Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
34 Results for "
human epithelial carcinoma
" in MedChemExpress (MCE) Product Catalog:
Products (34)
34 Results for "human epithelial carcinoma" in MCE Product Catalog:
32
32 Publications Verification
Synonyms: VS-6062
PF-562271 (VS-6062) is an orally active, ATP-competitive, reversible FAK/Pyk2 inhibitor, with an IC50 of 1.5 nM for FAK and 13 nM for Pyk2. PF-562271 induces tumor regression, and inhibits tumor growth, invasion and metastasis. PF-562271 exerts no effect on tumor necrosis, angiogenesis or apoptosis in an orthotopic mouse model of pancreatic ductal adenocarcinoma. When combined with Sunitinib (HY-10255A), PF-562271 reduces tumor vascularization, decreases serum alpha-fetoprotein levels and improves cachexia. PF-562271 can be used in research related to prostate cancer, breast cancer, pancreatic cancer, colon cancer, glioblastoma, lung cancer, pancreatic ductal adenocarcinoma and hepatocellular carcinoma .
32
32 Publications Verification
Synonyms: VS-6062 (besylate)
PF-562271 besylate (VS-6062 besylate) is an orally active, ATP-competitive, reversible FAK/Pyk2 inhibitor, with an IC50 of 1.5 nM for FAK and 13 nM for Pyk2. PF-562271 besylate induces tumor regression, and inhibits tumor growth, invasion and metastasis. PF-562271 besylate exerts no effect on tumor necrosis, angiogenesis or apoptosis in an orthotopic mouse model of pancreatic ductal adenocarcinoma. When combined with Sunitinib (HY-10255A), PF-562271 besylate reduces tumor vascularization, decreases serum alpha-fetoprotein levels and improves cachexia. PF-562271 besylate can be used in research related to prostate cancer, breast cancer, pancreatic cancer, colon cancer, glioblastoma, lung cancer, pancreatic ductal adenocarcinoma and hepatocellular carcinoma .
30
PF-562271 hydrochloride (VS-6062 hydrochloride) is an orally active, ATP-competitive, reversible FAK/Pyk2 inhibitor, with an IC50 of 1.5 nM for FAK and 13 nM for Pyk2. PF-562271 hydrochloride induces tumor regression, and inhibits tumor growth, invasion and metastasis. PF-562271 hydrochloride exerts no effect on tumor necrosis, angiogenesis or apoptosis in an orthotopic mouse model of pancreatic ductal adenocarcinoma. When combined with Sunitinib (HY-10255A), PF-562271 hydrochloride reduces tumor vascularization, decreases serum alpha-fetoprotein levels and improves cachexia. PF-562271 hydrochloride can be used in research related to prostate cancer, breast cancer, pancreatic cancer, colon cancer, glioblastoma, lung cancer, pancreatic ductal adenocarcinoma and hepatocellular carcinoma .
2
2 Cited Publications
Target:
Research Areas:
KDM4C-IN-1 is a histone lysine demethylase KDM4C inhibitor with an IC50 of 8 nM. KDM4C-IN-1 inhibits cancer cell proliferation. KDM4C-IN-1 can be used in the research of hepatocellular carcinoma and adenocarcinoma alveolar basal epithelial carcinoma .
2
2 Cited Publications
Cat. No.: HY-P70457
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TACSTD2; epithelial Glycoprotein-1; Prev. M1S1; Membrane Component, Chromosome 1, Surface Marker 1; GA733-1; Gastrointestinal Tumor-Associated Antigen GA7331; TROP2; Pancreatic carcinoma Marker Protein GA7331; Tumor-Associated Calcium Signal Transducer 2; Cell Surface Glycoprotein TROP2; EGP-1; Truncated TACSTD2; Membrane Component Chromosome 1 Surface Marker 1; GA7331; Pancreatic carcinoma Marker Protein GA733-1; EGP1; Trophoblast Cell Surface Antigen 2; GP50; Cell Surface Glycoprotein Trop-2; Tumor Associated Calcium Signal Transducer 2; 40kD Glycoprotein, Identified By Monoclonal Antibody GA733
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P704276
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TACSTD2; epithelial Glycoprotein-1; Prev. M1S1; Membrane Component, Chromosome 1, Surface Marker 1; GA733-1; Gastrointestinal Tumor-Associated Antigen GA7331; TROP2; Pancreatic carcinoma Marker Protein GA7331; Tumor-Associated Calcium Signal Transducer 2
Species:
Human
Source:
HEK293
Cat. No.: HY-W011696
CAS No.: 112-90-3
Synonyms: cis-1-Amino-9-octadecene, 80-90%
Research Areas:
F16 is a mitochondrial permeability transition pore (PTP) modulator with an EC50 of 30 μM in mice. F16 promotes PTP opening, accumulates in cancer cell mitochondria, and induces mitochondrial depolarization, swelling, cristae disruption, outer membrane rupture, ATP depletion, reactive oxygen species (ROS) production, cytochrome c release and mitochondrial uncoupling. F16 induces cell cycle arrest at the G1 (occasionally G2) phase, reduces the phosphotyrosine content of Neu, as well as the levels of phosphorylated PKB/Akt and phosphorylated MAP kinase, downregulates the protein expression levels of Neu and PKB, triggers apoptosis in cells with moderate Bcl-2 expression, and induces necrosis in cells with overexpressed Bcl-2. F16 can be used in research related to breast cancer and gastric cancer .
