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Results for "

h-MCH-R1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MCHR1 (GPR24) (5)
By Research Areas:	Metabolic Disease (4)

Inhibitors & Agonists

Peptides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P4745

hMCH-1R antagonist 1	MCHR1 (GPR24)	Metabolic Disease
hMCH-1R antagonist 1 (Compound 30) is an effective and selective antagonist of human melanin-concentrating hormone receptor 1 (hMCHR1) with an K_B value of 3.6 nM. HMCH-1R antagonist 1 can bind to *hMCHR1* and hMCHR2 with IC₅₀ values of 65 nM and 49 nM, respectively. HMCH-1R antagonistist 1 can be used for metabolic research ^[1].

HY-120608

BMS-814580	MCHR1 (GPR24)	Metabolic Disease
BMS-814580 is an orally active, highly efficacious *MCHR1* inhibitor with a K_i of 16.9 nM against hMCHR1. BMS-814580 shows antiobesity activities ^[1].

HY-161899

MCHR1 antagonist 4	MCHR1 (GPR24)	Others
MCHR1 antagonist 4 (Compound 2m) is a blood-brain barrier permeable *MCHR1* antagonist with K_i values of 0.74 nM and 0.76 nM for *hMCHR1* and *rMCHR1*, respectively. MCHR1 antagonist 4 is also an effective anti-obesity agent ^[1].

HY-181551

RGH-706	MCHR1 (GPR24)	Metabolic Disease
RGH-706 is an orally active, blood-brain barrier-permeable, selective *MCH1* receptor antagonist with an IC₅₀ of 6.2 nM against hMCHR1. RGH-706 shows no antagonistic activity against hMCH2 receptors. RGH-706 improves obesity. RGH-706 can be used in research related to obesity and Prader-Willi syndrome ^[1].

HY-119015

MCHR1 antagonist 6	MCHR1 (GPR24)	Metabolic Disease
MCHR1 antagonist 6 is a melanin-concentrating hormone receptor 1 (MCHR1) antagonist. MCHR1 antagonist 6 interacts with receptor residue D123 via its central basic group, and forms hydrogen bonds with receptor residue Q127 via its 2-amino-quinoline portion. MCHR1 antagonist 6 can be used for the research of obesity ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P4745

hMCH-1R antagonist 1	MCHR1 (GPR24)	Metabolic Disease
hMCH-1R antagonist 1 (Compound 30) is an effective and selective antagonist of human melanin-concentrating hormone receptor 1 (hMCHR1) with an K_B value of 3.6 nM. HMCH-1R antagonist 1 can bind to *hMCHR1* and hMCHR2 with IC₅₀ values of 65 nM and 49 nM, respectively. HMCH-1R antagonistist 1 can be used for metabolic research ^[1].

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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