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endothelin B receptors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Endothelin Receptor (25) Antibiotic (3) Apoptosis (1) Bacterial (4) Endogenous Metabolite (1) HIV (1) Integrin (1) Reference Standards (1) TGF-β Receptor (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (16) Endocrinology (7) Infection (6) Metabolic Disease (5) Neurological Disease (5)

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Targets Recommended: Endothelin Receptor Endothelin-Converting Enzyme (ECE)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0323

Sulfisoxazole 5 Publications Verification Sulfafurazole	Endothelin Receptor Bacterial Antibiotic	Infection Endocrinology Cancer
Sulfisoxazole (Sulfafurazole) is an orally active **endothelin receptor antagonist with IC₅₀** values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole is a sulfonamide antibacterial agent with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A .

HY-P0204A

Endothelin-3, human, mouse, rabbit, rat TFA 1 Publications Verification endothelin 3 (Rat,Human) TFA	Endothelin Receptor Integrin	Neurological Disease
Endothelin-3, human, mouse, rabbit, rat TFA (Endothelin 3 (Rat,Human) TFA) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat TFA stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat TFA plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat TFA acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat TFA can be used in studies related to distal aganglionosis .

HY-16465

IRL-1620 1 Publications Verification	Endothelin Receptor	Neurological Disease Endocrinology
IRL-1620 is a potent and selective endothelin receptor type B (ETB) agonist with a K_i of 16 pM.

HY-N7543

Schisantherin D	HIV Endothelin Receptor	Infection Metabolic Disease
Schisantherin D is a lignan. Schisantherin D can be isolated from Kadsura interior. Schisantherin D downregulates the expression of ETBR and inhibits the secretion of ECM and ET-1. Schisantherin D alleviates EtOH + ET-1-induced hepatocyte cytotoxicity. Schisantherin D potently inhibits HIV replication in cells .

HY-120295

A-192621 2 Publications Verification	Endothelin Receptor Apoptosis	Cardiovascular Disease Endocrinology
A-192621, a chemical probe, is a potent, nonpeptide, orally active and selective **endothelin B (ET_B) receptor antagonist with an IC₅₀ of 4.5 nM and a K_i of 8.8 nM. The selectivity of A-192621 is 636-fold higher than ET_A (IC₅₀ of 4280 nM and K_i of 5600 nM). A-192621 promotes apoptosis** in PASMCs. A-192621 alos causes elevation of arterial blood pressure and an elevation in the plasma ET-1 level .

HY-16465A

IRL-1620 TFA 1 Publications Verification	Endothelin Receptor	Cardiovascular Disease Neurological Disease Endocrinology
IRL-1620 (TFA) is a potent and selective endothelin receptor type B (ETB) agonist with a K_i of 16 pM .

HY-15404

Darusentan Lu-135252	Endothelin Receptor	Cardiovascular Disease Endocrinology
Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) *receptor* antagonist, which binds with a K_i of 1.4 nM to the ET-A receptor and a K_i of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors . Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a K_i of 13 nM .

HY-102029

Sarafotoxin S6c SRTX-c	Endothelin Receptor	Cardiovascular Disease
Sarafotoxin S6c (SRTX-c) is a potent **endothelin-B receptor** agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels .

HY-76520

Sitaxsentan IPI 1040; TBC-11251	Endothelin Receptor TGF-β Receptor	Cardiovascular Disease Metabolic Disease
Sitaxsentan (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC₅₀ of 1.4 nM and a K_i of 0.43 nM. Sitaxsentan exhibits an IC₅₀ for the ETB receptor of as high as 9800 nM. Sitaxsentan is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension .

HY-123744

PD-156707	Endothelin Receptor	Cardiovascular Disease Neurological Disease
PD-156707 is an orally active, nonpeptide and selective *Endothelin-A* receptor antagonist. PD-156707 binds to human ET-A and *ET-B* receptors with K_i values of 0.17 nM and 133.8 nM, respectively. PD-156707 shows reversal of established chronic hypoxic pulmonary hypertension in rats. PD-156707 can be used for the study of diseases associated with abnormal ET-A receptor activation, particularly pulmonary hypertension, stroke, and heart failure .

HY-B0323A

Sulfisoxazole diethanolamine Sulfafurazole diethanolamine	Endothelin Receptor Antibiotic Bacterial	Infection Endocrinology Cancer
Sulfisoxazole (Sulfafurazole) diethanolamine is an **endothelin receptor antagonist with IC₅₀** values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole diethanolamine is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole diethanolamine inhibits breast cancer exosome release by targeting endothelin receptor A .

