intracellular stores

By Targets:	Adenylate Cyclase (1) Biochemical Assay Reagents (1) Calcium Channel (7) Chloride Channel (1) Fluorescent Dye (1) Phospholipase (3) Potassium Channel (1) Prostaglandin Receptor (1) PTHR (1) Reference Standards (3)
By Research Areas:	Cardiovascular Disease (1) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1852

TIP 39, Tuberoinfundibular Neuropeptide 1 Publications Verification	Adenylate Cyclase PTHR	Neurological Disease
TIP 39, Tuberoinfundibular Neuropeptide is an endogenous PTH2 receptor agonist and antihypertensive agent. TIP 39, Tuberoinfundibular Neuropeptide selectively activates the PTH2 receptor with no activity on the PTH1 receptor, stimulates cAMP production, activates adenylate cyclase, and elevates intracellular calcium levels via mobilization from intracellular stores. TIP 39, Tuberoinfundibular Neuropeptide is highly conserved in humans, mice, and rats. TIP 39, Tuberoinfundibular Neuropeptide is applicable to research related to nociception and inflammation-induced pain .

HY-W039315

2,5-Anhydro-D-mannitol, 97%	Biochemical Assay Reagents	Metabolic Disease
2,5-Anhydro-D-mannitol, 97% is an antimetabolic fructose analogue. 2,5-Anhydro-D-mannitol, 97% depletes intracellular ATP, reduces oxygen consumption, regulates substrate oxidation, increases phosphomonoester levels, decreases inorganic phosphate levels, and promotes the release of intracellular calcium from intracellular calcium stores via phospholipase C-dependent activity in hepatocytes .

HY-142117

Adenophostin A	Calcium Channel Chloride Channel	Others
Adenophostin A is an IP₃ receptor (inositol 1,4,5-trisphosphate receptors) modulator and Ca ²⁺ releaser, with an IC₅₀ of 1.3 nM, an EC₅₀ of 1.4 nM, and a K_i of 0.18 nM in rats, and an IC₅₀ of 0.95 nM in humans. Adenophostin A activates IP₃ receptors, stimulates Ca ²⁺ release from intracellular stores and microsomes, inhibits the binding of [ ³H]IP₃ to plasma membrane receptors, and activates chloride channels. Adenophostin A resists phosphorylation and dephosphorylation by IP₃ metabolic enzymes to maintain its activity, and increases cytoplasmic [Ca ²⁺] levels via calcium mobilization from the endoplasmic reticulum of vascular smooth muscle cells. Adenophostin A is applicable to research related to hemorrhagic shock .

HY-N4237

Saikogenin D 1 Publications Verification	Prostaglandin Receptor Potassium Channel	Inflammation/Immunology
Saikogenin D is isolated from?Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca ²⁺]i due to Ca ²⁺ release from intracellular stores .

HY-117099

TMB-8	Calcium Channel	Neurological Disease
TMB-8 is a novel Ca 2+ antagonist. TMB-8 may exert inhibitory effects in smooth muscle by blocking Ca 2+ release from intracellular bound stores.

HY-120985

Araguspongin B	Calcium Channel	Neurological Disease
Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties.1 Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores.2 Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC₅₀ of 0.6 μM. It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.

HY-175408

Hepoxilin A3 methyl ester HxA3 methyl ester	Calcium Channel	Neurological Disease
Hepoxilin A3 methyl ester is the ester form of HxA3. Hepoxilin A3 methyl ester causes a receptor-induced rise in intracellular calcium through the release from intracellular stores in suspended human neutrophils .

HY-121966

Riparin Riparin III	Calcium Channel	Neurological Disease
Riparin is a nonspecific smooth muscle relaxant. Riparin exerts spasmolytic effect by inhibiting Ca ²⁺ influx and inhibiting the release of intracellular calcium ion stores .

HY-B1558

Bifemelane MCI-2016 free base	Calcium Channel	Neurological Disease
Bifemelane is a nootropic compound. Bifemelan causes the first peak by stimulating release from intracellular Ca ²⁺ stores and the second by capacitive entry through store–operated Ca ²⁺ channels. Bifemelane will be provided as a pharmacological tool for basic studies on astrocytes .

