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environmental endocrine disruptors

" in MedChemExpress (MCE) Product Catalog:

10

阻害剤およびアゴニスト

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生化学アッセイ試薬

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天然物

2

同位体標識化合物

Targets Recommended:
製品番号 製品名 Target 研究分野 構造式
  • HY-133668
    Monoethyl phthalate

    		Drug Metabolite Cytochrome P450 PPAR Endocrinology Cancer
    Monoethyl phthalate is an orally active PDX-1 activator and the major hydrolytic metabolite of Diethyl phthalate (HY-Y0284) in vivo, with reproductive toxicity. Monoethyl phthalate targets aromatase (aromatase/CYP19A1) and PPAR to induce cell proliferation. The plasma protein binding rate of Monoethyl phthalate in rats and humans is lower than that of Diethyl phthalate. It exhibits significant enterohepatic circulation in rats and mainly accumulates in liver tissues. Monoethyl phthalate shows no estrogenic activity in estrogen-dependent human breast cancer cells. Monoethyl phthalate can be used in studies of reproductive toxicity and related environmental endocrine disruption mechanisms .
    Monoethyl phthalate
  • HY-21197
    Perfluoroenanthic acid

    Perfluoroheptanoic acid; Tridecafluoroheptanoic acid; PFHpA

    		 PPAR Neurological Disease Metabolic Disease Inflammation/Immunology
    Perfluoroenanthic acid (Perfluoroheptanoic acid) is a kind of perfluoroalkyl carboxylic acid organic pollutant. Perfluoroenanthic acid has environmental persistence and bioaccumulation, and exposure can occur via oral, dermal and other routes. Perfluoroenanthic acid exhibits reproductive toxicity, neurotoxicity, hepatotoxicity, immunotoxicity and endocrine-disrupting effects. Perfluoroenanthic acid exerts definite adverse effects on development, spermatogenesis, neuronal activity and liver tissue .
    Perfluoroenanthic acid
  • HY-W036120
    Benzophenone-2

    2,2′,4,4′-Tetrahydroxybenzophenone

    		 Environmental Pollutants Glycosidase Estrogen Receptor/ERR Pregnane X Receptor (PXR) Metabolic Disease Endocrinology
    Benzophenone-2 (2,2',4,4'-Tetrahydroxybenzophenone) is an organic ultraviolet absorber that is widely used in personal care products and industrial products such as plastics and coatings. Benzophenone-2 is an endocrine disruptor that can interfere with estrogen receptors (ERα receptor) and pregnane X receptor (PXR receptor) activity, leading to reproductive toxicity, immune disorders, and metabolic abnormalities. Benzophenone-2 can inhibit the activity of α-glucosidase (IC50 = 49.72 μM), and can be used for research on diabetes .
    Benzophenone-2
  • HY-B2035
    Pretilachlor

    		Herbicide Caspase Cytochrome P450 MDM-2/p53 Interleukin Related Reactive Oxygen Species (ROS) Apoptosis Others
    Pretilachlor is a chloroacetamide herbicide with biological activities including endocrine disruption, oxidative stress induction, apoptosis induction, and immunotoxicity. Pretilachlor exerts its effects by interfering with hormone metabolism, inducing oxidative stress, activating apoptotic pathways, and inhibiting immune functions. Pretilachlor upregulates the transcription of P53, Mdm2, and Bbc3, and increases the activities of Caspase3 and Caspase9; it upregulates the transcription of genes in the HPG/HPT axis and the activity of aromatase; it induces oxidative stress, elevates ROS levels, and upregulates CAT, SOD, and GPX. Pretilachlor downregulates the transcription of CXCL-C1C, IL-1β, and IL-8. Pretilachlor disrupts the normal physiological processes and embryonic development of fish, exhibiting significant toxicity. Pretilachlor can be used in studies related to weeding, environmental pollution, and behavioral toxicity in fish .
    Pretilachlor
  • HY-B1970
    o,p'-DDT

    2,4'-DDT

    		 Insecticide Estrogen Receptor/ERR Endocrinology
    o,p'-DDT (2,4'-DDT) is a chlorinated organic pesticide with estrogenic activity. o,p'-DDT is persistent in the environment, can accumulate in organisms and disrupt the endocrine system. o,p'-DDT is used in agriculture as a pesticide, especially for controlling insect pests. The use of o,p'-DDT has led to toxic effects in organisms, raising widespread concern about its environmental and health effects. o,p'-DDT has also led to research into its long-term effects in ecosystems .
    o,p'-DDT
  • HY-W585831
    Bis(1,3-dichloro-2-propyl) phosphate

