Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
263 Results for "
epidermal growth factor receptor
" in MedChemExpress (MCE) Product Catalog:
Products (263)
263 Results for "epidermal growth factor receptor" in MCE Product Catalog:
57
Research Areas:
Cetuximab (C225) is a human IgG1 monoclonal antibody that inhibits epidermal growth factor receptor (EGFR), with a Kd of 0.201 nM for EGFR by SPR. Cetuximab has potent antitumor activity .
12
12 Cited Publications
Synonyms: T-DXd (solution); DS-8201 (solution); DS-8201a (solution)
Target:
Research Areas:
Trastuzumab deruxtecan (T-DXd; DS-8201a) (solution) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer .
12
12 Cited Publications
Synonyms: T-DXd; DS-8201; DS-8201a
Target:
Research Areas:
Trastuzumab deruxtecan (DS-8201a) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer .
5
5 Cited Publications
Cat. No.: HY-P0221
CAS No.: 137061-48-4
Synonyms: Pituitary Adenylate Cyclase Activating Polypeptide 38
Research Areas:
5
5 Cited Publications
Cat. No.: HY-N0447
CAS No.: 23513-08-8
4
4 Cited Publications
Synonyms: XL-647; EXEL-7647; KD-019
Tesevatinib (XL-647) is an orally available, blood-brain barrier-penetrant inhibitor of the epidermal growth factor receptor (EGFR). Tesevatinib significantly reduces cellular viability, with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Tesevatinib also inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM). Tesevatinib can inhibit tumor proliferation and exhibits antitumor activity .
3
3 Cited Publications
Cat. No.: HY-P7017
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HBEGF; Diphtheria Toxin receptor (Heparin-Binding EGF-Like growth factor); Prev. HEGFL; Heparin-Binding epidermal growth factor; Prev. DTR; Short Form Heparin-Binding EGF-Like growth factor; Prev. DTS; Heparin-Binding EGF-Like growth factor; Diphtheria To
Species:
Human
Source:
E. coli
3
3 Cited Publications
Cat. No.: HY-P7194
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HBEGF; Diphtheria Toxin receptor (Heparin-Binding EGF-Like growth factor); Prev. HEGFL; Heparin-Binding epidermal growth factor; Prev. DTR; Short Form Heparin-Binding EGF-Like growth factor; Prev. DTS; Heparin-Binding EGF-Like growth factor; Diphtheria To
Species:
Mouse
Source:
E. coli
3
3 Cited Publications
Cat. No.: HY-P7400
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HBEGF; Diphtheria Toxin receptor (Heparin-Binding EGF-Like growth factor); Prev. HEGFL; Heparin-Binding epidermal growth factor; Prev. DTR; Short Form Heparin-Binding EGF-Like growth factor; Prev. DTS; Heparin-Binding EGF-Like growth factor; Diphtheria To
Species:
Human
Source:
CHO
2
2 Cited Publications
Target:
Research Areas:
Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia .
2
2 Cited Publications
Synonyms: EGFR mutant-IN-3
Target:
Research Areas:
NT-1 (EGFR mutant-IN-3) is a potent mutant EGFR inhibitor and an analog of Osimertinib (HY-15772). This mutant EGFR inhibitor suppresses FGFR WT with an IC50 of 0.4 nM. NT-1 also inhibits EGFR L858R, EGFR Exon 19 deletion and EGFR T790M. NT-1 exerts deeper inhibition on p-EGFR and p-ERK, and induces tumor cell apoptosis. NT-1 can be used in colorectal cancer research .
2
2 Cited Publications
Cat. No.: HY-P72989
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EGFR; epidermal growth factor receptor Variant EX12_14del; Prev. ERBB; Cell Proliferation-Inducing Protein 61; ERBB1; Cell growth Inhibiting Protein 40; ERRP; receptor Protein-Tyrosine Kinase; receptor Tyrosine-Protein Kinase ErbB-1; Alternative Protein E
Species:
Mouse
Source:
HEK293
2
2 Cited Publications
Cat. No.: HY-P72987
Purity: ≥ 75%, as determined by reducing SDS-PAGE.
