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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
mouse SARS-CoV-2 infection model
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "mouse SARS-CoV-2 infection model" in MCE Product Catalog:
1
Cat. No.: HY-W722277A
Target:
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LCC-12 formate is a mitochondria-targeted Copper 2+ -selective binder and metabolic/epigenetic reprogramming agent. LCC-12 formate inhibits NAD (H) redox cycling and reduces the NAD (H) pool. LCC-12 formate downregulates the expression of inflammatory genes and improves outcomes in mouse models of bacterial sepsis, endotoxemia, and SARS-CoV-2 infection. LCC-12 formate can be used in research related to acute inflammation, endotoxemia, sepsis, and SARS-CoV-2 infection .
Cat. No.: HY-177332
CAS No.: 1783825-18-2
Target:
SLC-391 is an orally active AXL kinase inhibitor with an IC50 of 9.6 nM against AXL kinase. SLC-391 inhibits Gas6-induced AXL-dependent phosphorylation of Akt. SLC-391 inhibits SARS-CoV-2 infection, entry and replication in cells. SLC-391 suppresses cancer cell proliferation. SLC-391 inhibits tumor growth in mouse solid tumor xenograft models. SLC-391 can be used for the research of COVID-19, influenza virus infection, triple-negative breast cancer, chronic myeloid leukemia and non-small cell lung cancer .
Cat. No.: HY-157778
CAS No.: 2952554-69-5
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MK-7845 is an orally active and selective SARS-CoV-2 3CL protease (M pro) inhibitor with an IC50 of 8.7 nM. MK-7845 forms a reversible covalent adduct with the catalytic cysteine, interacting with histidine through its difluorobutyl P1 group. MK-7845 exhibits antiviral activity against the WA1/2020 wild-type, Delta, and Omicron strains. MK-7845 demonstrates in vivo efficacy in a mouse SARS-CoV-2 infection model, reducing lung viral load and preventing body weight loss. MK-7845 can be used for research related to SARS-CoV-2 viral infection .
Cat. No.: HY-172350
Research Areas:
WEHI-P8 is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor with an IC50 of 12 nM and a Kd of 9.0 nM. WEHI-P8 reduces viral load, body weight loss, pulmonary inflammation, immune cell infiltration and pro-inflammatory mediator levels in SARS-CoV-2-infected mice. WEHI-P8 prevents pulmonary hemorrhage, immune cell infiltration, fibrotic remodeling and neuroinflammation, and improves cognitive function in a mouse model of post-acute sequelae of SARS-CoV-2 infection (PASC). WEHI-P8 is applicable for the research of COVID-19 and PASC .
Cat. No.: HY-173148
CAS No.: 2892688-18-3
TKB272 is an orally active and selective antiviral agent targeting the main protease (Mpro) of SARS-CoV-2. It effectively blocks the infection and replication of various SARS-CoV-2 strains, including Omicron variants such as XBB.1.5 and EG.5.1. The enzymatic inhibitory activity of TKB272 shows an IC50 of 0.7 µM (against SARS-CoV-2WK-521 Mpro), and its antiviral activity at the cellular level reaches an EC50 as low as 2.6 nM (against BQ.1.1 strain in HeLahACE2-TMPRSS2 cells), with a cytotoxicity CC50 of 98 µM, indicating no apparent toxicity. In addition, TKB272 significantly suppresses the replication of SARS-CoV-2XBB.1.5 in B6.Cg-Tg(K18-hACE2)2-Prlmn/J transgenic mouse models. TKB272 holds promise for research in the field of SARS-CoV-2 infection .
Cat. No.: HY-180318
CAS No.: 2698348-97-7
MI-30 is an orally active SARS-CoV-2 3CLpro inhibitor (IC50 = 17.2 nM). MI-30 reduces viral load and lung lesions in a mouse model of SARS-CoV-2 infection. MI-30 may be used in coronavirus infection research .
Cat. No.: HY-181033
CAS No.: 3111610-68-2
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(M)-AVI-4773 is an orally active, blood-brain barrier permeable coronaviruses M Pro inhibitor with an IC50 of 2.5 nM aginst SARS-CoV-2 M Pro. (M)-AVI-4773 produces a rapid onset antiviral effect in mouse models of MERS-CoV and SARS-CoV-2 infection .
Cat. No.: HY-189669
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KP-S54 is an antiviral agent derived from GS-441524 (HY-103586) and also a SARS-CoV-2 Mac1 and MERS-CoV Mac1 inhibitor. KP-S54 blocks interferon-induced reversal of ADP-ribosylation, with an IC50 value of 44 nM against SARS-CoV-2 and an IC50 value of 91 nM against MERS-CoV. KP-S54 produced no detectable antiviral efficacy in a SARS-CoV-2-infected mouse model. KP-S54 can be used for research related to SARS-CoV and MERS-CoV infection .
Cat. No.: HY-170515A
CAS No.: 2231731-82-9
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(E),(Z)-RNF5 agonist 1 (Compound Analog-1) is a RNF5 agonist that can enhance the ubiquitination and degradation of SARS-CoV-2 E protein by RNF5. (E),(Z)-RNF5 agonist 1 effectively inhibits the replication of SARS-CoV-2 and significantly alleviates pulmonary pathological damage and systemic inflammatory response in mouse infection models. (E),(Z)-RNF5 agonist 1 has a strong cytotoxic effect on neuroblastoma and melanoma. (E),(Z)-RNF5 agonist 1 can be used for research on anti-cancer and anti-viral purposes .
Cat. No.: HY-P10466
CAS No.: 2377734-91-1
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Cat. No.: HY-P10466A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
