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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
leukodystrophy
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "leukodystrophy" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P76553
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PSAP; Saposin-A; Prev. GLBA; Saposin-C; Prev. SAP1; Saposin-D; Prev. SAP2; Variant Gaucher Disease And Variant Metachromatic leukodystrophy; Sphingolipid Activator Protein-1; Alternative Protein PSAP; Sphingolipid Activator Protein-2; PARK24; Proactivator
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P77159
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PSAP; Saposin-A; Prev. GLBA; Saposin-C; Prev. SAP1; Saposin-D; Prev. SAP2; Variant Gaucher Disease And Variant Metachromatic leukodystrophy; Sphingolipid Activator Protein-1; Alternative Protein PSAP; Sphingolipid Activator Protein-2; PARK24; Proactivator
Species:
Mouse
Source:
HEK293
Target:
Research Areas:
Psychosine (Galactosylsphingosine), a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease . Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell types including, most relevantly to globoid cell leukodystrophy (GLD), oligodendrocytes. Psychosine causes cell death at least in part via apoptosis. Psychosine also is an inhibitor of PKC .
Cat. No.: HY-145535
CAS No.: 151122-71-3
Synonyms: C24 3'-sulfo Galactosylceramide (d18:1/24:0)
Target:
Target:
Research Areas:
Lithium citrate is a lithium supplement that reduces excess brain N-acetylaspartate (NAA) in Canavan disease. Canavan disease is an autosomal recessive leukodystrophy caused by mutations in the aspartate acylase (ASPA) gene, which catalyzes the hydrolysis of N-acetylaspartate (NAA) to acetate and aspartate .
Cat. No.: HY-158725
CAS No.: 1292769-40-4
Target:
Research Areas:
N-Octadecenoyl-(cis-9) -Sulfatide is a glycolipid found in the brains of mice. N-Octadecenoyl-(cis-9) -Sulfatide can be used as a standard for the determination of C18:13 '-mergogalactosyllactose in dry blood stains of patients with chromatic leukodystrophy (MLD) by ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS) .
Cat. No.: HY-176782
CAS No.: 2148924-77-8
Target:
Research Areas:
Cer(d18:2_22:0) is a potential biomarker for Metachromatic Leukodystrophy .
Cat. No.: HY-158655
CAS No.: 1071654-84-6
Synonyms: (3'-Sulfo)Galβ-Cer (d18:1/17:0); N-Heptadecanoyl sulfatide; C17 Sulfatide
Target:
Research Areas:
C17 3'-Sulfo galactosylceramide (d18:1/17:0) is a member of the sulfatide class of glycolipids. C17 3'-Sulfo galactosylceramide (d18:1/17:0) can be used for the mass spectrometric quantitative urinary determination in metachromatic leukodystrophies .
Cat. No.: HY-182571
CAS No.: 15437-29-3
Target:
Research Areas:
AK-42 is a selective CLC-2 chloride channel inhibitor with human IC50 of 17 nM and rat IC50 of 14 nM. AK-42 binds to an extracellular vestibule above the channel pore, inhibits CLC-2 currents acutely and reversibly, including with auxiliary subunit GlialCAM coexpression. AK-42 acts as a selective tool compound for acute CLC-2 function modulation to probe CLC-2 neurophysiology. AK-42 can be used for the research of leukodystrophy and idiopathic generalized epilepsies .
Cat. No.: HY-186310
Research Areas:
ISRACT-02 is a eIF2B modulator. The Kd values of ISRACT-02 for eIF2B WT and eIF2B Δ-latch are 174 nM and 385 nM, respectively. Depending on the conformation of its amide bond (trans or cis), ISRACT-02 binds to and stabilizes the inactive conformation (I-state) or active conformation (A-state) of eIF2B, respectively. ISRACT-02 can be used in studies related to leukodystrophy, Alzheimer's disease, traumatic brain injury, and Down syndrome .
Cat. No.: HY-P77160
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PSAP; Saposin-A; Prev. GLBA; Saposin-C; Prev. SAP1; Saposin-D; Prev. SAP2; Variant Gaucher Disease And Variant Metachromatic leukodystrophy; Sphingolipid Activator Protein-1; Alternative Protein PSAP; Sphingolipid Activator Protein-2; PARK24; Proactivator
Species:
Rat
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