Cat. No.: HY-P2302
CAS No.: 136661-76-2
Target:
Research Areas:
Target:
Adrenergic Receptor ERK JNK p38 MAPK NF-κB AP-1 Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism TNF Receptor
Research Areas:
Desipramine is a first-generation tricyclic antidepressant. Desipramine selectively binds to norepinephrine transporter and blocks neuronal norepinephrine reuptake. Desipramine activates MAPK signaling via ERK1/2, JNK, and p38, represses NF-κB and AP-1 activity, and induces apoptosis via ROS elevation, mitochondrial membrane potential reduction, and intracellular calcium increase. Desipramine also shows anyi-inflammatory activity, inhibiting TNF-α production. Desipramine can be used for the research of hepatocellular cancer, inflammation, and neurological diseases .
Cat. No.: HY-174779
Human AREG mRNA encodes the human amphiregulin (AREG) protein, a member of the epidermal growth factor family. AREG interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development.
Cat. No.: HY-P990082
CAS No.: 1610010-57-5
Synonyms: APX-003; BD-0801
Target:
Research Areas:
Cat. No.: HY-N19312
CAS No.: 28164-57-0
Category:
Quinones Ebenaceae Phenols Polyphenols Benzene Quinones Plants
Cat. No.: HY-187100
CAS No.: 21856-94-0
Target:
Research Areas:
Bis(4-methylphenyl) diselenide is a symmetric aromatic organodiselenide with in vitro cytotoxicity against cancer cells. Bis(4-methylphenyl) diselenide can be used for the research of promyelocytic leukemia, epithelial carcinoma, renal cell adenocarcinoma, colorectal adenocarcinoma, and prostate cancer .
Cat. No.: HY-N17074
CAS No.: 2552582-20-2
Target:
Cat. No.: HY-P85834
Synonyms: ADMCKD; ADMCKD1; Breast carcinoma associated antigen DF3; Breast carcinoma-associated antigen DF3; CA 15-3; CA15 3; CA15 3 antigen; CA15-3; CA15.3; Cancer antigen 15-3; carcinoma associated mucin; carcinoma-associated mucin; CD 227; CD227; DF3 antigen; EMA; Episialin; epithelial Membrane Antigen; H23 antigen; H23AG; KL 6; KL-6; KL6; Krebs von den Lungen-6; MAM 6; MAM6; MCD; MCKD; MCKD1; Medullary cystic kidney disease 1; autosomal dominant; Medullary cystic kidney disease, autosomal dominant; MUC 1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1; MUC1-alpha; MUC1-beta; MUC1-CT; MUC1-NT; MUC1/ZD; MUC1_human; Mucin 1; Mucin 1 cell surface associated; Mucin 1 transmembrane; Mucin 1, cell surface associated; Mucin-1 subunit beta; Peanut reactive urinary mucin; Peanut-reactive urinary mucin; PEM; PEMT; Polymorphic epithelial mucin; PUM; Tumor associated epithelial membrane antigen; Tumor associated epithelial mucin; Tumor associated mucin; Tumor-associated epithelial membrane antigen; Tumor-associated mucin
Cat. No.: HY-P72015
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TACSTD2; epithelial Glycoprotein-1; Prev. M1S1; Membrane Component, Chromosome 1, Surface Marker 1; GA733-1; Gastrointestinal Tumor-Associated Antigen GA7331; TROP2; Pancreatic carcinoma Marker Protein GA7331; Tumor-Associated Calcium Signal Transducer 2
Species:
Human
Source:
HEK293
Cat. No.: HY-P70770
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TACSTD2; epithelial Glycoprotein-1; Prev. M1S1; Membrane Component, Chromosome 1, Surface Marker 1; GA733-1; Gastrointestinal Tumor-Associated Antigen GA7331; TROP2; Pancreatic carcinoma Marker Protein GA7331; Tumor-Associated Calcium Signal Transducer 2
Species:
Human
Source:
HEK293
Cat. No.: HY-P78223
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TACSTD2; epithelial Glycoprotein-1; Prev. M1S1; Membrane Component, Chromosome 1, Surface Marker 1; GA733-1; Gastrointestinal Tumor-Associated Antigen GA7331; TROP2; Pancreatic carcinoma Marker Protein GA7331; Tumor-Associated Calcium Signal Transducer 2
Species:
Human
Source:
HEK293
Cat. No.: HY-P74490
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TACSTD2; epithelial Glycoprotein-1; Prev. M1S1; Membrane Component, Chromosome 1, Surface Marker 1; GA733-1; Gastrointestinal Tumor-Associated Antigen GA7331; TROP2; Pancreatic carcinoma Marker Protein GA7331; Tumor-Associated Calcium Signal Transducer 2
Species:
Human
Source:
HEK293
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
