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Results for "

microtubule assembly

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Microtubule/Tubulin (40) ADC Payload (1) Akt (1) Amyloid-β (2) Antibody-Drug Conjugates (ADCs) (2) Apoptosis (11) Autophagy (5) Bacterial (1) Bcr-Abl (2) Checkpoint Kinase (Chk) (2) Drug Derivative (1) Endogenous Metabolite (1) Fungal (2) HIF/HIF Prolyl-Hydroxylase (1) HIV Protease (1) Isotope-Labeled Compounds (1) Kinesin (2) Mitosis (4) mTOR (1) Parasite (3) Polo-like Kinase (PLK) (2) Prolyl Endopeptidase (PREP) (1) Reference Standards (5) SphK (1) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (41) Infection (5) Metabolic Disease (1) Neurological Disease (4)

By Targets:

Microtubule/Tubulin (40)

ADC Payload (1)

Akt (1)

Amyloid-β (2)

Antibody-Drug Conjugates (ADCs) (2)

Apoptosis (11)

Autophagy (5)

Bacterial (1)

Bcr-Abl (2)

Checkpoint Kinase (Chk) (2)

Drug Derivative (1)

Endogenous Metabolite (1)

Fungal (2)

HIF/HIF Prolyl-Hydroxylase (1)

HIV Protease (1)

Isotope-Labeled Compounds (1)

Kinesin (2)

Mitosis (4)

mTOR (1)

Parasite (3)

Polo-like Kinase (PLK) (2)

Prolyl Endopeptidase (PREP) (1)

Reference Standards (5)

SphK (1)

Transmembrane Glycoprotein (1)

By Research Areas:

Cancer (41)

Infection (5)

Metabolic Disease (1)

Neurological Disease (4)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Microtubule/Tubulin Microtubule‐associated serine/threonine kinase (MAST) MARK MASTL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13520

Nocodazole Maximum Cited Publications 119 Publications Verification Oncodazole; R17934	Bcr-Abl Autophagy Microtubule/Tubulin Apoptosis Mitosis	Cancer
Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of *microtubule. Nocodazole binds to β-tubulin and disrupts microtubule* assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.

HY-15552

Podofilox 5+ Cited Publications Podophyllotoxin	Microtubule/Tubulin	Cancer
Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-115364

Parbendazole 5+ Cited Publications SKF 29044	Microtubule/Tubulin Parasite	Infection
Parbendazole is a potent inhibitor of *microtubule* assembly, destabilizes tubulin, with an EC₅₀ of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

HY-P4808

PHF6	Amyloid-β Autophagy	Neurological Disease
PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein .

HY-17435

4'-Demethylepipodophyllotoxin 2 Publications Verification 4'-O-demethylepipodophyllotoxin; 4'-DMEP	Microtubule/Tubulin	Cancer
4'-Demethylepipodophyllotoxin (4'-DMEP) is an intermediate compound that inhibits microtubule assembly.

HY-148870

Maytansinoid B	ADC Payload	Cancer
Maytansinoid B is a kind of ADC Cytotoxin. Maytansinoid B can be used to conjugates with antibodies to form antibody-drug conjugates (ADCs). Maytansinoids are known as antimitotic agents, binding to tubulin and inhibiting microtubule assembly. Maytansinoids induces G2/M arrest in the cell cycle to induce apoptosis .

HY-106008

Avanbulin BAL27862	Microtubule/Tubulin	Cancer
Avanbulin (BAL27862) is a potent, Colchicine site-binding, tubulin assembly inhibitor. Avanbulin inhibits tubulin assembly at 37 °C with an IC₅₀ of 1.4 μM. Avanbulin binds to tubulin with an apparent K_d value of 244 nM. Avanbulin can be used for the research of cancer and cell division .

HY-119357

TN-16	Microtubule/Tubulin Apoptosis Autophagy	Neurological Disease Cancer
TN-16 is a Microtubule polymerization inhibitor. TN-16 induces G₂/M cell cycle arrest, metaphase mitotic arrest and Apoptotic cell death in cells, and blocks late Autophagic flux by inhibiting autophagosome-lysosome fusion. TN-16 suppresses tumor growth in syngeneic mouse breast cancer models. TN-16 can be used in research related to neuroblastoma, cervical cancer, breast cancer and other tumors .

HY-N6773

Cytochalasin A	HIV Protease Fungal	Infection
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC₅₀=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .

