2016806-55-4
Chemical Structure
AZ13711265
- CAS No.: 2016806-55-4
- Formula:C28H35FN6O3S
- Molecular Weight:554.68
IUPAC Name: (5-((2-((3-(ethylsulfonyl)-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)amino)-5-fluoropyrimidin-4-yl)(methyl)amino)-2,4-dimethylphenyl)methanol
InChIKey: PNRMHHJAFUYMEV-VXKWHMMOSA-N
SMILES: OCC1=CC(N(C2=NC(NC3=CC=C(N4[C@](C5)([H])CN(C)[C@]5([H])C4)C(S(=O)(CC)=O)=C3)=NC=C2F)C)=C(C)C=C1C
Biological Activity: AZ13711265 is an orally active PAK1 inhibitor with high selectivity. AZ13711265 has IC50 values of 0.58 nM and 0.11 µM for PAK1 and pPAK1, respectively. AZ13711265 has low lipophilicity and low clearance, and can be used as an in vivo probe compound for PAK1. AZ13711265 can be used in the study of cancer[1].
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AZ13711265 | AZ13711265 is an orally active PAK1 inhibitor with high selectivity. AZ13711265 has IC50 values of 0.58 nM and 0.11 µM for PAK1 and pPAK1, respectively. AZ13711265 has low lipophilicity and low clearance, and can be used as an in vivo probe compound for PAK1. AZ13711265 can be used in the study of cancer. | |||||||||||||||||||||
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Keywords
