Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
lipophilic probe
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "lipophilic probe" in MCE Product Catalog:
Cat. No.: HY-D1459
CAS No.: 164106-16-5
Synonyms: DiA
Cat. No.: HY-119216
CAS No.: 2016806-55-4
AZ13711265 is an orally active PAK1 inhibitor with high selectivity. AZ13711265 has IC50 values of 0.58 nM and 0.11 µM for PAK1 and pPAK1, respectively. AZ13711265 has low lipophilicity and low clearance, and can be used as an in vivo probe compound for PAK1. AZ13711265 can be used in the study of cancer .
Cat. No.: HY-W099563
CAS No.: 14617-86-8
Cat. No.: HY-163286
CAS No.: 2738333-02-1
Cat. No.: HY-D3421
CAS No.: 3083251-08-2
Target:
Research Areas:
DiOC14 (3) (hydroxyethanesulfonate) is a water-soluble lipophilic carbocyanine green fluorescent membrane dye used as a fluorescent probe for living cell membranes and lipid bilayers. DiOC14 (3) (hydroxyethanesulfonate) acts as a lipophilic tracer that integrates into cell membranes, with its fluorescence generated upon membrane integration independent of enzymatic hydrolysis, pH, or membrane potential. The Ex/Em of DiOC14 (3) (hydroxyethanesulfonate) is 477/525 nm.
Cat. No.: HY-D3424
Target:
Research Areas:
AM3-25 is a lipophilic styrene fluorescent dye commonly used as a fixable probe for nerve endings and cell membranes. AM3‑25 bears an amino group at its hydrophilic end, enabling it to cross‑link with proteins during formaldehyde or glutaraldehyde fixation and thereby immobilizing the stained label.
Cat. No.: HY-D3007
Cat. No.: HY-134096
CAS No.: 78323-98-5
Synonyms: DNS-M
Target:
Research Areas:
Dansyl-morpholine (DNS-M) is a Fluorescent probe for lipid droplet imaging, cancer cell discrimination, and real-time tracking of lipid droplet dynamics. As a solvatochromic probe with a donor-π-acceptor structure, it relies on hydrophobic interaction for its mechanism of action: its good lipophilicity, confirmed by an oil-water partition coefficient LogP = 2.35, allows it to rapidly penetrate cell membranes, and it specifically localizes to the hydrophobic core of lipid droplets; its fluorescence is strongly enhanced in the nonpolar environment of lipid droplets, while it emits very weak fluorescence in polar environments like PBS buffer, and it exhibits a bathochromic shift in emission wavelength with increasing solvent polarity. It has negligible cytotoxicity, with cell viability remaining over 95% after 24-hour incubation with 100 μM of the probe, and it possesses excellent photostability, retaining over 97% of initial fluorescence intensity after 60 continuous laser scans. For cell imaging applications, its excitation/emission wavelengths for lipid droplet labeling are Ex/Em = 405/480−540 nm, and in a simulative lipid environment O/W emulsion, it has an excitation wavelength of ~346 nm and emission wavelength of ~500 nm, giving a Stokes shift of 154 nm[1].
Cat. No.: HY-W783351
CAS No.: 1416808-87-1
Synonyms: Coppersensor 790 acetoxymethyl ester
Target:
Research Areas:
CS790AM (Coppersensor 790 acetoxymethyl ester) is a cell-permeable, Cu +-targeted near-infrared fluorescent probe (λabs=760 nm, λem=790 nm) applicable to live cells. CS790AM can cross lipophilic cell membranes, and is converted into negatively charged CS790 under the action of intracellular esterases to be retained, thus enabling highly sensitive, reversible "turn-on" detection of labile Cu + pools in live cells and mice. CS790AM possesses excellent biocompatibility and selectivity, avoids interference from other metal ions, shows no obvious toxicity, and can be rapidly cleared. CS790AM allows long-term longitudinal monitoring of individual mice, visualizes copper levels in internal organs and isolated livers, and effectively evaluates abnormal copper accumulation in Wilson's disease models (Atp7b -/-) as well as dynamic changes after chelator treatment. CS790AM can be used for research on Wilson's disease and related copper metabolic disorders .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