HY-144894

AM-5308	Kinesin Microtubule/Tubulin	Cancer
AM-5308 is the inhibitor for KIF18A (IC₅₀=47 nM) that inhibits KIF18A-mediated microtubule ATPase activity. AM-5308 activates mitotic checkpoints, regulates cell division processes, including chromosome segregation and spindle assembly. AM-5308 exhibits antitumor activity .

HY-P4808A

PHF6 TFA	Amyloid-β Autophagy	Neurological Disease
PHF6 (VQIVYK) TFA is a self-assembly sequence capable of initiating the full-length tau protein aggregation. PHF6 TFA is mapped to the third microtubule-binding repeat region of the tau protein .

HY-132260

Naratuximab emtansine IMGN529; Debio 1562	Antibody-Drug Conjugates (ADCs) Apoptosis	Cancer
Naratuximab emtansine (IMGN529) is a CD37-targeted ADC consisting of a humanized IgG1 mAb coupled to the microtubule disruptor DM1. Naratuximab emtansine has high affinity and specificity for CD37, allowing ADC internalization, processing and intracellular release of DM1. Due to its ability to disrupt microtubule assembly, DM1 can subsequently induce cell cycle arrest and apoptosis .

HY-162143

SKI-349	SphK Akt mTOR	Cancer
SKI-349 is a dual-targeted inhibitor of sphingosine kinase 1/2 (SPHK1/2) and microtubule assembly (MDA). SKI-349 has anticancer activity. SKI-349 can inhibit the vitality, invasion, and AKT/mTOR signaling pathway of liver cells .

HY-16191

ELR510444 1 Publications Verification	Microtubule/Tubulin Apoptosis HIF/HIF Prolyl-Hydroxylase Mitosis	Cancer
ELR510444 is an orally active tubulin inhibitor with an IC₅₀ of 10 μM. ELR510444 binds to the colchicine-binding site on β-tubulin, inhibits tubulin assembly, depolymerizes microtubules and blocks HIF activity. ELR510444 induces cellular microtubule loss, abnormal mitotic spindle, mitotic arrest, apoptosis, morphological changes in tumor endothelial cells, and inhibits cancer cell proliferation, angiogenesis and tumor growth. ELR510444 can be used in research related to various cancers such as renal cell carcinoma .

HY-125374

Larotaxel XRP9881	Apoptosis	Cancer
Larotaxel (XRP9881) is a taxane analogue with preclinical activity against taxane-resistant breast cancer. Larotaxel (XRP9881) exerts its cytotoxic effect by promoting tubulin assembly and stabilizing microtubules, ultimately leading to cell death by apoptosis. It presents the ability to cross the blood brain barrier and has a much lower affinity for P-glycoprotein 1 than Docetaxel .

HY-19916

Lisavanbulin BAL-101553	Microtubule/Tubulin Checkpoint Kinase (Chk)	Cancer
Lisavanbulin (BAL-101553) is the prodrug of the microtubule targeting agent Avanbulin (BAL 27862) (HY-106008). Lisavanbulin is a BBB-penetrant and orally active antitumor agent, especially in tumors that express high levels of end-binding protein 1. Lisavanbulin has ability to target tumor cell proliferation and affects the tumor microenvironment by reducing tumor microvasculature. Lisavanbulin is also a *spindle assembly* checkpoint** activator. Lisavanbulin induces cell cycle arrest and subsequent death or aberrant chromosome segregation. Lisavanbulin can be studied in research for diffuse large B cell lymphoma (DLBCL) and glioblastoma .

HY-153384

EAPB 02303	Apoptosis Microtubule/Tubulin Mitosis	Cancer
EAPB 02303 is a *microtubule*-disrupting agent and inhibitor. EAPB 02303 induces mitosis arrest and impairment of spindle assembly. Thus, EAPB 02303 induces apoptosis and exhibits antitumor activity. EAPB 02303 also exhibits a potent synergy with Paclitaxel (HY-B0015) at lower concentrations .

HY-14934

Rosabulin STA 5312	Microtubule/Tubulin	Cancer
Rosabulin (STA 5312) is a potent and orally active *microtubule* inhibitor that inhibits microtubule assembly. Rosabulin has broad-spectrum anti-tumor activity .