Synonyms: EGFR; epidermal growth factor receptor Variant EX12_14del; Prev. ERBB; Cell Proliferation-Inducing Protein 61; ERBB1; Cell growth Inhibiting Protein 40; ERRP; receptor Protein-Tyrosine Kinase; receptor Tyrosine-Protein Kinase ErbB-1; Alternative Protein E
Species:
Human
Source:
Sf9 insect cells
2
Target:
Research Areas:
2
Target:
Research Areas:
2
2 Cited Publications
Cat. No.: HY-P73094
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ERBB2; P185erbB2; Prev. NGL; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (Neuro/Glioblastoma Derived Oncogene Homolog); HER2; V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog; NEU; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2 Isoform C; receptor Tyrosine-Protein Kinase ErbB-2; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2; Proto-Oncogene C-ErbB-2; Neuroblastoma/Glioblastoma Derived Oncogene Homolog; Proto-Oncogene Neu; receptor Tyrosine-Protein Kinase ErbB-2 Variant; P185(ErbB2); Truncated HER2 Splice Variant P100; C-ERB-2; receptor Protein-Tyrosine Kinase; C-ERB2; Metastatic Lymph Node Gene 19; MLN-19; Alternative Protein ERBB2; HER-2; C-Erb B2/Neu Protein; CD340; CD340 Antigen; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2; HER-2/Neu; Tyrosine Kinase-Type Cell Surface receptor HER2; Herstatin; Neuro/Glioblastoma Derived Oncogene Homolog; VSCN2; Human epidermal growth factor receptor 2; MLN19; Metastatic Lymph Node Gene 19 Protein; TKR1; Erb-B2 receptor Tyrosine Kinase 2; MLN 19
Species:
Human
Source:
HEK293
1
Target:
Research Areas:
Depatuxizumab mafodotin (ABT-414) is an antibody-drug conjugate (ADC). Depatuxizumab mafodotin specifically targets the epidermal growth factor receptor (EGFR). Depatuxizumab mafodotin can be used in the study of glioma, head and neck squamous cell carcinoma, non-small cell lung cancer, epidermoid carcinoma of the skin, and squamous cell carcinoma of the tongue .
1
Category:
Microorganisms Ketones, Aldehydes, Acids Phenols Polyphenols Disease Research Fields Cancer
Target:
1
1 Cited Publications
Cat. No.: HY-18764
CAS No.: 148556-27-8
Target:
Research Areas:
BpV(pic) potassium hydrate is a PTEN inhibitor with IC50 31 nM. BpV(pic) potassium hydrate is also an insulin simulator that activates insulin receptor kinase in cultured liver cancer cells, stimulates adipogenesis in adipocytes, and inhibits the dephosphorylation of autophosphorylated insulin receptors and epidermal growth factor receptors in rat hepatosomes .
1
1 Cited Publications
Cat. No.: HY-P74177
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EGFR; epidermal growth factor receptor Variant EX12_14del; Prev. ERBB; Cell Proliferation-Inducing Protein 61; ERBB1; Cell growth Inhibiting Protein 40; ERRP; receptor Protein-Tyrosine Kinase; receptor Tyrosine-Protein Kinase ErbB-1; Alternative Protein EGFR; Erb-B2 receptor Tyrosine Kinase 1; epidermal growth factor; Proto-Oncogene C-ErbB-1; EGFR VIII; HER1; NISBD2; epidermal growth factor receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog); NNCIS; Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian); PIG61; Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog; MENA; epidermal growth factor receptor Tyrosine Kinase Domain; epidermal growth factor receptor; epidermal growth factor receptor Variant EX12_15del
Species:
Human
Source:
HEK293
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
