19 Results for "

il 1r antagonist

" in MedChemExpress (MCE) Product Catalog:
Products (19)

19 Results for "il 1r antagonist" in MCE Product Catalog:

57
57 Publications Verification
Cat. No.: HY-108841
CAS No.: 143090-92-0
Purity:  99.40%
Synonyms: Kineret; Anakinra
Raleukin (Kineret) is a recombinant, nonglycosylated human interleukin-1 receptor (IL-1R) antagonist. Raleukin significantly reduces neutrophil accumulation in blood vessels and brain infarct volume as well as improves motor coordination performance in ischemic stroke mice model. Anakinra can be used to study chronic inflammatory disorders like rheumatoid arthritis and cardiovascular recurrence post-myocardial infarction .
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9
9 Cited Publications
Cat. No.: HY-P72566
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: il1rN; il-1ra; Interleukin 1 Receptor antagonist; Intracellular Interleukin-1 Receptor antagonist (Icil-1ra); ICil-1rA; Intracellular Interleukin-1 Receptor antagonist; il-1rN; Intracellular il-1 Receptor antagonist Type II; il1rA; Type II Interleukin-1 R
Species:  
Mouse
Source:  
E. coli
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6
6 Cited Publications
Cat. No.: HY-P1110
CAS No.: 185413-30-3
Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC50=8 nM) but not the human type II receptor (IC50=6.7 µM) or the murine type I receptor (IC50>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC50=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC50=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo .
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5
5 Cited Publications
Cat. No.: HY-P7029
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: il1rN; il-1ra; Interleukin 1 Receptor antagonist; Intracellular Interleukin-1 Receptor antagonist (Icil-1ra); ICil-1rA; Intracellular Interleukin-1 Receptor antagonist; il-1rN; Intracellular il-1 Receptor antagonist Type II; il1rA; Type II Interleukin-1 R
Species:  
Human
Source:  
E. coli
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2
2 Cited Publications
Cat. No.: HY-P7029A
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: il1rN; il-1ra; Interleukin 1 Receptor antagonist; Intracellular Interleukin-1 Receptor antagonist (Icil-1ra); ICil-1rA; Intracellular Interleukin-1 Receptor antagonist; il-1rN; Intracellular il-1 Receptor antagonist Type II; il1rA; Type II Interleukin-1 R
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-W011978
CAS No.: 1218-34-4
N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases .
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Cat. No.: HY-W704574
CAS No.: 77102-28-4
Mergetpa is a reversible Arg-carboxypeptidase inhibitor with high affinity. Mergetpa reduces B1R. Mergetpa blocks the overexpression of IL-1β protein and mRNA in glucose-fed rats. Mergetpa significantly increases the expression of IL-1β protein in the renal cortex. Mergetpa is used to block the conversion of kinins and B2 receptor antagonists into metabolites lacking the C-terminal arginine. Mergetpa inhibits the time-dependent enhancement of the response of isolated rabbit aorta to bradykinin. Mergetpa preserves the chemotactic activity of full-length SDF-1α on cells. Mergetpa reverses hyperglycemia, excessive weight gain, elevated levels of oxidative stress markers and overexpression of inflammatory markers in glucose-fed rats .
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Cat. No.: HY-P10474
CAS No.: 1200829-06-6
Target:  

Drug Isomer

Research Areas:  

