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Results for "

karyopherin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ras (1)
By Research Areas:	Cancer (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-170316

Ibetazol	Ras	Cancer
Ibetazol is a Importin β1 (KPNB1) inhibitor and nucleocytoplasmic transport disruptor. Ibetazol binds covalently to Cys585 of Importin β1, blocks both Importin β1-mediated direct transport and Importin α-dependent nuclear import processes, without affecting transport mediated by other nucleocytoplasmic transport proteins. Ibetazol induces cytoplasmic accumulation of Importin α1, and inhibits nuclear import of substrates carrying nuclear localization signals (NLS), including the NLS-cMyc reporter gene, RelA/p65 and SREBP1. Ibetazol triggers spindle malformation and chromosome misalignment by disrupting the mitotic function of Importin β1. Ibetazol inhibits the proliferation of cells expressing wild-type Importin β1. Ibetazol has a high activity-cytotoxicity window, lacks intrinsic fluorescence, and acts rapidly on nucleocytoplasmic transport processes. Ibetazol serves as a tool compound for investigating nuclear import processes specifically mediated by Importin β1 .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70837

	KPNB1 Protein, Human (His) Importin subunit beta-1; Importin-90; karyopherin subunit beta-1; Nuclear factor p97; Pore targeting complex 97 kDa subunit; PTAC97; KPNB1; NTF97	Human	E. coli
	KPNB1 is a key player in nuclear protein import, cooperating with adapter proteins such as importin-alpha to recognize nuclear localization signals (NLS) in cargo substrates. In autonomous mode, it acts as its own NLS receptor, facilitating docking of the import/substrate complex to the nuclear pore complex (NPC) via KPNB1. KPNB1 Protein, Human (His) is the recombinant human-derived KPNB1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70371

	Importin alpha-1/KPNA2 Protein, Human (His) rHuImportin subunit alpha-1/KPNA2, His; Importin Subunit Alpha-2; karyopherin Subunit Alpha-2; RAG Cohort Protein 1; SRP1-Alpha; KPNA2; RCH1; SRP1	Human	E. coli
	Importin alpha-1/KPNA2 is essential for nuclear protein import, acting as an adapter for the nuclear receptor KPNB1. It directly binds the substrate to the nuclear localization signal to form a complex that docks with the nuclear pore complex mediated by KPNB1. Importin alpha-1/KPNA2 Protein, Human (His) is the recombinant human-derived Importin alpha-1/KPNA2 protein, expressed by E. coli , with N-6*His labeled tag.

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Host:	Mouse (4) Rabbit (2)
Reactivity:	Human (2) mouse (2) Rat (2) Mouse (2) rat (2) human (4)
Application:	IHC-P (1) ICC/IF (4) IF-Tissue (5) IP (5) WB (6) FC (1) ELISA (4)
Isotype:	IgG (2) IgG1 (3) IgG2a (1)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (6)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P89596

	karyopherin 13 Antibody (YA8940)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat
	karyopherin 13 Antibody (YA8940) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to karyopherin 13.

HY-P89780

	karyopherin β3 Antibody (YA9124)	WB, ICC/IF, IF-Tissue, IP, ELISA	human
	karyopherin β3 Antibody (YA9124) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to karyopherin β3.

HY-P89936

	karyopherin α3 Antibody (YA9280)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat
	karyopherin α3 Antibody (YA9280) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to karyopherin α3.

HY-P810031

	karyopherin α5 Antibody (YA9375)	WB, ICC/IF, IF-Tissue, IP, ELISA	human
	karyopherin α5 Antibody (YA9375) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to karyopherin α5.

HY-P81670

	KPNA2 Antibody (YA1415) KPNA2; RCH1; SRP1; Importin subunit alpha-2; karyopherin subunit alpha-2; RAG cohort protein 1; SRP1-alpha	WB, FC	Human, Mouse, Rat
	KPNA2 Antibody (YA1415) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KPNA2.

HY-P86934

	KPNB1 Antibody (YA6627) IMB 1 antibody; IMB1 antibody; IMB1_HUMAN antibody; Impnb antibody; Importin 90 antibody; Importin beta 1 antibody; Importin beta 1 subunit antibody; Importin subunit beta-1 antibody; Importin-90 antibody; IPOB antibody; IMB 1 antibody; IMB1 antibody; IMB1_HUMAN antibody; Impnb antibody; Importin 90 antibody; Importin beta 1 antibody; Importin beta 1 subunit antibody; Importin subunit beta-1 antibody; Importin-90 antibody; IPOB antibody; karyopherin beta 1 antibody; karyopherin beta 1 subunit antibody; karyopherin subunit beta-1 antibody; KPNB 1 antibody; Kpnb1 antibody; MGC2155 antibody; MGC2156 antibody; MGC2157 antibody; NTF 97 antibody; NTF97 antibody; NTF97/Importin beta antibody; Nuclear factor P97 antibody; Pore targeting complex 97 kDa subunit antibody; PTAC97 antibody;	WB, IHC-P, IF-Tissue, IP	Human, Mouse, Rat
	KPNB1 Antibody (YA6627) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KPNB1.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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