41708-91-2
Chemical Structure
Diadenosine pentaphosphate
Synonym(s): Ap5A; P1,P5-Di(adenosine-5'-)pentaphosphate
- CAS No.: 41708-91-2
- Formula:C20H29N10O22P5
- Molecular Weight:916.37
InChIKey: OIMACDRJUANHTJ-XPWFQUROSA-N
SMILES: O[C@@H]1[C@H](O)[C@@H](COP(OP(OP(OP(OP(OC[C@@H](O2)[C@@H](O)[C@@H](O)[C@@H]2N3C=NC4=C(N)N=CN=C43)(O)=O)(O)=O)(O)=O)(O)=O)(O)=O)O[C@H]1N5C6=NC=NC(N)=C6N=C5
Biological Activity: Diadenosine pentaphosphate (Ap5A; P1,P5-Di(adenosine-5'-)pentaphosphate) is an endogenous generated diadenosine polyphosphate, possessing the dual identities of intracellular alarm signal and extracellular signaling molecule. Diadenosine pentaphosphate regulates calcium signaling in the nervous, cardiac and peripheral sensory systems by activating P2X1/P2X3/P2Y receptor and RyR2 channels (EC50 = 140 μM). Diadenosine pentaphosphate can be used in studies related to intracellular calcium release channels, cardiovascular diseases and nociception (pain)[1][3][2][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Diadenosine pentaphosphate | Diadenosine pentaphosphate (Ap5A; P1,P5-Di(adenosine-5'-)pentaphosphate) is an endogenous generated diadenosine polyphosphate, possessing the dual identities of intracellular alarm signal and extracellular signaling molecule. Diadenosine pentaphosphate regulates calcium signaling in the nervous, cardiac and peripheral sensory systems by activating P2X1/P2X3/P2Y receptor and RyR2 channels (EC50 = 140 μM). Diadenosine pentaphosphate can be used in studies related to intracellular calcium release channels, cardiovascular diseases and nociception (pain). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
[1]. Holden CP, et al. Diadenosine pentaphosphate increases levels of intracellular calcium in astrocytes by a mechanism involving release from caffeine/ryanodine- and IP3-sensitive stores. J Neurosci Res. 2000 Jan 15;59(2):276-82.
[Content Brief] - [2]. Abramochkin DV, et al. Diadenosine pentaphosphate affects electrical activity in guinea pig atrium via activation of potassium acetylcholine-dependent inward rectifier. The journal of physiological sciences : JPS. 2017 Jul;67(4):523-529. [Content Brief]
- [3]. Song L, et al. Diadenosine pentaphosphate is a potent activator of cardiac ryanodine receptors revealing a novel high-affinity binding site for adenine nucleotides. British journal of pharmacology. 2009 Mar;156(5):857-67. [Content Brief]
- [4]. Burgstahler R, et al. Diadenosine pentaphosphate is more potent than ATP at P2X receptors in isolated rat vagus nerve. Neuroreport. 2001 Mar 26;12(4):679-82. [Content Brief]
- [5]. Diez-Zaera M, et al. Diadenosine pentaphosphate regulates dendrite growth and number in cultured hippocampal neurons. Purinergic signalling. 2024 Apr;20(2):115-125. [Content Brief]
Keywords