HY-100168R

BAPTA (Standard)	Reference Standards Phospholipase	Others
BAPTA (Standard) is the analytical standard of BAPTA. This product is intended for research and analytical applications. BBAPTA is a selective and cell-impermeant chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA is widely used as an intracellular buffer for investigating the effects of Ca ²⁺ release from intracellular stores or influx via Ca ²⁺-permeable channels in the plasma membrane. BAPTA can also inhibit phospholipase C activity independently of their role as Ca ²⁺ chelators .

HY-100168AR

BAPTA tetrasodium (Standard)	Reference Standards Phospholipase	Others
BAPTA tetrasodium (Standard) is the analytical standard of BAPTA tetrasodium. This product is intended for research and analytical applications. BAPTA tetrasodium is a selective and cell-impermeant chelator for calcium. BAPTA tetrasodium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrasodium is widely used as an intracellular buffer for investigating the effects of Ca ²⁺ release from intracellular stores or influx via Ca ²⁺-permeable channels in the plasma membrane. BAPTA tetrasodium can also inhibit phospholipase C activity independently of their role as Ca ²⁺ chelators .

HY-100168BR

BAPTA tetrapotassium (Standard)	Reference Standards Phospholipase	Others
BAPTA tetrapotassium (Standard) is the analytical standard of BAPTA tetrapotassium (HY-100168B). This product is intended for research and analytical applications. BAPTA tetrapotassium is a selective and cell-impermeant chelator for calcium. BAPTA tetrapotassium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrapotassium is widely used as an intracellular buffer for investigating the effects of Ca ²⁺ release from intracellular stores or influx via Ca ²⁺-permeable channels in the plasma membrane. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca ²⁺ chelators .

HY-D3231

Ratio-Coppersensor-1	Fluorescent Dye	Others
Ratio-Coppersensor-1 is a selective ratiometric copper ion Fluorescent reporter (excitation wavelength: 480 nm; emission peak central wavelengths at 505 nm and 570 nm, respectively). Ratio-Coppersensor-1 exhibits extremely high selectivity for Cu ⁺ at cellular concentrations, outperforming other competing metal ions, and shows an approximately 20-fold change in fluorescence ratio upon Cu ⁺ binding. Ratio-Coppersensor-1 is capable of reflecting changes in Cu levels .

HY-N17738

Acetyljujuboside B	Calcium Channel	Cardiovascular Disease Inflammation/Immunology
Acetyljujuboside B is a saponin. Acetyljujuboside B can be isolated from seeds of Zizyphus jujuba Mill. var. spinosa. Acetyljujuboside B inhibits Ca ²⁺ influx. Acetyljujuboside B shows only sustained vasorelaxant effects, with no transient effect on NE-induced vasoconstrictions. Acetyljujuboside B inhibits histamine release from rat peritoneal exudate cells induced by the antigen-antibody reaction .

Cat. No.	Product Name	Type

HY-D3231

Ratio-Coppersensor-1	Fluorescent Dyes
Ratio-Coppersensor-1 is a selective ratiometric copper ion Fluorescent reporter (excitation wavelength: 480 nm; emission peak central wavelengths at 505 nm and 570 nm, respectively). Ratio-Coppersensor-1 exhibits extremely high selectivity for Cu ⁺ at cellular concentrations, outperforming other competing metal ions, and shows an approximately 20-fold change in fluorescence ratio upon Cu ⁺ binding. Ratio-Coppersensor-1 is capable of reflecting changes in Cu levels .

Ratio-Coppersensor-1

Fluorescent Dyes

Ratio-Coppersensor-1 is a selective ratiometric copper ion Fluorescent reporter (excitation wavelength: 480 nm; emission peak central wavelengths at 505 nm and 570 nm, respectively). Ratio-Coppersensor-1 exhibits extremely high selectivity for Cu ⁺ at cellular concentrations, outperforming other competing metal ions, and shows an approximately 20-fold change in fluorescence ratio upon Cu ⁺ binding. Ratio-Coppersensor-1 is capable of reflecting changes in Cu levels .

Cat. No.	Product Name	Type

HY-W039315

2,5-Anhydro-D-mannitol, 97%	Biochemical Assay Reagents
2,5-Anhydro-D-mannitol, 97% is an antimetabolic fructose analogue. 2,5-Anhydro-D-mannitol, 97% depletes intracellular ATP, reduces oxygen consumption, regulates substrate oxidation, increases phosphomonoester levels, decreases inorganic phosphate levels, and promotes the release of intracellular calcium from intracellular calcium stores via phospholipase C-dependent activity in hepatocytes .