HY-19916A

Lisavanbulin dihydrochloride BAL-101553 dihydrochloride	Microtubule/Tubulin Checkpoint Kinase (Chk)	Cancer
Lisavanbulin (BAL-101553) dihydrochloride is the prodrug of the microtubule targeting agent Avanbulin (BAL 27862) (HY-106008). Lisavanbulin dihydrochloride exhibits antitumor activity, especially in tumors that express high levels of end-binding protein 1. Lisavanbulin dihydrochloride has ability to target tumor cell proliferation and affects the tumor microenvironment by reducing tumor microvasculature. Lisavanbulin dihydrochloride is also a *spindle assembly* checkpoint** activator. Lisavanbulin dihydrochloride induces cell cycle arrest and subsequent death or aberrant chromosome segregation. Lisavanbulin dihydrochloride can be studied in research for diffuse large B cell lymphoma (DLBCL) and glioblastoma .

HY-120921

Zoxamide RH-7281	Fungal Microtubule/Tubulin	Infection
Zoxamide (RH-7281) is an oomycete Fungicide and covalent β-tubulin inhibitor. RH-7281 inhibits the assembly of tubulin into microtubules in vitro. Zoxamide binds covalently to β-tubulin, disrupting microtubule assembly and the cytoskeleton. Zoxamide blocks nuclear division in germinated hyphae of Phytophthora capsici and inhibits hyphal growth of Phytophthora capsici .

HY-163737

ST-401	Microtubule/Tubulin	Cancer
ST-401, a microtubule-targeting agent (MTA), is a brain-penetrant **microtubule (MT) assembly** inhibitor. ST-401 disrupts microtubule (MT) function through gentle and reverisible reduction in MT assembly that triggers mitotic delay and cell death in interphase. ST-401 shows a potent antitumor activity .

HY-13520R

Nocodazole (Standard) Oncodazole (Standard); R17934 (Standard)	Bcr-Abl Autophagy Microtubule/Tubulin Apoptosis Mitosis Reference Standards	Cancer
Nocodazole (Standard) is the analytical standard of Nocodazole. This product is intended for research and analytical applications. Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.

HY-134274A

8-Br-GTP tetrasodium 8-Bromoguanosine-5'-triphosphate tetrasodium	Bacterial	Metabolic Disease
8-Br-GTP (tetrasodium) (8-Bromoguanosine-5'-triphosphate (tetrasodium)) is a derivative of the energy substrate – GTP, for protein synthesis and gluconeogenesis. 8-Br-GTP (tetrasodium) inhibits the E. coli GTPase FtsZ with a K_i of 31.8 μM. 8-Br-GTP (tetrasodium) promotes the assembly of porcine brain microtubules .

HY-130559

SL-3-19	Microtubule/Tubulin Apoptosis	Cancer
SL-3-19 is a tubulin ligand. SL-3-19 exhibits antitumor activity against esophageal squamous cell carcinoma (ESCC) both in vitro and in vivo by inhibiting microtubule assembly, inducing G2/M phase cell cycle arrest and apoptosis, and disrupting tumor blood vessels. SL-3-19 has a higher activity than SL-1-73 (HY-130558). SL-3-19 can be used for the research of ESCC and other tumors .

HY-101989

Tubulin polymerization-IN-24	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-24 (compound HMBA) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly .

HY-13760

Tasidotin hydrochloride ILX651	Microtubule/Tubulin	Cancer
Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15, as an inhibitor of microtubule assembly and microtubule dynamics.

HY-119692

Curvulin	Microtubule/Tubulin	Others
Curvulin is a phytotoxin . Curvularin inhibits *microtubule* assembly and inhibits iNOS expression.

HY-15552S

Podofilox-d6	Microtubule/Tubulin	Cancer
Podofilox-d₆ is the deuterium labeled Podofilox. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II .

HY-15552R

Podofilox (Standard) Podophyllotoxin (Standard)	Reference Standards Microtubule/Tubulin	Cancer
Podofilox (Standard) is the analytical standard of Podofilox. This product is intended for research and analytical applications. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

HY-115364S

Parbendazole-d3 SKF 2904-d₃	Isotope-Labeled Compounds Microtubule/Tubulin Parasite	Infection
Parbendazole-d₃ is the deuterium labeled Parbendazole. Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

HY-115364R

Parbendazole (Standard) SKF 29044 (Standard)	Reference Standards Microtubule/Tubulin Parasite	Infection
Parbendazole (Standard) is the analytical standard of Parbendazole. This product is intended for research and analytical applications. Parbendazole is a potent inhibitor of *microtubule* assembly, destabilizes tubulin, with an EC₅₀ of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

HY-124519

Centmitor-1 Cent-1	Microtubule/Tubulin	Cancer
Centmitor-1 (Cent-1) is a mitotic arrest inducer. Centmitor-1 modulates *microtubule* plus-ends and reduced microtubule dynamics. In cells, Centmitor-1 causes mitotic arrest characterized by chromosome alignment defects, multipolar spindles, centrosome fragmentation, and activated spindle assembly checkpoint .

