptidase E
Target:
Áreas de investigación:
Elastase, Porcine pancreas (EC 3.4.21.36) is a single polypeptide chain of 240 amino acid residues, derived from pig pancreas. Elastase, Porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide. Elastase from porcine pancreas can induce emphysema in hamsters .
6
Target:
Áreas de investigación:
DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.
6
6 Cited Publications
Áreas de investigación:
HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1). HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist). HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases .
4
Category:
Rutaceae Extract Plant Flavonoids Neurological Disease Flavones Disease Research Fields Citrus Extract Cancer
Target:
3
3 Cited Publications
Referencia número: HY-19908
No. CAS: 1161921-82-9
Target:
Áreas de investigación:
BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE), with an IC50 of 65 pM.
3
3 Cited Publications
Target:
Áreas de investigación:
BOS-318 is a potent, slowly dissociating, highly selective, and cell-permeable furin inhibitor with IC50 value of 1.9 nM. BOS-318 protects ENaC from subsequent activation by neutrophil elastase. BOS-318 can be used for the rsearch for CF lung disease .
1
1 Cited Publications
Referencia número: HY-P4476
No. CAS: 72682-69-0
Target:
Áreas de investigación:
1
1 Cited Publications
Referencia número: HY-N2395
No. CAS: 13241-28-6
Category:
Quinones Plant Monophenols Anthraquinones Phenols Rheum palmatum L. Extract Disease Research Fields Polygonaceae Extract Cancer
Target:
1
1 Cited Publications
Referencia número: HY-N6876
No. CAS: 59472-23-0
Category:
Target:
1
1 Cited Publications
Referencia número: HY-19908B
No. CAS: 2446175-39-7
Target:
Áreas de investigación:
(R)-BAY-85-8501 is the less active Enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent inhibitor of Human Neutrophil Elastase (HNE), with an IC50 of 65 pM .
1
1 Cited Publications
Referencia número: HY-P70342
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MMP12; MMP-12; Matrix Metallopeptidase 12; MME; HME; ME; Matrix Metalloproteinase 12 (Macrophage elastase); Matrix Metallopeptidase 12 (Macrophage elastase); Macrophage Metalloelastase; Matrix Metalloproteinase-12; Macrophage elastase
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Target:
Áreas de investigación:
BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).
1
1 Cited Publications
Target:
Áreas de investigación:
BAY-677 is an inactive control for BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM . BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC) .
1
1 Cited Publications
Referencia número: HY-P71303
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINB1; Epididymis Secretory Protein Li 27; Prev. ELANH2; Peptidase Inhibitor 2; MNEI; HEL-S-27; PI2; M/NEI; LEI; PI-2; EI; Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 1, Isoform CRA_a; Leukocyte elastase Inhibitor; Protease Inhibitor 2 (Ant
Species:
Human
Source:
HEK293
Target:
Áreas de investigación:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