2,5-Anhydro-D-mannitol, 97%

Biochemical Assay Reagents

2,5-Anhydro-D-mannitol, 97% is an antimetabolic fructose analogue. 2,5-Anhydro-D-mannitol, 97% depletes intracellular ATP, reduces oxygen consumption, regulates substrate oxidation, increases phosphomonoester levels, decreases inorganic phosphate levels, and promotes the release of intracellular calcium from intracellular calcium stores via phospholipase C-dependent activity in hepatocytes .

HY-100168R

BAPTA (Standard)	Biochemical Assay Reagents
BAPTA (Standard) is the analytical standard of BAPTA. This product is intended for research and analytical applications. BBAPTA is a selective and cell-impermeant chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA is widely used as an intracellular buffer for investigating the effects of Ca ²⁺ release from intracellular stores or influx via Ca ²⁺-permeable channels in the plasma membrane. BAPTA can also inhibit phospholipase C activity independently of their role as Ca ²⁺ chelators .

BAPTA (Standard)

Biochemical Assay Reagents

BAPTA (Standard) is the analytical standard of BAPTA. This product is intended for research and analytical applications. BBAPTA is a selective and cell-impermeant chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA is widely used as an intracellular buffer for investigating the effects of Ca ²⁺ release from intracellular stores or influx via Ca ²⁺-permeable channels in the plasma membrane. BAPTA can also inhibit phospholipase C activity independently of their role as Ca ²⁺ chelators .

HY-100168BR

BAPTA tetrapotassium (Standard)	Biochemical Assay Reagents
BAPTA tetrapotassium (Standard) is the analytical standard of BAPTA tetrapotassium (HY-100168B). This product is intended for research and analytical applications. BAPTA tetrapotassium is a selective and cell-impermeant chelator for calcium. BAPTA tetrapotassium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrapotassium is widely used as an intracellular buffer for investigating the effects of Ca ²⁺ release from intracellular stores or influx via Ca ²⁺-permeable channels in the plasma membrane. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca ²⁺ chelators .

BAPTA tetrapotassium (Standard)

Biochemical Assay Reagents

BAPTA tetrapotassium (Standard) is the analytical standard of BAPTA tetrapotassium (HY-100168B). This product is intended for research and analytical applications. BAPTA tetrapotassium is a selective and cell-impermeant chelator for calcium. BAPTA tetrapotassium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrapotassium is widely used as an intracellular buffer for investigating the effects of Ca ²⁺ release from intracellular stores or influx via Ca ²⁺-permeable channels in the plasma membrane. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca ²⁺ chelators .

Cat. No.	Product Name	Target	Research Area

HY-P1852

TIP 39, Tuberoinfundibular Neuropeptide 1 Publications Verification	Adenylate Cyclase PTHR	Neurological Disease
TIP 39, Tuberoinfundibular Neuropeptide is an endogenous PTH2 receptor agonist and antihypertensive agent. TIP 39, Tuberoinfundibular Neuropeptide selectively activates the PTH2 receptor with no activity on the PTH1 receptor, stimulates cAMP production, activates adenylate cyclase, and elevates intracellular calcium levels via mobilization from intracellular stores. TIP 39, Tuberoinfundibular Neuropeptide is highly conserved in humans, mice, and rats. TIP 39, Tuberoinfundibular Neuropeptide is applicable to research related to nociception and inflammation-induced pain .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4237

Saikogenin D 1 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	Prostaglandin Receptor Potassium Channel
Saikogenin D is isolated from?Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca ²⁺]i due to Ca ²⁺ release from intracellular stores .

HY-N17738

Acetyljujuboside B	Structural Classification Terpenoids Plants Actaea simplex (DC.) Wormsk. ex Fisch. & C. A. Mey. Rhamnaceae Pentacyclic Triterpenoids Source Classification	Calcium Channel
Acetyljujuboside B is a saponin. Acetyljujuboside B can be isolated from seeds of Zizyphus jujuba Mill. var. spinosa. Acetyljujuboside B inhibits Ca ²⁺ influx. Acetyljujuboside B shows only sustained vasorelaxant effects, with no transient effect on NE-induced vasoconstrictions. Acetyljujuboside B inhibits histamine release from rat peritoneal exudate cells induced by the antigen-antibody reaction .

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intracellular stores

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