HY-17435R

4'-Demethylepipodophyllotoxin (Standard) 4'-O-demethylepipodophyllotoxin (Standard); 4'-DMEP (Standard)	Reference Standards Microtubule/Tubulin	Cancer
4'-Demethylepipodophyllotoxin (Standard) is the analytical standard of 4'-Demethylepipodophyllotoxin. This product is intended for research and analytical applications. 4'-Demethylepipodophyllotoxin (4'-DMEP) is an intermediate compound that inhibits microtubule assembly.

HY-133207

Myoseverin B	Microtubule/Tubulin	Cancer
Myoseverin B is a microtubule assembly inhibitor capable of inhibiting the polymerization of tubulin (IC₅₀ = 2 μM) and exhibiting low cytotoxicity in most cell types. Myoseverin B can be used in research as an antitumor agent .

HY-14919

Denibulin MN-029 free base	Microtubule/Tubulin	Cancer
Denibulin, a novel vascular-disrupting agent, inhibits microtubule assembly reversibly, disrupting tumor vascular endothelial cell cytoskeletons. Denibulin demonstrated tolerability and potential anti-vascular effects, warranting further investigation in cancer therapy .

HY-13224A

AZD4877 hydrochloride	Endogenous Metabolite	Cancer
AZD4877 hydrochloride is a synthetic dynein inhibitor with potential anti-tumor activity. AZD4877 selectively inhibits the microtubule dynein KSP (also known as kinesin-5 or Eg5), which may lead to inhibition of mitotic spindle assembly. The action of AZD4877 may activate the spindle assembly checkpoint, leading to cell cycle arrest at the mitotic stage. AZD4877 may induce cell death in actively dividing tumor cells. AZD4877 may be less likely to cause peripheral neuropathy associated with microtubule-targeted compounds as it is not involved in post-mitotic processes. AZD4877 is essential for the formation of bipolar spindles and the proper segregation of sister chromosomes .

HY-121634

DAP-81	Polo-like Kinase (PLK)	Others
DAP-81 is an inhibitory agent targeting Polo-like kinases (Plks), a class of evolutionarily conserved serine/threonine kinases. DAP-81 dose-dependently increases the number of monopolar spindles in treated cells. High-resolution live-cell microscopy revealed that Plk activity is required for the assembly and maintenance of bipolar mitotic spindles. Plk inhibition destabilizes centromeric microtubules while stabilizing other spindle microtubules, leading to the formation of monopolar spindles. Further testing of compounds based on "privileged scaffolds" such as the DAP scaffold may lead to the discovery of new cell division probes and anti-microtubule agents.

HY-144793

Deac-SS-Biotin	Microtubule/Tubulin	Cancer
Deac-SS-Biotin is a potent antitumor agent with improved tumor targeting effects and reduced off-target toxicities. Deac-SS-Biotin uptakes into the cells through biotin-mediated internalization. Deac-SS-Biotin combined with DTT (Glutathione mimetic) can effectively inhibit microtubule assembly and displays greater antitumor activity .

HY-121490

IMM-02	Apoptosis	Cancer
IMM-02 is a DID-DAD binding inhibitor with activity promoting actin assembly and microtubule stabilization. IMM-02 is able to trigger serum response factor-mediated gene expression and lead to cell cycle arrest and apoptosis. IMM-02 has shown the ability to slow tumor growth in a mouse colon cancer xenograft model .

HY-145827

KIF18A-IN-4	Kinesin Microtubule/Tubulin	Cancer
KIF18A-IN-4 is a moderately potent ATP and *microtubule* (MT) noncompetitive KIF18A inhibitor (IC₅₀=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity .

HY-185269

2'-Deoxy-PTX	Microtubule/Tubulin Drug Derivative	Cancer
2'-Deoxy-PTX is a Paclitaxel (HY-B0015) derivative and *microtubule* assembly inducer. 2'-Deoxy-PTX binds to GMPcPP-stabilized microtubules, with a Ka_app of 0.50 × 10 ⁶ M ^-1. 2′-Deoxy-PTX induces Tubulin to assemble into normal microtubules. 2'-Deoxy-PTX can be used for the research of prostate cancer .

HY-170864

BKS3031A	Microtubule/Tubulin	Neurological Disease Cancer
BKS3031A is the inhibitor for αβ-tubulin that binds to the colchicine binding site, and inhibits the microtubule assembly dynamics .

