10 Results for "

mamba

" in MedChemExpress (MCE) Product Catalog:
Products (10)

10 Results for "mamba" in MCE Product Catalog:

Cat. No.: HY-P10816
CAS No.: 1426656-94-1
Synonyms: Ac-(DLeu)LLLRVK-Amba
Target:  

Bacterial

Research Areas:  

Infection Cancer

PACE4 Inhibitory peptide C23 (Compound C23; Ac-(DLeu)LLLRVK-Amba)), a potent peptidomimetic inhibitor, is a PACE4 inhibitor. PACE4 Inhibitory peptide C23e shows antiproliferative effects against PCa cell lines (Ki = 5 nM; IC50 = 25 and 40 μM for DU145 and LNCaP, respectively). PACE4 Inhibitory peptide C23 also blocks tumor growth in vivo in LNCaP xenograft-bearing mice .
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Cat. No.: HY-P3269
CAS No.: 178805-91-9
Target:  

Calcium Channel

Research Areas:  

Cardiovascular Disease

Calciseptine is a natural polypeptide toxin found in the venom of the black mamba snake (Dendroaspis p. polylepis). Calciseptine is a highly effective and selective blocker of the L-type channel of the Cav1.2 subtype, with an IC50 value of 92 nM. Calciseptine has no effect on Cav3.1, Cav2.2, Cav2.1, Cav1.1, voltage-sensitive sodium channels and potassium channels. Calciseptine exhibits negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine can be used for research on cardiovascular diseases[1].
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Cat. No.: HY-P1441
CAS No.: 1609937-15-6
Target:  

Sodium Channel

Research Areas:  

Others

Mambalgin-1 is a toxin isolated from black mamba venom. Mambalgin-1 is a disulfide-rich polypeptide consisting of 57 amino acids and belongs to the family of three-finger toxins. Mambalgin-1 can bind to and stabilize ASICs (acid-sensing ion channels) in a physiologically relevant closed-channel conformation .
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Cat. No.: HY-P3065
CAS No.: 178036-64-1
Category:  

Natural Products Animals

Target:  

Calcium Channel

Calcicludine is a protein toxin from the venom of the green mamba that inhibits high-voltage-activated calcium channel, especially L-type calcium channel .
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Cat. No.: HY-P5835
CAS No.: 189201-23-8
Target:  

Potassium Channel

Research Areas:  

Neurological Disease

δ-Dendrotoxin is a K + channel blocker that can be obtained from the venom of the black mamba snake. δ-Dendrotoxin can be used in the study of neurological diseases .
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Cat. No.: HY-P5863
Synonyms: Mamb-2
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Mambalgin-2 (Mamb-2) is an acid-sensitive ion channels (ASICs) inhibitor and a venom peptide. Mambalgin-2 can be obtained from the venom of the African black mamba. Mambalgin-2 can be used in the study of pain and neurological diseases .
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Cat. No.: HY-P5798
Synonyms: FAS-I
Target:  

Cholinesterase (ChE)

Research Areas:  

Neurological Disease

Fasciculin-I is isolated from the mambas venom. Fasciculin-I exerts its toxic effects by inhibiting acetylcholinesterase (AChE). Fasciculin-I blocks α-neurotoxins of nicotinic acetylcholine receptors and cardiac toxins that interact with cell membranes .
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Cat. No.: HY-P705701
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Toxin MIT1; MIT 1; Black mamba intestinal toxin 1; Black mamba venom protein A
Species:  
Source:  
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Cat. No.: HY-P3269A
Target:  

Calcium Channel

Research Areas:  

Cardiovascular Disease

Calciseptine TFA, a polypeptide found in black mamba venom, is a selcetive Cav1.2 L-type calcium channel inhibitor with an IC50 of 92 nM. Calciseptine TFA binds to the pore domain shoulder at repeats III and IV of Cav1.2, stabilizing an inactivated conformation. Calciseptine TFA exhibits negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine TFA can be used for the research of cardiovascular diseases .
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Cat. No.: HY-P71906
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Black mamba toxin related protein; EG VEGF; EG-VEGF; EGVEGF; Endocrine-gland-derived vascular endothelial growth factor; mambakine; PK1; PRK1; PROK1; PROK1_HUMAN; Prokineticin 1; Prokineticin-1
Species:  
Source:  
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