    BDCPP

    		 Biochemical Assay Reagents Others
    Bis(1,3-dichloro-2-propyl) phosphate (BDCPP) is a metabolite of the flame retardant TDCPP (HY-108712) and has endocrine disrupting properties. Bis(1,3-dichloro-2-propyl) phosphate can be used in environmental monitoring, toxicology, and exposure assessment studies .
    Bis(1,3-dichloro-2-propyl) phosphate
  • HY-W011103
    Diheptyl phthalate

    		Biochemical Assay Reagents Environmental Pollutants Others
    Diheptyl phthalate is a class of phthalates consisting of two heptyl (C7) chains attached to a phthalic acid backbone. This compound is commonly used as a plasticizer in various polymer materials such as PVC to increase flexibility and durability. It can also be used as a lubricant, solvent or additive in various industrial applications such as coatings, adhesives and sealants. However, Diheptyl phthalate has been identified as an environmental pollutant and health hazard due to its potential for endocrine disruption and toxicity.
    Diheptyl phthalate
  • HY-133668S
    Monoethyl phthalate-d4

    		Isotope-Labeled Compounds Drug Metabolite Cytochrome P450 PPAR Cancer
    Monoethyl phthalate-d4 is the deuterium labeled Monoethyl phthalate. Monoethyl phthalate is an orally active PDX-1 activator and the major hydrolytic metabolite of Diethyl phthalate (HY-Y0284) in vivo, with reproductive toxicity. Monoethyl phthalate targets aromatase (aromatase/CYP19A1) and PPAR to induce cell proliferation. The plasma protein binding rate of Monoethyl phthalate in rats and humans is lower than that of Diethyl phthalate. It exhibits significant enterohepatic circulation in rats and mainly accumulates in liver tissues. Monoethyl phthalate shows no estrogenic activity in estrogen-dependent human breast cancer cells. Monoethyl phthalate can be used in studies of reproductive toxicity and related environmental endocrine disruption mechanisms .
    Monoethyl phthalate-d4
  • HY-B2035R
    Pretilachlor (Standard)

    		Herbicide Reference Standards Others
    Pretilachlor (Standard) is the analytical standard of Pretilachlor (HY-B2035). This product is intended for research and analytical applications. Pretilachlor is a chloroacetamide herbicide with biological activities including endocrine disruption, oxidative stress induction, apoptosis induction, and immunotoxicity. Pretilachlor exerts its effects by interfering with hormone metabolism, inducing oxidative stress, activating apoptotic pathways, and inhibiting immune functions. Pretilachlor upregulates the transcription of P53, Mdm2, and Bbc3, and increases the activities of Caspase3 and Caspase9; it upregulates the transcription of genes in the HPG/HPT axis and the activity of aromatase; it induces oxidative stress, elevates ROS levels, and upregulates CAT, SOD, and GPX. Pretilachlor downregulates the transcription of CXCL-C1C, IL-1β, and IL-8. Pretilachlor disrupts the normal physiological processes and embryonic development of fish, exhibiting significant toxicity. Pretilachlor can be used in studies related to weeding, environmental pollution, and behavioral toxicity in fish .
    Pretilachlor (Standard)
  • HY-21197S
    Perfluoroenanthic acid-13C4

    Perfluoroheptanoic acid-13C4; Tridecafluoroheptanoic acid-13C4; PFHpA-13C4

    		 Isotope-Labeled Compounds PPAR Neurological Disease Metabolic Disease Inflammation/Immunology
    Perfluoroenanthic acid- 13C4 (Perfluoroheptanoic acid- 13C4) is the 13C-labeled Perfluoroenanthic acid (HY-21197). Perfluoroenanthic acid (Perfluoroheptanoic acid) is a kind of perfluoroalkyl carboxylic acid organic pollutant. Perfluoroenanthic acid has environmental persistence and bioaccumulation, and exposure can occur via oral, dermal and other routes. Perfluoroenanthic acid exhibits reproductive toxicity, neurotoxicity, hepatotoxicity, immunotoxicity and endocrine-disrupting effects. Perfluoroenanthic acid exerts definite adverse effects on development, spermatogenesis, neuronal activity and liver tissue .
    Perfluoroenanthic acid-13C4

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