HY-106021

Tasidotin ILX651 free base	Microtubule/Tubulin Prolyl Endopeptidase (PREP)	Cancer
Tasidotin (ILX651 free base) is a tubulin inhibitor and competitive Prolyl Endopeptidase (PREP) inhibitor, with an IC₅₀ of 10 μM against bovine tubulin. Tasidotin exhibits high cerebrospinal fluid penetration in non-human primates. Tasidotin antagonizes microtubule assembly and induces an extended assembly lag phase, thereby inhibiting mitosis and cell proliferation, and exerts cytotoxic and oncolytic effects on cancer cells. Tasidotin is metabolized into polypeptides and proline inside cells, and its in vivo metabolism is mediated by prolyl endopeptidase. Tasidotin can be applied in research related to Burkitt's lymphoma, breast cancer, leukemia, melanoma, central nervous system malignancies and various solid tumors .

HY-182478

MDL-27048	Microtubule/Tubulin	Cancer
MDL-27048, a tubulin inhibitor, binds competitively, reversibly to the Colchicine (HY-16569)-binding site on tubulin heterodimers. MDL-27048 inhibits microtubule assembly, induces slow depolymerization of preassembled microtubules, disrupts microtubule polymerization-depolymerization dynamics, and disrupts cytoplasmic microtubule networks. MDL-27048 exerts growth inhibitory effects on human cancer cells, induces mitotic arrest, and does not disrupt actin filaments at microtubule-depolymerizing concentrations. MDL-27048 can be used for the research of malignant tumors .

HY-106008R

Avanbulin (Standard) BAL27862 (Standard)	Reference Standards Microtubule/Tubulin	Cancer
Avanbulin (Standard) is the analytical standard of Avanbulin (HY-106008). This product is intended for research and analytical applications. Avanbulin (BAL27862) is a potent, Colchicine site-binding, tubulin assembly inhibitor. Avanbulin inhibits tubulin assembly at 37 °C with an IC₅₀ of 1.4 μM. Avanbulin binds to tubulin with an apparent K_d value of 244 nM. Avanbulin can be used for the research of cancer and cell division .

HY-117759

Deacetoxyvinzolidine KAR-2	Microtubule/Tubulin	Cancer
Deacetoxyvinzolidine (KAR-2) is a bis-indol derivative with high anti-microtubular and anti-tumour activities. Deacetoxyvinzolidine exhibits high affinity for bovine purified brain tubulin (K_d of 3 μM) and inhibits microtubule assembly at a concentration of 10 nM. Deacetoxyvinzolidine does not possess anti-calmodulin activity. Deacetoxyvinzolidine can be used for the study of leukaemia .

HY-W072781

N-Deacetylthiocolchicine	Microtubule/Tubulin	Cancer
N-Deacetylthiocolchicine is a tubulin inhibitor with an IC₅₀ value of 2.2 nM in MDR-negative MDA-MB 231 breast cancer cells. N-Deacetylthiocolchicine exerts antiproliferative activity by binding to tubulin to interfere with microtubule assembly, arresting cells in mitosis during the cell cycle. N-Deacetylthiocolchicine is promising for research of malignancies such as breast cancer .

HY-130558

SL-1-73	Apoptosis Microtubule/Tubulin	Cancer
SL-1-73 is a tubulin ligand. SL-1-73 exhibits antitumor activity against esophageal squamous cell carcinoma (ESCC) both in vitro and in vivo by inhibiting microtubule assembly, inducing G2/M phase cell cycle arrest and apoptosis, and disrupting tumor blood vessels. SL-1-73 can be used for the research of ESCC and other tumors .

HY-N13795

3,4,3'-Tri-O-methylflavellagic acid	Polo-like Kinase (PLK) Microtubule/Tubulin	Cancer
3,4,3'-Tri-O-methylflavellagic acid is a flavonoid inhibitor that targets αβ-tubulin (colchicine binding site) and polo-like kinase-1 (PLK-1), and can be isolated from the roots of Anogeissus leiocarpus. 3,4,3'-Tri-O-methylflavellagic acid interferes with microtubule assembly dynamics and kinase activity, exhibiting anti-cancer cell proliferation and potent anti-nociceptive effects .

HY-Z9022

Iso cephalomannine	Microtubule/Tubulin	Cancer
Iso cephalomannine is a tubulin-targeting cytotoxic agent. Iso cephalomannine induces cytotoxicity in breast cancer cells. Iso cephalomannine can be used in breast cancer-related research .

Cat. No.	Product Name	Target	Research Area