Others

RYTVELA is a deriviative of the peptide antagonist of interleukin-1 receptor 1 (IL-1R1) d-(RYTVELA) (HY-P10353) that contains all L-amino acids .
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Cat. No.: HY-W011978S
N-Acetyl-L-tryptophan-d3 is the deuterium labeled N-Acetyl-L-tryptophan (HY-W011978). N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases .
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Cat. No.: HY-172409
CB1R antagonist 2 (Compound 11g) is the antagonist for cannabinoid receptor 1 (CB1R), that inhibits MAPK/NF-κB signaling pathway and exhibits anti-inflammatory activity. CB1R antagonist 2 inhibits LPS (HY-D1056)-induced IL-6, IL-1β and TNF-α expressions in RAW264.7. CB1R antagonist 2 ameliorates OVA-induced allergic rhinitis in mouse models .
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Cat. No.: HY-N19801
CAS No.: 54627-18-8
N-Palmitoyl-D-glucosamine is an orally active TLR4 antagonist. N-Palmitoyl-D-glucosamine stably binds MD-2 with, preventing LPS-induced NF-κB signaling, decreases pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), increases anti-inflammatory IL-10 and IL-1rα, and normalizes miR-20a-5p, miR-106a-5p, and miR-27a-3p levels. N-Palmitoyl-D-glucosamine decreases allodynia and prevents myelino-axonal degeneration of peripheral nerves. N-Palmitoyl-D-glucosamine can be used for the researches of keratitis and peripheral neuropathy .
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Cat. No.: HY-P75853
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: il1rN; il-1ra; Interleukin 1 Receptor antagonist; Intracellular Interleukin-1 Receptor antagonist (Icil-1ra); ICil-1rA; Intracellular Interleukin-1 Receptor antagonist; il-1rN; Intracellular il-1 Receptor antagonist Type II; il1rA; Type II Interleukin-1 R
Species:  
Cynomolgus
Source:  
E. coli
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Cat. No.: HY-P79293
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: il1rN; il-1ra; Interleukin 1 Receptor antagonist; Intracellular Interleukin-1 Receptor antagonist (Icil-1ra); ICil-1rA; Intracellular Interleukin-1 Receptor antagonist; il-1rN; Intracellular il-1 Receptor antagonist Type II; il1rA; Type II Interleukin-1 R
Species:  
Porcine
Source:  
E. coli
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Cat. No.: HY-P73894A
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: il1rN; il-1ra; Interleukin 1 Receptor antagonist; Intracellular Interleukin-1 Receptor antagonist (Icil-1ra); ICil-1rA; Intracellular Interleukin-1 Receptor antagonist; il-1rN; Intracellular il-1 Receptor antagonist Type II; il1rA; Type II Interleukin-1 R
Species:  
Rat
Source:  
E. coli
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Cat. No.: HY-P71876A
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: il1rN; il-1ra; Interleukin 1 Receptor antagonist; Intracellular Interleukin-1 Receptor antagonist (Icil-1ra); ICil-1rA; Intracellular Interleukin-1 Receptor antagonist; il-1rN; Intracellular il-1 Receptor antagonist Type II; il1rA; Type II Interleukin-1 R
Species:  
Equine
Source:  
E. coli
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Cat. No.: HY-P73187
Purity:  ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: il1rN; il-1ra; Interleukin 1 Receptor antagonist; Intracellular Interleukin-1 Receptor antagonist (Icil-1ra); ICil-1rA; Intracellular Interleukin-1 Receptor antagonist; il-1rN; Intracellular il-1 Receptor antagonist Type II; il1rA; Type II Interleukin-1 R
Species:  
Rat
Source:  
HEK293
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Cat. No.: HY-P73894
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: il1rN; il-1ra; Interleukin 1 Receptor antagonist; Intracellular Interleukin-1 Receptor antagonist (Icil-1ra); ICil-1rA; Intracellular Interleukin-1 Receptor antagonist; il-1rN; Intracellular il-1 Receptor antagonist Type II; il1rA; Type II Interleukin-1 R
Species:  
Rat
Source:  
E. coli
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Cat. No.: HY-P700110AF
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: il1rN; il-1ra; Interleukin 1 Receptor antagonist; Intracellular Interleukin-1 Receptor antagonist (Icil-1ra); ICil-1rA; Intracellular Interleukin-1 Receptor antagonist; il-1rN; Intracellular il-1 Receptor antagonist Type II; il1rA; Type II Interleukin-1 R
Species:  
Human
Source:  
E. coli
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Cat. No.: HY-P700197AF
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: il1rN; il-1ra; Interleukin 1 Receptor antagonist; Intracellular Interleukin-1 Receptor antagonist (Icil-1ra); ICil-1rA; Intracellular Interleukin-1 Receptor antagonist; il-1rN; Intracellular il-1 Receptor antagonist Type II; il1rA; Type II Interleukin-1 R
Species:  
Mouse
Source:  
E. coli
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