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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
82 Results for "
multidrug resistance protein
" in MedChemExpress (MCE) Product Catalog:
Products (82)
82 Results for "multidrug resistance protein" in MCE Product Catalog:
37
Research Areas:
MK-571 (L-660711) sodium is an orally active, potent and selective competitive leukotriene D4 (LTD4) receptor antagonist, with Ki values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). MK-571 sodium inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release .
32
32 Cited Publications
Synonyms: Peposertib; M3814
Nedisertib (Peposertib) is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity .
19
Target:
7
7 Cited Publications
Target:
Research Areas:
Y-320 is a potent, orally active phenylpyrazoleanilide immunomodulator. Y-320 inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Y-320 enhances TP53, DMD, and COL17A1 PTC readthrough by G418 and increases cellular protein levels and protein synthesis. Y-320 concomitants use of with a low dose of Paclitaxel (HY-B0015) significantly sensitized multidrug resistance (MDR) tumors by inducing G2/M phase arrest and apoptosis. Y-320 can be used for research of rheumatoid arthritis (RA) and cancer .
3
3 Cited Publications
Cat. No.: HY-P71140
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: S100A4; Fibroblast-Specific protein-1; Prev. CAPL; Murine Placental Homolog; Prev. MTS1; protein S100-A4; PEL98; Metastasin 1; P9KA; protein Mts1; 18A2; Calvasculin; FSP1; Leukemia multidrug resistance Associated protein; 42A; Malignant Transformation Sup
Species:
Human
Source:
E. coli
2
Target:
Research Areas:
Reversan (CBLC4H10) inhibits drug efflux mediated by P-glycoprotein (Pgp) and multidrug resistance protein 1 (MRP1), and exhibits oral activity. Reversan shows activity against glioblastoma multiforme and neuroblastoma models .
2
Target:
Research Areas:
Dofequidar (MS-209 free base) is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). Dofequidar has highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar competitively inhibits ABCB1/P-gp, ABCC1/MRP-1, blocks the efflux of chemotherapeutic agents, increases the drug concentration in cancer cells, and enhances the chemotherapeutic effect .
2
Target:
Research Areas:
Bifendate (DDB), extracted from Schisandrae chinensis, is an orally active anti-HBV agent against chronic hepatitis B. Bifendate inhibits ATG5-dependent autophagy and attenuates oleic acid-induced lipid accumulation with anti-oxidant properties in vitro. Bifendate can decrease alanine transaminase (ALT) level in mice. Bifendate attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Bifendate potently increases the activity of cytochrome proteins (CYPs) and reverse P-gp-mediated multi-drug resistance (MDR) .
2
Target:
Research Areas:
Sulfanitran is an antibacterial and anticoccidial agent used in poultry feeds. Sulfanitran also is a multidrug resistance protein 2 (MRP2) stimulator that can increase the affinity of MRP2 for estradiol-17-β-D-glucuronide (E217βG) .
2
Target:
Research Areas:
Dofequidar fumarate (MS-209) is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). Dofequidar fumarate has highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar fumarate competitively inhibits ABCB1/P-gp, ABCC1/MRP-1, blocks the efflux of chemotherapeutic agents, increases the drug concentration in cancer cells, and enhances the chemotherapeutic effect .
2
2
2 Cited Publications
Cat. No.: HY-P71084
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: S100A4; Fibroblast-Specific protein-1; Prev. CAPL; Murine Placental Homolog; Prev. MTS1; protein S100-A4; PEL98; Metastasin 1; P9KA; protein Mts1; 18A2; Calvasculin; FSP1; Leukemia multidrug resistance Associated protein; 42A; Malignant Transformation Sup
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P81118
Synonyms: ABC30 antibody;
abcC2 antibody;
ATP binding cassette sub family C (CFTR/MRP) member 2 antibody;
ATP binding cassette subfamily C member 2 antibody;
ATP-binding cassette sub-family C member 2 antibody;
Canalicular multidrug resistance protein antibody;
Canalicular multispecific organic anion transporter 1 antibody;
CMOAT antibody;
CMOAT1 antibody;
cMRP antibody;
DJS antibody;
KIAA1010 antibody;
MRP 2 antibody;
MRP2_HUMAN antibody;
multidrug resistance associated protein 2 antibody;
multidrug resistance-associated protein 2 antibody;
1
1 Cited Publications
Cat. No.: HY-P703175
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ABCB1; P-170; Prev. PGY1; ATP-Dependent Translocase ABCB1; Prev. MDR1; Phospholipid Transporter ABCB1; Prev. CLCS; Colchicin Sensitivity; multidrug resistance protein 1; ATP-Binding Cassette Sub-Family B Member 1; ATP-Binding Cassette, Sub-Family B (MDR/T
Species:
Human
Source:
HEK293
Category:
Alkaloids Leguminosae Other Diseases Plants Disease Research Fields Indigofera Indole Alkaloids
Target:
Cat. No.: HY-P2657
CAS No.: 138067-14-8
Research Areas:
YHO-13351 is an orally active ABCG2 inhibitor . YHO-13351 modulates the function of ABCG2, blocks BCRP-mediated compound efflux, downregulates the expression of breast cancer resistance protein at the post-transcriptional level, and reverses ABCG2-associated tolerance. YHO-13351 restores the toxicity of SN-38 to SN-38-resistant cancer cells and sensitizes cancer cells to Irinotecan. YHO-13351 is a water-soluble prodrug that is rapidly converted to YHO-13177 (HY-12757) in mice. YHO-13351 prolongs the median survival time of mice bearing cancer cell xenografts when combined with IMMU-132. YHO-13351 extends the survival time of tumor-bearing mice and inhibits the growth of xenograft tumors when combined with Irinotecan. YHO-13351 can be used for the research of breast cancer, gastric cancer, BCRP-mediated drug-resistant cancers, and cervical cancer .
Target:
Research Areas:
Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma .
Cat. No.: HY-P10856
CAS No.: 3085809-95-3
Target:
Research Areas:
Cat. No.: HY-N2416
CAS No.: 108885-68-3
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