HY-106337

SB 247083	Endothelin Receptor	Cardiovascular Disease
SB 247083 is a selective, competitive and orally active **endothelin-A receptor antagonist with a K_i of 0.41 nM. SB 247083 shows a K_i of 467 nM to endothelin-B receptor. SB 247083 shows a K_b** of 3.5 nM for ET-1-induced contraction of rat aorta. SB 247083 can be used for the research of cardiovascular disease .

HY-P3433

Sarafotoxin S6b	Endothelin Receptor	Cardiovascular Disease
Sarafotoxin S6b is a vasoconstrictor peptide, and a non-selective **endothelin receptor agonist. Sarafotoxin S6b can induce contraction in isolated human coronary arteries , the K_i** values of Coronary artery, Saphenous vein and Coronary artery are 0.27, 0.55 and 19.5 nM, respectively .

HY-118497

BMS 182874	Endothelin Receptor	Cardiovascular Disease Metabolic Disease
BMS 182874 is an orallyactive, highly selective **endothelin receptor (ET_A** receptor) antagonist, with IC₅₀ value of 0.150 μM, K_i of 0.055 μM. BMS 182874 reduces the arterial pressure of Deoxycorticosterone acetate (HY-B1472) induced hypertension model in rats, and can be used for cardiovascular disease research .

HY-P2057

PD 142893	Endothelin Receptor	Cardiovascular Disease
PD 142893 is a **endothelin-B receptor** antagonist .

HY-B0323R

Sulfisoxazole (Standard) Sulfafurazole (Standard)	Reference Standards Endothelin Receptor Bacterial Antibiotic	Infection Endocrinology Cancer
Sulfisoxazole (Standard) is the analytical standard of Sulfisoxazole. This product is intended for research and analytical applications. Sulfisoxazole (Sulfafurazole) is an orally active **endothelin receptor antagonist with IC₅₀** values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole is a sulfonamide antibacterial agent with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A .

HY-P1018

IRL 1038	Endothelin Receptor	Neurological Disease
IRL 1038 is an **endothelin B receptor selective antagonist with a K_i** of 6-11 nM .

HY-122237

ATZ-1993	Endothelin Receptor	Cardiovascular Disease
ATZ-1993 is an orally active, nonpeptide endothelin receptor subtype Aand endothelin receptor subtype B antagonist with pK_i values of 8.69, 7.20, respectively. ATZ-1993 has the potential for the research of intimal hyperplasia after balloon denudation of the carotid artery .

HY-117634

WS009B	Endothelin Receptor	Cardiovascular Disease
WS009B is a selective **endothelin receptor antagonist (ET-1: IC₅₀=0.67 μM; ET-2: IC₅₀**=0.8 μM). WS009B can be used in the study of cardiovascular diseases .

HY-103458

BMS 182874 hydrochloride	Endothelin Receptor	Cardiovascular Disease Metabolic Disease
BMS 182874 hydrochloride is an orallyactive, highly selective **endothelin receptor (ET_A** receptor) antagonist, with IC₅₀ value of 0.150 μM, K_i of 0.055 μM. BMS 182874 hydrochloride reduces the arterial pressure of Deoxycorticosterone acetate (HY-B1472) induced hypertension model in rats, and can be used for cardiovascular disease research .

HY-W781265

BE 24566B L-755,805	Endothelin Receptor Bacterial	Infection
BE 24566B is a polyketide fungal metabolite originally isolated from S. violaceusniger. It is active against B. subtilis, B. cereus, S. aureus, M. luteus, E. faecalis, and S. thermophilus (MICs=1.56, 1.56, 1.56, 1.56, 3.13, and 3.13 μg/mL, respectively). BE 24566B is an endothelin (ET) receptor antagonist (IC₅₀s=11 and 3.9 μM for ETA and ETB receptors, respectively).

HY-118497R

BMS 182874 (Standard)	Endothelin Receptor	Cardiovascular Disease Metabolic Disease
BMS 182874 (Standard) is the analytical standard of BMS 182874. This product is intended for research and analytical applications. BMS 182874 is an orallyactive, highly selective endothelin receptor (ETA receptor) antagonist, with IC50 value of 0.150 μM, Ki of 0.055 μM. BMS 182874 reduces the arterial pressure of Deoxycorticosterone acetate (HY-B1472) induced hypertension model in rats, and can be used for cardiovascular disease research .

HY-182561

Cgs 27830	Endothelin Receptor	Cardiovascular Disease
Cgs 27830 is an **endothelin receptor antagonist with 20-fold higher selectivity for ET-A** receptors over *ET-B* receptors. Cgs 27830 blocks activity of ET-A and *ET-B* receptors. Cgs 27830 does not alter basal vascular tone in the ovine fetal pulmonary circulation. Cgs 27830 prevents big-endothelin-1-induced pulmonary vasoconstriction in late gestation fetal lambs .

HY-P11751A

RES-701-3 peptide TFA	Endogenous Metabolite Endothelin Receptor	Cardiovascular Disease Infection
RES-701-3 peptide TFA is a class II lasso peptide. RES-701-3 peptide TFA can be isolated from the fermentation broth of Streptomyces species. RES-701-3 peptide TFA potently inhibits the binding of ET-1 to ET_B, with an IC₅₀ of approximately 5-10 nM. RES-701-3 peptide TFA is applicable to research related to systemic hypertension, myocardial infarction, and myocardial ischemia .

HY-P991964

Rendomab B4 Rendomab-B49	Endothelin Receptor	Cancer
Rendomab B4 (Rendomab-B49) is a monoclonal antibody targeting ETB. Rendomab B4 preferentially binds to ETB in the active conformational state and exhibits selectivity for ETB on melanoma cells. Rendomab B4 inhibits the G protein-dependent phospholipase C (PLC) pathway, blocks ET-3-induced Gαi/o-mediated inhibition of adenylate cyclase, and does not affect the activation of the ERK1/2 pathway. Rendomab B4 is applicable to melanoma-related research .

Cat. No.	Product Name	Target	Research Area

HY-P0204A

Endothelin-3, human, mouse, rabbit, rat TFA 1 Publications Verification endothelin 3 (Rat,Human) TFA	Endothelin Receptor Integrin	Neurological Disease
Endothelin-3, human, mouse, rabbit, rat TFA (Endothelin 3 (Rat,Human) TFA) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat TFA stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat TFA plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat TFA acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat TFA can be used in studies related to distal aganglionosis .

HY-16465

IRL-1620 1 Publications Verification	Endothelin Receptor	Neurological Disease Endocrinology
IRL-1620 is a potent and selective endothelin receptor type B (ETB) agonist with a K_i of 16 pM.

HY-16465A

IRL-1620 TFA 1 Publications Verification	Endothelin Receptor	Cardiovascular Disease Neurological Disease Endocrinology
IRL-1620 (TFA) is a potent and selective endothelin receptor type B (ETB) agonist with a K_i of 16 pM .

HY-102029

Sarafotoxin S6c SRTX-c	Endothelin Receptor	Cardiovascular Disease
Sarafotoxin S6c (SRTX-c) is a potent **endothelin-B receptor** agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels .

HY-P3433

Sarafotoxin S6b	Endothelin Receptor	Cardiovascular Disease
Sarafotoxin S6b is a vasoconstrictor peptide, and a non-selective **endothelin receptor agonist. Sarafotoxin S6b can induce contraction in isolated human coronary arteries , the K_i** values of Coronary artery, Saphenous vein and Coronary artery are 0.27, 0.55 and 19.5 nM, respectively .

HY-P2057

PD 142893	Endothelin Receptor	Cardiovascular Disease
PD 142893 is a **endothelin-B receptor** antagonist .

HY-P1018

IRL 1038	Endothelin Receptor	Neurological Disease
IRL 1038 is an **endothelin B receptor selective antagonist with a K_i** of 6-11 nM .

HY-P11751A

RES-701-3 peptide TFA	Endogenous Metabolite Endothelin Receptor	Cardiovascular Disease Infection
RES-701-3 peptide TFA is a class II lasso peptide. RES-701-3 peptide TFA can be isolated from the fermentation broth of Streptomyces species. RES-701-3 peptide TFA potently inhibits the binding of ET-1 to ET_B, with an IC₅₀ of approximately 5-10 nM. RES-701-3 peptide TFA is applicable to research related to systemic hypertension, myocardial infarction, and myocardial ischemia .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991964

Rendomab B4 Rendomab-B49	Endothelin Receptor	Cancer
Rendomab B4 (Rendomab-B49) is a monoclonal antibody targeting ETB. Rendomab B4 preferentially binds to ETB in the active conformational state and exhibits selectivity for ETB on melanoma cells. Rendomab B4 inhibits the G protein-dependent phospholipase C (PLC) pathway, blocks ET-3-induced Gαi/o-mediated inhibition of adenylate cyclase, and does not affect the activation of the ERK1/2 pathway. Rendomab B4 is applicable to melanoma-related research .

Schisantherin D	Schisandra sphenanthera Rehd. et Wils Infection Structural Classification Classification of Application Fields Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Source Classification	HIV Endothelin Receptor
Schisantherin D is a lignan. Schisantherin D can be isolated from Kadsura interior. Schisantherin D downregulates the expression of ETBR and inhibits the secretion of ECM and ET-1. Schisantherin D alleviates EtOH + ET-1-induced hepatocyte cytotoxicity. Schisantherin D potently inhibits HIV replication in cells .

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endothelin B receptors

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